Research and development - Events
Session DescriptionVisualizing the extracellular matrix (ECM) in real-time has long been a challenge. Dr. Kayvon Pedra’s group has developed a novel, cell-impermeant fluorophore that red-shifts and activates upon binding glycans. This allows for seamless, wash-free imaging of glycosylated ECM architecture—from in vitro models to in vivo mouse tumors—providing a powerful new tool for live fluorescence microscopy. Highlights of the presentationA cell-impermeable small molecule fluorophore turns on and red-shifts upon binding glycosylated biomolecules.Application of the dye to live biological samples enables wash-free visualization of extracellular matrix structure.Observations demonstrate no toxicity, a broad substrate profile, deep tissue penetration, and negligible photobleaching in a vari…