Interferon-lambda has potential to reduce transmission of COVID-19, says GlobalData
The spread of the COVID-19 can be slowed by the use of interferon-lambda, which has the ability to inhibit replication of COVID-19 in the lungs and gastrointestinal tracts. This reduced replication of the virus lessens the amount of viral shedding and can reduce the chances of viral transmission, says GlobalData a leading data analytics company.
Johanna Swanson, Product Manager at GlobalData, comments: “Interferon-lambda is a naturally occurring protein and promotes the innate immune system’s natural defenses against infection. This promotes an antiviral state and slows viral replication. Receptors for interferon-lambda are found in the linings of the lungs, liver, and intestines. These limited receptor locations are likely to result in fewer side effects, and interferon-lambda’s safety has been previously demonstrated by administration to over 3,000 hepatitis patients.
“This clinical trial of interferon-lambda is important to establish the absence of pro-inflammatory effects in the lungs of COVID-19 patients, as the triggering of immune cells by interferon could worsen lung inflammation. The efficacy or reducing viral spread must not be outweighed by a potential immune over reaction.
“Interferon-lambda must also be tested to ensure that it does not promote bacterial superinfections in COVID-19 patients, one of the side effects of interferons. These potential adverse events have not been seen in the administration to hepatitis patients, and could be lessened by a short duration of treatment in COVID-19 patients.”
4,000 of the world’s largest companies, including over 70% of FTSE 100 and 60% of Fortune 100 companies, make more timely and better business decisions thanks to GlobalData’s unique data, expert analysis and innovative solutions, all in one platform. GlobalData’s mission is to help our clients decode the future to be more successful and innovative across a range of industries, including the healthcare, consumer, retail, financial, technology and professional services sectors.