Vivoryon Therapeutics AG: Vivoryon Therapeutics Announces Update on Phase 2b Alzheimer's Clinical Trial, VIVIAD
DGAP-News: Vivoryon Therapeutics AG
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Vivoryon Therapeutics Announces Update on Phase 2b Alzheimer's Clinical Trial, VIVIAD
HALLE (SAALE)/MUNICH, Germany, 18 March 2020 - Vivoryon Therapeutics AG (Euronext Amsterdam: VVY, ISIN DE0007921835) announced today an update on the Phase 2b clinical trial testing the Company's lead candidate and first-in-class, highly specific and potent small molecule inhibitor of Glutaminyl cyclase, PQ912 in patients with early-stage Alzheimer's Disease.
The clinical trial named VIVIAD, derived from "advancing disease modifying treatment and non-invasive diagnostics of Alzheimer's disease," has been designed to test the efficacy and safety of various doses of PQ912 in 250 early-stage Alzheimer's patients in a randomized, placebo-controlled study over the course of 48 to 96 weeks. Prof. Dr. Scheltens, VU Amsterdam will act as coordinating investigator and VIVIAD intends to use a total of only 10 high-recruiting sites from Denmark, Germany and the Netherlands. The study is scheduled to enroll its first patient in Q2 2020 with the topline results expected towards the end of 2022.
The primary endpoints of the study are designed to assess the safety and tolerability of PQ912 in addition to its efficacy on working memory and attention. The secondary endpoints include long-term safety and tolerability of PQ912 and its efficacy on brain-activity, cognition and activities of daily living.
Vivoryon has also added exploratory parameters selected with the rationale of advancing less invasive diagnostic technologies. This will include the Winterlight Labs speech assessment, the use of EEG to test neuronal network activity and connectivity, as well as a set of blood-based biomarkers run by Nordic Bioscience. The inclusion of these parameters will further strengthen PQ912's data package and introduce more innovative and less demanding diagnostic tools to future patients.
Dr. Michael Schaeffer, CBO of Vivoryon Therapeutics commented:
About PQ912 in Alzheimer's Disease
About Vivoryon Therapeutics AG
Forward Looking Statements
18.03.2020 Dissemination of a Corporate News, transmitted by DGAP - a service of EQS Group AG.
|Company:||Vivoryon Therapeutics AG|
|Phone:||+49 (0)345 555 9900|
|Fax:||+49 (0)345 555 9901|
|Listed:||Regulated Unofficial Market in Berlin, Frankfurt, Munich, Stuttgart; Amsterdam|
|EQS News ID:||999459|
|End of News||DGAP News Service|