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Insights on the Enzyme Replacement Therapy Global Market to 2028 - Players Include Sanofi, BioMarin Pharmaceutical and Takeda Pharmaceutical -

DUBLIN--(BUSINESS WIRE)--The "Enzyme Replacement Therapy Market Forecast to 2028 - COVID-19 Impact and Global Analysis By Enzyme Type, Therapeutic Conditions, Route of Administration, and End User" report has been added to's offering.

The enzyme replacement therapy market is expected to grow from US$ 9,673.39 million in 2021 to US$ 15,184.70 million by 2028; it is estimated to grow at a CAGR of 6.8% from 2022 to 2028.

The report highlights trends prevailing in the market and factors driving the market growth. The growth of the global enzyme replacement therapy market is attributed to the rising prevalence of lysosomal storage diseases (LSDs) and rapid regulatory approval with other marketing benefits for drug with orphan drug designation. However, cutthroat competition among market players hinders the overall market growth.

Enzyme replacement therapy (ERT) is performed to treat congenital enzyme deficiencies by using enzymes or proteins having enzymatic activity. Animal, human, and recombinant engineered enzymes are a few sources of enzyme required for treatment. The therapy is generally applied in rare and lysosomal storage diseases, including Pompe's disease, Fabry's disease, Gaucher's disease, Tay-Sachs disease, and Hurler syndrome. The most common ERT method is IV infusions, in which the replacement enzyme is administered directly into the bloodstream through a controlled drip of fluids.

European Medicines Agency (EMA) approves orphan drugs. For instance, according to EMA, if a product that has an orphan drug designation receives EMA marketing approval for the indication for which it has such designation, the product is entitled to orphan market exclusivity. It means the EMA may not approve any other application to market a similar drug for the same indication for 10 years.

Impact of COVID-19 Pandemic on Global Enzyme Replacement Therapy Market

The COVID-19 pandemic significantly affected the global healthcare system. To combat the spread of SAR-CoV-2 virus, governments imposed stringent policies to prevent and reduce the infection and mortality rates. According to the Department of Emergency Medicine, in many cities across various countries in North America, emergency department (ED) visits decreased by ~40% in 2020. Moreover, outpatient appointments and elective treatments were postponed or replaced by telemedicine practices.

Market Dynamics


  • Rising Prevalence of Lysosomal Storage Diseases (LSDs)
  • Rapid Regulatory Approval with Other Benefits for Drug with Orphan Drug Designation


  • Cutthroat Competition among Market Players


  • Increasing Partnerships and Collaborations to Synergize the Business

Future Trends

  • Innovative Developments in ERT

Companies Mentioned

  • Sanofi
  • BioMarin Pharmaceutical Inc.
  • Takeda Pharmaceutical Company Limited
  • AbbVie Inc.
  • Janssen Pharmaceuticals (Johnson & Johnson Services, Inc.)
  • Alexion Pharmaceuticals, Inc (AstraZeneca)
  • Amicus Therapeutics
  • Recordati S.p.A.
  • CHIESI Farmaceutici S.p.A.
  • Pfizer Inc.

For more information about this report visit

Laura Wood, Senior Press Manager

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    • Businesswire
Last Updated: 12-Sep-2022