Kinarus Therapeutics Engages Great Health Companion Group to Explore Partnerships in China
Kinarus Therapeutics Holding AG
/ Key word(s): Partnership
Basel, Switzerland, 16 November 2022. Kinarus Therapeutics Holding AG (SIX: KNRS) (“Kinarus”), a clinical-stage biopharmaceutical company developing novel therapeutics to treat viral, respiratory, and ophthalmic diseases, announced today that it has engaged Great Health Companion Group Ltd (GHCG), a subsidiary of Hakim Unique Group, a global conglomerate from China, to explore partnering options to initiate Phase 2 testing of KIN001 to treat wet age-related macular degeneration (wAMD) and idiopathic pulmonary fibrosis (IPF). In addition, Kinarus and GHCG will explore further business opportunities which may include licensing or strategic partnerships.
Dr Alexander Bausch, CEO of Kinarus Therapeutics Holding AG, commented: “China has the world’s largest population and second largest economy. The China’s economic growth has increased their ability to invest heavily in innovation technology, infrastructure and healthcare for their population. Because of their vast aging population, healthcare demands require public and private organizations both domestic and internationally to collaborate to achieve mutual success. Furthermore Chinese partners have historically shown strong interest in Phase 2 clinical assets with proven potential to address unmet medical needs in China. KIN001 meets these criteria and for this reason, we are pleased to engage GHCG to represent us in China.
“Kinarus is prepared to launch Phase 2 trials in wAMD and IPF, and is currently conducting a Phase 2 trial of KIN001 in ambulatory Covid-19 patients aiming to reduce severity and duration of symptoms. We look forward to working closely with GHCG as we seek to accelerate the clinical development of KIN001 and to maximize the value and opportunities it represents.”
Kinarus Clinical Programs:
KIN001 is a patented combination of two active pharmaceutical ingredients (APIs): pamapimod and pioglitazone. Pamapimod is a highly selective clinical stage small molecule inhibitor of the p38 MAP kinase signaling pathway. Kinarus has obtained an exclusive worldwide license from Roche for the development of pamapimod in all therapeutic indications. p38 MAPK inhibitors were broadly considered to have blockbuster potential, with several compounds evaluated through mid-stage clinical trials. Most efforts were abandoned after finding that the initial therapeutic benefit of p38 MAPK inhibition decreased over time due to compensatory mechanisms that blocked its beneficial effects.
Kinarus has discovered a potential way to overcome this limitation. Kinarus has found that combining pamapimod with pioglitazone, a safe and well-tolerated marketed drug for the treatment of type 2 diabetes, leads to synergistic efficacy and increased duration of action in preclinical models of wAMD, IPF and other autoimmune/inflammation indications. The KIN001 drug combination thereby revives the important therapeutic potential of p38 MAPK inhibition. KIN001 enjoys broad patent protection in the US, EU, China, and other countries through at least 2037, with intellectual property wholly owned by Kinarus.
Kinarus Therapeutics Holding AG (www.kinarus.com) was founded in 2017 by experienced pharmaceutical executives in Basel, Switzerland. The Kinarus team utilizes its knowledge and drug development competencies to in-license and develop mid-stage clinical assets in which they have identified an increased probability of clinical and regulatory success and a rapid path to market. Kinarus possesses the exclusive worldwide license to pamapimod covering all indications.
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