Pharmaco - Articles
DailyUpdates 27th August, 2004: The inhibition of cyclin-dependent kinases (CDKs) represents an attractive approach to the treatment of cancer. Although this group of agents, led by Aventis' flavopiridol are poor monotherapeutic agents they exhibit sequence-dependent cytotoxic synergy when administered after standard chemotherapeutic drugs. Unfortunately, as demonstrated in a recent trial investigating the efficacy of a Taxotere-flavopiridol combination in metastatic breast cancer patients, toxi
Breast cancer is one of the most prevalent tumor types, with a little over 200,000 cases expected to be diagnosed in the this year. Mortality rates declined by 2.3% between 1990 and 2000 due to improvements in diagnosis and treatment and 5-year survival rates now stand at 97% for localized tumors,…
Breast cancer is one of the most prevalent tumor types, with a little over 200,000 cases expected to be diagnosed in the this year. Mortality rates declined by 2.3% between 1990 and 2000 due to improvements in diagnosis and treatment and 5-year survival rates now stand at 97% for localized tumors,…
ATLANTA--Aug. 25, 2004--Endovascular intervention, employing minimally invasive, catheter-based technologies, is expected to become the dominant therapeutic modality for atherosclerotic diseases in the lower limbs, according to a new report published by THE SAGE GROUP
----Endovascular intervention, employing minimally invasive, catheter-based technologies, is expected to become the dominant therapeutic modality for atherosclerotic diseases in the lower limbs, according to a new report published by THE SAGE GROUP (click here for the report). "Already the preferred initial interventional therapy for most types of lesions in aortoiliac disease, endovascular intervention is rapidly becoming the initial therapy for many types of femoropopliteal disease," stated Mary L. Yost, President of THE S…
----Endovascular intervention, employing minimally invasive, catheter-based technologies, is expected to become the dominant therapeutic modality for atherosclerotic diseases in the lower limbs, according to a new report published by THE SAGE GROUP (click here for the report). "Already the preferred initial interventional therapy for most types of lesions in aortoiliac disease, endovascular intervention is rapidly becoming the initial therapy for many types of femoropopliteal disease," stated Mary L. Yost, President of THE S…
DailyUpdates 26th August, 2004: The stabilization of atherosclerotic plaques has emerged as a strategy for reducing the incidence of stroke as well as other cardiovascular diseases. Previous studies have reported that blocking the activity of transforming growth factor-beta1 (TGF-beta1) can limit the progression of atherosclerosis and stabilize plaques in animal models. New data now suggests that increasing TGF-beta1 can also stabilize plaques in humans supporting the development of therapeutic
About 700,000 Americans suffer a new or recurrent stroke each year usually due to atherosclerosis in the carotid/vertebral arteries. Recovery from stroke is unpredictable and rarely complete and consequently 15-30% of ischemic stroke victims are permanently disabled and 20% require prolonged institu…
About 700,000 Americans suffer a new or recurrent stroke each year usually due to atherosclerosis in the carotid/vertebral arteries. Recovery from stroke is unpredictable and rarely complete and consequently 15-30% of ischemic stroke victims are permanently disabled and 20% require prolonged institu…
DailyUpdates 25th August, 2004: Despite legal appeals by Pfizer, Ivax's generic equivalent of the blockbuster gabapentin (Neurontin) went on sale earlier this month increasing the need for Pfizer to push the follow-on, pregabalin onto the US market. Pregabalin was approved by European authorities in July of this year for the treatment of peripheral neuropathic pain and as an adjunctive therapy for partial seizures in patients with epilepsy. Most recently a US study has been published data furthe
Approximately 9% of the population suffers from moderate to severe non-cancer-related pain, a figure that includes 40-70 million individuals with chronic pain. This condition precipitates other serious pathologies such as depression and is associated with an estimated pharmaceuticals market of US$1…
Approximately 9% of the population suffers from moderate to severe non-cancer-related pain, a figure that includes 40-70 million individuals with chronic pain. This condition precipitates other serious pathologies such as depression and is associated with an estimated pharmaceuticals market of US$1…
DailyUpdates 24th August, 2004: Heme oxygenase-1 (HO-1), one of the enzymes responsible for the production of carbon monoxide, is induced under conditions of ischemic stress. Clinical data has previously demonstrated that increased expression of HO-1 may limit post-transplant ischemia reperfusion injury, a major cause of reduced graft survival. Now researchers have reported that maintaining transplant recipients in an atmosphere of elevated carbon monoxide promotes extended graft survival
Since the first successful kidney transplantation more than 40 years ago, the treatment of end-stage organ failure has dramatically improved. Many organs are now transplanted, the most common of which include (procedures performed in the in 2001) the kidney (14,000), heart (2,000), liver (5,000) and l…
Since the first successful kidney transplantation more than 40 years ago, the treatment of end-stage organ failure has dramatically improved. Many organs are now transplanted, the most common of which include (procedures performed in the in 2001) the kidney (14,000), heart (2,000), liver (5,000) and l…
DailyUpdates 23rd August, 2004: The use of insulin forms the cornerstone of diabetes treatment. A body of data also suggests however that this hormone directly modulates both memory and mood suggesting that endogenous insulin may be of benefit to many of the 180 million people around the world with memory disorders, and especially those with co-morbid mood disturbances such as schizophrenic or depressed individuals. A recent study has shown that intra-nasal administration of insulin improves m
The aging population will contribute to an expansion of the already massive Alzheimer's disease therapy market. The number of sufferers is expected to grow from 16 million patients to 21 million by 2010 in the seven major pharmaceutical markets driving sales in these regions worth $4.7 billion…
The aging population will contribute to an expansion of the already massive Alzheimer's disease therapy market. The number of sufferers is expected to grow from 16 million patients to 21 million by 2010 in the seven major pharmaceutical markets driving sales in these regions worth $4.7 billion…
27-Aug-2010
Eventually, methods developed by research laboratories need to be transferable to face the rigours of external validation or the production line. Many researchers, however, are unaware that this procedure must be adequately documented, a crucial issue when it comes to regulation and outsourcing.
Steve Westcott MD Melbourn Scientific provides some pragmatic advice Any method must be capable of providing results that have integrity and are fit for purpose. Validation is a crucial way of ensuring that challenges such as a change of operator or small changes in analytical conditions will still result in reliable data. However, although the validation protocol states the challenges that are to be applied to the analytical process and the deviations from the norm that are considered acceptable,…
Steve Westcott MD Melbourn Scientific provides some pragmatic advice Any method must be capable of providing results that have integrity and are fit for purpose. Validation is a crucial way of ensuring that challenges such as a change of operator or small changes in analytical conditions will still result in reliable data. However, although the validation protocol states the challenges that are to be applied to the analytical process and the deviations from the norm that are considered acceptable,…
Pharmaceutical practices from manufacturing to marketing are coming under increasing scrutiny from watchdogs, regulators and shareholders. As huge fines and record settlements erode profits, Datamonitor's Andrew Jones argues that pharma companies must focus on tightening compliance...
Pharma companies have been making the headlines for all the wrong reasons recently. Reports in the press suggest that AstraZeneca will likely be found guilty by the EC of competition abuses following the charge in July 2003 of allegedly "misusing the patent system and other regulatory procedures for the marketing of drugs". AstraZeneca could face fines that reach as much as 10% of turnover. Eli Lilly is also in the spotlight for marketing abuses, being issued a subpoena over the marketing and promotional prac…
Pharma companies have been making the headlines for all the wrong reasons recently. Reports in the press suggest that AstraZeneca will likely be found guilty by the EC of competition abuses following the charge in July 2003 of allegedly "misusing the patent system and other regulatory procedures for the marketing of drugs". AstraZeneca could face fines that reach as much as 10% of turnover. Eli Lilly is also in the spotlight for marketing abuses, being issued a subpoena over the marketing and promotional prac…
27-Aug-2010
After my many years of conducting interviews and recruiting for both junior and senior employees, I have come to the conclusion that if there is one single thing that a person can do to secure a second interview or a desired position it is believe in themselves.
Self-Confidence or No Confidence? Having worked with young adults in a supportive role, assisting them to get their foot on the career ladder, it has become evident that generally speaking the one thing they have in common is a lack of confidence. At the other end of the scale, in my role as a sales manager I have come across some extremely confident – in some cases, even arrogant – candidates. Neither of these situations is ideal. In order for a prospective employer to hire you, they have to believe that you will be competent in…
Self-Confidence or No Confidence? Having worked with young adults in a supportive role, assisting them to get their foot on the career ladder, it has become evident that generally speaking the one thing they have in common is a lack of confidence. At the other end of the scale, in my role as a sales manager I have come across some extremely confident – in some cases, even arrogant – candidates. Neither of these situations is ideal. In order for a prospective employer to hire you, they have to believe that you will be competent in…
DailyUpdates 18th August, 2004: Researchers from at Arizona State University have demonstrated that beta amyloid light chain proteolytic antibody fragments can cleave beta-amyloid, altering the aggregation and neutralizing the cytotoxic effects of this peptide.
The aging population will contribute to an expansion of the already $30 billion neurodegenerative market. The market for Alzheimer's disease therapy is expected to grow from 16 million patients to 21 million by 2010 in the seven major pharmaceutical markets and represents a major component of this market. Alzheimer's disease drives sales in these regions worth $4.7 billion, a figure set to increase to $6.1 billion by the year 2005 and $ 7.8 billion by the year 2010 (for a full analysis of this field click here or here). …
The aging population will contribute to an expansion of the already $30 billion neurodegenerative market. The market for Alzheimer's disease therapy is expected to grow from 16 million patients to 21 million by 2010 in the seven major pharmaceutical markets and represents a major component of this market. Alzheimer's disease drives sales in these regions worth $4.7 billion, a figure set to increase to $6.1 billion by the year 2005 and $ 7.8 billion by the year 2010 (for a full analysis of this field click here or here). …
DailyUpdates 17th August, 2004: Researchers from Protein Design Laboratories report that an antibody-drug conjugate that links the chemotherapeutic agent Auristatin to a prostate cancer specific antibody, anti-TMEFF2 mAb, via a cathepsin B-sensitive linker prevents tumor growth in a murine model of prostate cancer.
DailyUpdates 17th August, 2004: Researchers from Protein Design Laboratories report that an antibody-drug conjugate that links the chemotherapeutic agent Auristatin to a prostate cancer specific antibody, anti-TMEFF2 mAb, via a cathepsin B-sensitive linker prevents tumor growth in a murine model of prostate cancer. Prostate cancer is one of the most common forms of solid tumors with 230,000 new cases expected to be identified this year in the alone. Prognosis is often goo…
DailyUpdates 17th August, 2004: Researchers from Protein Design Laboratories report that an antibody-drug conjugate that links the chemotherapeutic agent Auristatin to a prostate cancer specific antibody, anti-TMEFF2 mAb, via a cathepsin B-sensitive linker prevents tumor growth in a murine model of prostate cancer. Prostate cancer is one of the most common forms of solid tumors with 230,000 new cases expected to be identified this year in the alone. Prognosis is often goo…
Rigel's new intranasal inhibitor R112 could offer a useful alternative therapy for patients suffering from allergic rhinitis, as Datamonitor's Shaun Falkingbridge explains. Bolstered by supportive recent trial results, Rigel can now go on to seek partner firms to realize full commercialization of the drug...
R112 is an intranasal inhibitor to SYK, or spleen tyrosine kinase, which is a novel drug target for respiratory diseases such as allergic rhinitis and asthma. SYK is involved in immunoglobulin E signaling in mast cells, which play important roles in both early and late phase allergic reactions. R112 is the most advanced compound in development with this mechanism of action for allergic rhinitis: a multidose safety trial of 24 patients conducted in 2003 indicated that R112 has a favorab…
R112 is an intranasal inhibitor to SYK, or spleen tyrosine kinase, which is a novel drug target for respiratory diseases such as allergic rhinitis and asthma. SYK is involved in immunoglobulin E signaling in mast cells, which play important roles in both early and late phase allergic reactions. R112 is the most advanced compound in development with this mechanism of action for allergic rhinitis: a multidose safety trial of 24 patients conducted in 2003 indicated that R112 has a favorab…
The trade in discounted prescription drugs between Canada and the US has elicited considerable controversy on both sides of the border. Yet recent figures show that sales of drugs via Canadian pharmacies have not been as great as some had predicted. However, as Datamonitor's David Deon explains, pharmaceutical companies could go further by driving the expansion of online prescribing in the US...
and have generated about $545,000 in sales in the first five months of their state-sponsored websites offering Canadian drugs, according to figures made public last week. These are the first public accounting figures showing how much residents are using the websites, which were created by the governors of the two states. Yet the level of sales recorded represents a fraction of the cross-border bus…
and have generated about $545,000 in sales in the first five months of their state-sponsored websites offering Canadian drugs, according to figures made public last week. These are the first public accounting figures showing how much residents are using the websites, which were created by the governors of the two states. Yet the level of sales recorded represents a fraction of the cross-border bus…
The p38-MAPK pathway has long been targeted by the pharmaceutical industry in an attempt to identify new anti-inflammatory agents. The development of p38-MAPK inhibitors has however been impeded by adverse effects. Boston University researchers have now demonstrated that the lipoxin A4 (LXA4) mimic, ATLa inhibits the p38-MAPK cascade explaining in part its anti-inflammatory efficacy and offering a new approach to this promising pharmaceutical target. Although ATLa has a poor pharmacokinetic p
DailyUpdates 11th August: Lipoxin A4 (LXA4) mimics shown reduce inflammation by inhibiting the p38-MAPK pathway-further proof of concept for LXA4 analogues in preclinical development The p38-MAPK pathway has long been targeted by the pharmaceutical industry in an attempt to identify new…
DailyUpdates 11th August: Lipoxin A4 (LXA4) mimics shown reduce inflammation by inhibiting the p38-MAPK pathway-further proof of concept for LXA4 analogues in preclinical development The p38-MAPK pathway has long been targeted by the pharmaceutical industry in an attempt to identify new…
27-Aug-2010
Bacterial skin diseases like gangrene can now expect an onslaught of new specialist medications. However, skin infections make up a relatively small proportion of the $20.4 billion annual global antibacterial market, which, says Datamonitor's Amber Gibson, raises questions about why such conditions are the current focus of so much antibacterial product development...
Although skin and skin structure infections represent one of the most common types of bacterial ailments, they are still relatively infrequent when compared to respiratory tract and urinary tract infections. Skin and skin structure infections accounted for only 3% of the $6.5 billion US drugstore sales attributable to antibacterial infections in 2003. However, skin infections are the one sector of the anti-bacterial market wher…
Although skin and skin structure infections represent one of the most common types of bacterial ailments, they are still relatively infrequent when compared to respiratory tract and urinary tract infections. Skin and skin structure infections accounted for only 3% of the $6.5 billion US drugstore sales attributable to antibacterial infections in 2003. However, skin infections are the one sector of the anti-bacterial market wher…
By 2012, the anti-obesity drugs market will be worth an estimated $2.5 billion globally, compared to $526 million today. However, new drugs will not be the answer to the growing obesity problem. Datamonitor's Jasjeet Mohain argues that increasing education and awareness of the importance of good diet and exercise will remain crucial to combating obesity...
Datamonitor estimates that there are 127 million obese people in the , , , , , and the and over half of them reside in the . Despite increasing health awareness campaigns and attempts to slow down the startling increase in obesity rates, Datamonitor predicts that the prevalence of obesity will increase to 168 million in the alone by 2012. Health complications and comorbidities associated with obesity are a huge drain on national heal…
Datamonitor estimates that there are 127 million obese people in the , , , , , and the and over half of them reside in the . Despite increasing health awareness campaigns and attempts to slow down the startling increase in obesity rates, Datamonitor predicts that the prevalence of obesity will increase to 168 million in the alone by 2012. Health complications and comorbidities associated with obesity are a huge drain on national heal…
New clinical research presented at the 15th International AIDS Conference (IAC) shows that Fuzeon is proving to be remarkably effective in the first long-term trial of its benefits.
However, its administration by subcutaneous injection is precluding therapy in up to 80% of patients. Datamonitor's Laura Harris looks at some later line therapies that could be orally available, prompting greater uptake... Fuzeon (enfuvirtide) was developed by Roche and Trimeris and launched in the in March 2003, with European launches taking place throughout 2003 and 2004. It was licensed as a salvage therapy in patients who have demonstrated virologic failure to alternative antiretroviral (ARV) treatment and have developed resistant strains of HIV. Fuzeon is the first novel HIV drug to reach the market for…
However, its administration by subcutaneous injection is precluding therapy in up to 80% of patients. Datamonitor's Laura Harris looks at some later line therapies that could be orally available, prompting greater uptake... Fuzeon (enfuvirtide) was developed by Roche and Trimeris and launched in the in March 2003, with European launches taking place throughout 2003 and 2004. It was licensed as a salvage therapy in patients who have demonstrated virologic failure to alternative antiretroviral (ARV) treatment and have developed resistant strains of HIV. Fuzeon is the first novel HIV drug to reach the market for…
What exactly is a Curriculum Vitae? Is it a List of your Skills and Experience? Is it a Mini Biography? Is it a chance to get someone to fully appreciate your Skills and Achievements?
Truth be known, It’s none of these.
What is a CV? A CV in its purest form is nothing more and nothing less than a chance to market yourself to prospective recruiters and employers to increase your chances of being invited to an interview. A CV is an Interview-Winning Tool. It is not a Personal Biography, or a List of your skills and experience, it is a fluid document which means different things to different people, but is relevant to all. CV Myths Before looking at what makes a good CV, lets first dispel a few myths: ‘The more they know about me, the more chance they have of being impressed’ Wrong…
What is a CV? A CV in its purest form is nothing more and nothing less than a chance to market yourself to prospective recruiters and employers to increase your chances of being invited to an interview. A CV is an Interview-Winning Tool. It is not a Personal Biography, or a List of your skills and experience, it is a fluid document which means different things to different people, but is relevant to all. CV Myths Before looking at what makes a good CV, lets first dispel a few myths: ‘The more they know about me, the more chance they have of being impressed’ Wrong…
Acute pain resulting from conditions such as headache, muscle spasms, dental problems or following surgery, affects 90 million Americans every year. A recent study has demonstrated the analgesic activity of corticotropin-releasing-hormone (CRH) and has shown that this activity is probably due to activity within the central nervous system.
DailyUpdates 13th July: Acute pain resulting from conditions such as headache, muscle spasms, dental problems or following surgery, affects 90 million Americans every year. A recent study has demonstrated the analgesic activity of corticotropin-releasing-hormone (CRH) and has shown that this activity is probably due to activity within the central nervous system. It has been estimated that 9% of the population suffers from moderate to severe n…
DailyUpdates 13th July: Acute pain resulting from conditions such as headache, muscle spasms, dental problems or following surgery, affects 90 million Americans every year. A recent study has demonstrated the analgesic activity of corticotropin-releasing-hormone (CRH) and has shown that this activity is probably due to activity within the central nervous system. It has been estimated that 9% of the population suffers from moderate to severe n…
Recently published data from the GENOA study has demonstrated that dyslipidemia is highly prevalent in hypertensive adults and that this condition is insufficiently treated in more than half of the cases. As Datamonitor's Laurent Chanroux explains, the results lend further support to cross risk-factor, single pill combination therapies such as Pfizer's Caduet...
Less than one third of hypertensive adults with dyslipidemia are drug-treated, according to findings from the Genetic Epidemiology Network of Arteriopathy (GENOA) study. In addition, the research also showed that fewer than half of those treated achieve recommended lipid levels. This suggests a need for a more aggressive treatment of dyslipidemic hypertensives and highlights the potential of cross risk-factor single-pill combination…
Less than one third of hypertensive adults with dyslipidemia are drug-treated, according to findings from the Genetic Epidemiology Network of Arteriopathy (GENOA) study. In addition, the research also showed that fewer than half of those treated achieve recommended lipid levels. This suggests a need for a more aggressive treatment of dyslipidemic hypertensives and highlights the potential of cross risk-factor single-pill combination…
