Cholestasis Treatment Market Analysis Size, Share, Statistics, Trends, Strategy, Segmentation Analysis, Competitor Landscape, Regional Study and Forecast to 2026
Global Cholestasis Treatment Market – Insights
Cholestasis is a state in which the flow of bile from the liver stops or slows. The condition is divided into two basic types: obstructive and metabolic. The duct system that carries the bile from the liver is blocked in obstructive type of cholestasis. The condition may occur due to gallstone or malignancy. The metabolic type is characterized by issues in the formation of bile in the liver. Genetic factors or side effects of some drugs may lead to metabolic cholestasis. Itchiness, jaundice, pale stool, and dark urine are some of the symptoms of cholestasis.
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Obstetric cholestasis is one of the major types of cholestasis. According to the Royal College of Obstetricians and Gynecologists, obstetric cholestasis affects 0.7% of pregnancies in the multiethnic populations in addition to 1.2–1.5% of pregnant women of Indian or Pakistani origin, in England. Genetic and environmental factors impact the epidemiology of obstetric cholestasis. For instance, 2.4% of all pregnancies are affected in Chile.
Cholestasis may have adverse impact on lipid metabolism. Disturbance of the bile from the liver to the gut can lead to accumulation of toxic bile constituents in hepatocytes. This in turn my affect synthetic functionality and lead to low production of enzymes concerned in the lipoprotein metabolism. Decreasing HDL levels and rise of abnormal lipoprotein X in the plasma can disturb lipoprotein discharge at some stage in cholestasis. Therefore, association of cholestasis with several diseases is expected to promote development of efficient diagnostic tests, which is expected to boost growth of the global cholestasis treatment market.
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Global Cholestasis Treatment Market Taxonomy
On the basis of drug class, the global cholestasis treatment market is classified into:
- Bile Acids
- Vitamin Supplementation
Global Cholestasis Treatment Market: Drivers
High incidence of obstetric cholestasis is expected to boost growth of the global cholestasis treatment market. For instance, according to a report published in National Center for Biotechnology Information (NCBI), intrahepatic cholestasis of pregnancy (ICP) or obstetric cholestasis is the major liver disease during pregnancy. This reversible disease occurs in the second to third trimester with symptoms such as pruritus (severe itching of the skin) mainly in the palms and soles, serum aminotransferases, and high serum bile acid levels. Therefore, increasing number of pregnancies is also expected to boost growth of the market.
Cholestasis is hereditary condition, which has led to a substantial prevalence of the condition in children. According to NCBI, hereditary disorders of biliary atresia and intrahepatic cholestasis are the major causes of chronic liver disease amongst children. Such scenario is also expected to contribute to growth of the market during the forecast period. Increasing R&D related to cholestasis is also expected to boost the market growth. For instance, a study presented by the Icahn School of Medicine at Mount Sinai, New York at Digestive Disease Week 2019 in San Diego identified a link between intrahepatic cholestasis of pregnancy and nonalcoholic fatty liver disease.
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Global Cholestasis Treatment Market: Restraints
However, failure of therapies in the treatment of cholestasis is expected to hamper growth of the global cholestasis treatment market. For instance, in August 2019, a study by King’s College London published in The Lancet found that treatment with ursodeoxycholic acid does not reduce adverse perinatal outcomes in women suffering from intrahepatic cholestasis of pregnancy.
Global Cholestasis Treatment Market: Competitive Landscape
Major players operating in the global cholestasis treatment market include, Palmetto Health, Eli Lily and Company, Asklepion Pharmaceuticals, LLC, and Abbott Laboratories.
Major players operating in the market are focused on conducting clinical trials to expand their product portfolio. For instance, in July 2019, Genkyotex, a biopharmaceutical company, announced positive post-hoc analysis of phase 2 trial that assessed the use of Setanaxib, a NOX-1/4 enzyme inhibitor, for the treatment of cholestatic liver disease.
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