Pharmacy - Articles
05-May-2022
Pharmaceutical excipients can be classified into natural, semi-synthetic and fully synthetic compounds according to their sources.
Pharmaceutical excipients refer to the substances used in the production and formulation of medicines. They perform multiple functions in pharmaceutical preparations and are likely to affect the quality, safety and effectiveness of drugs. Pharmaceutical excipients can be classified into natural, semi-synthetic and fully synthetic compounds according to their sources. And based on their use, excipients can be divided into diluents, binders, disintegrants, lubricants, glidants and anti-caking agents, wetting agents and solubilizers. Among all varieties of excipients, how to select the most appropriate ones for a specific drug formulation project? The guidelines be…
Pharmaceutical excipients refer to the substances used in the production and formulation of medicines. They perform multiple functions in pharmaceutical preparations and are likely to affect the quality, safety and effectiveness of drugs. Pharmaceutical excipients can be classified into natural, semi-synthetic and fully synthetic compounds according to their sources. And based on their use, excipients can be divided into diluents, binders, disintegrants, lubricants, glidants and anti-caking agents, wetting agents and solubilizers. Among all varieties of excipients, how to select the most appropriate ones for a specific drug formulation project? The guidelines be…
Protein structure analysis is one of the core contents of protein engineering. It mainly collects a large amount of protein molecular structure information in order to establish a database of the relationship between structure and function, thereby laying a foundation for theoretical research on the relationship between protein structure and function. Protein structure analysis is of great significance for the strategic consideration and specific approach selection of protein engineering aiming at designing and constructing novel proteins.
Protein structure analysis is one of the core contents of protein engineering. It mainly collects a large amount of protein molecular structure information in order to establish a database of the relationship between structure and function, thereby laying…
Protein structure analysis is one of the core contents of protein engineering. It mainly collects a large amount of protein molecular structure information in order to establish a database of the relationship between structure and function, thereby laying…
Therapeutic proteins and oral vaccines have a wide range of applications and serve the needs of patients most in need of new therapeutics.
Therapeutic proteins and oral vaccines have a wide range of applications and serve the needs of patients most in need of new therapeutics. For instance, these medicines can treat inflammation, cancer, exposure to infectious agents, and genetic disorders. Furthermore, the advancement of protein-engineering technologies has allowed drug developers and manufacturers to fine-tune desired functional characteristics. As a result, they can improve both safety and efficacy. The development of therapeutic proteins and oral vaccines is a complex process. For instance, manufacturing a single protein drug involves over 5,000 steps, compared to as few as ten for a s…
Therapeutic proteins and oral vaccines have a wide range of applications and serve the needs of patients most in need of new therapeutics. For instance, these medicines can treat inflammation, cancer, exposure to infectious agents, and genetic disorders. Furthermore, the advancement of protein-engineering technologies has allowed drug developers and manufacturers to fine-tune desired functional characteristics. As a result, they can improve both safety and efficacy. The development of therapeutic proteins and oral vaccines is a complex process. For instance, manufacturing a single protein drug involves over 5,000 steps, compared to as few as ten for a s…
Molecular docking technology remains the most popular structure-based drug design method, which takes full advantage of protein-ligand interaction information. However, in virtual screening, compared with molecular docking, pharmacophore-based methods have obvious advantages in terms of computational cost and accuracy, and docking-based virtual screening methods show a higher false positive rate.
Structure-based Pharmacophore Molecular docking technology remains the most popular structure-based drug design method, which takes full advantage of protein-ligand interaction information. However, in virtual screening, compared with molecular docking, pharmacophore-based methods have obvious advantages in terms of computational cost and accuracy, and docking-based virtual screening methods show a…
Structure-based Pharmacophore Molecular docking technology remains the most popular structure-based drug design method, which takes full advantage of protein-ligand interaction information. However, in virtual screening, compared with molecular docking, pharmacophore-based methods have obvious advantages in terms of computational cost and accuracy, and docking-based virtual screening methods show a…
In a usual drug packaging test project, the following factors should be tested, including identification, solution appearance, UV absorbance, pH, total organic carbon, bioreactivity tests for polyethylene, polypropylene, polyethylene terephthalate, cyclic olefins and plasticized polyvinyl chloride, as well as chemical safety assessments.
The packaging materials used for pharmaceutical tablets are in direct contact with the pharmaceuticals. Therefore, as a pharmaceutical manufacturer, when selecting packaging materials, it is necessary to understand some properties and characteristics of packaging materials and containers, to ensure the efficacy and quality of medicines. What are the common pharmaceutical packaging materials? Glass: Glass has the advantages of being moisture-proof, easy to s…
The packaging materials used for pharmaceutical tablets are in direct contact with the pharmaceuticals. Therefore, as a pharmaceutical manufacturer, when selecting packaging materials, it is necessary to understand some properties and characteristics of packaging materials and containers, to ensure the efficacy and quality of medicines. What are the common pharmaceutical packaging materials? Glass: Glass has the advantages of being moisture-proof, easy to s…
22-Feb-2022
It is of great significance to study the stability of pharmaceutical preparations to ensure product quality, safety, and effectiveness.
The basic requirements of pharmaceutical preparations are safety, efficacy, and stability. Drug stability means that a drug product should maintain the same properties and characteristics as it was at the time of production and within the specified time frame. The stability of pharmaceutical preparations directly affects the effectiveness and safety of drugs. Therefore, it is of great significance to study the stability of pharmaceutical preparations to ensure product quality, safety, and effectiveness. Research Scope on Drug Stability Analysis Chemical stability refers to changes in drug content (or potency) due to chemical reactions such as hydrolysis and…
The basic requirements of pharmaceutical preparations are safety, efficacy, and stability. Drug stability means that a drug product should maintain the same properties and characteristics as it was at the time of production and within the specified time frame. The stability of pharmaceutical preparations directly affects the effectiveness and safety of drugs. Therefore, it is of great significance to study the stability of pharmaceutical preparations to ensure product quality, safety, and effectiveness. Research Scope on Drug Stability Analysis Chemical stability refers to changes in drug content (or potency) due to chemical reactions such as hydrolysis and…
Enzyme engineering is an enzyme technology. With the rapid development of enzymology research, especially the promotion of enzyme application, the basic principle of enzymology is combined with chemical engineering, thus forming enzyme engineering. Enzyme engineering is a technology for the mass production and application of enzyme preparations. Starting from the purpose of application, it combines the theory of enzymology with chemical engineering to study enzymes, and uses the catalytic properties of enzymes in a certain reaction device to convert raw materials into products. As far as the development of enzyme engineering itself is concerned, it includes the following main aspects.
Enzyme engineering is an enzyme technology. With the rapid development of enzymology research, especially t…
Enzyme engineering is an enzyme technology. With the rapid development of enzymology research, especially t…
Lactase is a disaccharidase present on the surface of mammalian small intestinal mucosal microvilli, and many beneficial intestinal bacteria have the ability to produce lactase. Lactase deficiency is present in most of the world's population, affecting nearly 2/3 of the world's population.
Lactase is a disaccharidase present on the surface of mammalian small intestinal mucosal microvilli, and many beneficial intestinal bacteria have the ability to produce lactase. Lactase deficiency is present in most of the world's population, affecting nearly 2/3 of the world's population. Polylactose is composed of glucose and galactose, these two monosaccharides are easily absorbed by the intestinal lumen and are an important source of human tissue structure and energy. The precondition for lacto…
Lactase is a disaccharidase present on the surface of mammalian small intestinal mucosal microvilli, and many beneficial intestinal bacteria have the ability to produce lactase. Lactase deficiency is present in most of the world's population, affecting nearly 2/3 of the world's population. Polylactose is composed of glucose and galactose, these two monosaccharides are easily absorbed by the intestinal lumen and are an important source of human tissue structure and energy. The precondition for lacto…
Cellulase (β-1,4-glucan-4-glucanohydrolase) is a general term for a group of enzymes that degrade cellulose to produce glucose. Cellulase is a kind of complex enzyme, including C1 enzyme, CX enzyme and glucosidase and other components. Among them, C1 enzyme and CX enzyme can decompose cellulose into cellobiose, and glucosidase can decompose cellobiose into glucose, thereby providing nutrients for the growth and development of microorganisms.
Cellulase (β-1,4-glucan-4-glucanohydrolase) is a general term for a group of enzymes that degrade cellulose to produce glucose. Cellulase is a kind of complex enzyme, including C1 enzyme, CX enzyme and glucosidase and other components. Among them, C1 enzyme and CX enzyme can decompose cellulose into cellobiose, and glucosidase can decompose cellobiose i…
Cellulase (β-1,4-glucan-4-glucanohydrolase) is a general term for a group of enzymes that degrade cellulose to produce glucose. Cellulase is a kind of complex enzyme, including C1 enzyme, CX enzyme and glucosidase and other components. Among them, C1 enzyme and CX enzyme can decompose cellulose into cellobiose, and glucosidase can decompose cellobiose i…
How does life appear on earth? This has always been an unsolved mystery. According to the Physicists Organization Network, Canadian researchers published a report in the latest issue of Science that an RNA polymerase played an important role in the birth of life on earth. The new research provides new insights into the mystery of the origin of life on earth, and also helps scientists estimate the possibility of life being born on other planets.
How does life appear on earth? This has always been an unsolved mystery. According to the Physicists Organization Network, Canadian researchers published a report in the latest issue of Science that an RNA polymerase played an important role in the birth of life on earth. The new research provides new insights into the mystery of the origin of life o…
How does life appear on earth? This has always been an unsolved mystery. According to the Physicists Organization Network, Canadian researchers published a report in the latest issue of Science that an RNA polymerase played an important role in the birth of life on earth. The new research provides new insights into the mystery of the origin of life o…
Chymotrypsin is a typical serine protease. As an endopeptidase that catalyzes the hydrolysis of protein peptide bonds, its realization form is mainly for the cleavage of the peptide bond formed by the carboxyl end of the aromatic amino acid-tryptophan, phenylalanine or tyrosine. Chymotrypsin is a typical serine protease and is currently one of the digestive enzymes of most vertebral animals.
Chymotrypsin is a typical serine protease. As an endopeptidase that catalyzes the hydrolysis of protein peptide bonds, its realization form is mainly for the cleavage of the peptide bond formed by the carboxyl end of the aromatic amino acid-tryptophan, phenylalanine or tyrosine. Chymotrypsin is a typical serine protease and is currently one of the digestive enzymes of most vertebral animals. Simi…
Chymotrypsin is a typical serine protease. As an endopeptidase that catalyzes the hydrolysis of protein peptide bonds, its realization form is mainly for the cleavage of the peptide bond formed by the carboxyl end of the aromatic amino acid-tryptophan, phenylalanine or tyrosine. Chymotrypsin is a typical serine protease and is currently one of the digestive enzymes of most vertebral animals. Simi…
The United States Pharmacopeia (USP) requires that all new drugs and generic drugs, whether they are on the market or under review or to be declared, must meet the requirements of the General Principles for the Control of Elemental Impurities Limits (USP).
From January 1, 2018, the United States Pharmacopeia (USP) requires that all new drugs and generic drugs, whether they are on the market or under review or to be declared, must meet the requirements of the General Principles for the Control of Elemental Impurities Limits (USP<232>). To perform elemental impurity analysis, below are some necessary steps that should be considered. The first step: Determine which elements to be verified Before all verification work begins, the element impurities that need to be tested must first be cla…
From January 1, 2018, the United States Pharmacopeia (USP) requires that all new drugs and generic drugs, whether they are on the market or under review or to be declared, must meet the requirements of the General Principles for the Control of Elemental Impurities Limits (USP<232>). To perform elemental impurity analysis, below are some necessary steps that should be considered. The first step: Determine which elements to be verified Before all verification work begins, the element impurities that need to be tested must first be cla…
23-Dec-2021
Microbial limit test is performed to determine whether drug products comply with an established specification for microbial quality.
Microbial limit test is performed to determine whether drug products comply with an established specification for microbial quality. USP <61> and USP <62> for objectionable organisms are usually the guidelines for testing as specified by FDA requirements. In most cases, the microbial limit test covers the following three test items: Total Aerobic Microbial Count In this step, the total number of aerobic organisms is determined, which is an important indicator to measure the hygienic quality of medicines. Total Combined Yeasts and Mold Count In this step, the number of contaminated viable bacteria (yeasts and mold) in the unit mass, volume…
Microbial limit test is performed to determine whether drug products comply with an established specification for microbial quality. USP <61> and USP <62> for objectionable organisms are usually the guidelines for testing as specified by FDA requirements. In most cases, the microbial limit test covers the following three test items: Total Aerobic Microbial Count In this step, the total number of aerobic organisms is determined, which is an important indicator to measure the hygienic quality of medicines. Total Combined Yeasts and Mold Count In this step, the number of contaminated viable bacteria (yeasts and mold) in the unit mass, volume…
23-Dec-2021
The quantitative analysis of a small amount of amorphous existence plays a vital role in the process of drug development and production.
In industrial production, the surface of the compound may become amorphous due to a small amount of structural damage. It is difficult for conventional instruments to detect this small amount of amorphous substance. Although the content of this amorphous substance is very low, it is very likely to affect the stability of the drug in the production and storage process, resulting in the failure of the entire development. Therefore, even the quantitative analysis of a small amount of amorphous existence plays a vital role in the process of drug development and production. Amorphous content determination and identification The qualitative and quantit…
In industrial production, the surface of the compound may become amorphous due to a small amount of structural damage. It is difficult for conventional instruments to detect this small amount of amorphous substance. Although the content of this amorphous substance is very low, it is very likely to affect the stability of the drug in the production and storage process, resulting in the failure of the entire development. Therefore, even the quantitative analysis of a small amount of amorphous existence plays a vital role in the process of drug development and production. Amorphous content determination and identification The qualitative and quantit…
21-Dec-2021
Microbial limit test is performed to determine whether drug products comply with an established specification for microbial quality.
Microbial limit test is performed to determine whether drug products comply with an established specification for microbial quality. USP <61> and USP <62> for objectionable organisms are usually the guidelines for testing as specified by FDA requirements. In most cases, the microbial limit test covers the following three test items: Total Aerobic Microbial Count In this step, the total number of aerobic organisms is determined, which is an important indicator to measure the hygienic quality of medicines. Total Combined Yeasts and Mold Count In this step, the number of contaminated viable bacteria (yeasts and mold) in the unit mass, volume…
Microbial limit test is performed to determine whether drug products comply with an established specification for microbial quality. USP <61> and USP <62> for objectionable organisms are usually the guidelines for testing as specified by FDA requirements. In most cases, the microbial limit test covers the following three test items: Total Aerobic Microbial Count In this step, the total number of aerobic organisms is determined, which is an important indicator to measure the hygienic quality of medicines. Total Combined Yeasts and Mold Count In this step, the number of contaminated viable bacteria (yeasts and mold) in the unit mass, volume…
There are non-functional excipients and functional excipients. The choice of excipients for oral solid preparations is affected by factors such as the pharmacological and chemical properties of the raw materials, the preparation process and the price of excipients.
Excipients are the general term for all materials in the prescription except the main active ingredients, such as binders, disintegrants, lubricants, fillers, etc. The choice of excipients for oral solid preparations is affected by factors such as the pharmacological and chemical properties of the raw materials, the preparation process and the price of excipients. There are non-functional excipients and functional excipients. Let’s take a look at the non-functional excipients that are commonly used in solid oral preparations. Dis…
Excipients are the general term for all materials in the prescription except the main active ingredients, such as binders, disintegrants, lubricants, fillers, etc. The choice of excipients for oral solid preparations is affected by factors such as the pharmacological and chemical properties of the raw materials, the preparation process and the price of excipients. There are non-functional excipients and functional excipients. Let’s take a look at the non-functional excipients that are commonly used in solid oral preparations. Dis…
27-Aug-2021
The liquid dosage form for oral administration for children not only has benefits like large dispersion and fast absorption, but also can improve the bioavailability of some drugs, which has a greater development prospect and clinical application value.
Solid preparations for oral administration for children have the advantages of convenient carrying and good stability, but for children, they are prone to dysphagia. The liquid dosage form for oral administration for children not only has benefits like large dispersion and fast absorption, but also can improve the bioavailability of some drugs, which has a greater development prospect and clinical application value. However, there are some technical difficulties that hinder the development of children's oral liquid preparations. Poor solubil…
Solid preparations for oral administration for children have the advantages of convenient carrying and good stability, but for children, they are prone to dysphagia. The liquid dosage form for oral administration for children not only has benefits like large dispersion and fast absorption, but also can improve the bioavailability of some drugs, which has a greater development prospect and clinical application value. However, there are some technical difficulties that hinder the development of children's oral liquid preparations. Poor solubil…
Disintegration is an early way to evaluate whether a drug is effective. The disintegration time is an important control index for tablets, capsules, and dripping pills. Disintegration means that the solid preparation disintegrates and dissolves or breaks into granules under specified conditions.
Disintegration is an early way to evaluate whether a drug is effective. The disintegration time is an important control index for tablets, capsules, and dripping pills. Disintegration means that the solid preparation disintegrates and dissolves or breaks into granules under specified conditions. Except for insoluble coating materials or broken capsule shells, all solid preparations should pass through the screen. Therefore, a disintegration test should be carried out to make sure that a drug is rele…
Disintegration is an early way to evaluate whether a drug is effective. The disintegration time is an important control index for tablets, capsules, and dripping pills. Disintegration means that the solid preparation disintegrates and dissolves or breaks into granules under specified conditions. Except for insoluble coating materials or broken capsule shells, all solid preparations should pass through the screen. Therefore, a disintegration test should be carried out to make sure that a drug is rele…
Oncology is the study of cancer treatments that extend beyond the normal curative scope. The primary focus is localized disease management through the delivery of targeted therapy to treat cancerous sites.
North America is home to many pharmaceutical companies that are pursuing research into the management of diseases such as prostate and breast cancer and skin cancer. One of the major segments gaining popularity with oncology drugs is the lung-cancer drugs. A number of promising lung cancers have been found to respond to the effects of oncology drugs in the test groups. The first such drug, Cisplatin, was tested in patients suffering from adenocarcinoma of the lung. It significantly prolonged survival time in these patients. The next drug in the line, Sawatagel, was also successful in tre…
North America is home to many pharmaceutical companies that are pursuing research into the management of diseases such as prostate and breast cancer and skin cancer. One of the major segments gaining popularity with oncology drugs is the lung-cancer drugs. A number of promising lung cancers have been found to respond to the effects of oncology drugs in the test groups. The first such drug, Cisplatin, was tested in patients suffering from adenocarcinoma of the lung. It significantly prolonged survival time in these patients. The next drug in the line, Sawatagel, was also successful in tre…
PharmaSources.com, an international B2B trade portal for the pharmaceutical verticals, is launching the virtual event E-Trade Season together with CPhI and P-MEC China from March to June 2021 to provide the pharmaceutical industry with online learning and trading opportunities. This includes months of informative content and targeted matchmaking service - delivering over 8 themed webinar series and showcasing high-quality pharma suppliers from different pharmaceutical sectors.
The webinars will cover topics of global pharma trends, pharma APIs supply chain, drug manufacturing and R&D, biopharmaceuticals technologies and dynamics, quality management, production technology and machinery, pharma packaging & delivery, and vitamins markets.
PharmaSources.com, an international B2B trade portal…
PharmaSources.com, an international B2B trade portal…
