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[London, U.K. and Marcy-l'Étoile, France – 26th September 2022] To mark Sepsis Awareness Month, the UK Sepsis Trust, an internationally renowned charity, and bioMérieux, a world leader in in vitro diagnostics with a long-standing commitment to the fight against sepsis, have released new survey data of health professionals to assess their knowledge and practice in the management of Sepsis. This survey was commissioned among 368 doctors across six European countries, including the UK. Key highlights include:

  • Cases of Sepsis are still being missed, despite UK clinicians being aware both of its seriousness and the Sepsis-3 definition*. 
  • This is reportedly due to staff shortages, which was detailed as the main barrier to delivering appropriate Sepsis management,1 leaving patients at significant risk.
  • Over two thirds (68%) of clinicians admit they miss some cases of Sepsis in the hospitals in which they work.[i]

Sepsis is a life-threatening condition in which the body’s response to infection causes organ damage. Globally, Sepsis is now recognised to claim more lives than cancer.[ii],[iii] Every year in the UK, a quarter of a million people are affected by sepsis, and five people die every hour because of it.[iv]

Early recognition and rapid diagnosis are essential for early patient management. Any delay in starting appropriate treatment is associated with increased mortality. A set of evidence-based clinical practices, known as Sepsis Bundles, have been defined internationally and the routine implementation of these bundles by clinicians can greatly improve outcomes for patients with sepsis. [v]

While most surveyed doctors recognise Sepsis is a serious condition, some cases are missed and delays in diagnosis remain in the hospital they work.

In the UK, surveyed health professionals are confronted with Sepsis on a regular basis, reporting that one in five (21%) patients they personally manage in hospital in a typical week have confirmed Sepsis.

Despite the fact that nearly all (99%) of respondents believed that developing Sepsis is serious, two thirds (67%) of the surveyed doctors agree that there is sometimes a delay in diagnosis, and over two thirds (68%) agree they do miss some cases in the hospitals in which they work.

Dr Ron Daniels, world leading Sepsis expert and Chief Executive of the UK Sepsis Trust, comments: “There is clear evidence within these data that action on Sepsis improvement work across the UK has been effective, with very high awareness of national and international standards for the recognition and treatment of Sepsis among UK clinicians. Hearteningly, this appears to be accompanied by a responsible attitude to antimicrobial prescribing, with  clinicians indicating that they would prescribe antibiotics in a case where there was a need for further diagnostic information.’

“However, there is much to be done. The current crisis in staffing within the NHS and a lack of access to timely diagnostics are causing harm for patients. With the increasing tendency to centralise laboratories within cities, organisations need to examine with a degree of urgency how they ensure the rapid processing and communication of time-sensitive tests to frontline clinicians.”

Staff shortages, high patient caseload, slow communication of test results and inability to rapidly reassess patients are identified as the main barriers to the adherence of the Sepsis Bundles. 

Almost all surveyed health professionals (97%) state the actions outlined in the Hour-1 Sepsis bundles are followed in their hospital to at least some extent. However, when prompted, only half (52%) of the healthcare professionals carry out all steps included in the Hour-1 Sepsis Bundle** for diagnosis and treatment of suspected Sepsis***, meaning that nearly half (48%) of patients are not receiving standard of care, increasing their risk of mortality.

The survey identified a number of reasons why there is a lack of adherence to the protocol. While the main barriers vary between countries, in the UK, the main ones identified are staff shortages (76%), high patient caseload (74%), test results not being communicated quickly enough (38%) and inability to rapidly reassess patients (36%).

While nearly all (99%) respondents agree early detection of sepsis can lead to significantly better outcomes, one in three (33%) said that a lack of rapid diagnostic tests is one of the main barriers to adhering to the stages outlined in the Sepsis Bundles.

“Diagnostic tests are vital for anyone suspected of sepsis, providing critical information on its presence and severity, the type and extent of infection at the source, how best to manage the patient and also to monitor their progress” said Mark Miller, Executive Vice President and Chief Medical Officer at bioMerieux. “Tests like blood cultures, other appropriate cultures, lactate and procalcitonin can give essential information for guiding optimal patient care in suspected and proven sepsis.”

More staff and training are identified as the top two areas to address existing knowledge gaps and improve patient outcomes.

Over three quarters (76%) of surveyed doctors selected that more staff are needed to improve adherence of sepsis bundles in the hospital where they work. 56% of health professionals also selected that training on what Sepsis Bundles are, or how to implement these in the hospitals within which they work, would improve adherence to these bundles.

Dr Daniels adds, “As healthcare systems continue to grapple with issues such as staff shortages and evolving patient needs, urgent action must be taken to ensure that there is consistent access to timely diagnostics to improve patient care and outcomes."

In 2021 bioMérieux and the UK Sepsis Trust published the results of a separate survey showing the need to accelerate awareness and education of the general population about sepsis. The current second survey is an evolution of the campaign to enhance awareness among health workers and institutions, to improve patient care with crucial and timely diagnostics, and to promote better adherence to international sepsis care guidelines.

[i] UK Sepsis Trust and bioMérieux, Adherence to Sepsis Bundle in Europe. July 2022.

[ii] Rudd, K. et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. The Lancet. 2020; 295: 200-11.

[iii] World Health Organisation. Cancer. Available at: Last accessed: September 2022.

[iv] The UK Sepsis Trust. Representing the UK Sepsis Trust. Available at: Last accessed: September 2022.

[v] Milano PK, et al. Sepsis Bundle Adherence Is Associated with Improved Survival in Severe Sepsis or Septic Shock. West J Emerg Med. 2018 Sep;19(5):774-781.

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Last Updated: 27-Sep-2022