Plasmid DNA Manufacturing Market Size Is Estimated to Grow at a CAGR of 23.7% By 2026 | Future Trends, Insights, Share, Dynamics and Global DNA Manufacturing Industry Overview
Global Plasmid DNA Manufacturing Market
Plasmid DNA (pDNA) plays a crucial role in modern healthcare, as it is used directly as a therapeutic agent in gene therapy or generation of vaccine antigens. Furthermore, pDNA is used as a master-template product to support production of new and emerging biopharmaceutical products and processes including RNA, in-vitro protein production, and cell therapies.
The global plasmid DNA manufacturing market was pegged at US$ 65.1 million in 2017, and is foreseen to exhibit a magnificent CAGR of 23.7% over the forecast period (2018-2026).
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Figure 1. Global Plasmid DNA Manufacturing Market Value (US$ Mn), by Region, 2017
Source: Coherent Market Insights Analysis (2019)
Increasing number of patients opting for gene therapies is expected to propel the global market expansion
Increasing number of patients opting for gene therapy is a major factor driving growth of the plasmid DNA manufacturing market. Gene therapy is a leading field in medical science, which promises new treatment development for patients suffering from various diseases. For instance, Adeno-associated AAV2 vectors carrying therapeutic gene (RPE65) intra-retinal injection leads to improved vision of individuals suffering from Leber’s Congenital Amaurosis.
Several clinical trials are being conducted on viral vectors and plasmid DNA manufacturing that are focused on the potential of gene therapy. Increasing investments in drug development and commercialization of these therapies in order to meet significant medical needs are factors driving the market growth. These genetic markers are associated with complex diseases, therefore it is important to study about the genetic information and its clinical application in designing clinical trials and gene therapy product manufacturing.
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As per the data published by the Journal of Gene Medicine in March 2018, an estimated 2,600 gene therapy clinical trials has been ongoing, were already completed, or had been approved in about 36 countries. Countries where the trials were conducted include the U.S., the U.K., Australia, Canada, China, France, Germany, Japan, Switzerland, the Netherlands, and others. Moreover, diseases targeted by gene therapies include cardiovascular diseases, cancer, inflammatory and infectious diseases, Hemophilia A and B, Severe Combined Immunodeficiency (SCID), ocular diseases, neurological diseases, and others.
Figure 2. Global Plasmid DNA Manufacturing Market Share (%), by Application, 2018 and 2026
Source: Coherent Market Insights Analysis (2019)
Collaborations by market players is expected to bolster the market growth in Europe
Europe is anticipated to witness significant growth in the global plasmid DNA manufacturing market, thanks to the increasing adoption of effective growth strategies, such as collaborations, by the key market players. For instance, in May 2018, PlasmidFactory GmbH & Co. KG collaborated with Sirion-Biotech GmbH, Vibalogics GmbH, and PROGEN for adeno-associated virus (AAV) vector manufacturing. This collaboration was done to accelerate timeline and to create easy workflow from plasmid manufacturing to GMP production, and analytics of recombinant AAV to fulfil the customers’ requirement of AAV vector.
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Leading Market Players
The most prominent players operating in the global plasmid DNA manufacturing market include Cobra Biologics and Pharmaceutical Services, VGXI, Inc., Aldevron, Kaneka Corporation, Nature Technology Corporation, PlasmidFactory GmbH & Co. KG, Cell and Gene Therapy Catapult, and Waisman Biomanufacturing.
- Global Plasmid DNA Manufacturing Market, By Product Type:
- High Quality (HQ) Plasmid DNA
- GMP Grade Plasmid DNA
- Non-GMP Grade Plasmid DNA
- Global Plasmid DNA Manufacturing Market, By Application:
- DNA Vaccines
- Gene Therapy
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