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Plasma Protease C1-inhibitor Treatment - Preclinical safety aspects on the potential prothrombotic risk, Market will grow at 18.2% CAGR, to be valued at US$ 10,603.4 Million by 2027

Global Plasma Protease C1-Inhibitor Treatment Market


Hereditary angioedema is a disorder characterized by low levels of functional C1 inhibitor protein and results in recurrent attacks of severe swelling. The swelling usually affects the face, legs, arms, airway, and intestinal tract. Plasma protease C1-inhibitors such as Berinet, Kalbitor, Firazyr, and Cinryze have been approved for the prophylactic and treatment of hereditary angioedema. It also help regulate important physiological pathways such as generation of kinins, fibrinolysis, blood coagulation, and complement activation. C1 inhibitor also inhibits kallikrein and chymotrypsin.

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Biopharmaceutical companies are focused on developing effective plasma protease C1-inhibitor therapies or drugs to treat various health conditions such as diabetic macular edema (DME), hereditary angioedema (HAE) and others, which in turn, is expected to propel the global plasma protease C1-inhibitor treatment market growth over the forecast period. For instance, in September 2019, Oxurion released positive topline data from a phase 1 study of THR-149, a plasma kallikrein inhibitor for the treatment of diabetic macular edema (DME).

Moreover, in December 2019, KalVista Pharmaceuticals, Inc., a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of small molecule protease inhibitors, announced results of the Phase 2 clinical trial evaluating the use of KVD001 in patients with diabetic macular edema (DME).

Furthermore, market players are adopting various inorganic growth strategies, such as partnership and collaboration, to develop innovative protease C1-inhibitor treatment, which is expected to augment the growth of the global plasma protease C1-inhibitor treatment market. For instance, in October 2017, KalVista Pharmaceuticals, Inc. entered into a collaboration agreement with Merck, known as MSD outside the U.S. and Canada for KVD001 (investigational plasma kallikrein inhibitors). The company’s investigational intravitreal (IVT) injection candidate is currently in development for potential treatment of diabetic macular edema (DME).

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The rare occurrence of hereditary angioedema and lower diagnosis rate is expected to hamper growth of the global plasma protease c1-inhibitor treatment market.

Market Taxonomy:

By Drug Type

  • C1-inhibitors
  • Kallikrein Inhibitor
  • Selective Bradykinin B2 Receptor Antagonist

By Dosage

  • Lyophilized
  • Injectable

By Distribution Channel

  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies

By Region

  • North America
  • Latin America
  • Europe
  • Asia Pacific
  • Middle East and Africa

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Regional Analysis:

North American is expected to witness robust growth in the global plasma protease C1-inhibitor treatment market due to increasing approvals of novel therapies in the region. For instance, in 2014, Pharming Healthcare received the United States Food and Drug Administration (USFDA) approval for Ruconest, a recombinant C1-esterase inhibitor for the treatment of acute attacks in adult and adolescent patients with HAE.

Competitive Analysis:

Major players active in the global plasma protease C1-inhibitor treatment market are CSL Behring LLC, Pharming Group N.V., Takeda Pharmaceutical Company Limited, Ionis Pharmaceuticals, Inc., Pharming Technologies B.V., Centogene AG, BioCryst Pharmaceuticals, and KalVista Pharmaceuticals, Inc.

Key Developments:

In April 2020, Pharming Group N.V. announced the encouraging results from five patients with confirmed COVID-19 (SARS-CoV-2) infections hospitalized with related severe pneumonia that were treated with RUCONEST (recombinant human C1 inhibitor) under a compassionate use program at the University Hospital Basel, Switzerland.

In June 2017, CSL Behring received the FDA approval for HAEGARDA (C1 Esterase Inhibitor Subcutaneous (Human)), the first and only subcutaneous therapy indicated for routine prophylaxis to prevent hereditary angioedema (HAE) attacks in adolescent and adult patients.

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Plasma Protease C1-inhibitor Treatment - Preclinical safety aspects on the potential prothrombotic risk, Market will grow at 18.2% CAGR, to be valued at US$ 10,603.4 Million by 2027

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Last Updated: 15-Jun-2021