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Monobody Based Therapeutic Drugs Market Outlook, Key Financials, Segmental Revenue and Geographical Revenue till 2026

Monobodies are categorized under synthetic binding proteins in which fibronectin type III domain (FN3) is utilized as a molecular scaffold. Monoboides are the best alternative to antibodies to offer target-binding proteins. The term monobody was devised by the Koide group in 1998. Monoboides can also be used as genetically encoded intracellular inhibitors. Adnexus (now a part of Bristol-Myers Squibb), uses monobody technology to inhibit tumor angiogenesis since 2007.

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Monobody is advanced technology which has a great potential to treat cancer

Monobody is independent of their environment and can be used as genetically encoded inhibitors. When a monobody binds to a protein then it works as an inhibitor of that protein. Hence it is a technology that has great potential in the treatment of cancer.

Pegdinetanib, also known as Adnectin, is an antagonist of vascular endothelial growth factor receptor 2 has entered clinical trial II for the treatment of glioblastoma. Adnectins are based on the 10th fibronectin type III domain designed to bind with high affinity and specificity to relevant targets. There are three solvent-accessible loops (BC, DE, and FG) which are responsible for binding. Various monobody proteins have been produced for clinical efficacy for the treatment of cancer and infections.  The market of monobody will gain high growth in developed region like America owing to its availability of advanced medical technology, good medical facilities, and medical infrastructure.

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With the success of therapeutic antibodies, researchers have developed an interest to produce molecules that bind to the target molecule efficiently and specifically. A popular alternative process is that the libraries of monobody being constructed which can be obtained by capturing the natural diversity of an antibody.

Research in the field of Monobody

Researchers at the University of Illinois, Chicago identified a monobody, NS1, which can block oncogene activity. 30% of all cancers are due to RAS mutation. RAS mutation is also found in 90% of pancreatic cancers and frequently occurs in colon cancer, lung cancer, and melanoma. The NS1 monobody binds to the RAS protein molecule and inhibits its oncogenic activity.

Monobody – An Advanced Alternative

Antibodies are successful tools used across diagnostic, therapeutics, and purification but they have disadvantages also such as high cost of the product and low stability. Alternative tools based on nucleic acid (aptamers), polypeptides (engineered binding proteins) and inorganic matrices have received attention recently. Monobodies have high potential in organ transplant in near future because they have specificity and affinity and this is expected to impact the market positively. Hence, successful outcomes will encourage the investors to develop this technology and address the huge unmet need for cancer patients undergoing antibody. Rising usage of monobodies as therapeutic drug can enhance patient situations and therefore companies are focusing on developing monobodies to be used as therapeutic drugs in the treatment of cancer.

Introduction of monobody will have a major impact in developed regions

The rate of organ transplantation in the U.S. is high. According to the National Kidney Foundation, there are currently 121,678 people waiting for an organ transplant in the U.S of which 100,791 await a kidney transplant. Monoclonal antibodies are used in successful transplants and are administered before transplant. It will become one of the major drivers for the monobody based therapeutic drug market. Monobody technology requires high investment to commercialize. The advancement of monobody technology to treat cancer will have an impact on the existing antibody treatment technologies.

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Key Developments

Research and development in the field of monobody-based therapies are expected to boost market growth. For instance, in August 2019, researchers from The University of Chicago characterized 42 Flublok-induced monoclonal antibodies and 38 Flucelvax-induced mAbs for avidity, cross-reactivity, and any selectivity towards the head versus the stalk domain to compare the fine specificity of the antibodies induced by recombinant hemagglutinin vaccine produced in insect cells (Flublok) and Flucelvax, prepared from virions produced in mammalian cells.

Similarly, in August 2019, researchers from the Icahn School of Medicine at Mount Sinai characterized monoclonal antibodies isolated from a patient with an active Zika virus infection that potently neutralized virus infection in Vero cells at the nanogram-per-milliliter range.

In June 2018, researchers from Bristol-Myers Squibb reported that 6200_A08, a novel gp41-binding Adnectin with potent anti-HIV activity is highly synergistic when linked to a CD4-binding Adnectin. Novel bispecific molecules of this type may serve as the next generation of potent antiviral agents.

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Last Updated: 19-Feb-2021