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One of the most exciting changes in the pharmaceutical sector over the last 10 years has been a shift from chemically synthesised drugs to focus more on a biologics. While biologics have the potential to revolutionise treatment for millions of people dealing with conditions such as rheumatoid arthritis, diabetes, autoimmune diseases and certain cancers, there is a significant wrinkle that needs attending to: delivery.
One of the most exciting changes in the pharmaceutical sector over the last 10 years has been a shift from chemically synthesised drugs to focus more on a biologics. While biologics have the potential to revolutionise treatment for millions of people dealing with conditions such as rheumatoid arthritis, diabetes, autoimmune diseases and certain cancers, there is a significant…

In the world of life sciences, leadership skills are not only highly valued but also critical for advancing your career. As the industry continues to evolve and become increasingly more complex, strong leadership skills will become essential for effective decision-making, problem-solving, and team management, particularly as new technologies continue to come into the mix.
In the world of life sciences, leadership skills are not only highly valued but also critical for advancing your career. As the industry continues to evolve and become increasingly more complex, strong leadership skills will become essential for effective decision-making, problem-solving, and team management, particularly as new technologies continue to come into the mix. In this article, we provide 9 ways to develop your…

Unlock the power of digital twins in healthcare with Healthcare IT Consulting Services. Optimize integration for improved diagnostics and personalized patient care.
The healthcare industry has witnessed a transformative wave of technological advancements in recent years. And one such technological advancement that has taken the medical world to greater heights is the integration of digital twins. Originally popularized in manufacturing and industrial sectors, digital twins have now found their way into healthcare, offering unprecedented opportunities for personalized medicine, improved diagnostics, efficient drug discovery, and enhanced patient outcomes. According to MarketsandMarkets research, the global digital twins in the healthcare market are rapidly growing and poised to be worth $1.6…

Technological advancements, climate change, and geopolitical tensions have transformed the global manufacturing landscape in recent decades. Along the way, academics and industry experts have explored concepts such as Industry 4.0 which encompasses the industrial internet of things, and ‘smart’ manufacturing, to help define the multitude of ways in which technological innovation has changed manufacturing processes.
Technological advancements, climate change, and geopolitical tensions have transformed the global manufacturing landscape in recent decades. Along the way, academics and industry experts have explored concepts such as Industry 4.0 which encompasses the industrial internet of things, and ‘smart’ manufacturing, to help define the multitude of ways in which technological innovation…

In your journey toward mental well-being, understanding the intricate interplay between brain chemistry and mental health is vital. Psychopharmacology, the study of how drugs affect the mind, plays a pivotal role in the treatment of various mental disorders.
In your journey toward mental well-being, understanding the intricate interplay between brain chemistry and mental health is vital. Psychopharmacology, the study of how drugs affect the mind, plays a pivotal role in the treatment of various mental disorders. Understanding the Basics of Psychopharmacology At its core, psychopharmacology explores the effects of medications on the brain, aiming to rectify imbalances in neurotransmitters — the chemical messengers that facilitate communication between nerve cells.1 Through a comprehensive un…

The public health threats that impact adults have begun affecting children. While science has made considerable advances in combating infectious diseases, modern demands have created additional problems. One is the increase in pediatric fatty liver. What can you do if you’re a parent or caregiver? How do you treat fatty liver in children? What new medicines offer hope, and what can you do to mitigate symptoms or reverse disease progression?
The public health threats that impact adults have begun affecting children. While science has made considerable advances in combating infectious diseases, modern demands have created additional problems. One is the increase in pediatric fatty liver. What can you do if you’re a parent or caregiver? How do you treat fatty liver in children? What new medici…

There have been several changes to the pharmaceutical and biotech regulatory landscape in 2023. The short and long-term impacts of these changes are relatively unknown; however, all could shape the regulatory landscape for life sciences in 2024 and beyond. What are the regulatory changes? 1. Reform of the European Union’s Pharmaceutical Legislation. 2. Medicines & Healthcare products Regulatory Agency’s (MHRA’s) International Recognition Procedure (IRP). 3. Food and Drug Administration’s (FDA’s) Benefit-Risk guidance. 4. European Medicines Agency’s (EMA’s) revised CTIS transparency rules.
There have been several changes to the pharmaceutical and biotech regulatory landscape in 2023. The short and long-term impacts of these changes are relatively unknown; however, all could shape t…

Nanopore full-length transcriptome sequencing is an innovative technique that utilizes Oxford Nanopore Technologies' (ONT) sequencing platform to obtain comprehensive and uninterrupted high-quality full-length sequences of transcripts. This cutting-edge approach enables researchers to accurately identify various structural variations within transcripts, including alternative splicing, gene fusion, selective polyadenylation of alternative polyadenylation sites (APAs), allele-specific expression, and other alterations in transcript structure. Additionally, this method facilitates precise quantification of transcript expression levels, encompassing both messenger RNA (mRNA) and polyA+ long non-coding RNA (lncRNA).
Nanopore full-length transcriptome sequencing is an innovative technique th…

Exosomes are small extracellular vesicles that contain RNA, proteins, and lipids. These vesicles play a crucial role in intercellular communication and have been implicated in various physiological and pathological processes. Exosome RNA-Seq is a powerful technique that can be used to study the RNA content of exosomes and gain insight into their function and regulation. In this guide, we will provide an overview of the key steps involved in exosome RNA-Seq and highlight some important considerations for beginners.
Exosomes are small extracellular vesicles that contain RNA, proteins, and lipids. These vesicles play a crucial role in intercellular communication and have been implicated in various physiological and pathological processes. Exosome RNA-Seq is a powerful technique that…

The quantification and analysis methods of exosomal RNA are also key factors in exploring the dynamic changes of exosomal RNA in the tumor microenvironment. Currently, commonly used methods for quantifying and analyzing exosomal RNA include qPCR, sequencing, microarray, etc.
The Relationship Between Exosomes and Cancer Exosomes are nanoscale vesicles derived from intracellular lysosomes that shuttle a variety of biomolecules, such as nucleic acids, proteins, lipids, amino acids and metabolites, and play a key role in regulating intercellular communication. Exosomes can be secreted by almost all types of cells, including immune cells, blood cells, neuronal cells, epithelial cells, and cancer cells. Exosomes contain various types of RNA molecules, including miRNA, mRNA, and even long non…

Epigenetics has been defined as the study of stable alterations in gene expression potentials that arise during development and cell proliferation, or alterations in DNA function without alterations in DNA sequence. Modern epigenetic features refer to the alteration of DNA and/or associated proteins without nucleotide sequence variance, which transmits the data contained to the next generation. It has been considered that diseases are generally influenced by obtained biological alterations, but it is becoming evident that any phenotype is the result of a complex interplay between genotype, epigenome, and environment. Epigenetics concentrates on pathways that control how and when specific genes are turned on and/or off, while epi-genomics assess epigenetic changes in a cell or whole organism across many genes.

Oxford Nanopore Technologies (ONT) sequencing has witnessed significant progress in recent years, becoming a key player in the genomics field. As the technology matures, so does the bioinformatics analysis of ONT data. Researchers have been diligently developing specialized tools and algorithms to better utilize the unique characteristics of ONT data, such as long read lengths and ionic current signals. This article explores the latest bioinformatics advancements that enable enhanced base calling, base modification detection, error correction, assembly, and alignment of ONT data.
Oxford Nanopore Technologies (ONT) sequencing has witnessed significant progress in recent years, becoming a key player in the genomics field. As the technology matures, so does the bioinformatics analysi…

Cell cycle checkpoints are essential for maintaining genomic stability and preventing cancer. By understanding how cell cycle checkpoints work, scientists can develop new ways to treat cancer and other diseases.
The cell cycle is a complex process that involves the growth and division of a cell. It is divided into four phases: G1, S, G2, and M. During each phase, the cell undergoes a series of events that prepare it for the next phase. Cell cycle checkpoints are control mechanisms that ensure that the cell cycle proceeds in a timely and orderly manner.   There are three major cell cycle checkpoints: G1 checkpoint: This checkpoint occurs at the end of the G1 phase. It ensures that the cell has grown to a sufficient size and that all of the necessary nutrients and components are pr…

In order to fully understand the catalytic activity of enzymes, researchers have conducted a wide range of MD simulation studies on several types of enzyme catalytic processes and discussed the whole process in detail.
Enzyme catalysis includes complex processes such as the transport of substrates to the active area, selective catalysis of chemical reactions, and product release. Any chemical or non-chemical process may be a crucial step in determining enzyme activity due to the complex environmental effects of proteins. Molecular dynamics (MD) method is a motion equations of the multi-particle system developed based on Newtonian classical mechanics. MD simulates the microscopic process of the system over time to obtain the particle phase trajectory of the system, and studies the equi…

Search the best 845 Clinical Research Jobs across Europe, USA and Australasia. Register now and upload your CV to let the jobs come to you!
845 Clinical Research Jobs Today - Search Now - https://bit.ly/47PzAY8. For nearly 25 years, PharmiWeb has been bringing you the latest clinical research jobs from the best Employers and Agencies across Europe and the USA. Search the latest job vacancies here:   - Clinical Research Associate (261) - https://bit.ly/40XQQIo - Clinical Trials Manager / Administrator (114) - https://bit.ly/3T16AZ6 - Clinical Operations (96) - https://bit.ly/3sQNSJf - Clinical Project Manager (59) - https://bit.ly/47QWYEt - Study Start Up (58) - https://bit.ly/3T1W0RD - Clinical Development (37) - https://bit.ly/3R2pbSc - Pharmacovigilance (27) - https://bit.l…

Search 2,663 Jobs on PharmiWeb.jobs - the latest Life Science, Pharma, Biotech, Clinical Research jobs across Europe, the US and Australasia.
November 28th 2023., PharmiWeb.jobs, the leading job board for Life Sciences and pharma jobs, currently has 2,663 Pharma & Life Science job vacancies. Stay ahead in your Life Science career with up-to-date job listings, industry articles, and career advice. Search Now - https://bit.ly/46AN8Wg Clinical Research (851) - https://bit.ly/47NjLBP Sales / Commercial (224) - https://bit.ly/3N4CGPQ Quality (216) - https://bit.ly/3N5IHMu Data Management / Statistics (207) - https://bit.ly/3RfmOwx Regulatory Affairs (192) - https://bit.ly/3MZSIuz R & D (181) - https://bit.ly/3QX19bi Project Management (159) -…

The gene therapy market has emerged as a groundbreaking field in modern medicine, with a market size reaching USD 6.36 billion in 2023. This dynamic market is expected to experience rapid growth, projected at a Compound Annual Growth Rate (CAGR) of 22.8% during the forecast period from 2024 to 2032, ultimately reaching a staggering value of USD 40.39 billion by 2032.
The gene therapy market has emerged as a groundbreaking field in modern medicine, with a market size reaching USD 6.36 billion in 2023. This dynamic market is expected to experience rapid growth, projected at a Compound Annual Growth Rate (CAGR) of 22.8% during the forecast period from 2024 to 2032, ultimately reaching a staggering value of USD 40.39 billion by 2032. In this comprehensive guide, we will provide an in-depth expl…

The Patient Engagement Solutions Market is centered around the tools, technologies, and strategies employed to actively involve patients in their healthcare journey.
In the rapidly evolving landscape of healthcare, patient engagement has emerged as a pivotal focus area for healthcare providers and technology companies alike. The Patient Engagement Solutions Market has experienced remarkable growth and is poised for continued expansion. This in-depth guide aims to provide you with a comprehensive understanding of the Patient Engagement Solutions Market, including its overview, dynamics, trends, segmentation, growth drivers, recent developments, scope, analysis, COVID-19 impact, key players, and frequently asked questions (FAQs). Patient Engagement Solutions Market Overview: The Patient Enga…

Capillary Electrophoresis (CE) is an analytical technique used in the development and quality control of protein drugs. From medium optimization, clone screening, formulation stability research and purification process monitoring, to protein characterization, related impurity detection, protein structure identification and protein drug product quality control, CE is required in all aspects of protein drug development. For example, for protein purity determination, sodium dodecyl sulfate-capillary gel electrophoresis (CE-SDS) is better compared to SDS-PAGE. To determine protein isoelectric point, capillary isoelectric focusing (CIEF) is more accurate than the traditional gel strip method. For the characterization of glycosylation heterogeneity of glycoprotein drugs, CE can achieve high-resolution analysis.

In the realm of biological sciences, bile acids stand as pivotal molecules, playing a multifaceted role in various physiological processes within organisms. Bile acids are specialized molecules synthesized from cholesterol within the liver. These amphipathic compounds possess a hydrophilic region (carboxylic acid moiety) and a hydrophobic region (steroid backbone). Their distinctive structure enables them to serve as integral components in the process of lipid digestion and absorption.
In the realm of biological sciences, bile acids stand as pivotal molecules, playing a multifaceted role in various physiological processes within organisms. Bile acids are specialized molecules synthesized from cholesterol within the liver. These amphipathic compounds possess a hydrophilic region (carboxylic…