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Protein Expression Market surpassed US$ 3.2 billion in 2021, owing to increasing demand for protein biologics | insightSLICE

The global Protein Expression market size was estimated to be US$ 3.2 billion in 2021 and is expected grow at a CAGR of 10.5% between 2023 to 2032.

The information for protein synthesis is encoded in DNA, which is subsequently decoded by strictly controlled regulatory processes to produce messenger RNA (mRNA).

Transcription is the act of transferring information from DNA to mRNA, whereas translation is the process of producing protein depending on the sequence dictated by those mRNA molecules. Only after the mRNA sequence is translated in the ribosomes, a polypeptide is created which can then be converted to a functional protein by post-translational modifications in the cytosol.

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Global Protein Expression Market Key Segments:

By Expression System

  • Prokaryotic
  • Mammalian Cell
  • Insect Cell
  • Yeast
  • Others

By Application

  • Therapeutic
  • Industrial
  • Research

By End-user

  • Pharmaceutical & Biotechnological Companies
  • Academic Research
  • Contract Research Organizations
  • Others

By Geography

  • North America
    • United States
    • Canada
    • Rest of North America
  • Europe
    • Germany
    • United Kingdom
    • Italy
    • France
    • Spain
    • Rest of Europe
  • Asia Pacific
    • Japan
    • India
    • China
    • Australia
    • Rest of Asia Pacific
  • Middle East & Africa
    • UAE
    • Saudi Arabia
    • South Africa
    • Rest of the Middle East & Africa
  • South America
    • Brazil
    • Rest of South America

Uses of Protein Expression technologies in biomedical field:

Several pharmaceutical companies are now largely reliant on protein expression to develop new therapies with minimal side effects. Besides biological protein synthesis, we can also perform artificial recombinant protein expressions by use of chemical synthesis, in-vivo, and in-vitro protein expression.

Several protein production systems are now utilized in biotechnology, healthcare, and biomedical field. For purpose of RNA processing, reverse transcriptase is employed, whereas DNA polymerase is specifically used for PCR, and cloning can be done by use of restriction enzymes.

These chemicals are also utilized in conjunction to synthesize proteins that are exploited in drug development as target antigens or as potential therapeutics.

The advancement of gene editing and recombinant technology has resulted in a plethora of alternatives for recombinant protein production and isolation for scientific, medical, and industrial purposes. Because of substantial breakthroughs in biotechnology, massive recombinant protein synthesis (or expression) and purification are now achievable.

The key players of the Global Protein Expression Market are:

Our protein expression market research report examines some of the major players worldwide. Among the major manufacturers highlighted in the report are Agilent Technologies, Inc., Bio-Rad Laboratories, Inc., Merck Group, New England BioLabs, Inc., Oxford Expression Technologies Ltd., Promega Corporation, Qiagen N.V., Thermo Fisher Scientific, Inc., Takara Bio, Inc. (Takara Holdings Inc.), and LGC Biosearch Technologies.

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Factors influencing the growth of Protein Expression Market:

Biologics have proven to be essential in the treatment of a broad spectrum of health complications. The growing need for biologicals increases the chance that protein expression methods will be used in their manufacture. Simultaneous bioprocessing has also developed as a cutting-edge technique for the growth of both upstream and downstream processes, as well as the production of protein therapies.

The protein expression market is now very profitable as a result of the rising use of bioinformatics and genetic engineering in the pharmaceutical and medical industries.

The pandemic had a favorable effect on the protein expression business as well. Adequate knowledge of the involvement of numerous proteins in the SARS-CoV-2 infection cycle and COVID-19 development has sped up the discovery of preventative and therapeutic therapies.

The large field of proteomics offered all of the necessary tools to help with this challenge. Researchers demonstrated that advances in proteomics research will not only speed up efforts to avert the coronavirus pandemic but will also be effective in addressing other issues.

Growth forecast for different types of Protein Expression systems:

Because it is substantially easier to use and achieve crucial research objectives, the prokaryotic protein expression sector held the highest percentage of more than forty percent. Due to attractive characteristics such as large-scale recombinant protein biosynthesis in a short period and on a reduced budget, the segment is likely to maintain its position during the forecast period.

The mammalian cell category is likewise predicted to grow quickly during the forecast period. Several pharmaceutical firms have begun to use mammalian expression systems to produce and manufacture proteins in transient or stable cell lines.

The employment of these systems, however, is defined by the purpose, and strategy may alter as needed. Microbiological expression, for example, is excellent for antigen manufacturing, structural investigation, and activity studies where the post-translational modification is not required.

Vaccine and treatment manufacturers, on the other hand, prefer mammalian cells due to sophisticated post-translational modification processes. As a result, rising process requirements for mammalian expression systems will drive this industry forward shortly.

Due to rising demand and customer tolerance, cell-free protein expression is now being used. In-vitro cell-free protein expression is achieved without the need for living cells. This method has several benefits over other protein expression techniques, and as a result, it is commonly employed.

Cell-free protein approaches are becoming more popular due to benefits such as enhanced speed, the potential to express hazardous proteins, and the versatility of amino acids without selective labeling, among others.

As a result, this novel technology can accelerate the growth of the cell-free expression sector and is therefore expected to boost the protein expression market.

Regional performance of Protein Expression Market

North America, Europe, Asia Pacific, the Middle East, and Latin America are all covered in our protein expression market report. The North American market now accounts for the majority of revenue in the protein expression sector.

This substantial market share can be attributed to the presence of major competitors in the industry, increased R&D investment, and robust biosimilar portfolios. Collaboration between businesses and academic institutions has been acknowledged as one of the most effective development strategies used in this region.

Because of expanding protein therapy approvals in a variety of treatments, particularly in India and China, Asia Pacific is likely to be the fastest-growing market for protein expression kits throughout the projection period.

Furthermore, the expanding focus on proteomics and genomics work, as well as increased efforts by institutions to produce breakthrough protein therapies, have provided attractive positive chances for the Asia Pacific market throughout the forecast period.

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Hindering factors for growth of Protein Expression Market

Protein expression generates crude proteins, which are then extracted and purified. Because of the inherent complexity of proteins, protein expression and purification are typically problematic. Certain sequences or structural features inside a protein may affect the production and stability of recombinant proteins if they are not appropriately extracted or purified.

Overexpression or accumulation of the target protein may cause unexpected physiological changes such as misfolded proteins or protein breakdown. These issues hamper the adoption of protein therapeutic solutions, delaying the protein expression market’s growth.

Because of their excellent quality and purity, protein expression equipment and reagents are expensive. As a result of such high prices, the overall production cost of bioactive proteins skyrockets. Although protein expression methods based on E. coli are not expensive, however large-scale synthesis can be pricey.

Such high pricing of protein expression systems and reagents in commercial and research applications, especially in developing countries, may be prohibitive and lead to a reduction in the uptake of innovative treatments.

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Last Updated: 09-Nov-2022