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Creative Enzymes Launches DSPE-PEG-Maleimide for Targeted Drug Delivery

Creative Enzymes, a professional enzyme provider located in New York, always hammers at researches and trials in order to provide customers with various enzymes as many as possible. The product manager of Creative Enzymes announced the launch of DSPE-PEG(5000) Maleimide and DSPE-PEG(2000) Maleimide, which can be used to synthesize functional conjugates.


DSPE-PEG-Maleimide (DSPE-PEG-MAL) is a linear heterobifunctional PEGylation reagent containing DSPE phospholipids and maleimide. It is a useful self-assembly reagent that can be used to prepare PEGylated liposomes or micelles, and it also provides thiol or cysteine reactive maleimide groups. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the reactive maleimide to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide.


DSPE PEG maleimide is one of Creative Enzymes reactive phospholipid PEG reagents, which can react with sulfhydryl (thiol, -SH) groups. DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) is a highly hydrophobic saturated 18C phospholipid. On the other hand, PEG linker (polyethylene glycol) has good hydrophilicity and water solubility.


Maleimide-functional DSPE PEG has excellent reactivity to sulfhydryl/thiol groups derived from various molecules. The reaction between maleimide and mercaptan is easy to proceed at neutral pH. Maleimide PEG DSPE is one of the most commonly used reactive phospholipids, which can bind antibodies, peptides or other ligands to the surface of liposomes and other lipid PEG nanoparticles. Pegylated phospholipids have longer blood circulation time and higher stability of encapsulated drugs.


“Creative Enzymes has developed a series of thiol-reactive maleimide phospholipid PEG products with high purity, various molecular weights and excellent chemical reactivity. These lipid PEG conjugates show excellent amphiphilicity and provide excellent advantages for the formulation and delivery of small and large molecule drugs.” Said the Senior Scientist of Creative Enzymes.


“Our company has recently launched DSPE-PEG(5000) Maleimide and DSPE-PEG(2000) Maleimide, these products will have better market prospects based on large demands and their specific features.” He added.


Creative Enzymes has a professional research and development team of enzyme products and services. Team members have a high level of expertise and rich experience. Therefore, the company can provide customers with comprehensive, professional, and one-stop solutions.


About Creative Enzymes

Creative Enzymes is a remarkable supplier and manufacturer in Enzymology field. Equipped with advanced technique platform, Creative Enzymes is able to offer high-quality and professional services for customers. Its products and services are widely used in academic and pharmaceutical industries. 



Address: Shirley, NY 11967, USA


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Last Updated: 22-Jun-2021