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Profacgen Helps Accelerate GPCR Study with Various Services

Profacgen, a global provider of drug screening and profiling services that offers a comprehensive panel of services designed to speed and simplify drug discovery research, now offers professional high-throughput GPCR screening service for identification of potential GPCR-targeting drugs.


G protein-coupled receptors (GPCRs) are also known as seven-transmembrane domain receptors. They are present only in eukaryotes. Because of their extensive involvement in cellular signal transduction, GPCRs have emerged as important drug targets. Nearly 40% of modern drugs are targeted by GPCRs, and 20% of the top 50 best-selling drugs are associated with GPCRs.


Structural features and important roles in signal transduction make GPCRs perfect drug targets. GPCR screening and analysis technology is now widely used in new drug screening for infectious diseases, cardiovascular disease, mental illness, acquired immunodeficiency syndrome (AIDS), diabetes, cancer and so on.


Based on years’ experience, Profacgen now provides a comprehensive list of services to help with its customers’ GPCR study. The services range include: cell membrane preparation, signal detection and high-throughput screening.


The following signal detection assays are available at Profacgen now:

Cell based functional assay: second messengers (cAMP, calcium, IP1, IP3), reporter genes

Ligand-receptor binding assay (using radio-labeled isotope ligand): arrestin recruitment, receptor internalization

Cell based high content screening (HCS)


The company can conduct rapid profiling of its customers’ compounds against a panel of GPCRs or perform more in-depth EC50/IC50 determinations. Scientists at Profacgen can also help design customized GPCR analytical scheme based on different requirements and preliminary results, such as GPCR agonist screening, GPCR antagonist screening, GPCR allosteric modulator screening, GPCR inverse agonist screening, etc.


“Specializing in both standard and customized assays, we are focused on providing our clients cost-effective, high quality, reproducible data and flexible solutions with fast turnaround.” Commented Crystal, the chief marketing staff at Profacgen.


Visit to get more detailed information about the GPCR screening service provided by Profacgen.

Profacgen Helps Accelerate GPCR Study with Various Services

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Last Updated: 22-Dec-2021