PharmiWeb.com - Global Pharma News & Resources
08-Nov-2022

NanoString Technologies Releases Operating Results for Third Quarter of 2022

Generated Orders for ~60 Spatial Biology Instruments, Representing ~70% Growth Year-over-Year, Including Orders for ~40 CosMx Spatial Molecular Imagers

SEATTLE--(BUSINESS WIRE)--#earnings--NanoString Technologies, Inc. (NASDAQ:NSTG), a leading provider of life science tools for discovery and translational research, today reported financial results for the third quarter ended September 30, 2022.


Third Quarter Financial Highlights

  • Product and service revenue of $29.5 million
  • GeoMx® Digital Spatial Profiler (DSP) revenue of $9.3 million. GeoMx DSP revenue includes:
    • Instrument revenue of $4.7 million
    • Consumables revenue of $4.6 million, annualized pull-through of approximately $58,000 per installed system
  • nCounter® revenue, inclusive of all service revenue, of $20.2 million. nCounter revenue includes:
    • Instrument revenue of $3.3 million
    • Consumables revenue of $12.0 million, annualized pull-through of approximately $44,000 per installed system
    • Service revenue of $4.9 million
  • Cash, cash equivalents and short-term investments balance of $230.5 million

“During the third quarter we delivered on our top priority, which is growing our spatial biology customer base. We generated orders for approximately 60 spatial instruments, representing growth of about 70% over the prior year,” said Brad Gray, president & CEO of NanoString. “We currently have orders for more than 100 CosMx systems which we expect to begin generating revenue as we ship our first CosMx systems in the coming weeks.”

“The third quarter and year-to-date 2022 have presented challenges as our business mix has continued to evolve, and we have taken steps to streamline our cost structure while maintaining our investments in spatial biology. With our strong balance sheet and 2023 revenue backlog, we expect improved profitability in the future and to reach cash break-even with our current financial resources,” stated NanoString’s CFO Tom Bailey.

Operational Highlights

Spatial Biology

  • Spatial Biology System Orders: Secured customer orders for approximately 60 spatial biology systems, including approximately 20 GeoMx DSP systems and approximately 40 CosMx™ Spatial Molecular Imager (SMI) systems, bringing total CosMx orders to date to more than 100 systems
  • CosMx Publication in Nature Biotechnology: Published a paper describing the technical details and performance of the CosMx SMI, including the spatial imaging of 1,000 RNAs and 100 proteins in mapped at single-cell and subcellular resolution generated from non-small cell and breast cancer tissue
  • GeoMx Studies Featured on Covers of Two Major Scientific Journals: Peer-reviewed papers using the GeoMx Human Whole Transcriptome Atlas (WTA) and the GeoMx Cancer Transcriptome Atlas, respectively, featured on the covers of the August issue of Nature Genetics and the September 18 issue of Clinical Cancer Research
  • Visiopharm Collaboration: Announced a collaboration with Visiopharm for co-development of integrated workflows for GeoMx and the AtoMx Spatial Informatics Platform that leverage AI-driven image analysis capabilities of Visiopharm
  • GeoMx Installed Base: Grew installed base to approximately 330 GeoMx DSP systems as of September 30, 2022, representing 47% growth over the prior year
  • GeoMx Publications: Continued growth of peer-reviewed publications utilizing GeoMx DSP technology, with approximately 30 new publications in the third quarter, bringing the cumulative total to approximately 160 peer-reviewed publications as of September 30, 2022

nCounter

  • nCounter Installed Base: Grew installed base to approximately 1,105 nCounter Analysis Systems as of September 30, 2022, representing 7% growth over the prior year
  • Publications: Surpassed 6,100 cumulative peer-reviewed publications utilizing nCounter technology as of September 30, 2022

Corporate

  • Portfolio Prioritization and Streamlined Cost Structure: Adjusting cost and organization structure to support objective of reaching cash flow breakeven utilizing existing balance sheet resources by maintaining key investments in spatial biology while realigning manufacturing capacity and reducing certain non-critical commercial and R&D initiatives

2022 Outlook

The company updated its 2022 outlook, with results expected as follows:

  • Orders for over 200 spatial biology systems, consistent with previous guidance
  • Cumulative orders for approximately 140 CosMx systems expected by the end of 2022, representing a total revenue value of more than $30 million
  • Total product and service revenue of $125 to $127 million, as compared to previous guidance of $140 to $150 million, reflecting an order mix that is weighted more heavily to CosMx, with material CosMx revenue recognition expected to begin in 2023
  • nCounter revenue, inclusive of all service revenue, of $83 to $84 million, as compared to previous guidance of $90 to $95 million
  • Adjusted EBITDA loss of approximately $100 million, as compared to previous guidance of $75 to $85 million

Financial Results

We have elected to present selected non-GAAP, or adjusted, financial measures, including Adjusted EBITDA. These adjusted financial measures are calculated excluding certain items that may make it more challenging to compare our GAAP operating results across periods. Such items may include collaboration revenue, stock-based compensation, depreciation and amortization, or one-time charges such as transaction related fees and expenses or restructuring charges and severance costs. A reconciliation of adjusted financial measures to the nearest comparable GAAP financial measure can be found in the tables at the end of this press release.

(dollars in thousands)

Three Months Ended September 30,

 

GAAP

 

Non-GAAP Adjusted

 

2022

 

2021

 

2022

 

2021

Product and service revenue

$

29,466

 

 

$

36,924

 

 

$

29,466

 

 

$

36,924

 

Collaboration revenue

 

75

 

 

 

226

 

 

 

 

 

 

 

Total revenue

 

29,541

 

 

 

37,150

 

 

 

29,466

 

 

 

36,924

 

Cost of product and service revenue

 

13,723

 

 

 

17,154

 

 

 

12,572

 

 

 

16,346

 

Gross Margin

 

53

%

 

 

54

%

 

 

57

%

 

 

56

%

Research and development

 

16,992

 

 

 

19,117

 

 

 

14,542

 

 

 

16,566

 

Selling, general and administrative

 

33,767

 

 

 

30,253

 

 

 

28,442

 

 

 

23,757

 

Adjusted EBITDA

 

N / A

 

 

 

N / A

 

 

$

(26,090

)

 

$

(19,745

)

 

 

 

 

 

 

 

 

Non-operating expense, net

 

(1,749

)

 

 

(1,887

)

 

 

(1,749

)

 

 

(1,887

)

Net loss

$

(36,690

)

 

$

(31,261

)

 

$

(27,839

)

 

$

(21,632

)

 

 

 

 

 

 

 

 

 

Nine Months Ended September 30,

 

GAAP

 

Non-GAAP Adjusted

 

2022

 

2021

 

2022

 

2021

Product and service revenue

$

92,305

 

 

$

101,950

 

 

$

92,305

 

 

$

101,950

 

Collaboration revenue

 

535

 

 

 

680

 

 

 

 

 

 

 

Total revenue

 

92,840

 

 

 

102,630

 

 

 

92,305

 

 

 

101,950

 

Cost of product and service revenue

 

44,353

 

 

 

48,258

 

 

 

41,117

 

 

 

46,108

 

Gross Margin

 

52

%

 

 

53

%

 

 

55

%

 

 

55

%

Research and development

 

51,755

 

 

 

51,342

 

 

 

43,972

 

 

 

43,608

 

Selling, general and administrative

 

106,234

 

 

 

83,907

 

 

 

88,063

 

 

 

66,432

 

Adjusted EBITDA

 

N / A

 

 

 

N / A

 

 

$

(80,847

)

 

$

(54,198

)

 

 

 

 

 

 

 

 

Non-operating expense, net

 

(5,927

)

 

 

(5,116

)

 

 

(5,927

)

 

 

(5,116

)

Net loss

$

(115,429

)

 

$

(85,993

)

 

$

(86,774

)

 

$

(59,314

)

 

 

 

 

 

 

 

 

Supplemental Information

As a supplement to the table above, we have posted to the investor relations section of our website, at https://investors.nanostring.com/financials/quarterly-results/default.aspx, supplemental financial data that include our adjusted financial measures as compared to the nearest comparable GAAP financial measures, for the third quarter and the nine months ended September 30, 2022 and for each quarter of and the full year of 2021.

Conference Call

Management will host a conference call today beginning at 1:30 pm PT / 4:30 pm ET to discuss these results and answer questions. Investors and other interested parties can register for the call in advance by visiting https://investors.nanostring.com/events-and-presentations/default.aspx. After registering, an email confirmation will be sent including dial-in details and unique conference call codes for entry. Registration is open throughout the call, but to ensure connection for the full call, registration in advance is recommended. The link to the webcast and audio replay will be made available at the Investor Relations website: www.nanostring.com. A replay of the call will be available beginning November 7, 2022 at 7:30pm ET through midnight ET on November 14, 2022. To access the replay, dial (866) 813-9403 or (929) 458-6194 and reference Conference ID: 931170. The webcast will also be available on our website for one year following the completion of the call.

Non-GAAP, or Adjusted, Financial Information

We believe that the presentation of non-GAAP, or adjusted, financial information provides important supplemental information to management and investors regarding financial and business trends relating to our financial condition and results of operations. Reconciliation of adjusted financial measures to the most directly comparable financial result as determined in accordance with GAAP are included at the end of this press release following the accompanying financial data. A reconciliation of adjusted guidance measures to corresponding GAAP measures is not available on a forward-looking basis without unreasonable effort due to the uncertainty regarding certain expenses that may be incurred in the future. For further information regarding why we believe that these adjusted measures provide useful information to investors, the specific manner in which management uses these measures and some of the limitations associated with the use of these measures, please refer to “Notes Regarding Non-GAAP Financial Information” at the end of this press release.

About NanoString Technologies, Inc.

NanoString Technologies is a leading provider of life science tools for discovery and translational research. The company provides three platforms that allow researchers to map the universe of biology. The nCounter® Analysis System, cited in more than 6,100 peer-reviewed publications, offers a way to easily profile the expression of hundreds of genes, proteins, miRNAs, or copy number variations, simultaneously with high sensitivity and precision. NanoString’s GeoMx® Digital Spatial Profiler enables highly multiplexed spatial profiling of RNA and protein targets in various sample types, including FFPE tissue sections, and has been cited in approximately 160 peer-reviewed publications. The CosMx™ Spatial Molecular Imager, with commercial availability expected in 2022, enables highly sensitive, high-resolution imaging of hundreds to thousands of RNAs or proteins directly from single cells within morphologically intact whole tissue sections. For more information, visit www.nanostring.com.

Forward-Looking Statements

This news release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995. These forward-looking statements include statements regarding expectations for demand for our products and growth in our business, future revenue growth, future operating results, future cash flows, the impact of adjustments to our cost and organization structure, the impact of the COVID-19 pandemic on our operations and future financial performance, the impact of new products and expansion into new markets, the growth trajectory of our nCounter, GeoMx and CosMx franchises, the anticipated launch of new products and technology and our estimated 2022 operating results and our anticipated GAAP and non-GAAP operating results. Such statements are based on current assumptions that involve risks and uncertainties that could cause actual outcomes and results to differ materially. These risks and uncertainties, many of which are beyond our control, include market acceptance of our products; delays or denials of regulatory approvals or clearances for products or applications; the extent and duration of the impact of the COVID-19 pandemic and adverse conditions in the general domestic and global economic markets; the effects of ongoing litigation; the impact of competition; the impact of expanded sales, marketing, product development and clinical activities on operating expenses; delays or other unforeseen problems with respect to manufacturing and product development; as well as the other risks set forth in our filings with the Securities and Exchange Commission. These forward-looking statements speak only as of the date hereof. NanoString Technologies disclaims any obligation to update these forward-looking statements.

The NanoString logo, NanoString, NanoString Technologies, GeoMx, CosMx, and nCounter are trademarks or registered trademarks of NanoString Technologies, Inc., in the United States and/or other countries.

NANOSTRING TECHNOLOGIES, INC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(In thousands, except per share amounts)

(Unaudited)

 

Three Months Ended

September 30,

 

Nine Months Ended

September 30,

 

2022

 

2021

 

2022

 

2021

Revenue:

 

 

 

 

 

 

 

Instruments

$

8,023

 

 

$

14,495

 

 

$

26,664

 

 

$

38,056

 

Consumables

 

16,582

 

 

 

18,028

 

 

 

51,897

 

 

 

51,972

 

Services

 

4,861

 

 

 

4,401

 

 

 

13,744

 

 

 

11,922

 

Total product and service revenue

 

29,466

 

 

 

36,924

 

 

 

92,305

 

 

 

101,950

 

Collaboration

 

75

 

 

 

226

 

 

 

535

 

 

 

680

 

Total revenue

 

29,541

 

 

 

37,150

 

 

 

92,840

 

 

 

102,630

 

Costs and expenses:

 

 

 

 

 

 

 

Cost of product and service revenue

 

13,723

 

 

 

17,154

 

 

 

44,353

 

 

 

48,258

 

Research and development

 

16,992

 

 

 

19,117

 

 

 

51,755

 

 

 

51,342

 

Selling, general and administrative

 

33,767

 

 

 

30,253

 

 

 

106,234

 

 

 

83,907

 

Total costs and expenses (a) (b)

 

64,482

 

 

 

66,524

 

 

 

202,342

 

 

 

183,507

 

Loss from operations

 

(34,941

)

 

 

(29,374

)

 

 

(109,502

)

 

 

(80,877

)

Other income (expense):

 

 

 

 

 

 

 

Interest income

 

774

 

 

 

153

 

 

 

1,331

 

 

 

502

 

Interest expense

 

(1,887

)

 

 

(1,876

)

 

 

(5,650

)

 

 

(5,614

)

Other income expense, net

 

(579

)

 

 

(223

)

 

 

(1,286

)

 

 

79

 

Total other expense, net

 

(1,692

)

 

 

(1,946

)

 

 

(5,605

)

 

 

(5,033

)

Net loss before provision for income taxes

 

(36,633

)

 

 

(31,320

)

 

 

(115,107

)

 

 

(85,910

)

Provision for income taxes

 

(57

)

 

 

59

 

 

 

(322

)

 

 

(83

)

Net loss

$

(36,690

)

 

$

(31,261

)

 

$

(115,429

)

 

$

(85,993

)

Net loss per share, basic and diluted

$

(0.79

)

 

$

(0.69

)

 

$

(2.49

)

 

$

(1.90

)

Weighted average shares used in computing basic and diluted net loss per share

 

46,529

 

 

 

45,558

 

 

 

46,320

 

 

 

45,170

 

 

 

 

 

 

 

 

 

(a) Includes $5.5 million and $8.3 million of stock-based compensation expense for the three month period ended September 30, 2022, and 2021, respectively, and $19.6 million and $23.7 million for the nine months ended September 30, 2022 and 2021, respectively.

(b) Includes $1.6 million and $1.5 million of depreciation and amortization expense for the three month period ended September 30, 2022 and 2021, respectively, and $5.2 million and $4.3 million for the nine months ended September 30, 2022 and 2021, respectively.

 

NANOSTRING TECHNOLOGIES, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(In thousands)

(Unaudited)

 

September 30, 2022

 

December 31, 2021

Assets

 

 

 

Current assets:

 

 

 

Cash and cash equivalents

$

117,069

 

$

107,068

Short-term investments

 

113,384

 

 

241,821

Accounts receivable, net

 

27,273

 

 

40,130

Inventory, net

 

45,761

 

 

31,486

Prepaid expenses and other

 

15,221

 

 

7,115

Total current assets

 

318,708

 

 

427,620

Property and equipment, net

 

40,374

 

 

27,043

Operating lease right-of-use assets

 

18,586

 

 

19,226

Other assets

 

5,932

 

 

5,592

Total assets

$

383,600

 

$

479,481

Liabilities and Stockholders’ Equity

 

 

 

Current liabilities:

 

 

 

Accounts payable

$

16,829

 

$

14,283

Accrued liabilities

 

4,898

 

 

6,765

Accrued compensation and other employee benefits

 

14,733

 

 

17,466

Customer deposits

 

1,071

 

 

1,278

Deferred revenue and other liabilities, current portion

 

8,026

 

 

7,474

Operating lease liabilities, current portion

 

5,382

 

 

4,889

Total current liabilities

 

50,939

 

 

52,155

Deferred revenue and other liabilities, net of current portion

 

3,757

 

 

3,527

Long-term debt, net

 

226,250

 

 

225,144

Operating lease liabilities, net of current portion

 

19,726

 

 

21,693

Total liabilities

 

300,672

 

 

302,519

Total stockholders’ equity

 

82,928

 

 

176,962

Total liabilities and stockholders’ equity

$

383,600

 

$

479,481

Notes Regarding Non-GAAP Financial Information. In addition to our results reported in accordance with U.S. generally accepted accounting principles (“GAAP”), we believe certain non-GAAP, or adjusted, measures are useful in evaluating our operating performance. We use adjusted financial measures to evaluate our ongoing operations and for internal planning and forecasting purposes. We believe that adjusted financial measures, when taken collectively, may be helpful to investors because it provides consistency and comparability with past financial performance. However, adjusted financial information has limitations as an analytical tool and should not be considered in isolation or as a substitute for financial information presented in accordance with U.S. GAAP. In particular, other companies, including companies in our industry, may calculate similarly titled non-GAAP or adjusted measures differently or may use other measures to evaluate their performance, all of which could reduce the usefulness of our adjusted financial measures as tools for comparison. A reconciliation is provided below for adjusted financial measures to the most directly comparable financial measure stated in accordance with U.S. GAAP. Investors are cautioned that there are a number of limitations associated with the use of non-GAAP, or adjusted, financial measures as analytical tools. Investors are encouraged to review the related U.S. GAAP financial measures and the reconciliation of these adjusted financial measures to their most directly comparable U.S. GAAP financial measure, and not to rely on any single financial measure to evaluate our business.

Expenses excluded from non-GAAP, or adjusted, cost of product and service revenue, research and development expense and selling, general and administrative expense and net loss. We exclude stock-based compensation expense and depreciation and amortization expense, which are non-cash expenses, from certain of our adjusted financial measures because we believe that excluding such items provides meaningful supplemental information regarding operational performance. We exclude certain expenses related to collaborations, recoveries of certain previously remitted state and local taxes, cloud computing arrangement implementation expenses, litigation expenses, and other business development expenses from certain of our adjusted financial measures because such expenses have no direct correlation to the continuing operation of our business as such expenses are non-recurring or non-operating in nature, and therefore we believe excluding these items provides meaningful supplemental information regarding operational performance.

Adjusted EBITDA. Adjusted EBITDA is a non-GAAP financial measure defined as GAAP net loss adjusted for collaboration revenue, stock-based compensation expense, depreciation and amortization, net interest expense, other non-operating expense or income, provision for income tax and other special items as determined by management, including certain expenses related to collaborations, recoveries of certain previously remitted state and local taxes, cloud computing arrangement implementation expenses, litigation expenses, and other business development expenses.

The following tables reflect the reconciliation between GAAP and non-GAAP measures (in thousands).

 

Three Months Ended September 30,

 

Nine Months Ended

September 30,

 

2022

 

2021

 

2022

 

2021

Net loss - GAAP

$

(36,690

)

 

$

(31,261

)

 

$

(115,429

)

 

$

(85,993

)

Collaboration revenue

 

(75

)

 

 

(226

)

 

 

(535

)

 

 

(680

)

Stock-based compensation

 

5,519

 

 

 

8,284

 

 

 

19,644

 

 

 

23,689

 

Depreciation and amortization

 

1,647

 

 

 

1,467

 

 

 

5,151

 

 

 

4,347

 

Interest expense, net

 

1,113

 

 

 

1,723

 

 

 

4,319

 

 

 

5,112

 

Other (income) expense, net

 

579

 

 

 

223

 

 

 

1,286

 

 

 

(79

)

Provision for income taxes

 

57

 

 

 

(59

)

 

 

322

 

 

 

83

 

Other business development expenses

 

 

 

 

 

 

 

393

 

 

 

115

 

Litigation expenses

 

1,604

 

 

 

 

 

 

3,534

 

 

 

 

Recovery of certain previously remitted state and local taxes

 

 

 

 

 

 

 

 

 

 

(896

)

Cloud computing arrangement implementation expenses

 

156

 

 

 

104

 

 

 

468

 

 

 

104

 

Adjusted EBITDA - non-GAAP

 

(26,090

)

 

 

(19,745

)

 

 

(80,847

)

 

 

(54,198

)

Non-operating expense, net

 

(1,749

)

 

 

(1,887

)

 

 

(5,927

)

 

 

(5,116

)

Net loss - non-GAAP

$

(27,839

)

 

$

(21,632

)

 

$

(86,774

)

 

$

(59,314

)

 

 

 

 

 

 

 

 

 

Three Months Ended September 30, 

 

Nine Months Ended

September 30,

 

2022

 

2021

 

2022

 

2021

GAAP Total revenue

$

29,541

 

 

$

37,150

 

 

$

92,840

 

 

$

102,630

 

Collaboration revenue

 

(75

)

 

 

(226

)

 

 

(535

)

 

 

(680

)

Non-GAAP Total revenue

$

29,466

 

 

$

36,924

 

 

$

92,305

 

 

$

101,950

 

 

 

 

 

 

 

 

 

GAAP Cost of product and service revenue

$

13,723

 

 

$

17,154

 

 

$

44,353

 

 

$

48,258

 

Stock-based compensation

 

(740

)

 

 

(631

)

 

 

(2,015

)

 

 

(1,656

)

Depreciation and amortization

 

(411

)

 

 

(177

)

 

 

(1,221

)

 

 

(494

)

Non-GAAP Cost of product and service revenue

$

12,572

 

 

$

16,346

 

 

$

41,117

 

 

$

46,108

 

 

 

 

 

 

 

 

 

GAAP Gross Margin

 

53

%

 

 

54

%

 

 

52

%

 

 

53

%

Non-GAAP Gross Margin

 

57

%

 

 

56

%

 

 

55

%

 

 

55

%

 

 

 

 

 

 

 

 

GAAP Research and development

$

16,992

 

 

$

19,117

 

 

$

51,755

 

 

$

51,342

 

Stock-based compensation

 

(1,743

)

 

 

(1,598

)

 

 

(5,304

)

 

 

(4,639

)

Depreciation and amortization

 

(707

)

 

 

(953

)

 

 

(2,479

)

 

 

(2,980

)

Other business development activities

 

 

 

 

 

 

 

 

 

 

(115

)

Non-GAAP Research and development

$

14,542

 

 

$

16,566

 

 

$

43,972

 

 

$

43,608

 

 

 

 

 

 

 

 

 

GAAP Selling, general and administrative

$

33,767

 

 

$

30,253

 

 

$

106,234

 

 

$

83,907

 

Stock-based compensation

 

(3,036

)

 

 

(6,055

)

 

 

(12,325

)

 

 

(17,394

)

Depreciation and amortization

 

(529

)

 

 

(337

)

 

 

(1,451

)

 

 

(873

)

Other business development activities

 

 

 

 

 

 

 

(393

)

 

 

 

Litigation expenses

 

(1,604

)

 

 

 

 

 

(3,534

)

 

 

 

Recovery of certain previously remitted state and local taxes

 

 

 

 

 

 

 

 

 

 

896

 

Cloud computing arrangements implementation expense

 

(156

)

 

 

(104

)

 

 

(468

)

 

 

(104

)

Non-GAAP Selling, general and administrative

$

28,442

 

 

$

23,757

 

 

$

88,063

 

 

$

66,432

 

 


Contacts

Doug Farrell
Vice President, Investor Relations & Corporate Communications
dfarrell@nanostring.com
Phone: 206-602-1768

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Last Updated: 08-Nov-2022