APOL 1 Mediated Kidney Disease Market Size and Share 2021 Global Industry Analysis By 2030
The APOL1 gene is part of the APOL gene family that plays a significant role in innate immunity, our body’s In-built system to fight threats. It is located in many tissues, including the kidneys. APOL 1 Mediated Kidney Disease Market: Global Industry Analysis 2015 – 2019 and Opportunity Assessment, 2020 – 2030
Certain variants in the APOL1 gene causes damage to the parts of the kidney which filter blood that can lead to kidney disease or even kidney failure. Focal segmental glomerulosclerosis is one type of kidney disease that can be caused by APOL1 gene variants.
APOL1-mediated FSGS is a kidney disorder that results in higher levels of protein in the urine, or proteinuria.This excess levels of protein can lead to symptoms such as swelling in the legs and feet and weight gain.
Current therapy doesn’t address the elementary cause of the disease. High-doses of steroids for a short span is often used, but they don’t always work and can lead to various side effects.
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APOL 1 Mediated Kidney Disease Market: Drivers and Restraints
The restricted treatment and government financing for research on rare diseases are estimated to drive the APOL 1 Mediated Kidney Disease Market.
For instance, in 2015, the U.S. Food and Drug Administration (FDA) and European Commission both approved Sparsentan, as orphan medication for the treatment of FSGS.
This Sparsentan is presently being assessed in a Phase III trials which are expected to finish in December 2022. Moreover, Expanding research & development for FSGS drugs by different producers is likewise propelling the development of the APOL 1 Mediated Kidney Disease Market
For example, Pfizer Inc. is going through the clinical trials for the assessment of the drug, PF-06730512 in grown-ups with primary segmental glomerulosclerosis. This medication is as of now in the Phase II study and is required to finish in June 2021.
However, the Lack of awareness among people in regards to this disease and higher expenses of dialysis treatment is hampering the growth of APOL 1 Mediated Kidney Disease Market.
For example, as indicated by an article published in the University of Michigan 2017, awareness among patients with FSGS is significantly lower when the patients are in the primary phase of FSGS, which is restricting the growth of the APOL 1 Mediated Kidney Disease Market.
APOL 1 Mediated Kidney Disease Market: Overview
The APOL 1 mediated kidney disease market is primarily driven by the rising disease incidences, increasing focus towards rare diseases, and rising R&D activity.
Moreover, the well-structured healthcare facilities, early adoption of therapies and diagnosis options, and better reimbursement policies provide a lucrative opportunity for the growth of an APOL 1 mediated kidney disease market.
Moreover, the high patient awareness level and favourable regulatory policies are considered a positive opportunity for the growth of APOL 1 mediated kidney disease market.
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APOL 1 Mediated Kidney Disease Market: Regional Wise Outlook
Geographically, the APOL 1 mediated kidney disease market is segmented into seven regions viz. South Asia, East Asia, Europe, Latin America, North America, Oceania, and the Middle East and Africa. North America is projected to lead the APOL 1 Mediated Kidney Disease Market owing to the higher prevalence of FSGS along with the increase in chronic kidney diseases.
For example, about the annual report by the U.S. Renal Data System 2017, the overall charge of kidney disease, kidney failure with dialysis, and kidney transplantation are highest in the U.S., thus driving the growth of the APOL 1 Mediated Kidney Disease Market.
Asia Pacific region is estimated to witness major growth in the APOL 1 Mediated Kidney Disease market because of the collaboration agreements and partnerships amongst various players.
For example, Oraxion Therapeutics, Inc., i.e. the subsidiary of Indian company Aten Porus, is going through the preclinical and efficacy study of the drug, ORX-301 that can be used in the FSGS treatment.
While, In February 2018, Oraxion Therapeutics, Inc., has an Option Agreement with the U.S-based Biopharmaceutical Company. Additionally, in this agreement, the U.S. based company obtained exclusive rights for extended clinical studies and license of the drug in the U.S.
Major players operating in APOL 1 Mediated Kidney Disease Market are
- GlaxoSmithKline plc. Novartis AG
- Variant Pharmaceuticals, Inc.
- ChemoCentryx, Inc.
- Retrophin, Inc.
- AbbVie, Inc.
- Pfizer, Inc.
- AstraZeneca plc.
- Sanofi S.A
- Teva Pharmaceutical Industries Ltd.
The report is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts, and industry participants across the value chain.
The report provides an in-depth analysis of parent market trends, macro-economic indicators, and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographies.
- Market Segments
- Market Dynamics
- Market Size
- Supply & Demand
- Current Trends/Issues/Challenges
- Competition & Companies involved
- Technology Matrix
- Value Chain
The regional analysis of the APOL 1 Mediated Kidney Disease Market report includes
- North America
- Latin America
- South Asia
- East Asia
- The Middle East and Africa
APOL 1 Mediated Kidney Disease Market Report Highlights:
- Overview of the Global Healthcare Market
- Evolution of the technology
- Changing market dynamics in the industry
- In-depth market segmentation
- Historical, current and projected market size in terms of value
- Recent industry trends and developments
- Competitive landscape
- Strategies of key players and products offered
- Potential and niche segments, geographical regions exhibiting promising growth
- A neutral perspective on market performance
- Must-have information for market players to sustain and enhance their market footprint.
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APOL 1 Mediated Kidney Disease Market: Segmentation
Tentatively, the global APOL 1 mediated kidney disease market has been segmented based on product type, distribution channels and geography.
- Primary Focal Segmental Glomerulosclerosis
- Secondary Focal Segmental Glomerulosclerosis
- Drug Therapy
By distribution channel
- Hospital Pharmacies
- Retail Pharmacies
- Online Pharmacies