Polymer-drug Conjugates Market Size Share Industry Growth, Trends, Key Countries Analysis By Leading Players With Forecast to 2026
SEATTLE, April 12, 2021, (PHARMIWEB) — Global Polymer-drug Conjugates Market
Polymer-drug conjugates are nano-sized drug products that are widely used for treating cancer and hepatitis nowadays. Currently, polymers are being synthesized to be sensitive to specific enzymes that are apparent in diseased tissue. Conventional polymers are used in polymer-drug conjugates, such as cellulose and chitin, which can be degraded through enzymatic activity and acidity. The drugs remain attached to the polymer and are not activated until the enzymes associated with the diseased tissue begin functioning. Hence, the entire process significantly aids in minimizing damage to healthy tissues.
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Global Polymer-drug Conjugates Market Overview
An all-new pipeline of drugs developed using polymer-drug conjugates is likely to propel the growth of the global polymer-drug conjugates market. For instance, in March 2016, the National Cancer Institute (NCI) initiated its phase II clinical study for CRLX101 – which is a nanoparticle drug conjugate composed of 20(S)-Camptothecin conjugated to a linear, cyclodextrin-polyethylene glycol-based polymer – for the treatment of metastatic prostate cancer, and the trial is scheduled to be completed by March 2020.
On the other hand, limited use of polymer-drug conjugates is expected to restrain the global market development. According to an article published in Bioengineering and Translational Medicine 2016, polymer-drug conjugates are formed by covalent linkage between the drug and the polymer. The article further explained that all drugs do not have chemical functional groups for covalent conjugation. Furthermore, lack of standard and optimized preclinical or clinical protocols to evaluate polymer-drug conjugate stability, tumor penetration, metabolism, and toxicity is another significant factor impeding the global market growth.
Global Polymer-drug Conjugates Market – Regional Analysis
North America is projected to hold a dominant position in the global polymer-drug conjugates market, due to the escalating number of clinical trials in the U.S. For instance, in January 2018, Apellis Pharmaceuticals announced to conduct phase III clinical study for APL-2 in the U.S. APL-2 is a synthetic cyclic peptide drug conjugated to a polyethylene glycol polymer for the treatment of geographic atrophy associated with age-related macular degeneration.
Furthermore, increasing research activities on novel Drug Delivery Systems (DDS) in Asia Pacific is expected to contribute to significant market growth for polymer drug conjugates in the region. For instance, in August 2018, Osaka University, in collaboration with Tokyo Institute of Technology, Japan, developed a DDS using polyethylene glycol and polylysine block copolymer, with ubenimex conjugate (PEG-b-PLys (Ube). Intravenous injection of ubenimex with these polymers in mice, found to reduce the tumor size significantly. Such results are likely to provide a significant momentum to market growth in the region during the forecast period.
The key players operating in the global polymer-drug conjugates market include Access Pharma, Abeona Therapeutics, Inc., ADAMA India Private Limited, Avadel, GlaxoSmithKline Plc, JenKem Technology USA, Lipotek, Sansheng Pharmaceutical Group, Landec Corporation, and Gowan Company.
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By Product Type,
- PEG-a-interferon 2b
- 1 PEG-L-asparaginase
- North America
- Asia Pacific
- Latin America
- Middle East
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