Articles

Enzymes, nature's molecular architects, have been at the heart of industrial processes for decades. Today, the dynamic field of Enzyme Engineering and Modification is driving these biocatalysts towards unprecedented capabilities, triggering a wave of transformative applications across diverse sectors.
Enzymes, nature's molecular architects, have been at the heart of industrial processes for decades. Today, the dynamic field of Enzyme Engineering and Modification is driving these biocatalysts towards unprecedented capabilities, triggering a wave of transformative applications across diverse sectors.   Decoding Enzyme Engineering Enzyme Engineering stands as a cornerstone of modern biotechnology, involving the strategic redesign of enzymes to amplify their inherent functionalities or int…

The expedition of harnessing the therapeutic potential of probiotics is intricately intertwined with Industrial Development Services, a pivotal enabler in propelling probiotic research and application.
In the realm of modern health and wellness, the symbiotic relationship between humans and their gut microbiota has taken center stage. Probiotics, or "friendly bacteria," have garnered immense interest for their potential to influence various physiological processes, from digestive health to immune modulation. The expedition of harnessing the therapeutic potential of probiotics is intricately intertwined with Industrial Development Services, a pivotal enabler in propelling probiotic research and application.   Deciphering Probiotics Probiotics, as live microorganisms, are predominantly s…

Europe is known for its innovative and cutting-edge advancements in the field of life sciences. From groundbreaking research to transformative technologies, this continent is at the forefront of shaping the future of healthcare and biotechnology. In this article, we outline 5 of the top life science workplaces in Europe, based on rankings given by The Great Place to Work Institute to Europe’s leading multinational workplaces.
Europe is known for its innovative and cutting-edge advancements in the field of life sciences. From groundbreaking research to transformative technologies, this continent is at the forefront of shaping the future of healthcare and biotechnology. In this article, we outline 5 of the top life science workplaces in Europe, based on rankings given by The Great Place to Wo…

Hiring a fraudulent candidate can lead to severe consequences such as compromised research, regulatory violations, financial losses, damaged reputation, and even jeopardised patient safety. In this article, we outline 10 ways you can proactively look out for fraudulent candidates and prevent them from infiltrating your organisation, helping to preserve the integrity, quality, and success of your work and your workforce.
Fraudulent candidates are individuals who intentionally deceive employers by misrepresenting their qualifications, skills, or experience during the job application process. In the life science industry, these candidates pose a significant threat to employers. The industry relies heavily on trust, accuracy, and ethical conduct to ensure the safety and efficacy of health produ…

Fc-Fusion proteins exhibit intricate structural diversity and complex glycosylation modifications, necessitating sophisticated techniques for accurate analysis. This article outlines various methodologies for characterizing Fc-Fusion glycosylation, emphasizing the importance of site-specific information to elucidate their functional and safety implications.
Fc-Fusion proteins exhibit intricate structural diversity and complex glycosylation modifications, necessitating sophisticated techniques for accurate analysis. This article outlines various methodologies for characterizing Fc-Fusion glycosylation, emphasizing the importance of site-specific information to elucidate their functional and safety implications.   Glycoprotein Analysis Approaches Glycoprotein analysis is tailored based o…

Cytokines represent a class of small protein molecules that exhibit diverse biological activities. These molecules are synthesized and secreted primarily by immune cells (including monocytes, macrophages, T cells, B cells, and NK cells) as well as certain non-immune cells (such as endothelial cells, epidermal cells, and fibroblasts) upon specific stimulation. Cytokines play pivotal roles in regulating intrinsic and adaptive immunity, hematopoiesis, cell growth, pluripotent cells, and tissue repair.
Cytokines represent a class of small protein molecules that exhibit diverse biological activities. These molecules are synthesized and secreted primarily by immune cells (including monocytes, macrophages, T cells, B cells, and NK cells) as well as certain non-immune cells (such as endothelial cel…

Proximity labeling techniques represent a cutting-edge approach wherein a decoy protein of interest is fused with an enzyme capable of indiscriminately labeling neighboring proteins. These labeled proteins are referred to as "prey" proteins.
Proximity labeling techniques represent a cutting-edge approach wherein a decoy protein of interest is fused with an enzyme capable of indiscriminately labeling neighboring proteins. These labeled proteins are referred to as "prey" proteins.   The field of protein labeling has witnessed significant advancements, prominently featuring proximity-tagging enzymes. Among these, Biotin-dependent biotin identification (BioID) utilizing biotin ligase mutants, primarily the biotin ligase (BirA), has been instrumental. BirA labels lysine residues of proximat…

In the fast-paced and ever-changing pharmaceutical landscape, where complexities, risks, rewards, and returns run high, strategic excellence requires superior decision-making. In this article, we describe the role of competitive intelligence, dispel misconceptions, address challenges, and highlight its advantages in devising winning strategies for pharma companies.
In the ever-evolving landscape of pharmaceutical development, where complexities, costs, and risks run high, staying ahead of the competition requires more than just luck—it demands informed decision-making at every step. Among a multitude of decision-making methods, competitive Intelligence (CI) emerges as the key tool, enabling strategic foresight, innovative adaptation, and successful drug roll-out plans. In this article, we, …

In this article, we outline 6 ways to make the most out of easy apply job applications, with tips on how to make your applications stand out against your peers and make a strong first impression to recruiters and hiring managers across the life science industry.
An easy apply job application refers to a streamlined process that allows you to easily submit your applications for a job without encountering too many barriers or lengthy procedures. One example of an easy apply job application is LinkedIn’s Easy Apply feature. Introduced in 2011, this is designed to enable jobseekers to quickly send out applications without leaving the LinkedIn platform. Despite presenting the main benefit of streamlining the initial job application stage, easy apply job applications often receive a large volume…

As employers in the life science industry, it’s essential to offer attractive employee benefits that can help attract and retain top talent. Whilst providing competitive salaries is undoubtedly important, there are other things you must do in order to stand out against your competitors, especially if you don’t have the budget to compete with the compensation packages being offered by industry leaders.
As employers in the life science industry, it’s essential to offer attractive employee benefits that can help attract and retain top talent. Whilst providing competitive salaries is undoubtedly important, there are other things you must do in order to stand out against your competitors, especially if you don’t have the budget to compete with the compensation packages being offered by industry…

In this healthcare app development guide we will discuss all the key points you need to know before transforming your idea into reality. Let's dive into it.
People are increasingly using healthcare applications to assess their health via statistics, data, and analysis.There are situations where patients may not necessarily have to physically go to a hospital and meet doctors for assistance.   That's why it is crucial for the healthcare industry to embrace the development of mobile apps for healthcare.  But just developing a Healthcare application is not enough, it's crucial to pay attention to app features and presentation. Most healthcare apps fail to meet the modern customers requirements. That is why we need to know more before launching the application.    In this…

In recent years, nucleic acid therapy involving various types of ribonucleic acids (RNAs), including messenger RNA (mRNA), small interfering RNA (siRNA), and microRNA (miRNA), has rapidly emerged as a new cornerstone of modern medicine. Among them, the mRNA-based vaccines developed, particularly the COVID-19 vaccine, have played a significant role in combating the novel coronavirus (SARS-CoV-2) responsible for severe acute respiratory syndrome. The remarkable speed of sequence design and the ease of large-scale production associated with mRNA-based technologies have provided novel possibilities in addressing urgent and ever-evolving medical crises.
In the present context of successful mRNA drugs, the further synthesis of linear mRNA into circular RNA (circRNA) through end-to-end connec…

Antibody-drug conjugates (ADCs), as emerging anticancer drugs, can deliver highly cytotoxic molecules directly to cancer cells to kill them.
ADC is a monoclonal antibody covalently bound to cytotoxic chemical substances (payload) through linker. ADC linker plays a key role in the therapeutic effect of ADC, and its characteristics greatly affect the therapeutic index, pharmacodynamics and pharmacokinetics of ADC. For example, the linkage between linker-mAb determines the drug-antibody ratio (DAR), which determines the homogeneity and stability of ADC. In order to ensure the selectivity and efficacy of ADC, linker should strive to achieve three key features : (1) High cycle stability: Payload will not be released before it reaches the target, thereby minimizing the off-target effect…

Antibody-drug conjugates (ADCs) have revolutionized the field of targeted cancer therapy by combining the specificity of monoclonal antibodies with the potency of cytotoxic drugs. ADCs have shown remarkable clinical success, leading to several FDA-approved therapies. However, the development of the next generation of ADCs presents new strategies and challenges that must be addressed to improve efficacy, safety, and therapeutic index. This article explores the innovative approaches taken to optimize ADC design, enhance tumor targeting, and overcome resistance mechanisms, while also discussing the challenges faced in the development of these promising therapeutics.
Improved Linker and Payload Selection: The selection of suitable linkers and cytotoxic payloads greatly impacts ADC stability, ef…

In recent years, bioconjugation has emerged as a powerful strategy for improving drug delivery and enhancing therapeutic efficacy. By linking drugs to various biological entities, such as proteins, antibodies, nanoparticles, or targeting moieties, bioconjugation enables precise and targeted delivery of therapeutic agents to desired sites. This article aims to provide an overview of different bioconjugation strategies employed for various drug classes, highlighting their advantages, challenges, and potential applications.
Bioconjugation involves the covalent linkage of drugs or drug carriers to biological macromolecules, thereby enhancing their stability, solubility, and pharmacokinetics. This conjugation strategy allows for targeted delivery, sustained release, and controlled distribution o…

In today’s ever-evolving healthcare industry, clinical data management plays a crucial role in ensuring the accuracy and integrity of medical research and clinical trials. To excel in this field, you’ll need an impressive skill set that demonstrates to employers that you have what it takes to thrive in what can be a challenging career. In this article, we highlight 8 essential skills needed to secure a job in clinical data management.
In today’s ever-evolving healthcare industry, clinical data management plays a crucial role in ensuring the accuracy and integrity of medical research and clinical trials. To excel in this field, you’ll need an impressive skill set that demonstrates to employers that you have what it takes to thrive in what can be a challenging career. In this article, we high…

In the pharmaceutical industry, a vendor refers to an external entity or supplier that provides goods, materials, services, or specialized expertise to pharmaceutical companies. These vendors play a crucial role in supporting various aspects of the pharmaceutical business, ranging from research and development to manufacturing and distribution of medicinal products. They are an integral part of the pharmaceutical supply chain and contribute to the overall success of pharmaceutical operations.
In the pharmaceutical industry, a vendor refers to an external entity or supplier that provides goods, materials, services, or specialized expertise to pharmaceutical companies. These vendors play a crucial role in supporting various aspects of the pharmaceutical business, ranging from research and dev…

During the research and development process of pharmaceutical preparations, comprehensive and reliable interaction studies are essential.
Pharmaceutical formulations consist of active pharmaceutical ingredients (APIs) and excipients. Appropriate excipient selection is critical to the final quality of pharmaceutical products. When designing pharmaceutical preparations, the choice of excipients should not only consider the dosage form factors and excipient functions but also the interaction and compatibility between APIs and excipients. Therefore, during the research and development process of pharmaceutical preparations, comprehensive and reliable interaction studies are essential. These studies not only serve as a foundat…

Post-translational modifications (PTMs) are essential chemical alterations that occur on proteins after their synthesis. These modifications play a crucial role in regulating protein function, cellular signaling, and overall biological processes. To unravel the mysteries of PTMs and understand their functional implications, scientists have developed PTM prediction tools that utilize computational approaches. In this article, we will explore the significance of PTMs, the power of PTM predictions, and their applications in protein research.
Post-translational modifications (PTMs) are essential chemical alterations that occur on proteins after their synthesis. These modifications play a crucial role in regulating protein function, cellular signaling, and overall biological processes. To unrave…

Arterial stiffness is a novel cause of premature heart damage among adolescents, according to a new follow-up study. The study was conducted in collaboration between Texas Children's Hospital and Baylor College of Medicine in the US, the University of Bristol in the UK, the University of Exeter in the UK, and the University of Eastern Finland, and the results were published in Atherosclerosis.
Arterial stiffness is a novel cause of premature heart damage among adolescents, according to a new follow-up study. The study was conducted in collaboration between Texas Children's Hospital and Baylor College of Medicine in the US, the University of Bristol in the UK, the University of Exeter in the UK, and the University of Eastern Finland, and the results were published in Atherosclerosis. Left ve…