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Amerigo Scientific Launches KCC2 Ion Channel for Researchers

Amerigo Scientific, a distribution company focused on providing critical products and services to the biomedical and life science research communities, now introduces KCC2 Ion Channel for research uses. This KCC2 can help scientists in the exploration, advancement, and validation of new molecules as well as therapeutic antibodies.

The plasma membrane neuron-specific chloride potassium symporter is responsible for establishing the chloride ion gradient in neurons by maintaining low intracellular chloride concentrations. It is a key mediator of synaptic inhibition, cellular protection against excitotoxicity and may also act as a modulator of neuroplasticity.

KCC2 (potassium chloride co-transporter 2) is a powerful therapeutic target especially in the treatment of such conditions including pain and epilepsy. Present in the membranes of all living cells, ion channels are pore-forming proteins that ensure the flow of charged ions from one side of a membrane to the other. Ion channel mediated ion regulation and selective transport underpin numerous fundamental physiological processes.

Due to complexity and diversity of ion channels, the relative paucity of native and stable structures of channels precludes rational drug design. Amerigo Scientific's full-length and wild-type ion channel proteins as suitable pharmacological tools are valuable for multiple applications such as molecules screening, antibody development, and structural biology studies.

Amerigo Scientific offers high-quality purified membrane proteins involved in a wide range of diseases for many discovery programs. This new product is an addition of its purified membrane proteins portfolio. Other products such as M2 Ion Channel are also available at Amerigo Scientific. "Our KCC2 co-transporter maintains its structural and functional integrity, and is purified and stabilized as a full-length and wild-type (natural) protein. They are pure, natural, unaltered, and can be combined with a variety of compounds including agonists, antagonists and allosteric modulators," said Nina Cooper, Ph.D., the chief scientist at Amerigo Scientific.

"Amerigo Scientific specializes in selecting the most reliable bioreagents from worldwide manufacturers and distributing them to researchers. We have strong capability in logistics and familiarity with customs clearance procedures that can enable fast global delivery of thousands of most needed bioreagents, such as antibodies, assay kits, and biospecimens," added Nina.

For more information about the KCC2 Ion Channel, please visit

About Amerigo Scientific

Amerigo Scientific is a distribution company that focuses on providing critical products and services to the biomedical and life science research communities. Although it is a new company, Amerigo Scientific's founder has had more than 20 years of rich experience in the biomedical and biochemical fields, and has established close contacts with key personnel in top international pharmaceutical and biotech companies, academic research institutes, and government research agencies. It has a professional team, as most of its employees own a graduate (Ph.D. or master) degree in life science, so they can understand customers' questions or concerns and are always ready to provide individualized customer service with high standard.

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Last Updated: 24-Dec-2021