Pharmacy - Articles

First-in-class antibody-drug conjugate (ADC) that targets Nectin-4, which is a cell surface protein highly expressed in bladder cancer. Preclinical data suggest that the anticancer activity of it is attributed to its binding to cells expressing Nectin-4, followed by internalization and release of the anti-tumor agent monomethyl auristatin E (MMAE) into the cell. This is believed to inhibit cell proliferation (cell cycle arrest) and induce programmed cell death (apoptosis).
The biologics license application (BLA) has been accepted for Enfortumab Vedotin for the treatment of locally advanced or metastatic urothelial carcinoma in patients who have previously received PD-1/PD-L1 inhibitors and platinum-containing chemotherapy. Enfortumab Vedotin is the first domestically submitted targeted an…

St.John's is an acute General Public Voluntary Hospital located in Limerick, Ireland. The hospital has 99 beds and various out-patient and in-patient specialties. The Clinical Pharmacy team at St. John's Hospital was previously using Excel spreadsheets to screen patients at admission, assign them a risk score, and perform Medicines Reconciliation and Clinical Pharmacist review. This system was inefficient and time-consuming, and they were on the lookout for a digital system to help them with day-to-day operations. This article is a case study on how MEG's Clinical Pharmacy module was implemented at St. John's Hospital and how it helped the pharmacy team. MEG is a Quality Management System designed to replace inefficient and time-consuming quality software solutions, assisting hospitals in improving patient safety, providing better care, and boosting positive patient outcomes.

T-cell therapy is a cutting-edge form of immunotherapy that utilizes the body's own immune system to target and eliminate cancer cells. This innovative approach involves modifying and reprogramming T cells to express specific receptors that enable them to recognize and attack cancer cells.
In recent years, medical research and innovation have witnessed remarkable advancements in the field of immunotherapy, specifically in the realm of T-cell therapy. T-cell therapy is an emerging form of cancer treatment that harnesses the body's own immune system to target and eliminate cancer cells. This groundbreaking approach holds immense promise for patients battling various types of cancer and has the potential to revolutionize the landscape of cancer treatment. At the core of T-cell therapy lies th…

Tn5 transposase, as an enzyme has been broadly applied to the field of biotech, really needs to be accompanied by a brief introduction/protocol on its construction, preparation, and application to optimize the consequence brought by its participation.
      As an enzyme that has several applications in the field of biotech, Tn5 transposase, a bacterial transposase working in a “cut-and- paste” mode with amplification, can insert specific DNA sequences into a variety of substrates, including plasmids, bacterial chromosomes, and artificial DNA constructs. The following content will introduce the usage method of Tn5 transposase and the application of Tn5 transposase into genomic research and pharmaceuticals.        To get ready for any further application, T…

Ageing global populations are increasing the demand for new drugs to treat diseases, both common and rare. The active pharmaceutical ingredients (APIs) needed for the research which will find the treatment for these diseases are therefore more important than ever. However, access to them is strained after supply chain disruption resulting from the pandemic and the was in Ukraine. As such, maximising the efficiency of the research conducted with versatile laboratory equipment is now of major importance.
Demand for innovative pharmaceutical products is growing because of the need to treat an ageing population with increasingly complex conditions. However, ongoing supply chain disruptions mean drug developers may only have access to small amounts of compound to work with, limiting the work the…

Colorectal cancer is classified into four stages: stage 0, stage I-cancer in the inner layers of the colon, stage II-cancer spreads through the muscle wall of the colon, stage III-cancer spreads to lymph nodes, and stage IV-cancer spreads to other organs.
Colorectal cancer, also known as colon cancer or rectal cancer, is a type of cancer that affects the colon or rectum. It is the third most common cancer in both men and women worldwide, with an estimated 1.8 million new cases and 900,000 deaths in 2018 alone. In this article, we will discuss the causes, symptoms, diagnosis, treatment, and prevention of colorectal cancer. Colorectal cancer is one of the most commonly found and lethal cancers developed in individuals with the combined influence of genetic and environmental factors. Accordin…

The global lab automation market is projected to reach USD 7.1 billion by 2028 from USD 5.1 billion in 2022, growing at a CAGR of 5.8%
Overview of Growth Trends, Applications, Benefits, and Future Outlook: The Lab Automation market is a rapidly growing industry that is focused on the automation of laboratory processes and systems. This market is driven by the need to reduce operational costs and increase efficiency, as well as the need to improve accuracy and consistency in laboratory results. Lab automation solutions include automated laboratory equipment, robotic systems, laboratory information management systems, laboratory software, and other related services. These solutions are used in a variety of industries, including pharmaceuticals, medical diagnostics, biotechnology, and research…

Are you safeguarded against time-consuming audits at your wound ulcer care facility? We can assist for wound care medical billing process.
Due to the increasingly complex regulatory requirements that change frequently, it is becoming more difficult for doctors to receive payment in a timely and suitable manner. Due to these issues, claims are rejected and CMS audits are unsuccessful, both of which result in penalties that can be up to three times the original invoice amount. Does this sound familiar to you in terms of past experiences? Let’s now understand how to expedite your wound care medical billing process with ease, shall we? Immediately explain the collection procedure For medical claims billing efforts to be more effective, open and honest contact with patients is cruci…

This resource provides answers to frequently asked questions (FAQs) about the billing process for speech-language pathology (SLP) services.
Many people perceive January 1 as a good time to set goals and broaden their knowledge or skill set. Some may learn a new language, while others may read more novels throughout the year. One New Year’s resolution for speech-language pathologists might be to brush up on Speech Language Pathology (SLP) Billing best practices. After all, with Medicare’s recent reduction in reimbursement for therapy services, making every claim count in the new year will be more critical than ever. With that in mind, here are common questions about Insurance billing for outpatient services that every SLP should be aware of: Do SLPs work with patients or clients? S…

Growing up in Romania, influenced by her family, Dr Carmen Guguta, global head of business development at Technobis Crystallization Systems, had an interest in science from a very young age. At five years old, Guguta was already fascinated by chemical reactions, and specifically remembers one of her cousins conducting a colour change experiment for her. On International Women’s Day, Guguta shares her story of growing up as a female in the lab.
The future of science is female ~ Inspiring more females into science for International Women’s Day ~   Growing up in Romania, influenced by her family, Dr Carmen Guguta, global head of business development at Technobis Crystallization Systems, had an interest in science from a very young age. At five years old, Guguta was already fascinated by c…

the pharmaceutical industry is undergoing significant changes, with emerging trends that will shape its future. Companies that stay up-to-date with these trends and invest in the right technologies and strategies will be better positioned to succeed in this dynamic and challenging industry. From personalized medicine and digital therapeutics to data analytics and AI, there are plenty of opportunities for innovation and growth in the years to come.
The pharmaceutical industry has undergone a lot of changes in recent years. With advancements in technology, changing consumer behavior, and increasing regulatory scrutiny, companies in this sector must stay up-to-date with the latest trends in order to remain competitive. In this article, we will explore the top emerging trends that are expected…

Santosh Sahu, CEO and founder of Charac, discusses the importance of digital transformation in keeping pharmacies afloat
With health services across the country under severe pressure, community pharmacies are finding themselves on the brink. Over 400 pharmacies closed in the last year[1], with one in ten chemist shops closing since 2015. Unless something is done, even more pharmacies are forecast to shut down. As pharmacies are built to function as the first point of contact for people looking for healthcare advice, it is crucial that they are given the necessary support to fulfil such a role. Pharmacy troubles Analysts have recently revealed that pharmacies are suffering a £67,500 annual shortfall due to a lack of government funding in line with economic growth[2]. In addition to funding c…

With the NHS under immense pressure and pharmacies increasingly under the spotlight, digital solutions can help them adapt to best serve patients.
Stories of NHS waiting lists and a shortage of GPs are becoming all too common headlines in the British press, with pharmacies often pointed towards as a solution to ease the stress felt deeply in the healthcare sector.   However, pharmacies have their own set of pressures to contend with. Indeed, between 2015 and 2022, some 40% community pharmacies closed in 20% of the most deprived areas of England[1], with a recent study revealing that over 90% of pharmacies are experiencing staff shortages.[2]     With recently reappointed health secretary Steve Barclay just this month stating that he is looking at how England can progress ‘Pha…

As drug delivery vehicles, liposomes have low toxicity and immunogenicity, and the high biocompatibility and biodegradability of their components—phospholipids can increase the in vivo drug concentrations and protect drugs from degradation.
Due to the amphiphilic nature of lipids in liposomes, they can serve as candidate vehicles for drug delivery, and liposomes have received more attention than other systems because of their remarkable ability to deliver drugs to their target sites. Advantages of Liposomes as Drug Delivery Vehicles As drug delivery vehicles, liposomes have low toxicity and immunogenicity, and the high biocompatibility and biodegradability of their components—phospholipids can increase the in vivodrug concentrations and protect drugs from degradation. They can be easily mo…

Liposomes vary in size, composition and charge and can be used as carriers for a wide range of drug molecules.
Liposomes are a novel drug delivery system (DDS). They are bimolecular vesicles that form spontaneously when phospholipids are dispersed in water. Liposomes vary in size, composition and charge and can be used as carriers for a wide range of drug molecules, such as chemotherapeutic agents, antimicrobial and antiviral drugs, antiparasitic drugs, genetic material, vaccines, therapeutic proteins, and anti-inflammatory agents. Liposomal formulations have unique advantages in both safety and efficacy, so they are one of the most rapidly developing formulations in recent years. In the past 30 years, research in the field of liposomes has made great progress. Various types…

24/7 Medical Billing Services help Physicians improve their practice’s revenue and efficiency by 30% by reducing their operational cost up to 40%. and streamline their medical billing process to operate effortlessly.
Navigating the insurance claim can be challenging for mental health practitioners, mainly if you are into individual or small facility practice. While most large medical facilities have an entire dedicated department trained in researching, submitting, and following up on the billing and the claims, you might be ‘winging it. It is because mental health billing is more complex and complicated than other medical billing. In fact, there is a lack of uniformity in the billing process. In most medical practices, standardized tests and services are performed. However, in me…

Ceramides are composed of sphingosine analogs and long-chain fatty acids bound by amide bonds, and are the most important of the sphingolipid compounds. Ceramide is synthesized and secreted by lamellar vesicles, which together with cholesterol (25%) and free fatty acids (15%) constitute the intercellular lipids (ceramide 50%) involved in maintaining the skin barrier function. It also has various physiological and pharmacological functions, such as regulation of cellular immunity, delaying aging, and antitumor.
Ceramides are composed of sphingosine analogs and long-chain fatty acids bound by amide bonds, and are the most important of the sphingolipid compounds. Ceramide is synthesized and secreted by lamellar vesicles, which together with cholesterol (25%) and free fatty acids (15%) constitu…

The degradation pathway of the drug is closely related to the molecular structure of the drug. The ester group or amide bond in the molecular structure may be hydrolyzed under acid-base catalysis conditions.
Benefits of forced degradation test The degradation pathway of the drug is closely related to the molecular structure of the drug. The ester group or amide bond in the molecular structure may be hydrolyzed under acid-base catalysis conditions. Provide support for drug safety. When toxicologically relevant impurities are not readily available, toxicological evaluation of samples degraded to a certain extent can provide a supportive basis for drug safety and impurity limit determination. It is helpful for metabolite research. Some degradation products are also metabolites, and the m…

With the development of biotechnology in the modern information age, the research, development and utilization of enzymes have become more and more in-depth, and correspondingly, the application of enzymes in medicine has become more and more extensive.
With the development of biotechnology in the modern information age, the research, development and utilization of enzymes have become more and more in-depth, and correspondingly, the application of enzymes in medicine has become more and more extensive.   The relationship between enzymes and certain diseases The diseases caused by the lack of enzymes in the human body are mostly congenital or hereditary. For example, albinism is caused by the lack of tyrosine hydroxylase, and patients with broad bean disease or sensitivity to primaqui…

The biological function of restriction enzymes is derived from the defense of foreign DNA from invading cells. The restriction-modification system of bacteria makes the DNA bases of bacteria to be methylated and modified, so that they are not recognized and cut by their own restriction enzymes.
The biological function of restriction enzymes is derived from the defense of foreign DNA from invading cells. The restriction-modification system of bacteria makes the DNA bases of bacteria to be methylated and modified, so that they are not recognized and cut by their own restriction enzymes.   The development of restriction endonucleases In the early 1960s, Werner Arber came up with the idea that there was an enzyme that would cut the DNA of a virus, thereby limiting the virus' proliferation.…