Isomerase Enhances Process Innovation Capabilities for Protein Discovery and Production

Isomerase, a leader in contract fermentation process development, is proud to announce the integration of its process innovation capabilities into its end-to-end platform for protein discovery and production, IsoZym. Our Process Innovation facility enables us to scale processes from the lab to manufacturing scale, providing clients with specialised, flexible and cost-effective fermentation solutions.

Upstream Bioprocess Development (USP)

• Generation and validation of cell banks: Working cell banks (WCBs) and master cell banks (MCBs).
• Inoculation of media and seed cultures.
• Production of fermentation media.
• Fermentation phase and harvesting.
• Improved titres, rates, and yields: Reduced unwanted side-products and accelerated process optimisation with statistical experimental design.

Downstream Bioprocess Development (DSP)

• Cell separation: Centrifugation, membrane filtration.
• Cell disruption: Homogenisation or sonication.
• Extraction: Solvent extraction.
• Isolation: Initial enrichment of the target product.
• Purification: Final purification of the product to levels required for release.
• Drying: Lyophilisation or spray drying.
• Lab-scale DSP for compound supply.
• Fully developed DSP for tech transfer to CDMO.
• Design of Experiments (DoE) approaches used throughout.

CDMO Tech Transfer and Scale Up

• Generating robust processes and detailed documentation.
• Generating and sending out requests for quote (RFQ): Leveraging Isomerase’s large network of CDMOs.
• Selection of the most appropriate supplier.
• Technical transfer of the process.
• Management of process life cycle: Putting “boots on the ground”.
• Reduced risks and costs: Minimised roadblocks and delays during scale-up means quicker time to market.

Process Innovation Facility

As part of our bioprocess development services, we provide access to our Process Innovation facility at Solopark, Cambridge. Utilising our experience, and Design of Experiments (DoE) as well as quality by design (QbD) approaches, we offer comprehensive bioprocess development services on scales including microtiter plate, 3 L and 7 L stirred tank reactors, as well as 20/30 L in-place sterilised tanks.

Upstream Process Development             

Downstream Process Development 

Tech Transfer and Scale Up

Why Choose Isomerase as Your Process Innovation Partner?

At Isomerase, we provide end-to-end Upstream and Downstream process development expertise, from lab-scale microbial fermentation to pilot-scale and full-scale manufacturing. Our team of bioprocess engineers, molecular biologists, and analytical chemists, ensure a collaborative, multidisciplinary approach to increase the likelihood of commercial success.

With a strong commitment to innovation and responsible biotechnology, Isomerase delivers customised, high-quality solutions to help clients de-risk scale-up, enhance process efficiency, and accelerate time to market.

To learn more about how we can collaborate on your process innovation project contact us on our website (Contact Us - Isomerase) or email us at bd@isomerase.com.