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Profacgen Updated Its Service for Isothermal Titration Calorimetry

Profacgen, a US-based company specialized in protein related services, updated its one-stop services for isothermal titration colorimetry measurement to help scientists with their protein interaction analysis research.


Isothermal titration calorimetry (ITC) is a technique used to quantitatively study the interactions of various biomolecules. It directly measures the heat released or absorbed during the binding of biomolecules. ITC is the only technique able to determine all binding parameters simultaneously in one assay. ITC can determine the affinity of the binding partner in the natural state without modification of the binding partner by fluorescence labeling or immobilization techniques.


ITC has several advantages over other techniques for studying biomolecular interactions: it does not require any chemical modification or immobilization of any binding partner; the molecular weight of the reactant is not restricted, and it is not affected by spectroscopic properties of reactants. ITC has been utilized in many research fields, like protein-ligand interactions, protein-protein interactions, self association, or other chemical and physical processes involved in biomedical and drug development.


Powered by its best knowledge of physical chemistry and structural biology, as well as advanced analysis instruments, including MicroCal iTC200, Profagen now offers professional services for isothermal titration calorimetry measurement:


  • High sensitivity for binding constant as low as nM
  • Small sample quantities as low as 20 ┬ÁM
  • Full service packing from sample preparation to data analysis
  • Regular ITC assays
  • Data fitting and interpretation
  • Quantification and characterization based on molecular mechanisms


With a team of experienced scientists in the study of PPIs, Profacgen offers a list of other assays including: Yeast Two-Hybrid Screening, Membrane-based Yeast Two-Hybrid Screening, Surface Plasmon Resonance (SPR), Co-Immunoprecipitation (Co-IP), Pull-Downs and Bio-layer Interferometry (BLI).


Visit to know more details about the professional one-stop services for isothermal titration calorimetry offered by Profacgen.


About Profacgen

Profacgen provides process development and cGMP manufacturing services for biological active ingredients. We have ready access to state-of-the-art biopharmaceutical product development and manufacturing facilities and our staff scientists have demonstrable expertise in all aspects of biopharmaceutical manufacturing, from facility design and operation to the ability to provide best advice relating to product development.

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Last Updated: 26-Feb-2021