Articles
Explore the complex role of the IL-36 cytokines, members of the IL-1 superfamily. Learn how these molecular structures influence inflammation signaling pathways, their potential therapeutic benefits for various inflammatory diseases including psoriasis, rheumatoid arthritis, and inflammatory bowel disease,
IL-36, A Member of IL-1 Superfamily, Emerging Target for Treating Inflammatory Diseases Introduction to IL-36 Family Twenty years ago, Interleukin 36 (IL-36) was discovered as a member of the IL-1 superfamily. Its gene is located on chromosome 2 in an IL gene cluster, including IL1A - IL1B - IL37 - IL36G - IL36A - IL36B - IL36RN - IL38 - IL1RN, with IL-36 encoding genes transcribed far away from the centromere. There are four known subtypes of IL-36, which have been renamed multiple times…
IL-36, A Member of IL-1 Superfamily, Emerging Target for Treating Inflammatory Diseases Introduction to IL-36 Family Twenty years ago, Interleukin 36 (IL-36) was discovered as a member of the IL-1 superfamily. Its gene is located on chromosome 2 in an IL gene cluster, including IL1A - IL1B - IL37 - IL36G - IL36A - IL36B - IL36RN - IL38 - IL1RN, with IL-36 encoding genes transcribed far away from the centromere. There are four known subtypes of IL-36, which have been renamed multiple times…
Natural Killer (NK) cells play a critical role in the innate immune surveillance against cancer and viral infections. They are the "first responders" capable of spontaneously recognizing abnormal cells in the body, swiftly eliminating them through targeted cytotoxic mechanisms, and effectively producing pro-inflammatory cytokines and chemokines to recruit and activate other immune cells to initiate adaptive responses. Therefore, understanding the mechanisms of NK cell activation and identifying methods to stimulate their activation are crucial for the development of anti-tumor and antiviral drugs.
Mechanisms of NK Cell Activation NK cells are regulated by a dynamic balance between a series of activating and inhibitory receptors. Normal cells express major histocompatibility complex class…
Mechanisms of NK Cell Activation NK cells are regulated by a dynamic balance between a series of activating and inhibitory receptors. Normal cells express major histocompatibility complex class…
28-Jun-2023
Thymic Stromal Lymphopoietin (TSLP) is a multifunctional cytokine that acts on various cell types, including dendritic cells, T cells, B cells, neutrophils, mast cells, eosinophils, and innate lymphoid cells, affecting their maturation, survival, and recruitment. It is well-known for its role in promoting type 2 immune responses, such as allergic diseases. In 2021, a monoclonal antibody targeting TSLP was approved for the treatment of severe asthma.
TSLP and TSLPR TSLP (Thymic Stromal Lymphopoietin) is a member of the four-helix bundle cytokine family and is a distant homolog of IL-7. As the name suggests, TSLP was initially identified in the mouse thymic stromal cell line Z210R, as a factor that promotes the proliferation and development of immature B cells. Subsequently, TSLP was found to…
TSLP and TSLPR TSLP (Thymic Stromal Lymphopoietin) is a member of the four-helix bundle cytokine family and is a distant homolog of IL-7. As the name suggests, TSLP was initially identified in the mouse thymic stromal cell line Z210R, as a factor that promotes the proliferation and development of immature B cells. Subsequently, TSLP was found to…
28-Jun-2023
First-in-class antibody-drug conjugate (ADC) that targets Nectin-4, which is a cell surface protein highly expressed in bladder cancer. Preclinical data suggest that the anticancer activity of it is attributed to its binding to cells expressing Nectin-4, followed by internalization and release of the anti-tumor agent monomethyl auristatin E (MMAE) into the cell. This is believed to inhibit cell proliferation (cell cycle arrest) and induce programmed cell death (apoptosis).
The biologics license application (BLA) has been accepted for Enfortumab Vedotin for the treatment of locally advanced or metastatic urothelial carcinoma in patients who have previously received PD-1/PD-L1 inhibitors and platinum-containing chemotherapy. Enfortumab Vedotin is the first domestically submitted targeted an…
The biologics license application (BLA) has been accepted for Enfortumab Vedotin for the treatment of locally advanced or metastatic urothelial carcinoma in patients who have previously received PD-1/PD-L1 inhibitors and platinum-containing chemotherapy. Enfortumab Vedotin is the first domestically submitted targeted an…
As a recruiter or hiring manager in the life science industry, identifying the strongest job candidate requires a comprehensive evaluation of not only hard skills, qualifications, and experiences, but soft skills too. In this article, we guide you through the key aspects to consider when spotting the most promising candidates for your life science organisation, from assessing technical expertise and academic credentials to drive and cultural fit.
As a recruiter or hiring manager in the life science industry, identifying the strongest job candidate requires a comprehensive evaluation of not only hard skills, qualifications, and experiences, but soft skills too. In this article, we guide you through the key aspects to consider when spotting the most promising candidates for your life science…
As a recruiter or hiring manager in the life science industry, identifying the strongest job candidate requires a comprehensive evaluation of not only hard skills, qualifications, and experiences, but soft skills too. In this article, we guide you through the key aspects to consider when spotting the most promising candidates for your life science…
Differentially Expressed Genes (DEGs) are genes that exhibit significant differences in expression levels between two or more conditions or experimental groups. In genetics and genomics research, gene expression refers to the process through which the information encoded in a gene's DNA sequence is transformed into functional proteins or RNA molecules.
What are Differentially Expressed Genes (DEGs) in Genetics? Differentially Expressed Genes (DEGs) are genes that exhibit significant differences in expression levels between two or more conditions or experimental groups. In genetics and genomics research, gene expression refers to the process through which the information encoded in a gene's DNA sequence is transformed into functional proteins or RNA molecules. When studying gene expre…
What are Differentially Expressed Genes (DEGs) in Genetics? Differentially Expressed Genes (DEGs) are genes that exhibit significant differences in expression levels between two or more conditions or experimental groups. In genetics and genomics research, gene expression refers to the process through which the information encoded in a gene's DNA sequence is transformed into functional proteins or RNA molecules. When studying gene expre…
Single-Cell RNA Sequencing (scRNA-seq) offers several advantages in drug discovery, primarily through target identification. By analyzing complex tissues and diseases at the cellular level, scRNA-seq allows researchers to identify distinct cell subtypes and their gene expression profiles. This knowledge enhances our understanding of disease mechanisms and aids in the discovery of new therapeutic targets. By comparing healthy and diseased tissues, researchers can pinpoint differentially expressed genes specific to certain cell types or disease states.
Advantages of Single-Cell RNA Sequencing in Drug Discovery Single-Cell RNA Sequencing (scRNA-seq) offers several advantages in drug discovery, primarily through target identification. By analyzing complex tissues and diseases at the cellular le…
Advantages of Single-Cell RNA Sequencing in Drug Discovery Single-Cell RNA Sequencing (scRNA-seq) offers several advantages in drug discovery, primarily through target identification. By analyzing complex tissues and diseases at the cellular le…
Prokaryotes, like eukaryotes, are organisms that store their genetic information in the form of deoxyribonucleic acid (DNA). However, prokaryotes differ from eukaryotes in that their genetic material is not enclosed within a membrane-bound organelle nucleus. Instead, it is located in a region of the cell known as the nucleoid. Additionally, prokaryotes possess another DNA-containing structure called plasmids, which consist of looped chromosomes.
Introduction: Prokaryotes, like eukaryotes, are organisms that store their genetic information in the form of deoxyribonucleic acid (DNA). However, prokaryotes differ from eukaryotes in that their genetic material is not enclosed within a membrane-bound organelle nucleus. Instead, it is located in a region of the cell known as the nucleoid. Addition…
Introduction: Prokaryotes, like eukaryotes, are organisms that store their genetic information in the form of deoxyribonucleic acid (DNA). However, prokaryotes differ from eukaryotes in that their genetic material is not enclosed within a membrane-bound organelle nucleus. Instead, it is located in a region of the cell known as the nucleoid. Addition…
Prokaryotes, like eukaryotes, are organisms that store their genetic information in the form of deoxyribonucleic acid (DNA). However, prokaryotes differ from eukaryotes in that their genetic material is not enclosed within a membrane-bound organelle nucleus. Instead, it is located in a region of the cell known as the nucleoid. Additionally, prokaryotes possess another DNA-containing structure called plasmids, which consist of looped chromosomes.
Introduction: Prokaryotes, like eukaryotes, are organisms that store their genetic information in the form of deoxyribonucleic acid (DNA). However, prokaryotes differ from eukaryotes in that their genetic material is not enclosed within a membrane-bound organelle nucleus. Instead, it is located in a region of the cell known as the nucleoid. Addition…
Introduction: Prokaryotes, like eukaryotes, are organisms that store their genetic information in the form of deoxyribonucleic acid (DNA). However, prokaryotes differ from eukaryotes in that their genetic material is not enclosed within a membrane-bound organelle nucleus. Instead, it is located in a region of the cell known as the nucleoid. Addition…
Living organisms are categorized based on various characteristics, and one classification system revolves around their cellular components, structure, and function. Consequently, organisms, including microorganisms, can be classified as either eukaryotes or prokaryotes...
Overview of Microbial Eukaryotes Living organisms are categorized based on various characteristics, and one classification system revolves around their cellular components, structure, and function. Consequently, organisms, including microorganisms, can be classified as either eukaryotes or prokaryotes. The primary distinction between the two lies in the presence of membrane-bound organelles, including a true nucleus, which is found in eukaryotes but absent in prokaryotes. While it is commonly known that bacteria, for examp…
Overview of Microbial Eukaryotes Living organisms are categorized based on various characteristics, and one classification system revolves around their cellular components, structure, and function. Consequently, organisms, including microorganisms, can be classified as either eukaryotes or prokaryotes. The primary distinction between the two lies in the presence of membrane-bound organelles, including a true nucleus, which is found in eukaryotes but absent in prokaryotes. While it is commonly known that bacteria, for examp…
27-Jun-2023
Researchers have delved into the exploration of various modifications of PNA nucleobases that could enhance their properties and increase their chemical space.
Structure and Properties of PNA Peptide nucleic acids (PNAs) are sophisticated oligonucleotide analogs that feature nucleobases, a peptide backbone, as well as an N-terminus and a C-terminus. The nucleobases embedded in PNAs are the classic adenine (A), guanine (G), cytosine (C), and thymine (T), all of which can also be found in DNA. However, the nucleobases in PNAs are not attached to the conventional deoxyribose or ribose sugar. Instead, they are coupled to an N-(2-aminoethyl) glycine monomer, which then goes on to create a peptide bond with the neighboring monomer. This unique chemical makeup of PNAs imbues them with an exception…
Structure and Properties of PNA Peptide nucleic acids (PNAs) are sophisticated oligonucleotide analogs that feature nucleobases, a peptide backbone, as well as an N-terminus and a C-terminus. The nucleobases embedded in PNAs are the classic adenine (A), guanine (G), cytosine (C), and thymine (T), all of which can also be found in DNA. However, the nucleobases in PNAs are not attached to the conventional deoxyribose or ribose sugar. Instead, they are coupled to an N-(2-aminoethyl) glycine monomer, which then goes on to create a peptide bond with the neighboring monomer. This unique chemical makeup of PNAs imbues them with an exception…
In today’s tough economic climate, compounded by cutbacks and budget constraints, you’re likely encountering even greater difficulties when it comes to winning new clients for your pharmaceutical recruitment agency. As businesses continue to navigate through uncertain times, the competition to secure skilled professionals has become increasingly fierce, making it more important than ever for you to differentiate yourselves and demonstrate your value as trusted partners.
Becoming the preferred partner in a challenging economy In today’s tough economic climate, compounded by cutbacks and budget constraints, you’re likely encountering even greater difficulties when it comes to winning new clients for your pharmaceutical recruitment agency. As businesses continue to navigate through uncertain t…
Becoming the preferred partner in a challenging economy In today’s tough economic climate, compounded by cutbacks and budget constraints, you’re likely encountering even greater difficulties when it comes to winning new clients for your pharmaceutical recruitment agency. As businesses continue to navigate through uncertain t…
Baby Food Market grew at a CAGR of 5.9% between2017-2021 and is estimated to be US$ 89,678.5Mn in 2022. Currently, the market is anticipated to grow at a CAGR of 5.4% and is expected to reach a valuation of US$ 1,51,738.0 Mn by 2032 end.
According to a recent survey conducted by ChemView Consulting, the Global Baby Food Market grew at a CAGR of 5.9% between2017-2021 and is estimated to be US$ 89,678.5Mn in 2022. Currently, the market is anticipated to grow at a CAGR of 5.4% and is expected to reach a valuation of US$ 1,51,738.0 Mn by 2032 end. The study offers a thorough overview of the market segments that were created by fusing many factors, including product type, service provider, and geographic regions. In addition to this, the signific…
According to a recent survey conducted by ChemView Consulting, the Global Baby Food Market grew at a CAGR of 5.9% between2017-2021 and is estimated to be US$ 89,678.5Mn in 2022. Currently, the market is anticipated to grow at a CAGR of 5.4% and is expected to reach a valuation of US$ 1,51,738.0 Mn by 2032 end. The study offers a thorough overview of the market segments that were created by fusing many factors, including product type, service provider, and geographic regions. In addition to this, the signific…
Herb & Spice Extracts Market grew at a CAGR of 4.8% between 2017-2021 and is estimated to be US$ 11,943.2 Mn in 2022. Currently, the market is anticipated to grow at a CAGR of 4.6% and is expected to reach a valuation of US$ 18,725.7 Mn by 2032 end.
According to a recent survey conducted by ChemView Consulting, the Global Herb & Spice Extracts Market grew at a CAGR of 4.8% between 2017-2021 and is estimated to be US$ 11,943.2 Mn in 2022. Currently, the market is anticipated to grow at a CAGR of 4.6% and is expected to reach a valuation of US$ 18,725.7 Mn by 2032 end. Herbs seeds, stems, and flowers are used to make herbal extracts. Spice extracts are flavourings made from stems, nuts, berries, barks, and vegetables that are sweet and sou…
According to a recent survey conducted by ChemView Consulting, the Global Herb & Spice Extracts Market grew at a CAGR of 4.8% between 2017-2021 and is estimated to be US$ 11,943.2 Mn in 2022. Currently, the market is anticipated to grow at a CAGR of 4.6% and is expected to reach a valuation of US$ 18,725.7 Mn by 2032 end. Herbs seeds, stems, and flowers are used to make herbal extracts. Spice extracts are flavourings made from stems, nuts, berries, barks, and vegetables that are sweet and sou…
Lithium-Ion Battery Recycling Market was worth US$ 3,874.6 Mn and is expected to grow at a CAGR of 21.3% over the forecast period. While the historical CAGR is 4.1%, the market is expected to hit US$ 26,719.9 Mn by 2032 end.
According to a research survey conducted by ChemView Consulting, in 2022, the Global Lithium-Ion Battery Recycling Market was worth US$ 3,874.6 Mn and is expected to grow at a CAGR of 21.3% over the forecast period. While the historical CAGR is 4.1%, the market is expected to hit US$ 26,719.9 Mn by 2032 end. The forecast periods. Stringent authorities’ guidelines round secure battery disposal coupled with bottlenecks in virgin fabric sourcing is anticipated to resource the call for battery recycling throughout main economies. The sourc…
According to a research survey conducted by ChemView Consulting, in 2022, the Global Lithium-Ion Battery Recycling Market was worth US$ 3,874.6 Mn and is expected to grow at a CAGR of 21.3% over the forecast period. While the historical CAGR is 4.1%, the market is expected to hit US$ 26,719.9 Mn by 2032 end. The forecast periods. Stringent authorities’ guidelines round secure battery disposal coupled with bottlenecks in virgin fabric sourcing is anticipated to resource the call for battery recycling throughout main economies. The sourc…
Liquid Packaging Carton Market was worth US$ 20.6 Bn and is expected to grow at a CAGR of 6.0% over the forecast period. The market is expected to hit US$ 32.8 Bn by 2030 end.
According to a research survey conducted by ChemView Consulting, in 2022, the Global Liquid Packaging Carton Market was worth US$ 20.6 Bn and is expected to grow at a CAGR of 6.0% over the forecast period. The market is expected to hit US$ 32.8 Bn by 2030 end. The growing inclination of the overall populace in opposition to packaged meals & beverages is expected to enlarge call for for the Liquid Packaging Cartons marketplace for the duration of the projection period. Further, the innovation in packaging, the growing industrialization & urbanization, and the recyclable nature of c…
According to a research survey conducted by ChemView Consulting, in 2022, the Global Liquid Packaging Carton Market was worth US$ 20.6 Bn and is expected to grow at a CAGR of 6.0% over the forecast period. The market is expected to hit US$ 32.8 Bn by 2030 end. The growing inclination of the overall populace in opposition to packaged meals & beverages is expected to enlarge call for for the Liquid Packaging Cartons marketplace for the duration of the projection period. Further, the innovation in packaging, the growing industrialization & urbanization, and the recyclable nature of c…
Demand for workflow optimization in healthcare, regulatory requirements and government initiatives to fuel the adoption of healthcare RCM, increasing adoption of cloud based healthcare RCM, strategic initiatives associated with healthcare revenue cycle management, are some of the major factors driving the growth of the healthcare revenue cycle management market.
Healthcare Revenue Cycle Management refers to the overall process of identifying, collecting and managing the practice’s revenue from payers based on the services offered. A successful healthcare revenue cycle management process is necessary for a healthcare practice to maintain financial viability and continue offering good patient care. Rising Potential of RCM Outsourcing in the Healthcare Segment Triggers the Growth of the Health…
Healthcare Revenue Cycle Management refers to the overall process of identifying, collecting and managing the practice’s revenue from payers based on the services offered. A successful healthcare revenue cycle management process is necessary for a healthcare practice to maintain financial viability and continue offering good patient care. Rising Potential of RCM Outsourcing in the Healthcare Segment Triggers the Growth of the Health…
Calcium Sulphate Market was worth US$ 1,22,564.9 Mn and is expected to grow at a CAGR of 4.2% over the forecast period. The market is expected to hit US$ 1,84,945.3 Mn by 2032 end. From 2017–2021, when the market’s CAGR was 3.6%, the market underwent significant growth.
According to a recent survey conducted by ChemView Consulting, in 2022, the Global Calcium Sulphate Market was worth US$ 1,22,564.9 Mn and is expected to grow at a CAGR of 4.2% over the forecast period. The market is expected to hit US$ 1,84,945.3 Mn by 2032 end. From 2017–2021, when the market’s CAGR was 3.6%, the market underwent significant growth. Calcium Sulphate is an inorganic substance, generally referred to as gypsum, having molecular formulation CaSO4. Calcium Sulphate has fantast…
According to a recent survey conducted by ChemView Consulting, in 2022, the Global Calcium Sulphate Market was worth US$ 1,22,564.9 Mn and is expected to grow at a CAGR of 4.2% over the forecast period. The market is expected to hit US$ 1,84,945.3 Mn by 2032 end. From 2017–2021, when the market’s CAGR was 3.6%, the market underwent significant growth. Calcium Sulphate is an inorganic substance, generally referred to as gypsum, having molecular formulation CaSO4. Calcium Sulphate has fantast…
he Zika Virus has emerged as a significant global health concern in recent years. Understanding the market dynamics and epidemiology associated with this virus is crucial for healthcare professionals.
The Zika Virus has emerged as a significant global health concern in recent years. Understanding the market dynamics and epidemiology associated with this virus is crucial for healthcare professionals, researchers, and pharmaceutical companies. In this blog, we will delve into the Zika Virus market size, leading companies, key strengths of the market report, prevalent cases in different countries, pipeline developments, treatment options, symptoms, and available drugs. What is Zika Virus? Zika Virus is a mosquito-borne viral infection primarily transmitted by the Aedes mosquito. It was first i…
The Zika Virus has emerged as a significant global health concern in recent years. Understanding the market dynamics and epidemiology associated with this virus is crucial for healthcare professionals, researchers, and pharmaceutical companies. In this blog, we will delve into the Zika Virus market size, leading companies, key strengths of the market report, prevalent cases in different countries, pipeline developments, treatment options, symptoms, and available drugs. What is Zika Virus? Zika Virus is a mosquito-borne viral infection primarily transmitted by the Aedes mosquito. It was first i…
The electroplating intermediate is a material used in the electroplating process to adjust characteristics such as grain size, gloss, thickness and plating speed.
The electroplating intermediate is a material used in the electroplating process to adjust characteristics such as grain size, gloss, thickness and plating speed. Most of them are configured as electroplating additives. Then, it is added to the electroplating production process for additional use. According to different types of plating, it can be divided into nickel plating intermediate, copper plating intermediate, tin plating intermediate, gold plating intermediate, silver plating intermediate, etc. According to different functions, it can be divided into surfactant, brightener, wetting agent, softener, anti-fogging agent,…
The electroplating intermediate is a material used in the electroplating process to adjust characteristics such as grain size, gloss, thickness and plating speed. Most of them are configured as electroplating additives. Then, it is added to the electroplating production process for additional use. According to different types of plating, it can be divided into nickel plating intermediate, copper plating intermediate, tin plating intermediate, gold plating intermediate, silver plating intermediate, etc. According to different functions, it can be divided into surfactant, brightener, wetting agent, softener, anti-fogging agent,…
