Articles

Glucose oxidase, also known as β-D-glucose: oxygen 1-oxidoreductase, is an enzyme that catalyzes the oxidation of β-D-glucose (a simple sugar) into D-glucono-δ-lactone and hydrogen peroxide. This enzyme, primarily derived from the Aspergillus niger and Penicillium species, requires a co-factor, flavin adenine dinucleotide (FAD) for its activity.
Devising innovative tools and high-quality solutions to cater to food industry needs has been an ongoing pursuit in the scientific community for many years. One such strategy that has garnered significant attention is the utilization of enzymes, specifically glucose oxidase (food grade). Its wide-range applicability makes it a highly sought-after biotechnological tool in diverse food applications, providing many beneficial attributes, such as improv…

The Menstrual Cup Market has been on an extraordinary growth trajectory, achieving a global value of USD 1077.78 million in 2023.
Welcome to our comprehensive guide on the Menstrual Cup Market. In this in-depth article, we aim to provide a detailed exploration of every aspect of this market, from its overview and dynamics to the latest trends, segmentation, growth prospects, recent developments, and the impact of COVID-19. We've meticulously compiled all the essential information in user-friendly language to ensure an engaging and informative reading experience. Menstrual Cup Market Overview: The Menstrual Cup Market has been on an extraordinary growth trajectory, achieving a global value of USD 1077.78 million in 2023. This remarkable surge can be attributed to the increasing awareness su…

The Menstrual Cup Market has been on an extraordinary growth trajectory, achieving a global value of USD 1077.78 million in 2023.
Welcome to our comprehensive guide on the Menstrual Cup Market. In this in-depth article, we aim to provide a detailed exploration of every aspect of this market, from its overview and dynamics to the latest trends, segmentation, growth prospects, recent developments, and the impact of COVID-19. We've meticulously compiled all the essential information in user-friendly language to ensure an engaging and informative reading experience. Menstrual Cup Market Overview: The Menstrual Cup Market has been on an extraordinary growth trajectory, achieving a global value of USD 1077.78 million in 2023. This remarkable surge can be attributed to the increasing awareness su…

Vulcanization accelerators act as special compounds that minimize the degradation of rubber and speed up the vulcanization process.
Why should vulcanization accelerators be used? After more than 100 years of development, the world rubber industry has become an important traditional industry in many developed countries. However, rubber products cannot withstand extreme high and low temperatures, which causes them to become fragile and susceptible to degradation during seasonal changes. American inventors discovered that removing sulfur from rubber and then heating it would allow the rubber to retain its elasticity and harden. This process is known as vulcanization. Vulcanization accelerators act as special compounds that minimize the degradation of rubber and speed up the vulcaniza…

The far-infrared rays released by graphene can enhance human immunity and allow the body to enhance its self-healing function, promote endocrine stability and reduce the risk of various diseases invading the body.
Graphene first appeared in the laboratory in 2004. At that time, two British scientists, Andre Geim and Prof Kostya Novoselov, discovered that they could get thinner and thinner graphite flakes in a very simple way. They peeled the graphite flakes from the graphite, and then glued the two sides of the flakes to a special tape. When the tape was peeled off, the graphite flakes were divided in two. Keep doing this, the sheets get thinner and thinner, and in the end, they get a sheet made of just one layer of carbon atoms, which is graphene. The two scientists won the Nobel Prize in…

Biopharmaceutical manufacturing has long been dominated by traditional cell-based expression systems, with Escherichia coli serving as a cornerstone for the production of therapeutic proteins. This established paradigm, while effective, is now being challenged by a revolutionary alternative: cell-free expression system. Representing a cutting-edge approach, these systems eliminate the need for cellular culture, ushering in a new era of efficiency and customization in biomanufacturing.
The global cell free expression market, valued at USD 275 million in 2023 and projected to grow at a CAGR of 7.5% until 2035, underscores the increasing recognition of the industry of the transformative potential of this technology. In this dynamic landscape, where precision and speed are paramount, cell-free…

The toxicity of chemical substances that may cause cancer can be divided into three levels: genotoxicity, mutagenicity and carcinogenicity. Most carcinogens and mutagens are genotoxic, but not all genotoxic impurities are mutagenic or carcinogenic.
Genotoxic impurities (GTI) refer to compounds that can directly or indirectly damage cellular DNA, produce gene mutation or in vivo mutagenesis, and have the possibility or tendency to cause cancer. The fundamental purpose of studying genotoxic impurities is to control and reduce the risk that they may cause cancer in humans. Carcinogens can be divided into genotoxic carcinogens and non-genotoxic carcinogens according to their mechanism of action. Most of the carcinogens encountered in drug development and production are genotoxic…

Anisole is used in organic synthesis, and is also used as a solvent, spice and insect repellent. It can also be used as a solvent for recrystallization, thermostat filler, a refractive index meter, a spice, and an organic synthesis intermediate.
What are Anisole and Its Chemical Property? Benzyl ether, also known as anisole, is an organic compound with the chemical formula C7H8O. It has a pleasant fennel like aroma and is used in organic synthesis, as well as solvent, fragrance, and insect repellent. When anisole and a base are heated together, the ether bond is easily broken. When heated to 130°C with hydrogen iodide, it decomposes to generate methyl iodide and phenol. When heated with aluminum trichloride and aluminum tribromide, it decomposes into halomethane and phenoxide. Heated to 380…

Strengthening your employer brand through thought leadership is valuable for several reasons. Firstly, it will allow your organisation to establish itself as a trusted authority in the life science industry. You can position your company as a go-to source for industry knowledge and expertise by consistently sharing valuable insights, research findings, and thought-provoking content.
Strengthening your employer brand through thought leadership is valuable for several reasons. Firstly, it will allow your organisation to establish itself as a trusted authority in the life science industry. You can position your company as a go-to source for industry knowledge and expertise by consistently sharing valuable insights, research findings, and thought-provoking content. This enhances your reputation…

Sulfamethoxazole is mainly used in the treatment of bacterial infections such as urinary tract infections, bronchitis, and prostatitis.
Sulfamethoxazole is a crystal or white powder with the chemical name N-(5-methyl-3-isoxazolyl)-4-aminobenzenesulfonamide. It is a sulfonamide bacteriostatic antibiotic that is effective against gram negative and positive bacteria such as Listeria monocytogenes and E.coli. It is mainly used in the treatment of bacterial infections such as urinary tract infections, bronchitis, and prostatitis.  Application in the treatment of bacterial infections Sulfamethoxazole was introduced to the United States in 1961. It is now mostly used in combination with trimethoprim. The combination has been included on the WHO Model List of Essential Medicine…

Cardiovascular drugs are drugs used to treat diseases of the cardiovascular system, including lipid-lowering drugs, anti-heart failure drugs, anti-arrhythmic drugs, anti-hypertensive drugs, anti-anginal drugs and other chemical drugs. 
Cardiovascular disease is a serious threat to human life and health. Reasonable prevention and drug treatment are the cornerstones of tackling cardiovascular disease. Cardiovascular APIs are main components of drugs used to treat diseases of the cardiovascular system, including lipid-lowering drugs, anti-heart failure drugs, anti-arrhythmic drugs, anti-hypertensive drugs, anti-anginal drugs and other chemical drugs.  Antihypertensive Series There are many types of antihypertensive drugs, and different types of drugs have different curative effects o…

Scotland is set to benefit from a new centre of excellence for manufacturing cutting-edge medicines after a multi-million-pound fund was announced in the Autumn Statement today (22nd November 2023).
The Centre will focus on developing innovative and sustainable manufacturing techniques in an emerging area of medicine known as oligonucleotides.    Oligonucleotides can cover a wide variety of diseases, from cancer to Alzheimers, and have the potential to unlock medicines for conditions currently considered untreatable and create more effective medicines for larger patient populations such as heart disease.    The Oligonucleotide Manufacturing Innovation Centre of Excellence will be the second facility opened by the Centre for Process Innovation (CPI) within the Advanced M…

How to target the remaining 80% of the proteome, especially those known to be disease-related, is a major challenge in biomedical research. Scientists are now using a naturally occurring protein degradation system in cells to overcome this problem.
Background The use of small molecules to selectively regulate the function of proteins is the cornerstone of the development of medicine. However, only about 20% of proteins in human proteomes are thought to be regulated by this mechanism because they have functional ligand pockets (such as enzyme active sites). From the drug development point of view, these proteins are defined as proprietary proteins and are more likely to bind to small molecule drugs with high affinity. How to target the remaining 80% of the proteome, especially those known to…

LNPs are composed of different lipids, making quality control easier compared to other types of carriers such as macromolecules or viruses.
During the COVID-19 pandemic, the success of mRNA vaccines has greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as a template for protein synthesis in ribosomes. Despite its utility, the instability of mRNA necessitates appropriate carriers for in vivo delivery. Currently, lipid nanoparticles (LNPs) are the most mature approach for protecting mRNA from degradation and enhancing its intracellular delivery. To further optimize the therapeutic efficacy of mRNA, researchers have developed a series of site-specific LNPs. Through local or systemic administration, these site-specific L…

Currently, bispecific ADCs are still in the early stages of development globally, with only a few products entering the clinical development stage, and all of them are in early clinical stages.
With the rapid development of antibody-drug conjugate (ADC), more and more companies have entered the field of ADC research and development, and various types of ADC technologies and branches have emerged. Bispecific antibody conjugates (BsAb ADCs) are one of the emerging new technologies. The high specificity of bispecific antibodies enables more precise targeting of tumor cells. On the other hand, promoting the coordinated endocytosis of the two targets through cross-linking can improve the efficiency of toxins entering tumor cells. Currently, bispecific ADCs are still in the early stages of d…

Antimicrobial peptides refer to a variety of peptides with inhibitory or bactericidal activity in vivo, usually containing 20-60 amino acid residues with a molecular weight of 2000-7000 Da.
What are Antimicrobial Peptides? Antimicrobial peptides (AMPs) are naturally occurring peptide molecules found in various organisms, including humans, animals, plants, and microorganisms. These peptides play a crucial role in the innate immune system's defense against microbial infections, exhibiting antimicrobial properties that can inhibit the growth or kill bacteria, fungi, viruses, and even some parasites. AMPs possess broad-spectrum activity, targeting various pathogens. AMPs typically rapidly disrupt the integrity of microbial cell membranes, leading to cell lysis and death. This rapid m…

siRNA, with a molecular weight of about 13 kDa, recruits the RNA-induced silencing complex (RISC) to mRNA through base pairing, thereby inhibiting protein translation. The mRNA is targeted for cleavage through the catalysis of the RISC protein Ago2, a member of the Argonaute family. In addition, other Ago proteins (Ago1, Ago3, and Ago4) catalyze endonuclease-mediated degradation of non-specific mRNA by locating the bound mRNA in processing bodies (P-bodies).
Limitations of siRNA as a proprietary drug Naked siRNA is easily degraded by nucleases in blood, and its relatively high molecular weight, negative charge, and hydrophilicity make it difficult to penetrate cell membranes. siRNA tends to accumulate in the kidney and be excreted in urine or is captured by the reticuloendothelial system (…

New Gens & Associates research focuses on the evolving role and importance of local affiliates in efforts to make global regulatory processes more consistent and effective through optimised systems and tools. Steve Gens outlines the findings.
Achieving regulatory excellence in Life Sciences companies depends on a combination of process optimisation, effective global systems, high data quality, and better Affiliate collaboration. One weak link in that chain could risk compromising all of the other efforts and investment. Yet highly manual processes, specific local market requirements, and tool usage inconsistencies have often meant a gap in global information visibility and flow which adds risk to key regulatory processes. These processes include submission forecasting and planning; product…

Heart disease is a leading cause of death in the United States. The Centers for Disease Control and Prevention cite one American dies every 33 seconds because of cardiovascular disease.1 Due to the staggering numbers, heart dysfunction is a well-researched subject. Every finding brings new knowledge to the surface — and one recently led to the discovery of ferroptosis.
Heart disease is a leading cause of death in the United States. The Centers for Disease Control and Prevention cite one American dies every 33 seconds because of cardiovascular disease.1 Due to the staggering numbers, heart dysfunction is a well-researched subject. Every finding brings new knowledge to the surface — and one recently led to the discovery of ferroptosis. Ferroptosis is a form of cell death associated with many…

Everyone wants the best outcome possible when they’re a patient or caregiver in the healthcare industry. Technology makes that easier to achieve. The advantages of digitalization enhance the industry’s efficiency, productivity, and quality control. Those in the pharmaceutical industry particularly stand to benefit from digitization. These are the most important ways digital technologies are revolutionizing pharmaceutical manufacturing and the industry as a whole.
Everyone wants the best outcome possible when they’re a patient or caregiver in the healthcare industry. Technology makes that easier to achieve. The advantages of digitalization enhance the industry’s efficiency, productivity, and quality control. Those in the pharmaceutical industry particularly stand to benefit from digitization…