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Specialised commissioning continues to be an issue of significance and uncertainty for both the NHS and industry. What do the latest reports of regional push back on the plans for devolution to Integrated Care Boards (ICBs) mean? Learn more about our upcoming webinar here.
For the past 2 years, Pharma, Medtech, and Diagnostic companies have identified the delegation of specialised commissioning to the new Integrated Care Boards (ICBs) as a key risk to their UK market access strategies. With its importance to income and the high risk of change devolution seems to promise, specialised commissioning is an obvious issue for providers of these products to place at the top of their risk logs. The devolution plans are also a risk for the NHS. Not least, because around two-thirds of the income of a…
We are delighted to announce that the second edition of our popular introductory guide: ‘Market access and reimbursement in key European markets’ is now available. Our market access experts have updated the reimbursement routes and added new market insights for 2023/24.
We are delighted to announce that the second edition of our popular introductory guide: ‘Market access and reimbursement in key European markets’ is now available. Our market access experts have updated the reimbursement routes and added new market insights for 2023/24. In this introductory guide, our Global market access experts present an overview of the reimbursement landscape in key European healthcare systems. We highlight the differences between key markets and provide a high-level guide for…
Maria Dimitrova (Consultant – HTA) and Samantha Gillard (Director – HTA) provide an overview of the EU Joint Clinical Assessment (JCA) and what it means for Pharma and Medical Device manufacturers launching new technologies from 2025.
What is the EU JCA? In January 2022, the European Parliament enacted a new EU Health Technology Assessment (HTA) Regulation, with the aim of standardising clinical assessment of medicines and high-risk medical devices across the EU and avoiding duplication of work. Currently, Pharma and Medtech manufacturers have to submit evidence individually in each of the 27 EU markets; the intention of the JCA is that at least some of the assessment can be done centrally. The JCA report will act as a universal information source for relative treatment effects, safety…
In the realm of healthcare, the pervasive use of medical device coating has undeniably propelled advancements, enhancing the efficacy and functionality of critical instruments. Yet, this progress is not without consequence, as the environmental impact of these coatings looms large.
As of 2023, the global medical device coatings market stands at an estimated USD 7.7 billion, poised for a continuous upward trajectory at a compounded annual growth rate (CAGR) of 7.7%. The World Health Organization (WHO) reports an astounding two million medical devices globally, underlining the ubiquity of these coatings in modern healthcare. Against this backdrop, the imperative for environmental sustainability in medical device coating becomes paramount. The conundrum lies in balancing the relentless pursui…
In the dynamic realm of pharmaceutical innovation, DNA Encoded Libraries (DELs) have emerged as a transformative force, reshaping the landscape of drug discovery.
With the global DNA encoded library market estimated at USD 840 million in 2023 and a projected compound annual growth rate (CAGR) of 16%, their significance cannot be overstated, DELs, integrating cutting-edge technologies from X-Chem, Haystack Sciences, and ZebiAI, are revolutionizing hit identification and lead optimization. Pioneering companies like Relay Therapeutics exemplify the tangible impact of DELs in targeting proteins linked to conditions such as cystic fibrosis and lung diseases. As Pharma leaders navigate the intricate terrain of DNA sequencing, chemical libraries, and machine learning, this guide illuminates the s…
This comprehensive guide to healthcare covers three main aspects: mental health, physical health, and diseases. Mental health, often unseen, is about our cognitive, behavioral, and emotional wellbeing. It’s crucial at every stage of life and affects how we handle stress, relate to others, and make decisions. Common mental health disorders include depression, anxiety disorders, schizophrenia, eating disorders, and addictive behaviors. Physical health is the more visible aspect of healthcare. It involves maintaining a healthy body through good nutrition, regular exercise, and a healthy lifestyle. Common physical health conditions include heart disease, stroke, cancer, diabetes, and respiratory diseases. Diseases pose significant challenges in healthcare. They can be acute or chronic and can affect both mental and physical health.
Buffer solutions play an important role in most biopharmaceutical processes, such as purification, isolation, filtration, protein capturing, chromatographic filtration, crystallization steps, and reactions. Being a vital formulation of drug development, buffers are also used to control pH and maintain the stability of drugs in their final form. Buffer manufacturing requires space, higher titers, resources, and a lean operation system, which adds to the cost of drug development. Conventional buffer manufacturing is tedious and consumes time. To overcome the challenges, pharmaceutical industries are either looking for advanced tech-driven buffer manufacturing or outsourcing buffers from third-party vendors.
Recently, the trend of outsourcing buffer manufacturing system has been adopted by ph…
Cell cytometry is a powerful technology that allows rapid multi-parametric analysis of single cells inside the solution. It utilizes fluorescent light signals that pass through the cell suspension and read through detectors such as photomultiplier tubes and photodiodes. The signals are then converted into electronic signals and transferred on the computer devices to create standard written format data files. This novel technology has enabled scientists to do clinical research more efficiently. Cell cytometry plays a crucial role in determining the immune system response, particularly during cancer immunotherapy and drug development.
In both Allogeneic and Autologous cell therapy products, cell cytometry helps to evaluate key drug parameters that help to understand the effectiveness of the…
The antibiotics market, valued at a staggering USD 36 billion in 2023, stands as a critical pillar in global healthcare, combating bacterial infections—one of the leading causes of death worldwide. However, as multi-drug resistant bacteria infections loom larger, the arsenal of antibiotics faces depletion, with shortages in key players like penicillin and amoxicillin intensifying the challenge.
Traditional discovery methods, strained by these shortages and hindered by the rise of antimicrobial resistance, are struggling to keep pace. In this tumultuous landscape, the emergence of Artificial Intelligence (AI) becomes a beacon of hope, offering transformative potential. This article delves into the intricacies of the antibiotics market, exploring challenges posed by multi-drug resistant bacte…
In the intricate landscape of bioprocessing, the precision of buffer manufacturing emerges as a critical factor shaping the success of pharmaceutical and biotechnological endeavors. As we navigate the digital age, the art and science of buffer production have evolved significantly, becoming a fascinating journey marked by innovation and sophistication.
The importance of precise buffer design in bioprocessing cannot be overstated. Buffers, aqueous solutions tasked with controlling pH in drug manufacturing processes, serve as the unsung heroes, ensuring the stability of biologics and small molecules throughout production and in their final forms. This becomes particularly pertinent in an era where the global buffer preparation market is projected to grow at a notable CAGR of around 5.9% until…
Chromatography, a sophisticated analytical technique, plays a pivotal role in various industries, offering a powerful means of separating and analyzing complex mixtures. Derived from the Greek words "chroma" (color) and "grapho" (to write), chromatography enables the detailed examination of compounds within a sample, allowing for precise identification and quantification. Its significance extends across pharmaceuticals, biotechnology, environmental science, food and beverages, and more.
The roots of chromatography can be traced back to the early 20th century when Mikhail Tswett introduced the concept of liquid-phase chromatography. Over the years, chromatography techniques have evolved significantly, driven by technological advancements and a growing demand for more sophisticated analytical…
what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper!
Introduction In the early years, your phone’s predictive text made you wonder, then came Gmail’s Smart Reply feature that utilizes machine learning to provide one-sentence responses. Since then we have come a long way, all thanks to Generative AI or GenAI. This technology is now capable of creating art, composing coherent paragraphs, writing code, and even assisting scientists in clinical research. But what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper! What is Generative AI? Generative AI, in simple terms, is a type of artificial intelligence that can create things on its own, like writing text, generating…
New reports published today by CPI reveal the UK urgently needs to deliver a HealthTech industrial strategy to avoid falling behind in the rapidly growing HealthTech sector in the UK.
The reports warn that unless the Government steps in to support the industry, the UK could be losing out on highly skilled jobs and billions of pounds in revenue.     In 2021, the UK HealthTech sector consisted of 4,353 businesses with a £30bn turnover employing over 145,600 people across 4802 UK sites, according to data from the Office for Life Sciences.      UK MedTech abroad    Challenges and Opportunities for UK HealthTech Manufacturing Scale Up highlights that many companies have, or are considering, moving overseas to benefit from more competitive pricing and…
Interleukin-6 (IL-6) is the principal member of the cytokine IL-6 superfamily[1-2]. This protein is comprised of 212 amino acids and has a mass of 21–26 kDa. As a cytokine, IL-6 participates in the innate immune response[3]. IL-6 potently induces acute-phase proteins, C-reactive protein (CRP), several complement system proteins, and the coagulation cascade[4]. IL-6 also regulates body thermogenesis by acting as an endogenous pyrogen; stimulates hematopoietic precursor growth; and promotes T and B lymphocyte differentiation and maturation[5-6].
Function Introduction of IL-6 Interleukin-6 (IL-6), a versatile cytokine, plays a pivotal role in immune regulation, inflammatory responses, as well as cell proliferation and differentiation. Produced by a range of cell types including T cells, B ce…
Traumatic brain injuries (TBIs) often have devastating effects. However, in the future, pharmacological interventions could play a pivotal role in mitigating the long-term consequences of TBIs, offering positive outcomes to individuals affected by this life-altering condition. Ongoing research and promising developments suggest the future holds immense potential for pharmacological interventions in TBI treatment.
Traumatic brain injuries (TBIs) often have devastating effects. However, in the future, pharmacological interventions could play a pivotal role in mitigating the long-term consequences of TBIs, offering positive outcomes to individuals affected by this life-altering condition. Ongoing research and promising developments suggest the future holds immense potential for pharmacological…
what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper!
Introduction In the early years, your phone’s predictive text made you wonder, then came Gmail’s Smart Reply feature that utilizes machine learning to provide one-sentence responses. Since then we have come a long way, all thanks to Generative AI or GenAI. This technology is now capable of creating art, composing coherent paragraphs, writing code, and even assisting scientists in clinical research. But what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper! What is Generative AI? Generative AI, in simple terms, is a type of artificial intelligence that can create things on its own, like writing text, generating…
Medical Advisors play a crucial role in the healthcare industry by providing valuable guidance on medical care. They primarily perform case reviews to evaluate previous medical actions and determine whether to confirm the initial physician's findings and recommendations. They also build partnerships and networks with various medical professionals, such as prescribing physicians, medical investigators, pharmacists, and scientists, to enhance the quality of medical care delivered to patients.
Medical Advisors play a crucial role in the healthcare industry by providing valuable guidance on medical care. They primarily perform case reviews to evaluate previous medical actions and determine whether to confirm the initial physician's findings and recommendations. They also build partnerships and…
The healthcare industry is on the brink of a transformational revolution, driven by cutting-edge technologies like Artificial Intelligence (AI), Big Data analytics, and Personalized Medicine.
The healthcare industry is on the brink of a transformational revolution, driven by cutting-edge technologies like Artificial Intelligence (AI), Big Data analytics, and Personalized Medicine. These advancements are reshaping the way healthcare is delivered, making it more efficient, precise, and patient-centric. In this article, we explore the future of healthcare and the profound impact of AI, Big Data, and Personalized Medicine. AI: Revolutionizing Diagnosis and Treatment Artificial Intelligence has emerged as a powerful tool in healthcare. Machine learning algorithms can analyze vast datasets, inclu…
The strain on the NHS is a familiar and perpetual struggle, with everything from funding issues to staffing problems and growing waiting lists mounting. In fact, the waiting list for hospital treatments rose to a record of nearly 7.5 million in May this year and cancer treatment times are currently at an all-time high. At the beginning of this year, only 54.7% of patients waited under 62 days for treatment after an urgent GP referral, compared with the target of 85%.
The strain on the NHS is a familiar and perpetual struggle, with everything from funding issues to staffing problems and growing waiting lists mounting. In fact, the waiting list for hospital treatments rose to a record of nearly 7.5 million in May this year and cancer treatment times are currently at an all-time high. At the b…
The healthcare industry is on the brink of a transformational revolution, driven by cutting-edge technologies like Artificial Intelligence (AI), Big Data analytics, and Personalized Medicine.
The healthcare industry is on the brink of a transformational revolution, driven by cutting-edge technologies like Artificial Intelligence (AI), Big Data analytics, and Personalized Medicine. These advancements are reshaping the way healthcare is delivered, making it more efficient, precise, and patient-centric. In this article, we explore the future of healthcare and the profound impact of AI, Big Data, and Personalized Medicine. AI: Revolutionizing Diagnosis and Treatment Artificial Intelligence has emerged as a powerful tool in healthcare. Machine learning algorithms can analyze vast datasets, inclu…