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16-May-2025

Complex Regional Pain Syndrome (CRPS) Market to Reach USD 129.2 Million by 2033 amid Rising Chronic Pain Cases and Advancements in Drug Therapies | FMI

The global complex regional pain syndrome market is projected to experience steady growth over the next decade, driven by rising chronic pain incidences, improved patient awareness, and evolving therapeutic innovations. According to a comprehensive market analysis by Future Market Insights (FMI), the CRPS market is currently valued at USD 103.7 million in 2023 and is expected to reach USD 129.2 million by 2033, expanding at a modest CAGR of 2.2% over the forecast period (2023 to 2033).

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Increasing Prevalence of CRPS Driving Market Growth

CRPS is a chronic, debilitating pain disorder typically triggered by trauma or injury, often affecting the limbs. It is categorized into two types:

  • Type I (Reflex Sympathetic Dystrophy): Occurs without confirmed nerve injury.
  • Type II (Causalgia): Develops following a distinct nerve injury.

Although the precise cause remains unknown, around 90% of CRPS cases are linked to physical injuries, including fractures, surgical interventions, or soft tissue trauma. CRPS patients often present with peripheral nerve abnormalities and elevated inflammatory markers such as cytokines—common among those with autoimmune and inflammatory disorders.

While the prognosis varies from patient to patient, with some recovering over time, others experience long-term disabilities. Research also indicates a higher incidence among females, who are affected three times more than males. A UK-based study reveals that 1 in every 3,800 people develops CRPS annually.

Regional Outlook: North America at the Helm

North America: Market Share – 58.5%

North America stands as the undisputed leader in the global CRPS market. The region’s dominance stems from heightened awareness of disease remittance therapy, favorable reimbursement structures, substantial healthcare expenditure, and a robust clinical pipeline of emerging therapies.

The United States, holding a 48.7% market share, has been instrumental in propelling regional growth through aggressive research and high adoption of innovative drug therapies. With growing access to quality care and supportive regulatory pathways, North America is expected to maintain its lead with a CAGR of 2.1% over the forecast period.

Europe: Market Share – 14.5%

Europe trails behind North America but maintains a notable market presence, primarily due to strong public health initiatives and increasing CRPS awareness.

Asia Pacific: Emerging Hotspot for Growth

Asia Pacific is set to witness substantial expansion during the forecast period. As urbanization accelerates and chronic pain disorders become more prevalent, the region is poised for strong market uptake. Asia Pacific held a 35% market share in 2022, reflecting its rising prominence.

Countries such as China (CAGR: 2.5%), India (2.0%), and Australia (1.8%) are seeing surging demand for CRPS treatment, thanks to increasing healthcare investments and faster drug approval frameworks.

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Therapy Trends: Drug-Based Treatments Take Center Stage

Among therapy types, drug-based therapies dominate the market with a 38.2% market share. The growing elderly population, increasing number of surgeries, and the prevalence of other chronic pain disorders like back pain and migraines are contributing factors.

Popular drug categories for CRPS treatment include:

  • Analgesics
  • Antidepressants
  • Corticosteroids
  • Other pain management medications

Drug therapy is expected to grow at a CAGR of 2% between 2023 and 2033. Additionally, physical therapies and invasive options like Spinal Cord Stimulation (SCS) and Intrathecal Drug Pumps are being adopted in advanced cases.

Distribution Insights: Hospitals Remain Primary Access Points

Hospital pharmacies remain the leading distribution channel, accounting for 48.2% of the market. These facilities continue to serve as central points for patient care, diagnostics, and prescription fulfillment. Other channels such as drug stores, retail pharmacies, and online platforms are gaining traction but still lag behind in overall contribution.

Competitive Landscape: Innovation and Pipeline Development Key to Leadership

The CRPS market remains moderately competitive, with a mix of established pharmaceutical giants and emerging players focusing on novel therapies and drug delivery technologies.

Key players in the global market include:

  • Mallinckrodt Pharmaceuticals
  • GlaxoSmithKline plc (GSK)
  • Mylan N.V.
  • Teva Pharmaceutical Industries Ltd.
  • AbbVie Inc.
  • ACTAVIS
  • Zydus Pharmaceuticals Inc.
  • Sandoz
  • Janssen Global Services LLC
  • Medline Plus

Recent Industry Developments

  • August 2022: GSK submitted a New Drug Application (NDA) for Momelotinib, targeting unmet needs in anemia-linked myelofibrosis, gaining FDA acceptance.
  • June 2022: Mallinckrodt Pharmaceuticals resubmitted its NDA for Terlipressin, an investigational treatment for hepatorenal syndrome (HRS), highlighting the company’s focus on life-threatening conditions with limited treatment options.

Stay Ahead of Healthcare Market Disruptions! https://www.futuremarketinsights.com/industry-analysis/therapy-area

Key Segments Profiled in the Complex Regional Pain Syndrome (CRPS) Industry Survey

By Therapy Type:

  • Physical Therapy
  • Therapy via Drugs
    • Analgesics
    • Antidepressants
    • Corticosteroids
    • Others
  • Surgical Sympathectomy
  • Intrathecal Drug Pumps
  • Spinal Cord Stimulation

By Route of Administration:

  • Oral Therapy
  • Intravenous Therapy

By Distribution Channel:

  • Hospital Pharmacy
  • Drug Stores
  • Retail Pharmacy
  • E-Commerce

By Region:

  • North America
  • Latin America
  • Europe Complex
  • Asia Pacific
  • The Middle East and Africa

Future Outlook

The global CRPS market is likely to maintain steady growth through 2033, driven by an increasing number of diagnoses, the development of more effective and targeted treatments, and enhanced access to healthcare in emerging economies. Strategic market expansion, particularly in Asia Pacific and Latin America, coupled with continued R&D investments, will be essential for industry players looking to gain competitive advantage.

As stakeholders continue to prioritize early diagnosis, patient education, and personalized pain management, the CRPS market is expected to witness further breakthroughs that will redefine chronic pain care for millions of patients globally.

About Future Market Insights (FMI)

Future Market Insights, Inc. (ESOMAR certified, recipient of the Stevie Award, and a member of the Greater New York Chamber of Commerce) offers profound insights into the driving factors that are boosting demand in the market. FMI stands as the leading global provider of market intelligence, advisory services, consulting, and events for the Packaging, Food and Beverage, Consumer Technology, Healthcare, Industrial, and Chemicals markets. With a vast team of over 400 analysts worldwide, FMI provides global, regional, and local expertise on diverse domains and industry trends across more than 110 countries.

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Last Updated: 16-May-2025