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Biopharmaceutical Manufacturers Tighten their Grip on Protein A Resin Market

Future Market Insights’ recent report on the protein a-resins market concludes that the market is anticipated to witness robust growth across the upcoming decade’s forecast period.

Growing investments in synthetic biology is accelerating adoption of protein engineered products in order to manufacture protein infused drugs and formulations. A significant advancement has been noticed in the field of monoclonal antibodies (mAbs) which are used to treat a host of chronic and infectious diseases. Protein A-resins are exhaustively utilized for the purification of mAbs, a key driver enhancing the growth prospects for the upcoming forecast period.

Significant growth acceleration in the protein a-resins market was witnessed when GE Healthcare launched its MabSelect PrismA chromatography resin in 2017. Designed to purify bispecific antibodies (BsAbs) in a single step, protein a-chromatography has provided 90% purity levels. The resin makes effective usage of Protein-A ligand and a novel agarose bead to achieve dynamic binding capacities.

On a similar plane, MIT chemists have devised an automated flow synthesis machine which significantly reduces the time required for synthetic protein generation. The enhanced capacity of the machine allows for greater loading of multiple amino acids within a span of few hours. This automation is anticipated to attract investors, providing a stimulus to the market during the forecast period.

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“Credible research is being undertaken with regard to monoclonal antibodies to ascertain its possible application areas, prompting an increase in protein A-resins usage, anticipated to register positive year-on-year growth with manufacturers focusing on technological advancements,” according to an FMI analyst.

Key Takeaways from FMI’s Protein A-Resins Market Report

  • Protein A-Resins market shall expand at a CAGR of 8.2% throughout 2020
  • Natural protein A-resins shall account for the maximum share of revenue throughout the forecast period
  • By application, the antibody purification segment accounted for the maximum share in 2019 and is anticipated to retain the same during the forecast period
  • Agarose-based matrix is the most prominent medium utilized in the protein A-resins market
  • Biopharmaceutical manufacturers make extensive usage of protein a-resins due to extensive applications in manufacturing protein-based drugs
  • North America shall emerge as a leader in the protein a-resins market, with the United States contributing 70% of the revenue pie

Protein A-Resins Market- Key Trends

  • Demand for purification of antibodies is especially strong in the immunotherapy segment. For instance, the US FDA has approved immunotherapy to treat CD19 positive hematological cancers
  • Also, protein A-chromatography is useful for purifying FGFR4 which is marked in CAR-T therapy by chimeric antigen receptors
  • Mixed-mode chromatography is providing fertile ground for biomolecule purification which otherwise are extremely difficult to purify using conventional chromatography techniques. Improved yield, immense room for facilitating protein interaction and minimal feed manipulation before binding are the advantages accelerating their usage

Protein-A Resins Market- Region-wise Analysis

  • Asia Pacific is emerging as a promising growth avenue during the forecast period. Rising demand for immunotherapy drugs to treat chronic ailments is expected to elevate the regional market to a higher pedestal
  • Uptake of protein A-resins in the Latin American and European markets is increasing. Rising investments in protein-based research is attracting market players to establish their businesses across these regions
  • Massive clinical trials in the field of synthetic biologics and monoclonal antibodies is expected to increase uptake of protein A-resins across the North American market

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Protein-A Resins Market- Competitive Landscape

The protein A-resins market is characterized by constant innovations and product approvals in the bio therapeutics domain, which provides them with a competitive edge over each other. Market players are constantly launching new products to cater to cardiovascular ailments, immune therapy, cancer and microbial infections.

In May 2020, Avantor doled out its new protein A-chromatography resin titled PROchievA which uses a novel, proprietary ligand to provide the best in-class purification in critical protein A-chromatography steps of monoclonal antibodies manufacturing. The product demonstrates excellent dynamic binding capacities compared to other resins on the market.

Also, Novasep produces the AbSoulte High Cap Protein A-Media, an optimized silica-based medium for the capture of monoclonal and polyclonal antibodies. This media is well-adapted to all fermentation volumes while offering the highest dynamic and static binding capacities and subsequently high productivity at increased velocities.

Protein A Resins Market Taxonomy

Product Type

  • Natural Protein A Resin
  • Recombinant Protein A Resin

Matrix Type

  • Agarose Based Matrix
  • Glass or Silica Based
  • Organic Polymer Based


  • Immunoprecipitation
  • Antibody Purification


  • Hospitals
  • Ambulatory Surgical Centers
  • Catheterization Laboratories


North America

  • U.S
  • Canada

Latin America

  • Argentina
  • Brazil
  • Mexico
  • Rest of Latin America


  • EU-5
  • Russia
  • Rest of Europe

South Asia

  • India
  • Rest of South Asia

East Asia

  • China
  • Japan
  • South Korea


  • Australia
  • New Zealand


  • GCC
  • Southern Africa
  • Turkey
  • Rest of MEA

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More Insights on the Protein A Resins Market

Future Market Insights brings the comprehensive research report on forecasted revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2015 to 2030. The global protein A-resin market is segmented in detail to cover every aspect of the market and present a complete market intelligence approach to the reader. The study provides compelling insights on market on basis of product type in detail covering every aspect of the market based on prominent segments across seven major regions. 

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About Future Market Insights (FMI)

Future Market Insights (FMI) is a leading provider of market intelligence and consulting services, serving clients in over 150 countries. FMI is headquartered in London, the global financial capital, and has delivery centers in the U.S. and India. FMI’s latest market research reports and industry analysis help businesses navigate challenges and take critical decisions with confidence and clarity amidst breakneck competition. Our customized and syndicated market research reports deliver actionable insights that drive sustainable growth. A team of expert-led analysts at FMI continuously track emerging trends and events in a broad range of industries to ensure that our clients prepare for the evolving needs of their consumers.

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Last Updated: 08-Apr-2021