Articles

Digital twins are a virtual replica of a physical object, system, or process. In the pharmaceutical industry, digital twins are especially useful in drug discovery and production, but they still have much unrealized potential.
Could digital twins permanently change the pharmaceutical sector? While this cutting-edge technology already has applications in the clinical and drug production fields, it needs to be utilized more. Here’s how industry professionals can use this revolutionary technology. What Is a Digital Twin? A digital twin is a virtual replica of a physical object, individual, system or process. It replicates the asset’s form, features and functionality to produce a digitalized, three-dimensional copy that is basically indistinguishable from its real-world counterpart. The main co…

According to a new report published today, urgent action is required to develop skills and retrain staff in the UK’s pharmaceutical sector to take advantage of a predicted boom in RNA medicines and treatments.
It highlights that the workforce could need at least 150 future capabilities to meet RNA vaccine and treatment demand.    This includes developing novel equipment and reagents to increase efficiencies within RNA therapeutics manufacturing. The report also highlights the need to enhance technical and digital capabilities so companies can scale up manufacturing.     The report urges the industry to plan for the future roles, novel equipment and capabilities needed to develop and provide innovative treatments and medicines.    Meanwhile, the industry s…

The healthcare landscape is in the process of being dramatically transformed by the advent of digital health technology, driving innovation and revolutionizing healthcare delivery. Artificial Intelligence (AI) and Machine Learning (ML) are particularly poised to impact several healthcare domains, from diagnostics and treatment to patient monitoring and management.
The healthcare landscape is in the process of being dramatically transformed by the advent of digital health technology, driving innovation and revolutionizing healthcare delivery. Artificial Intelligence (AI) and Machine Learning (ML) are particularly poised to impact several healthcare domains, from diagnostics and treatment to patient monitoring and management. These technologies hold significant promise, especially in underfun…

Bioinformatics is an interdisciplinary field that integrates computer science, mathematics, statistics, and biology to manage and analyse biological data. This field is crucial to the life sciences industry for its role in understanding complex biological processes, leading to significant advances in drug discovery, genetic research, and personalised medicine.
Bioinformatics is an interdisciplinary field that integrates computer science, mathematics, statistics, and biology to manage and analyse biological data. This field is crucial to the life sciences industry for its role in understanding complex biological processes, leading to significant advances in drug discovery, genetic research, and personalised medicine. The role of bioinformaticians is expansive and vital. They develop algorith…

If new digital capabilities and top-notch data are critical to process efficiency and competitive advantage, it makes no sense to leave validation (proof that they fulfil what’s required) until the latter stages of the project lifecycle, say Ulrich Lein and Stefani Godoy Herrera of MAIN5.
Any systems relevant to GxP (‘good practices’) must be validated as fulfilling their intended purpose. Yet, too often, computer system validation (CSV) or assurance (CSA) is treated as a distracting compliance exercise, when it could be used to ensure strategic benefits – such as seamless data sharing, and repurposing of data across functional boundaries. The alternative is projects not delivering and having to be reworked, at great expense and delay. Ultimately, it could mean patients failing to gain prom…

Pharmacovigilance, specifically adverse event case intake, is a prime candidate for disruption by AI. Here, ArisGlobal’s Emmanuel Belabe explores how far Generative AI and Large Language Models have come in enabling human-like decision-making and processing, and the broader opportunity beyond.
Pharmacovigilance processes are designed to uphold the safety of marketed human medinical products over time, once authorised for patient consumption, but as the ocean of available data continues to rise in volume, the task of discerning and acting on important signals is becoming ever harder. It’s odd then that approaches to post-market Safety monitoring have changed little in decades First there’s the increasing array of formats through which cases come to light, not to mention the proliferating ran…

Recent top global hires for large-cap, mid-cap, and public companies, covering a broad range of disciplines and sectors across Life Sciences, Health, and Tech.
CEO/ C-suite/ Board Function Focus area Location CEO Medical equipment (publicly listed) US/ UK Chief Development Officer Biotech (publicly listed) Europe Chief R&D Officer Mental healthcare (publicly listed) US Chief Technology Officer AI-enabled drug discovery (publicly listed) Europe Chief, Operations & Supply Chain Speciality pharma (mid-cap) Europe Board Director Biopharma (publicly listed) US Board Director Novel enzymes (publicly listed) Nordics Group General Counsel Animal health (large-cap) Europe       Commercial / Fun…

Inpatient services refer to medical treatments and care that require a patient to be admitted to a hospital or healthcare facility for at least one night. These services encompass a wide range of medical care, including surgeries, childbirth, severe illnesses, and chronic disease management. Inpatient services are a critical component of the healthcare system, ensuring patients receive comprehensive care and monitoring when outpatient services are insufficient. The rising incidence of chronic diseases such as diabetes, cardiovascular diseases, and cancer has significantly contributed to the growth of the inpatient services market. As these conditions often require complex and prolonged treatments, the demand for inpatient services has surged, leading to the expansion of healthcare facilities and the adoption of advanced medical technologies.

The development of antibody cocktails is a complex and meticulous process that requires a deep understanding of target biology, antibody engineering, and combinatorial approaches.
What is Antibody Cocktail Therapy? Antibody cocktail therapy is a treatment that mixes two or more monoclonal antibodies together. By combining the properties of different antibodies, this therapy can target multiple targets simultaneously, thereby enhancing the effectiveness of treatment and reducing the development of drug resistance. Antibody cocktail therapy has broad application prospects in fields such as tumors and autoimmune diseases. How to Develop Antibody Cocktail Therapy? The development of antibody cocktails is a complex and meticulous process that requires a deep understanding of target biology, anti…

We are delighted to announce that the second edition of our popular introductory guide: ‘Market access stakeholders and processes for medical devices in key European markets’ is now available. Our market access experts have updated the guide with European market insights for 2024/25, along with a new section covering the US market.
An introductory guide to market access stakeholders and processes for medical devices in key European markets and the USA In this introductory guide, our Global market access experts provide an overview of the commercial launch landscape for medical devices in the USA and key European healthcare systems. We highlight the differences between selected markets and provide a go-to guide for those looking to bring medical device innovations to the…

Calum Jones (Associate Director – Health Economics) shares his experience of speaking at the 2024 HTAi Annual Meeting. Calum participated in the panel discussion: ‘Surrogate Endpoints in Health Technology Assessment (HTA): From Trials to Economic Evaluations
  Calum Jones (Associate Director – Health Economics) shares his experience of speaking at the 2024 HTAi Annual Meeting. Calum participated in the panel discussion: ‘Surrogate Endpoints in Health Technology Assessment (HTA): From Trials to Economic Evaluations’. On 18th June, I had the distinct pleasure of participating in an expert panel at the HTAi annual meeting held in the picturesque city of Seville, Spain. The session, titled ‘Surrogate Endpoints in Health Technology Assessment (HTA): From Trials to Economi…

Native Bacillus licheniformis protease stands out as a significant player in the realm of enzymatic solutions, offering a wide array of benefits and applications due to its unique properties.
Enzymes play a pivotal role in various industrial processes, catalyzing biochemical reactions with precision and efficiency. Among the diverse classes of enzymes, proteases are essential components with the ability to break down proteins into amino acids, enabling various biological functions and industrial applications. Native Bacillus licheniformis protease stands out as a significant player in the realm of enzymatic solutions, offering a wide array of benefits and applications due to its unique properties.   Understanding Bacillus licheniformis Protease Bacillus licheniformis, a common Gram-pos…

Enzymes are the fundamental building blocks of life, playing crucial roles in countless biological processes. One such remarkable enzyme is Native Porcine Prolidase, which has garnered significant attention in the scientific community due to its unique properties and diverse applications. In this article, we will delve into the intricacies of this remarkable enzyme, exploring its structure, function, physiological importance, and the ways in which it is leveraged in various industries.
Enzymes are the fundamental building blocks of life, playing crucial roles in countless biological processes. One such remarkable enzyme is Native Porcine Prolidase, which has garnered significant attention in the scientific community due to its unique properties and diverse applications. In this article, we…

Bile, a complex fluid produced by the liver and stored in the gallbladder, plays a crucial role in the digestion and absorption of fats, fat-soluble vitamins, and other essential nutrients. Ox bile extract powder, derived from the bile of oxen, is a natural supplement that has garnered significant interest in the scientific and healthcare communities for its versatile physiological functions and potential therapeutic applications.
Bile, a complex fluid produced by the liver and stored in the gallbladder, plays a crucial role in the digestion and absorption of fats, fat-soluble vitamins, and other essential nutrients. Ox bile extract powder, derived from the bile of oxen, is a natural supplement that has garnered significant interest in the scientific and healthcare communities for its versa…

Leading Swiss peptide and oligonucleotide manufacturer Bachem explains the considerations behind choosing between peptide synthesis methodologies
The demand for the manufacturing of polypeptides has radically increased since the recent introduction of new diabetes, obesity and cardiovascular disease peptide drugs. Consequently, peptide API manufacturing has seen a radical industrial intensification in line with increased commercialization to drive efficiency, improve quality and lower cost.   To achieve this at a commercial scale, peptide APIs can be produced through two principle processes: synthetic or recombinant.   Both methodologies offer unique advantages, with their own respective drawbacks. Thus, it’s vital to ensure that stakeholders are fully aware of the limits and st…

Lab-made mini-organs are revolutionizing the future of life science research with their remarkable potential. These tiny, three-dimensional structures, grown from stem cells, closely resemble real human organs. The uses of mini-organs span across various subjects, including disease modeling and drug development, offering unprecedented insights and innovative solutions to some of healthcare’s most challenging problems.
Lab-made mini-organs are revolutionizing the future of life science research with their remarkable potential. These tiny, three-dimensional structures, grown from stem cells, closely resemble real human organs. The uses of mini-organs span across various subjects, including disease modeling and drug development, offering unprecedented insights and innovative solutions to some…

Scientists have predicted that the first person who will live to 150 has already been born.1 While this number may sound far-fetched, researchers have developed several interventions to extend the human lifespan. Innovations such as artificial intelligence, stem cell therapy, precision medicine, and telemedicine are changing how healthcare providers diagnose and treat illnesses, ultimately increasing the average life expectancy. But how exactly is technology helping us live longer?
Scientists have predicted that the first person who will live to 150 has already been born.1 While this number may sound far-fetched, researchers have developed several interventions to extend the human lifespan. Innovations such as artificial intelligence, stem cell therapy, precision medicine, and telemedicine…

There is constant innovation across industries as time passes. While other sectors are vital, life science has seen critical advancements globally. How are researchers able to achieve these fantastic breakthroughs? Consider the intersection of life sciences and technology. Here’s what you need to know about the various life sciences and their recent innovations.
There is constant innovation across industries as time passes. While other sectors are vital, life science has seen critical advancements globally. How are researchers able to achieve these fantastic breakthroughs? Consider the intersection of life sciences and technology. Here’s what you need to know about the various life sciences and their recent innovations. Why Innovations Are Critical to Life Science Research You expect parts…

The design and synthesis of hydrophobic amino acids hold immense significance in various scientific domains, including drug development, biochemistry, and materials science.
Hydrophobic amino acids are vital components in the realm of protein structure and function. While hydrophilic amino acids establish interactions with water molecules in the cellular environment, hydrophobic amino acids tend to congregate in the interior of proteins, contributing to their three-dimensional fold and stability.    The synthesis of hydrophobic amino acids involves intricate chemical processes aimed at constructing these organic molecules with specific structural characteristics while ensuring high purity and yield. One common method for synthesizing hydrophobic amino acids is through solid-phase…

Antibody-drug conjugates (ADCs) have emerged as a promising class of targeted therapeutics in the field of oncology.
These molecules combine the specificity of monoclonal antibodies with the cytotoxic potency of small molecule drugs, thereby enabling precise delivery of potent anticancer agents to tumor cells while minimizing harm to healthy tissues. The efficacy of ADCs hinges on a delicate interplay between various components, with the payload playing a crucial role in determining the therapeutic potential of these complex molecules.   ADC payloads, also known as cytotoxic or chemotherapeutic agents, are the active drug molecules that are conjugated to the antibody component of an ADC. These payloads are designed to induce cell death within targeted cancer cells, thereby achieving th…