Articles

Nitric oxide (NO) plays a pivotal role in regulating various physiological processes, including vasodilation, platelet aggregation inhibition, neurotransmission, and antimicrobial activity. One of the key mechanisms by which NO exerts its effects is through protein S-nitrosylation. S-Nitrosylation involves the transfer of a nitroso group to cysteine residues, resulting in the formation of S-nitrosothiols (SNO). This reversible post-translational modification dynamically regulates protein activity, localization, stability, and intermolecular interactions, akin to the well-known phosphorylation process.
Introduction Nitric oxide (NO) plays a pivotal role in regulating various physiological processes, including vasodilation, platelet aggregation inhibition, neurotransmission, and antimicrobial…

Absolute Quantification (AQUA) is an innovative and powerful targeted quantitative proteomics technique that has gained widespread popularity across various proteomics studies. This cutting-edge approach allows for precise and accurate measurement of protein levels and their post-translational modification states.
Introduction: Absolute Quantification (AQUA) is an innovative and powerful targeted quantitative proteomics technique that has gained widespread popularity across various proteomics studies. This cutting-edge approach allows for precise and accurate measurement of protein levels and their post-translational modification states. By synthesizing peptides with stable isotopes as internal standards, AQUA effectively mimics native peptides generated through proteolysis. Moreover, thes…

Vaccine excipients can include adjuvants, stabilizers, preservatives, and additives. Each excipient serves a specific purpose in ensuring that vaccines are effective.
Infectious diseases seriously threaten human health, and various infectious diseases may cause millions of severe cases and even death every year. Vaccination has been one of the most effective public health interventions in history, preventing millions of deaths worldwide. However, the success of vaccines relies not only on the antigens they carry but also on additional components known as vaccine excipients. Vaccine excipients play a crucial role in the development and manufacturing of vaccines. These are substances added to the vaccine formulation to enhance its stability, efficacy, and safety. Vaccine excipients can includ…

In today's Pharmaceutical Industry, standard operating procedures (SOPs) play a vital role in daily operations. A Standard Operating Procedure is a documented set of step-by-step of instructions that outline the approved methods and practices for carrying out specific tasks or processes within an organization. In the context of a pharmaceutical company, SOPs play a crucial role in ensuring quality, compliance, and safety across a company's entire operations.
In today's Pharmaceutical Industry, standard operating procedures (SOPs) play a vital role in daily operations.  A Standard Operating Procedure is a documented set of step-by-step of instructions that outline the approved methods and practices for carrying out specific tasks or processes within an organization. In the context of a phar…

In this article, we’ve put together a list of the best life science organisations to work for in the UK, using the official rankings awarded by The Great Place to Work Institute in 2023.
In this article, we’ve put together a list of the best life science organisations to work for in the UK, using the official rankings awarded by The Great Place to Work Institute in 2023. Read the full article on PharmiWeb.Jobs.

Dive into our informative blog to discover how Clinion EDC's advanced AI-enabled features can revolutionize clinical trials. Read now to unlock valuable insights
Electronic Data Capture (EDC) software has revolutionized clinical trials, enabling clinical research teams to streamline data management and enhance operational efficiency. However, the true potential of EDC is realized when coupled with advanced features that leverage artificial intelligence (AI) and machine learning (ML). Among the sea of options, Clinion EDC stands out as a game-changer. Discover how Clinion EDC’s advanced AI-enabled features like eProtocol Automation, Global Libraries, AI Medical Coding and Remote SDV Automation set it apart from the competition, making it the ideal choice for accelerating your tr…

With the continuous development of high technology, the rapid analysis and detection technology of modern drugs has also been continuously improved.
Pharmaceutical analysis is a form of using all chemical, physical, biological, microbial and other means and methods to study the chemical properties of drugs. During the testing process, the stability of the drug itself, biological components and clinical drug use must be considered. With the continuous development of high technology, the rapid analysis and detection technology of modern drugs has also been continuously improved. Chromatography technology is a rapid detection method, and with continuous development, chromatographic detection technology is expected to have higher performance, higher stability and faster speed, which can ba…

The latest application of photocatalysis is for disease treatment, and the photocatalytic mosquito trap developed by Akira Fujishima has already been used in areas where malaria is rampant.
Photocatalyst is a general term for semiconductor materials with photocatalytic function represented by nano-scale titanium dioxide. The representative photocatalyst material is titanium dioxide, which can produce strong oxidizing substances under light irradiation, and can be used to decompose organic compounds, some inorganic compounds, bacteria and viruses. Photocatalyst Materials The commonly used photocatalyst semiconductor materials are titanium dioxide. ZrO2, ZnO, CdS, WO3, Fe2O3, PbS, SnO2, ZnS, SrTiO3, and SiO2 are also photocatalyst materials. Since 2000, it has been found that s…

Molecular dynamics simulation is a powerful and widely employed computational method that investigates the motion and interactions of molecules under different conditions, revealing the structure, dynamics, and physical-chemical properties of molecules. This article aims to delve into the fundamental principles, applications, and key techniques of molecular dynamics simulation, providing you with a better understanding of its significance and implications in the field.
Molecular dynamics simulation is a powerful and widely employed computational method that investigates the motion and interactions of molecules under different conditions, revealing the structure, dynamics, and physical-chemical properties of molecules. This article aims to delve into the fundamental principles, applications,…

Explore how cutting-edge innovations, advanced data analytics, and seamless connectivity are revolutionizing patient care, enhancing operational efficiency, and shaping the next chapter of healthcare delivery
Incredible technological advancements have made telemedicine a reality, defying previous doubts. In the upcoming months of 2023 can expect even more remarkable breakthroughs and technological trends in the field of healthcare, paving the way for further progress and innovation. Based on the 2022 Future of Healthcare Report, we can expect more advancements in digital technology and higher patient expectations in the coming years. The report also highlights the rise of flexible healthcare delivery systems and increased competition in the healthcare industry. Payer organizations are aimin…

Recent top global hires for large-cap, mid-cap, and public companies, covering a broad range of disciplines and sectors across Life Sciences, Health and Tech.
CEO/ C suite/ Board Function Focus area Location General Counsel Biotech (publicly listed) US Chief Scientific Officer Biotech (publicly listed) US Chief Medical Officer Precision medicine (publicly listed) APAC Chief Business Officer Biopharma (publicly listed) Europe Chief Commercial Officer Drug delivery (mid-cap) Europe Chief Operations Officer Prosthetics products (mid-cap) Europe Board Director Surgical technologies (publicly listed) US Board Director Biotech (publicly listed) US Commercial / Functional / Strategic Leadership Function Focus area …

AI is already transforming the recruitment landscape, with 85% of recruiters agreeing that this technology is a useful tool in the hiring process. New developments and use cases for AI are being unleashed at an astonishing rate, and if you aren’t already looking at how you can use this technology to your advantage, now is the time to do so. In this article, we’ve focused on LinkedIn; sharing 6 different ways you can utilise ChatGPT to transform your social recruiting strategy.
AI is already transforming the recruitment landscape, with 85% of recruiters agreeing that this technology is a useful tool in the hiring process. New developments and use cases for AI are being unleashed at an astonishing rate, and if you aren’t already looking at how you can use this technology to your advantage, no…

Interleukin-2 (IL-2) is a 15kDa secretory protein with a 4-alpha-helical bundle structure. As a T-cell related growth factor, IL-2 can enhance the killing activity of NK cells and promote B cells to produce immunoglobulins. In addition, it aids in the development of regulatory T cells (Tregs), thereby producing peripheral T cell immune tolerance, as well as regulating the proliferation and differentiation of activated T cells. This article deliberates these traits and applications of IL-2, as an introductory material in the field of immunotherapy.
Interleukin-2 (IL-2) is a 15kDa secretory protein with a 4-alpha-helical bundle structure. As a T-cell related growth factor, IL-2 can enhance the killing activity of NK cells and promote B cells to produce immunoglobulins. In addition, it aids i…

Learn about the IL-17 family and its receptor complex in immune responses with Beta LifeScience. Explore our IL-17 series target proteins known for their high purity, variety, and activity. Take a look at these crucial proteins, highlighting their importance in immunity, antibody screening, and function evaluation.
Autoimmune disease target - IL-17 Family IL-17 plays an important role in promoting autoimmune diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis (AS). Currently, five large-molecule biopharmaceuticals targeting IL-17/IL-17R are available worldwide, including four IL-17 monoclonal antibodies and one IL-17RA monoclonal antibody, namely Secukinumab(Novartis), Ixekizumab(Eli Lilly), Netakimab(Biocad), Brodalumab(Kyowa Hakko Kirin), and Bimekizumab(UCB). &nbs…

Vascular Endothelial Growth Factor (VEGF) is a highly biologically active functional glycoprotein. It is a specific and potent mitogen for endothelial cells, playing a role in their proliferation, migration, and lumen formation. VEGF is involved in angiogenesis and increases capillary permeability. It can induce abnormal growth of tumor blood vessels, hinder the effective delivery of anti-tumor drugs to tumor tissues, and stimulate the production of new blood vessel growth factors.
Tumors and Blood Vessel Growth Tumor, as an abnormal mass of cells, has blood vessels of various sizes that can be seen everywhere on the surface and deep within it. Nutrients for life are continuously supplied to the depths of tumor cells through these blood vessels. As the tumor continues to grow, nearby bloo…

Matrix metalloproteinases (MMPs) are a family of enzymes belonging to the metzincin superfamily. There are 23 different types of secreted or membrane-anchored endopeptidases in the human body. It's been applied to the field of diagnostic research nowadays. This article is a brief introduction to the MMP3 family and its usage.
The MMP Family Matrix metalloproteinases (MMPs) are a family of enzymes belonging to the metzincin superfamily. There are 23 different types of secreted or membrane-anchored endopeptidases in the human body. MMPs are capable of degrading ECM proteins such as collagen, gelatin, laminin, fibronectin, fibrinogen, elastin, and proteoglycans. They were once considered regulators of the extracellular matrix. MMPs have multiple structural domains, including a signal peptide (…

Unquestionably, it has been a challenging couple of years for the healthcare industry as the country faced the largest public health crisis in living memory. In response, the industry has swelled. During the last 12 months for instance, new analysis shows that recruitment appears high on the agenda with a 37% increase in the number of people hired by the sector in 2022.
Unquestionably, it has been a challenging couple of years for the healthcare industry as the country faced the largest public health crisis in living memory. In response, the industry has swelled. During the last 12 months for instance, new analysis shows that recruitment appears high on the agenda with a 37% increase in the number of people hired by the sector in 2022. Recruitment software company Occupop has crunched the…

Medical coding, in particular, plays a crucial role in ensuring accurate and efficient reimbursement for healthcare providers.
The healthcare industry operates within a complex framework of regulations and processes. Medical coding, in particular, plays a crucial role in ensuring accurate and efficient reimbursement for healthcare providers. However, navigating the intricacies of medical coding can be challenging and time-consuming for healthcare professionals. That's where a professional billing company steps in. In this article, we will explore the complexities of medical coding and discuss how a billing company can provide valuable assistance to healthcare providers. Understanding the Importance of Medical Coding Accurate medical coding is essential for several reasons. Firstly, it…

Initial research indicates that PerinelineTM, which received Orphan Drug Designation in 2022 may improve neuroplasticity and neuroregeneration to enable new synapses to be made. Pre-clinical data indicates that the therapy may improve mobility in both acute and chronic cases.
Initial research indicates that PerinelineTM, which received Orphan Drug Designation in 2022 may improve neuroplasticity and neuroregeneration to enable new synapses to be made. Pre-clinical data indicates that the therapy may improve mobility in both acute and chronic cases. In partnership with AscellaHealth, NeuroSolv Therapeutics is seeking to expand the clinical trial development programme and accelerate regulatory approval procedures to optimise the prospect of bringing PerinelineTM to market. Initial data from pr…

Good Clinical Practice (GCP) guidelines form the backbone of ethical and high-quality Clinical research by TechnoBridge. These guidelines establish internationally recognized standards for the design, conduct, and reporting of clinical trials involving human participants. In this article, we explore the importance of GCP guidelines in safeguarding participant rights and ensuring data integrity.
Introduction:- Good Clinical Practice (GCP) guidelines form the backbone of ethical and high-quality Clinical research by TechnoBridge. These guidelines establish internationally recognized standards for the design, conduct, and reporting of clinical trials involving human participants. In this article, we explore the importance of GCP guidelines in safeguarding participant rights and ensuring data i…