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[2021] Proteinase K Market Expected to Rise Steadily throughout 2027 | Thermo Fisher Scientific Inc., Merck KGaA, Qiagen N.V., F. Hoffmann-La Roche Ltd., New England Biolabs, Worthington Biochemical Corporation

SEATTLE, May 04, 2021, (PHARMIWEB) —


Proteinase K is a broad-spectrum protease that cleaves peptide bonds between aliphatic and aromatic amino acids’ carboxylic groups. It is favorable for general protein digestion in biological samples.

The global proteinase K market is expected to reach US$ 35.5 million by the end of 2027, with a value of US$ 21.9 million in 2019.

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Increased investment for R&D in molecular biology is expected to propel growth of the global proteinase K market during the forecast period.  Princeton University funded six scientific findings in February 2020, including one that focuses on discovering a novel approach to controlling fat metabolism by developing drugs that target an enzyme called Nocturnin, which controls fat accumulation and energy use.


Rising adoption of proteinase K in research and development for rare diseases is expected to provide robust growth opportunities for companies operating in the global proteinase K market. Researchers from Scripps Research announced in April 2019 that they had identified a group of small molecules that avoid structural changes to proteins that cause AL amyloidosis, a rare and progressive condition, by labelling light chains with fluorophores and coupling shape changes to proteinase K cleavage.


In industrial processes, due to poor thermal stability of proteinase K, the aminolysis and hydrolysis reactions are reduced, which is expected to hamper growth of the global proteinase K market.

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Market Trends:

Proteinase K is increasingly being used to remove DNA from food samples in order to search for the existence of genetically modified species. One such application includes mixing frozen northern shrimp homogenates with Lysis Solution CBV and Proteinase K after homogenization in 200 l of water.

The focus of key companies in the market on adopting strategic partnerships to extend their portfolio of products. In July 2018, Norgen Biotek Corp. collaborated with Diversigen Inc. to deliver a comprehensive service that includes sample selection, ambient temperature stabilisation for transport and logistics, and the purification of high-quality, inhibitor-free nucleic acids from all forms of microbiome samples and formats.

Competitive Landscape:

Key companies contributing in the global proteinase K market are Norgen Biotek Corp., Worthington Biochemical Corporation, F. Hoffmann-La Roche Ltd., Thermo Fisher Scientific Inc., Meridian Biosciences Inc., Qiagen N.V., Promega Corporation, Merck KGaA, New England Biolabs, Sisco Research Laboratories Pvt. Ltd., and BIORON GmbH.

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Detailed Segmentation

By Form:

    • Lyophilized Powder Form
    • Liquid Form

By Application:

    • Purification of DNA & RNA
    • In situ Hybridization
    • Mitochondria Isolation
    • Enzyme Removal

By End User:

    • Contract Research Organization
    • Academic Institutes
    • Biotechnology Companies
    • Diagnostic Laboratories

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Last Updated: 24-Oct-2021