Epigenetics Market Outlook, Key Financials, Segmental Revenue and Geographical Revenue till 2026
Global Epigenetics Market – Insights
Epigenetics is the study of heritable phenotype changes that do not involve alterations in the DNA sequence. Chromatin remodeling, DNA methylation, histone modification, genomic imprinting, X chromosome inactivation, and non-coding RNA regulation that affects gene transcription are some of the epigenetic alterations. Epigenetics has a significant impact on developmental biology, oncology, and drug development, non-oncological disorders such as Alzheimer ’s disease and respiratory disease, and forensic science. It finds application in identification of tissue origin, distinguishing between identical twins, paternity testing, and estimating postmortem interval.
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Increasing application and R&D in epigenetics to augment growth of the global epigenetics market
Increasing R&D in epigenetics of the genome (study called epigenomics) is expected to fuel growth of the global epigenetics market over the forecast period. Genome-wide epigenetics can significantly impact disease diagnosis. Moreover, increasing adoption of epigenetics for cancer research is also expected to boost growth of the market. For instance, in April 2018, Constellation Pharmaceuticals invested US$ 100 million for R&D of cancer epigenetics platform and ongoing ProSTAR and ORIOn-E trials, which are engineered to assess the efficacy of CPI-1205 and CPI-0610 used for cancer therapy.
Increasing government support for R&D in epigenetics is expected to boost growth of the global epigenetics market. For instance, in 2017, National Institutes of Health (NIH) planned to award 10 grants for supporting social epigenomics research in health disparities. The National Institute on Minority Health and Health Disparities (NIMHD), a part of the National Institutes of Health, committed US$ 26.2 million for nine awards over the term of five year. Moreover, in 2011, epigenetic related research was awarded US$ 11 million grant by the U.S. National Institute of Environmental Health Sciences. In same year, European Commission launched US$ 52.1 million project named BLUEPRINT, which aims to generate 100 reference epigenomes of healthy and leukaemic cells. Moreover, increasing number of projects related to whole genome sequencing including Human Genome Project has led to high adoption of epigenetic-based products, thereby aiding in growth of the market.
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Furthermore, high prevalence of cancer is boosting growth of the global epigenetics market over the forecast period. For instance, the Cancer Research UK, predicted the global cancer prevalence to be 32.5 million in 2012, which is expected to increase by 68% by 2030. Furthermore, according to National Cancer Institute (NCI), the number of undiagnosed cancer patients reached nearly 14.5 million in 2014, and the number is expected to reach 19 million by 2024. High incidence of chronic diseases is also expected to fuel the market growth. For instance, according to the Centers for Disease Control and Prevention (CDC), 2012, about half of the adult in U.S, accounting to 117 million, suffers from one or more chronic health conditions such as heart disease, stroke, cancer, type 2 diabetes, obesity, and arthritis
High cost associated with epigenetics to hinder growth of the global epigenetics market
High M&R and purchasing cost of instruments such as next generation sequencing or qPCR that is used in epigenetics is expected to be hamper growth of the global epigenetics market.
North America to hold dominant position in the global epigenetics market
The market in North America is expected to account for the largest market share over the forecast period. This is expected to increasing government investment in R&D in epigenetics. Asia Pacific is expected to witness the fastest growth in the global epigenetics market over the forecast period. This is owing to increasing prevalence of cancer in the region. For instance, according to an article in Japanese Journal of Clinical Oncology in 2012, more than 70% of total cancer mortality is reported in Asia Pacific and it is projected to rise continuously to 16 million by 2025.
Global Epigenetics Market – Competitive Landscape
Key players in the market are focused on adopting collaboration and partnership strategies to expand their product portfolio. For instance, in 2012, Epizyme partnered with Summit, a subsidiary of Celgene, to develop personalized therapeutics for patients with genetically defined cancers by inhibiting histone methyl transferases (HMTs), an important epigenetic target class. Under this agreement, Celgene will receive an exclusive license outside the U.S. to some of Epizyme’s programs for the period of three years and has the right to extend this option period for one year with additional funding. Moreover, In January 2016, Merck collaborated with the Cancer Research Technology in U.K. to develop inhibitors of protein arginine methyltransferase 5 (PRMT5).
Kay players in the global epigenetics market include Merck Millipore Limited, Illumina Inc., Thermo Fisher Scientific Inc., Zymo Research Corporation, Diagenode s. a., Bio-Rad Laboratories, Inc., Qiagen Inc., Enzo Life Sciences, Inc., and New England Biolabs Inc.
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Global Epigenetics Market: Taxonomy
By Product Type
- Kits & Reagents
- Developmental Biology
- Drug Development
- Metabolic diseases
By End User
- Academic & Research Institutes
- Pharmaceuticals & Biopharmaceutical Companies
- Contract Research Organizations (CROs)
- North America
- Latin America
- Asia Pacific
- Middle East
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