Anti-body Coupled T Receptor Therapy Market Size, Industry Share, Latest Trend by Top 10 Leading Players by Forecast 2023 | Exclusive Reportage by Coherent Market Insights
Anti-body coupled T receptor (ACTR) therapy is a type of immunotherapy, used for cancer treatment, in which body’s own immune response is used to kill the cancerous cells. Anti-body coupled T receptor therapy uses T cells from body, engineered it to express specific T cell receptor, multiplying it in lab and then administering it along with targeting antibodies. The major advantage of this therapy is that T cells do not attack normal antigens from blood circulation. However, they do attack antigens attached to cancerous cells. As tumor specific monoclonal antibodies are given together with ACTR T cells, this approach is very much possible. Moreover, it is a cost-efficient therapy, when compared to other cancer therapies. It is possible to have minimum side effects and greater therapeutic benefits, by adjusting the amount of targeting antibody.
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Global Anti-body Coupled T Receptor Therapy Market- Drivers
Increasing occurrence cancer around the globe is expected to drive growth of the global anti-body coupled T receptor therapy market. According to World Health Organization (WHO), cancer is one of the leading non-communicable disease and second leading cause of death globally. According to International Agency for Research on Cancer (IARC) in 2012, there were around 14.1 million new cases, 8.8 million deaths, and 32.6 million people living with cancer worldwide. Moreover, according Leukemia and Lymphoma Society report, 2017, the U.S. alone is expected to witness prevalence of 816,834 and 80,500 annual new cases of lymphoma. Thus, such high number of cancer patient would propel the global anti-body coupled T receptor therapy market.
Furthermore, ACTR therapy is better in its approach than other adoptive T cell transfer technologies such as CAR-T cell therapy. CAR-T therapy products such as Kymriah (Novartis AG) or Yescarta (Gilead Lifescience, Inc.) has side effects such as cytokine release syndrome and neurological toxicity. This is expected to drive adoption of ACTR therapy and thereby propelling growth of the global anti-body coupled T receptor therapy market in the near future. Moreover, CAR-T therapy finds applications in typical cancers such as non-Hodgkin lymphoma, acute lymphoblastic leukemia, and multiple myeloma. ACTR therapy is also used in solid tumorous cancer such as neuroblastoma and breast cancer.
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Global Anti-body Coupled T Receptor Therapy Market- Restraints
High cost of product can be a major factor challenging growth of the market. For instance, Kymriah, which is a CAR-T therapy costs around US$ 475,000 per patient. Considering such high cost for CAR-T therapy it can be assumed that anti-body coupled T receptor therapy can also costs on similar line as it works in same segment of immuno oncology, which restrain growth of the global anti-body coupled T receptor therapy market.
Key companies in the market are focused on various strategies such as collaboration and agreement, in order to gain competitive edge in the market. Unum Therapeutics is currently the only company that is working actively in anti-body coupled T receptor therapy. It has several product in its pipeline, and they vary based on the technology used for expression of receptor in patients T cell such as mRNA or viral vector. There is also combination of different monoclonal antibodies to be used for coupling such as rituximab, and trastuzumab. In phase one clinical trial, rituximab coupled t receptor therapy found to produce desired therapeutic effects. In 2015, Seattle Genetics, Inc. and Unum Therapeutics, Inc. entered into a strategic collaboration and license agreement to develop and commercialize novel antibody-coupled T-cell receptor (ACTR) therapies for cancer. This collaboration would enable study of different combination of the tumor-specific monoclonal antibodies with T receptor and cater to patient specific treatment needs.
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