Clinical research - Articles

GPC3, with its full name Glypican-3, is a member of the heparan sulfate proteoglycan family and is connected to the cell surface through the glycosylphosphatidylinositol anchor on the cell membrane. The GPC3 gene was first detected in a rat epithelial cell line in 1988. In the human body, the GPC3 protein expressed by the GPC3 gene is significantly different in different developmental stages and different tissues, such as low expression or no expression in gastric cancer, breast cancer, ovarian cancer and other cancers, but often in hepatocellular carcinoma is overexpressed.
The Structure of GPC3 GPC3, or Glypican-3, is an oncofetal glycoprotein tethered to the cell membrane via a glycophosphatidylinositol (GPI) anchor[1-2]. Its core protein comprises 580 amino acids and weighs in at 70 k…

Choosing the right eClinical vendor is the cornerstone of successful trials. An inadequate choice can lead to a cascade of challenges, from data inaccuracies to operational inefficiencies.
Choosing the right eClinical platform vendor is the cornerstone of successful trials. An inadequate choice can lead to a cascade of challenges, from data inaccuracies to operational inefficiencies. In this complex landscape, Clinion isn’t just a platform — it’s a seasoned guide adeptly navigating clinical trials with transparency, precision, and an innate understanding of the challenges. Now, let’s break down the core reasons why Clinion is the linchpin for your clinical trial success. Reason 1: User-Centric All the Way Clinion’s platform is designed with you in mind. From trial inception to completion…

Clinion has secured the top spot on the list of Clinical Trial Management Solutions for the year 2023
Austin, TX — November 08, 2023 Clinion is Named as The Top Clinical Trial Management Solution Provider of 2023 by Medhealth Review We are proud to announce that Clinion has secured the top spot on the list of Clinical Trial Management Solutions for the year 2023. This remarkable recognition underscores our commitment to transforming the landscape of clinical trials with cutting-edge AI-enabled technology. At Clinion, we’ve always aimed for excellence, and this achievement is a testament to our dedication to providing innovative solutions that streamline and enhance the entire clinical trial process. Our fully integrated eClinical software platform, equipped with EDC, IWRS/RTSM, CTMS, ePRO,…

The 18th Project Portfolio and Resource Management Excellence Conference, set for February 13-15, 2024 in Northern New Jersey, is a crucial event for industry leaders. The conference focuses on optimizing resource management, aligning project strategies, navigating market pressures, and embracing innovation. With a lineup of industry experts and insightful sessions, attendees can expect to gain actionable strategies and valuable connections.
Northern New Jersey, February 13-15, 2024 In an ever-evolving pharmaceutical and biotechnology landscape, effective portfolio and project management are paramount. The 18th Project Portfolio and Resource Management Excellence Conference, set to take place in Northern New Jersey from February 13th to 15th, 2024, promises to be a crucible of insights and…

what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper!
Introduction In the early years, your phone’s predictive text made you wonder, then came Gmail’s Smart Reply feature that utilizes machine learning to provide one-sentence responses. Since then we have come a long way, all thanks to Generative AI or GenAI. This technology is now capable of creating art, composing coherent paragraphs, writing code, and even assisting scientists in clinical research. But what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper! What is Generative AI? Generative AI, in simple terms, is a type of artificial intelligence that can create things on its own, like writing text, generating…

Including figures and images in clinical research enables researchers to illustrate their findings in a clear, effective, and engaging way. Despite their importance, it can be difficult to manually check images for accuracy — introducing the risk of integrity issues. Here Dr. Dror Kolodkin-Gal, founder of image integrity software developer Proofiger, explains best practice for image checking in clinical research.
Including figures and images in clinical research enables researchers to illustrate their findings in a clear, effective, and engaging way. Despite their importance, it can be difficult to manually check images for accuracy — introducing the risk of integrity issues. Here Dr. Dror Kolodkin-Gal, founder of image integrity software developer Proofiger, explains best practice for imag…

Interleukin-6 (IL-6) is the principal member of the cytokine IL-6 superfamily[1-2]. This protein is comprised of 212 amino acids and has a mass of 21–26 kDa. As a cytokine, IL-6 participates in the innate immune response[3]. IL-6 potently induces acute-phase proteins, C-reactive protein (CRP), several complement system proteins, and the coagulation cascade[4]. IL-6 also regulates body thermogenesis by acting as an endogenous pyrogen; stimulates hematopoietic precursor growth; and promotes T and B lymphocyte differentiation and maturation[5-6].
Function Introduction of IL-6 Interleukin-6 (IL-6), a versatile cytokine, plays a pivotal role in immune regulation, inflammatory responses, as well as cell proliferation and differentiation. Produced by a range of cell types including T cells, B ce…

The realm of modern medicine stands on the shoulders of groundbreaking scientific discoveries and milestones that have shaped our understanding of diseases, treatments, and patient care. Amongst these milestones, one particular event emerged as a turning point in the history of medical research – the first recorded clinical trial.
The realm of modern medicine stands on the shoulders of groundbreaking scientific discoveries and milestones that have shaped our understanding of diseases, treatments, and patient care. Amongst these milestones, one particular event emerged as a turning point in the history of medical research – the first recorded clinical trial. Taking place in the year 1747, this remarkable trial conducted by Scottish naval surgeon James Lind offers a captivating glimpse into t…

Here, we’ve provided a list of some of the top training providers for clinical research to help you advance your career, whether you’re just starting out in the industry or are seeking to enhance your existing skills. These organisations are renowned for their commitment to offering high-quality education and training, helping to propel the industry forward and advocate for excellence in clinical research.
Here, we’ve provided a list of some of the top training providers for clinical research to help you advance your career, whether you’re just starting out in the industry or are seeking to enhance your existing skills. These organisations are renowned for their commitment to offering high-quality education and training, helping to propel the industry forward and advocate for excellence in…

- Understanding the definition and role of CD19 in the immune system. - Introduction to the structure, composition, and signal pathway of CD19. - Knowledge about CD19 related diseases and research purpose products
What is CD19 Understanding CD19: Definition and Role in the Immune System CD19, also known as Cluster of Differentiation 19, is a cell surface protein belonging to the immunoglobulin superfamily. It serves as a crucial marker for B cells, playing a pivotal role in the human immune system. While predominantly found on the surface of B cells, CD19 is rarely expressed on other immune cells. Its significance lies in its involvement in B cell development and activation, making it a valuable target for research and clinical applications. The Structural Composition of CD19 The human CD…

what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper!
Introduction In the early years, your phone’s predictive text made you wonder, then came Gmail’s Smart Reply feature that utilizes machine learning to provide one-sentence responses. Since then we have come a long way, all thanks to Generative AI or GenAI. This technology is now capable of creating art, composing coherent paragraphs, writing code, and even assisting scientists in clinical research. But what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper! What is Generative AI? Generative AI, in simple terms, is a type of artificial intelligence that can create things on its own, like writing text, generating…

Let's delve into the specifics of interoperability and its profound impact on the realm of clinical trials
In the fast-evolving landscape of clinical trials, the journey from fragmentation to collaboration is driven by the pivotal concept of interoperability. It's not just a term; it's the driving force that's propelling clinical research into a new era of efficiency, collaboration, and patient-centricity. Clinical trial professionals, armed with an understanding of this transformative approach, can harness its potential to streamline processes, enhance data quality, and ultimately expedite the development of life-changing therapies. Let's delve into the specifics of interoperability and its profound impact on the realm of clinical trials. Cracking the Code of Interoperability: Bridging th…

Clinical research is a highly dynamic and rapidly growing field with diverse opportunities for career growth and professional advancement. If you’re a Clinical Research Associate (CRA) wanting to climb the ladder, there are several critical steps to take, ranging from gaining specialised certifications to expanding your professional network. In this article, we provide 8 strategies for advancing your clinical research career, helping you to move into senior CRA roles and beyond.
Clinical research is a highly dynamic and rapidly growing field with diverse opportunities for career growth and professional advancement. If you’re a Clinical Research Associate (CRA) wanting to climb the ladder, there are several critical steps to take, ranging from gaining specialised certifications to expanding…

In this comprehensive article, we will delve deep into the synergy of AI and clinical trials, explore the benefits of leveraging AI, showcase real-world examples, and peek into the future of this transformative technology.
Artificial intelligence (AI) is revolutionizing the world of clinical trials, offering unprecedented opportunities to streamline processes, improve accuracy, and accelerate the development of life-saving treatments. Synergy of AI and Clinical Trials Clinical trials are the backbone of clinical advancements, but they are often plagued by challenges such as slow recruitment, data management inefficiencies, and high costs. AI steps in as a powerful ally, addressing these challenges with finesse. 1. Faster Recruitment AI-powered algorithms can analyze vast datasets to id…

DLL3 (DELTA-LIKE Protein 3) is encoded by the human gene and belongs to the Delta-Like protein family. It is a transmembrane protein involved in cell signaling, cell fate determination, and cell differentiation. The Delta-Like protein family comprises ligands that interact with NOTCH receptors, crucial for cell development and differentiation. DLL3 plays a pivotal role in neurogenesis, contributing to the generation of neurons during embryonic development. DLL3 has garnered significant interest in cancer research, particularly in certain types of cancer. Elevated DLL3 expression has been detected in some small cell lung cancer (SCLC) and other neuroendocrine tumors. As a result, targeted treatment approaches have been developed to inhibit DLL3, providing a potential treatment strategy for these aggressive cancers.

B-lymphocyte antigen CD20 (called CD20) is known as an activated-glycosylated phosphoprotein which is expressed on the surface of all B-cells. CD20 is involved in the regulation of trans-membrane Ca2+ conductance and also play critical roles in cell‐cycle progression during human B cell proliferation and activation.
Structure of CD20 The CD20 protein presents a unique arrangement, featuring four membrane-spanning domains. Notably, both the amino and carboxy termini of the protein are positioned within the cytoplasm. An intriguing aspect of this structure is the existence of a short extracellular segment comprising approximately 43 residues, found between the third and fourth transmembrane regions[1]. This distinctive configuration, deeply embedded in the cell membrane, serves to prevent t…

Interleukin-1 family is a family of cytokine proteins, which includes IL-1α, IL-1β, IL-18 and a series of related molecules. Members of the IL-1 family play an important role in immune regulation and inflammatory responses. By binding to specific receptors, they trigger intracellular signaling, triggering inflammation, activation of immune cells, and modulation of biological effects
IL-1α and IL-1β: Key Players in Inflammation and Disease Pathogenesis IL-1α and IL-1β represent the prototypical and crucial members of the IL-1 family, which are synthesized by various cells, including monocytes, macrophages, dendritic cells, and others. These interleukins assume a significant regulatory function in the inflammatory response, stimulating immune cells to generate additional inflammatory mediat…

Programmed death protein 1 (PD1) is a common immunosuppressive member on the surface of T cells and plays an imperative part in downregulating the immune system and advancing self-tolerance. Its ligand programmed cell death ligand 1 (PDL1) is overexpressed on the surface of malignant tumor cells, where it binds to PD1, inhibits the proliferation of PD1-positive cells, and participates in the immune evasion of tumors leading to treatment failure. The PD1/PDL1-based pathway is of great value in immunotherapy of cancer and has become an important immune checkpoint in recent years.
The Structure and Function of PD-1 PD-1 is a type I membrane protein composed of 288 amino acids. As a member of the CD28/CTLA-4 family of T cell regulators, PD-1 plays a crucial role in modulating T cell responses…

Thermo Fisher Scientific (US) and Tecan Group (Switzerland) are Leading Players in the Lab Automation Market
Introduction In the fast-paced world of scientific research and discovery, time and precision are of the essence. Laboratories across the globe are constantly seeking ways to optimize their workflows, reduce manual errors, and enhance overall efficiency. This quest for progress has led to the rapid growth of the Lab Automation Market, offering innovative solutions that redefine the way science is conducted. From pharmaceuticals to biotechnology, from academics to industrial applications, Lab Automation has become an indispensable tool, empowering researchers and scientists alike. The global lab automation market is projected to reach USD 7.1 billion by 2028 from USD 5.1 billion in 20…

Dickkopf-1 (DKK1), is a protein that plays a critical role in regulating the Wnt signaling pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and embryonic development. It is an important antagonist of the Wnt pathway, meaning that it inhibits Wnt signaling by binding to specific receptors and preventing the activation of downstream signaling molecules.
Introduction to DKK1 Dickkopf-1 (DKK1), is a protein that plays a critical role in regulating the Wnt signaling pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and embryonic development. It is an important antagonist of the Wnt pathway, meaning that it inhibits Wnt signaling by binding to specific receptors and preventing the acti…