Biotech - Articles

Lipids represent a diverse and complex group of compounds that are chemically and structurally non-homogeneous. These molecules are primarily characterized by their solubility in organic solvents and their insolubility in water. In nature, lipids encompass a variety of substances, including fatty acids and their derivatives, such as esters and amines.
Lipids represent a diverse and complex group of compounds that are chemically and structurally non-homogeneous. These molecules are primarily characterized by their solubility in organic solvents and their insolubility in water. In nature, lipids encompass a variety of substances, including fatty acids and their derivatives, such as esters and amines. Additionally, they include compounds that are related to the biosynthesis and functional role…

Research has highlighted the significant role of free fatty acids in various metabolic disorders. Elevated levels of FFAs are closely linked to abnormal glucose and lipid metabolism, contributing to a range of cardiovascular diseases. Conditions such as obesity, hypertension, hyperinsulinemia, and type 2 diabetes have all been associated with dysregulated fatty acid levels. Thus, monitoring and understanding free fatty acids is essential for assessing metabolic health.
Fatty acids are a vital class of carboxylic acid compounds characterized by hydrocarbon chains attached to carboxyl groups. These compounds are predominantly found in esterified forms within various lipids, including neutral lipids, phospholipids, and glycolipids. Collectively, these are often referred to as fatty acid esters…

Currently, there are more than 160 PROTAC projects under development worldwide, of which nearly 20 projects are in clinical development. These projects involve a variety of disease targets, including cancer, inflammation, and neurodegenerative diseases.
What Is PROTAC Technology? Proteolytic targeting chimera (PROTAC) is a new type of drug design technology that works by inducing the degradation of target proteins. Unlike conventional small molecules that typically inhibit protein function, PROTACs facilitate the ubiquitination and subsequent degradation of specific proteins. This bifunctional molecule consists of two distinct elements: a ligand that engages a target protein of interest and a second ligand that recruits the E3 ubiquitin ligase, a component of the ubiquitin-proteasome system…

tiakis Biotech AG today announced the results of its randomized, double-blind, placebo-controlled clinical Phase Ib/II COMCOVID trial evaluating Tiprelestat for the treatment of patients hospitalized due to COVID-19. Tiprelestat was safe and well tolerated, with initial signs of clinical efficacy.
Kiel, Germany, December 9, 2024 – tiakis Biotech AG, a clinical-stage biopharmaceutical company developing novel therapeutics for life-threatening pulmonary and cardiovascular diseases, today announced the results of its randomized, double-blind, placebo-controlled clinical Phase Ib/II COMCOVID trial evaluating Tiprelestat for the treatment of patients hospitalized due to COVID-19. In 2021, tiakis Biotech received support from the German Federal Ministry of Education and Research (“BMBF”) to initi…

Next-generation sequencing (NGS) has revolutionized the field of genomics by enabling researchers to generate vast amounts of sequence data in a single experiment. This technology is particularly valuable in applications such as metagenomics, where it allows for the analysis of complex microbial communities, such as those found in the human gut.
Next-generation sequencing (NGS) has revolutionized the field of genomics by enabling researchers to generate vast amounts of sequence data in a single experiment. This technology is particularly valuable in applications such as metagenomics, where it allows for the analysis of complex microbial communities, such as those found in the human gut. However, despite its advantages, NGS is not without its challenges. The quality of the raw sequencing da…

This explosion of information presents both remarkable opportunities and significant challenges for researchers. In this era of big data, bioinformatics has emerged as a crucial field, making substantial strides in the analysis and interpretation of complex biological datasets. As a result, there is a pressing need for the development of sophisticated computational techniques and tools that facilitate effective data analysis and visualization, ultimately enhancing our understanding of intricate biological processes.
The advent of next-generation sequencing (NGS) technologies and advanced sequencers has led to an unprecedented surge in biological data generated by the scientific community. This explosion of information presents both remarkable opportunities and significant challenges for res…

Illumina sequencing, a hallmark of second-generation sequencing technology, has revolutionized genomics research. This method employs a sophisticated reversible dye terminator technology to accurately determine the sequence of DNA molecules. The process begins with the fragmentation of DNA samples into short segments, typically ranging from 100 to 150 base pairs (bp).
In the rapidly evolving field of genomics, sequencing technologies play a crucial role in advancing our understanding of genetic material. Among the most prominent methods are Illumina sequencing and nanopore sequencing, each offering unique advantages and capabilities that cater to different research needs.   What is Illumina Sequencing? Illumina sequencing, a hallmark of second-generation sequencing technology, has revo…

The significance of degradome sequencing lies in its ability to provide a more accurate and reliable identification of miRNA target genes compared to traditional bioinformatics predictions. By directly analyzing mRNA degradation fragments, researchers can validate miRNA interactions with target genes more effectively, thus simplifying subsequent experimental validation.
Degradome sequencing, also known as parallel analysis of RNA ends (PARE) sequencing, is a cutting-edge technique that leverages high-throughput sequencing and bioinformatics to investigate the degradation products of mRNA. This method is particularly valuable for identifying the target genes regulated by microRNAs (miRNAs), which are small, endogenous non-coding RNAs approximately 22 nucleotides in length. miRNAs play crucia…

Traditional RNA sequencing methods typically analyze bulk samples containing thousands to millions of cells, which can obscure the unique characteristics of individual cells. Since the pioneering scRNA-seq study in 2009, there has been a surge of interest and research in this field, primarily driven by specialized laboratories equipped with advanced wet-lab techniques, bioinformatics expertise, and computational resources.
Introduction to Single-Cell RNA Sequencing Single-cell RNA sequencing (scRNA-seq) represents a groundbreaking advancement in genomic techniques, allowing researchers to detect and quantify messenger RNA (mRNA) molecules at the single-cell level. This capability is crucial for understanding cellular responses and the intricate dynamics of biological systems. Traditional RN…

Selecting the right stability partner is crucial for accelerating your product’s journey to market while ensuring its safety and compliance. A partner with expertise in evolving regulatory requirements, a tailored approach to study design, and robust analytical methodologies can make all the difference in achieving product success. Here, contract research organisation Broughton highlights the top three tips in choosing a stability partner and explains how its extensive expertise positions it as a leader in stability testing.
Selecting the right stability partner is crucial for accelerating your product’s journey to market while ensuring its safety and compliance. A partner with expertise in evolving regulatory requirements, a tailored approach to study design, and robust analytical methodol…

MXene have many important application prospects in biomedical imaging, electromagnetic interference shielding, and wearable devices.
MXene is a two-dimensional transition metal carbide or nitride that is widely used in many fields due to its unique physical and chemical properties. Here are some of the main applications of MXene: Energy storage and conversion: MXene shows great potential in the field of energy storage and conversion. MXene has high conductivity, high specific surface area and excellent mechanical strength, which makes it perform well in a variety of energy storage devices such as supercapacitors, lithium-ion batteries, sodium-ion batteries, etc. The application of MXene in supercapacitors is mainly due to its high specific surface area and fast ion transport ability. Studie…

Mannitol is widely used in the biomedical and pharmaceutical industries due to its unique properties and potential applications.
What Is Mannitol? Mannitol, chemical formula C6H14O6, is a white, crystalline powder with a sweet taste. It is classified as a sugar alcohol, which means it has characteristics of both sugars and alcohols. Mannitol is widely used in the biomedical and pharmaceutical industries due to its unique properties and potential applications. Production and Sources of Mannitol Mannitol can be extracted from various natural sources, such as seaweed, or produced synthetically. Mannitol is widely produced in nature by various organisms including algae, fungi, bacteria, and plants. Researchers are exploring sustainable and cost-effective methods for large-scale mannitol…

Oral liquid formulations hold a special place, offering alternatives particularly appealing for specific populations and addressing unique formulation challenges.
In the ever-evolving world of pharmaceutical development, the quest to innovate and improve the delivery of drug substances remains a top priority. Among the many formulation strategies, oral liquid formulations hold a special place, offering alternatives particularly appealing for specific populations and addressing unique formulation challenges. The Necessity of Oral Liquid Formulations Developing an oral liquid formulation is often necessary when traditional solid dosage forms, like tablets or capsules, become impractical or less effective. This requirement frequently arises in populations such as pediatrics or geriatrics,…

There are significant differences between titanium dioxide nanomaterials and non-nano titanium dioxide in many aspects, mainly reflected in physical properties, chemical properties and application fields.
From the perspective of physical properties, nanoscale titanium dioxide has a larger specific surface area and higher surface activity due to its small particle size (usually between 1 and 150 nanometers). This characteristic allows nanotitanium dioxide to exhibit unique properties in terms of optical, electrical and thermal properties. Titanium dioxide nanomaterials have unique physical properties, which are mainly related to their nanoscale characteristics. First, titanium dioxide nanomaterials usually have a hexagonal crystal structure, of which hexagon is the most common morp…

Chitin and chitosan, naturally occurring polysaccharides, have emerged as a prominent class of biopolymers with immense potential across various scientific and industrial fields.
Chitin and chitosan, naturally occurring polysaccharides, have emerged as a prominent class of biopolymers with immense potential across various scientific and industrial fields. Their unique properties, biodegradability, and inherent biocompatibility make them attractive alternatives to synthetic materials. It is worth mentioning that chitin and chitosan materials in fiber form have attracted a lot of attention due to their versatility and potential applications in different fields. As high-quality chemical companies like Alfa Chemistry continue their research and development in the field of chitin and chitosan fi…

The biotech industry is a whirlwind of innovation, constantly pushing the boundaries of science to develop groundbreaking treatments and technologies. But navigating this complex landscape requires specialized knowledge and strategic guidance. That's where biotech consulting companies come in. They can fill knowledge gaps inside organizations and provide an infusion of expertise at critical junctions that allow drug development programs to move forward on the optimal path.
The biotech industry is a whirlwind of innovation, constantly pushing the boundaries of science to develop groundbreaking treatments and technologies. But navigating this complex landscape requires specialized knowledge and strategic guidance. That's where biotech consulting companies come in. They can fill knowledge gaps…

Polygonum cuspidatum, commonly known as Japanese Knotweed. Its extract is a rich source of resveratrol, a polyphenolic compound celebrated for its numerous health benefits
In the vast world of herbal supplements, one name that stands out is Polygonum cuspidatum, commonly known as Japanese Knotweed. Its extract is a rich source of resveratrol, a polyphenolic compound celebrated for its numerous health benefits. From anti-aging to cardiovascular protection, resveratrol has gained considerable attention in both scientific circles and the wellness community. This blog will serve as a comprehensive guide to understanding Polygonum cuspidatum extract, resveratrol, and why you should consider incorporating it into your wellness routine. What is Polygonum Cuspidatum? Polygonum cuspidatum is a large…

Microorganisms have different growth requirements. When culturing them in the laboratory, it is essential to take note of these conditions because these are needed to be replicated in order to successfully grow microbial cultures in the laboratory. As mentioned in the previous article, one of the conditions needed to be taken into consideration is the oxygen requirement of the microorganisms. Some common microorganisms such as Escherichia coli and Bacillus sp. are usually cultured in the laboratory and used as reference organisms in microbiological studies. These organisms are relatively easier to culture because they are aerobic organisms and do not require complex culture conditions for growth.
  Microorganisms have different growth requirements. When culturing them in the laboratory…

When a ribosome is affixed to the polypeptide (protein) it is making, the ribosome-nascent chain complex (RNC) is the compilation of molecules that make up the ribosome. One of several methods can be used to halt the synthesis of the nascent polypeptide. RNCs are made and purified in labs to study the dynamics, biochemistry, folding, and interactions that the ribosome and proteins undergoing synthesis.
  When a ribosome is affixed to the polypeptide (protein) it is making, the ribosome-nascent chain complex (RNC) is the compilation of molecules that make up the ribosome. One of several methods can be used to halt the synthesis of the nascent polypeptide. RNCs are made and purified in labs to study the dynamics, biochemistry, folding, and interactions that the ribosome and proteins unde…

Analysis of variance (ANOVA) is a powerful statistical method that allows researchers to compare the means of two or more groups and determine if they are significantly different. It is a popular tool for testing hypotheses in a variety of fields in biology, including ecology, genetics, physiology, and biochemistry. In this article, we will explore how to choose the right type of ANOVA for your research question and design an experiment using ANOVA in several steps.
  Analysis of variance (ANOVA) is a powerful statistical method that allows researchers to compare the means of two or more groups and determine if they are significantly different. It is a popular tool for testing hypotheses in a variety of fields in biology, including ecology, genetics, physiology, and biochemistry.…