Articles

Learn about the IL-17 family and its receptor complex in immune responses with Beta LifeScience. Explore our IL-17 series target proteins known for their high purity, variety, and activity. Take a look at these crucial proteins, highlighting their importance in immunity, antibody screening, and function evaluation.
Autoimmune disease target - IL-17 Family IL-17 plays an important role in promoting autoimmune diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis (AS). Currently, five large-molecule biopharmaceuticals targeting IL-17/IL-17R are available worldwide, including four IL-17 monoclonal antibodies and one IL-17RA monoclonal antibody, namely Secukinumab(Novartis), Ixekizumab(Eli Lilly), Netakimab(Biocad), Brodalumab(Kyowa Hakko Kirin), and Bimekizumab(UCB). &nbs…

Vascular Endothelial Growth Factor (VEGF) is a highly biologically active functional glycoprotein. It is a specific and potent mitogen for endothelial cells, playing a role in their proliferation, migration, and lumen formation. VEGF is involved in angiogenesis and increases capillary permeability. It can induce abnormal growth of tumor blood vessels, hinder the effective delivery of anti-tumor drugs to tumor tissues, and stimulate the production of new blood vessel growth factors.
Tumors and Blood Vessel Growth Tumor, as an abnormal mass of cells, has blood vessels of various sizes that can be seen everywhere on the surface and deep within it. Nutrients for life are continuously supplied to the depths of tumor cells through these blood vessels. As the tumor continues to grow, nearby bloo…

Matrix metalloproteinases (MMPs) are a family of enzymes belonging to the metzincin superfamily. There are 23 different types of secreted or membrane-anchored endopeptidases in the human body. It's been applied to the field of diagnostic research nowadays. This article is a brief introduction to the MMP3 family and its usage.
The MMP Family Matrix metalloproteinases (MMPs) are a family of enzymes belonging to the metzincin superfamily. There are 23 different types of secreted or membrane-anchored endopeptidases in the human body. MMPs are capable of degrading ECM proteins such as collagen, gelatin, laminin, fibronectin, fibrinogen, elastin, and proteoglycans. They were once considered regulators of the extracellular matrix. MMPs have multiple structural domains, including a signal peptide (…

Unquestionably, it has been a challenging couple of years for the healthcare industry as the country faced the largest public health crisis in living memory. In response, the industry has swelled. During the last 12 months for instance, new analysis shows that recruitment appears high on the agenda with a 37% increase in the number of people hired by the sector in 2022.
Unquestionably, it has been a challenging couple of years for the healthcare industry as the country faced the largest public health crisis in living memory. In response, the industry has swelled. During the last 12 months for instance, new analysis shows that recruitment appears high on the agenda with a 37% increase in the number of people hired by the sector in 2022. Recruitment software company Occupop has crunched the…

Medical coding, in particular, plays a crucial role in ensuring accurate and efficient reimbursement for healthcare providers.
The healthcare industry operates within a complex framework of regulations and processes. Medical coding, in particular, plays a crucial role in ensuring accurate and efficient reimbursement for healthcare providers. However, navigating the intricacies of medical coding can be challenging and time-consuming for healthcare professionals. That's where a professional billing company steps in. In this article, we will explore the complexities of medical coding and discuss how a billing company can provide valuable assistance to healthcare providers. Understanding the Importance of Medical Coding Accurate medical coding is essential for several reasons. Firstly, it…

Initial research indicates that PerinelineTM, which received Orphan Drug Designation in 2022 may improve neuroplasticity and neuroregeneration to enable new synapses to be made. Pre-clinical data indicates that the therapy may improve mobility in both acute and chronic cases.
Initial research indicates that PerinelineTM, which received Orphan Drug Designation in 2022 may improve neuroplasticity and neuroregeneration to enable new synapses to be made. Pre-clinical data indicates that the therapy may improve mobility in both acute and chronic cases. In partnership with AscellaHealth, NeuroSolv Therapeutics is seeking to expand the clinical trial development programme and accelerate regulatory approval procedures to optimise the prospect of bringing PerinelineTM to market. Initial data from pr…

Good Clinical Practice (GCP) guidelines form the backbone of ethical and high-quality Clinical research by TechnoBridge. These guidelines establish internationally recognized standards for the design, conduct, and reporting of clinical trials involving human participants. In this article, we explore the importance of GCP guidelines in safeguarding participant rights and ensuring data integrity.
Introduction:- Good Clinical Practice (GCP) guidelines form the backbone of ethical and high-quality Clinical research by TechnoBridge. These guidelines establish internationally recognized standards for the design, conduct, and reporting of clinical trials involving human participants. In this article, we explore the importance of GCP guidelines in safeguarding participant rights and ensuring data i…

Polyethylene glycol (PEG), a compound composed of repeated ethylene glycol units [-(CH2CH2O)n], is also known as Macrogols. PEG and PEG derivatives have the characteristics of non-irritation, good water solubility, good compatibility, etc. . At the same time, they possess excellent lubricity, moisture retention and dispersibility so that they can be used as adhesives, antistatic agents and softeners, and widely applied in cosmetics, pharmaceuticals, chemical fibers, rubber, plastics, paper, paint, electroplating, pesticides, metal processing and food processing industries.
This article will introduce PEG chemical structure, PEG synthesis, and PEG properties. Synthesis of PEG Polyethylene glycol (PEG) can be synthesized via anionic polymerization of ethylene oxide and any hydroxyl…

Average drug-to-antibody ratio (DAR) and drug load distribution are two vital properties of antibody drug conjugates (ADCs). Over the years, several ADC bioanalytical methods have been developed to better estimate these properties for early development and routine quality control applications. In this article, we provide an overview of the most widely used methods for the detailed analysis of DAR in these molecules.
Average drug-to-antibody ratio (DAR) and drug load distribution are two vital properties of antibody drug conjugates (ADCs). Over the years, several ADC bioanalytical methods have been developed to better estimate these properties for early development and routine quality control applications. In this article, we provide an overview of the most widely used methods…

Oligosaccharides are basically carbohydrates formed by the union of three to six units of simple sugars or monosaccharides. However, in rare cases, as many as ten units of sugars have been seen to form an Oligosaccharide. They are either formed by combining molecules of monosaccharides or are formed from the breaking of complex sugars called polysaccharides. Very few oligosaccharides are found in nature from plants. To mention a few; Raffinose is formed of 3 molecules of monosaccharides, melibiose, gentianose and fructose. One oligosaccharide is obtained from arthropod’s blood and in a few plants which are Maltotriose which consists of three molecules of glucose. The molecular formula of Oligosaccharide is C37H62N2O29. It has a calorific va;ue of 1.5-2 cal/gm and is usually found in legumes, garlic, pear, watermelon and white onion. Many fruits also contain fructo-oligosaccharide.

Surfactants can increase the solubility of poorly soluble drugs in the dispersion medium, because surfactants can form micelles.
Surfactants have become a flexible and diverse class of fine chemical products due to their physical and chemical effects such as wetting or anti-sticking, emulsification or demulsification, foaming or defoaming, solubilization, dispersion, washing, anti-corrosion, etc. Currently, surfactants are most widely used as detergents in daily life, but they have been found potentially useful in many other fields. Characteristics of Surfactant Solubilization Surfactants can increase the solubility of poorly soluble drugs in the dispersion medium, because surfactants can form micelles, and surfactants are amphiphilic, if the polarity of the drug is small and the…

Pheromones have been widely used in pest management internationally in recent years as they are green and environmentally friendly, making fruit and vegetable safer.
Insect pheromones are compounds used to express various information such as aggregation, foraging, mating, and vigilance. Insect pheromones exist in insects in nature, and all insects produce and recognize pheromones. Insect pheromones have been widely used in pest management internationally in recent years as they are green and environmentally friendly, making fruit and vegetable safer. What are insect pheromones made of? Insect pheromones are mainly composed of alkanes and alkenes, most of which are straight-chain unsaturated acetates with 10-18 carbons and their alcohols or aldehydes, and a few contain epoxy s…

Valuation is a frequently employed practice in the pharma industry. It plays a pivotal role in a multitude of decision-making processes including new product planning, opportunity assessment, fund raising, investment, licensing, partnering and M&A. In this article, we address some of the critical aspects that must be considered when conducting valuation of pharmaceutical companies and their assets.
Valuation is a frequently employed practice in the pharma industry. It plays a pivotal role in a multitude of decision-making processes including new product planning, opportunity assessment, fund raising, investment, licensing, partnering and M&A. In this article, we address some of the critical aspects that must be considered when conducting valuation of pharmaceutical companies and their a…

In today’s competitive job market and taxing economy, finding the right talent for your organisation whilst sticking to tight budgets can be a real challenge – yet it’s not impossible. By implementing cost-effective strategies, you can streamline your hiring procedures, attract qualified candidates, and make efficient use of your resources.
In today’s competitive job market and taxing economy, finding the right talent for your organisation whilst sticking to tight budgets can be a real challenge – yet it’s not impossible. By implementing cost-effective strategies, you can streamline your hiring procedures, attract qualified candidates, and make efficient use of your resources. This article will explore a range of practical approaches and techniques to enhance your hiring efforts whilst main…

It has become fashionable recently to bemoan a current skills gap in the UK life sciences sector that is said to be frustrating future growth. Prime Minister, Rishi Sunak, lit the touchpaper earlier this year when he suggested the country could become a science and technology ‘superpower’, with life sciences at the vanguard of this bold new ambition.
It has become fashionable recently to bemoan a current skills gap in the UK life sciences sector that is said to be frustrating future growth. Prime Minister, Rishi Sunak, lit the touchpaper earlier this year when he suggested the country could become a science and technology ‘superpower’, with life sciences at the vanguard of this bold new ambition. Few players in the industry appeared to disagree but, in their very British way, some are alrea…

Carbon fiber composite materials have begun to find use in various industries and its charm has been gradually recognized worldwide.
Carbon fiber is a new type of fiber material with high strength and with a carbon content of more than 95%. It is a microcrystalline graphite material obtained by piling up organic fibers such as flake graphite microcrystals along the fiber axial direction, and then undergoing carbonization and graphitization treatments. Carbon fiber is a new material with excellent mechanical properties. Its specific gravity is less than 1/4 of that of steel. The tensile strength of carbon fiber resin composites is generally above 3500Mpa, which is 7-9 times that of steel. The tensile modulus of elasticity is 23000 to 43000Mpa, also higher than steel. Performance of…

2D materials have gained attention due to their excellent electrical, thermal, and mechanical properties.
2D materials are layered materials composed of single or multiple atomic layers in terms of thickness and stacked between van der Waals forces. Initially, 2D semiconducting materials mainly focused on carbon-based materials, such as carbon nanotubes and graphene. According to a study by IBM, graphene chips have shown greater performance and improvement in power consumption compared to silicon-based chips. For instance, the chip speed of the 7 nm silicon-based chip will only be enhanced by 20% when it is narrowed down to 5 nm, whereas the 7 nm graphene chip demonstrated 300X greater speed than the 7 nm silicon-based chip. Research data have proven that carbon-based 2D materials can bette…

Ox bile extract powder, derived from ox bile, is a natural product with a wide range of applications. It contains essential components such as bile acids, cholesterol, bilirubin, and fatty acids. Through meticulous preparation processes, it is transformed into a powdered form, enhancing its stability and convenience. Ox bile extract powder exhibits diverse applications in the fields of pharmaceuticals, the food industry, and scientific research. This article delves into its origin, preparation methods, and significant roles across various domains.
Introduction: Ox bile extract powder, derived from ox bile, is a natural product with a wide range of applications. It contains essential components such as bile acids, cholesterol, bilirubin, and fatty acids. Through meticulous preparation proces…

Enzymes, as crucial catalysts in biological systems, play a significant role in scientific research and industrial applications. To enhance efficiency in research and application, enzyme scientists have continuously sought innovative enzyme tools. Leading the way in this quest for innovation, Creative Enzymes has introduced a remarkable series of enzyme tools called the SuperCut Series. This article aims to provide an in-depth exploration of the groundbreaking features and wide-ranging potential applications of the SuperCut Series, showcasing its pivotal role in the field of enzyme science.
Enzymes, as crucial catalysts in biological systems, play a significant role in scientific research and industrial applications. To enhance efficiency in research and application, enzyme scientists have…

Microneedling is currently most widely used in the cosmetic field and has been commercialized for many years.
Microneedles (MN) is a new type of physical permeability-enhancing technology. It consists of multiple micron-scale fine needle tips connected to the base in an array. The needle body is generally 10-2000 microns high and 10-50 microns wide. The length, size and shape of the microneedles can be individually designed according to the needs of the application. When the microneedle delivers the drug, the active ingredient is loaded into the microneedle array, and the concentration gradient between the drug and the subcutaneous tissue fluid forms a driving force, causing the drug to be slowly released into the body. In addition to the advantages of a transdermal delivery system, it also…