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Profacgen Provides Comprehensive Solutions for PEGylation

Profacgen, with years of experience in bioconjugation services, now provides a full spectrum of quality solutions from single reagents to comprehensive PEGylation service to meet different needs.


The introduction of polyethylene glycol (PEG) into biomolecules and drugs enhances the stability and pharmacological properties of proteins, peptides, antibody-drug conjugates, and small molecule drugs. As a synthetic polymer with high hydrophilicity, PEG is widely used to prolong the circulation time of proteins, increase the water solubility of therapeutic molecules as well as reduce the immunogenicity of biological drugs. To date, PEGylation has been used successfully in 12 commercially available drugs. The earliest PEGylation technology for protein modification has recently been transferred to small molecule drugs, which has triggered a new wave of research boom in the pharmaceutical industry.


The binding of PEG has been shown to be a powerful tool for dissolving biomolecules, reducing the immunogenicity of ADCs, and increasing the stability of drug circulation. It is also widely used in materials science, cosmetics science and other industrial applications. Profacgen provides a comprehensive set of PEGylation services for proteins, peptides, oligonucleotides and small molecules, and custom synthesis of PEG derivatives.


In addition, Profacgen offers a large selection of functionalized PEG products with high purity to fit the diverse needs of its customers. Its current mono-functional PEG products, including amine-reactive PEGs, carboxyl-reactive PEGs and thiol-reactive PEGs, utilize simple but reliable chemistry to deliver highly efficient PEGylation of its customers’ target proteins. When PEGylation and crosslinking are needed at the same time, customers can easily choose one of Profacgen’s homo/hetero-bifunctional PEGs.


“Besides our diversified product line, we also accept specific requests from you. We deliver custom synthesis of innovative PEGylation reagents and derivatives to meet the unique requirements of your projects. We are always ready for help.” Commeted Crystal, the chief marketing staff at Profacgen.


More detailed information about the PEGylation products and services at Profacgen can be viewed here:


About Profacgen

Profacgen provides process development and cGMP manufacturing services for biological active ingredients. We have ready access to state-of-the-art biopharmaceutical product development and manufacturing facilities and our staff scientists have demonstrable expertise in all aspects of biopharmaceutical manufacturing, from facility design and operation to the ability to provide best advice relating to product development.

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Last Updated: 24-Nov-2020