Articles
Mass spectrometry is one of the most important techniques for antibody drug analysis. It is divided based on its applications in analyzing primary structures and advanced structures.
Mass spectrometry is one of the most important techniques for antibody drug analysis. It is divided based on its applications in analyzing primary structures and advanced structures. The significant improvement in the performance of the mass spectrometer is mainly based on the development of two ionization technologies: one is the medium-assisted laser desorption/ionization technology, and the other is the electrospray ionization technology. The emergence of these two ionization technologies enables mass spectrometry, which can only detect small molecules, to detect biological macromolecules. In the past…
Mass spectrometry is one of the most important techniques for antibody drug analysis. It is divided based on its applications in analyzing primary structures and advanced structures. The significant improvement in the performance of the mass spectrometer is mainly based on the development of two ionization technologies: one is the medium-assisted laser desorption/ionization technology, and the other is the electrospray ionization technology. The emergence of these two ionization technologies enables mass spectrometry, which can only detect small molecules, to detect biological macromolecules. In the past…
ICH Q6B provides a set of internationally recognized principles for the characterization of biotechnology products to support the market application of monoclonal antibodies. Before monoclonal antibody drugs are marketed, they must go through a detailed monoclonal antibody characterization process to ensure quality and safety.
ICH Q6B provides a set of internationally recognized principles for the characterization of biotechnology products to support the market application of monoclonal antibodies. Before monoclonal antibody drugs are marketed, they must go through a detailed monoclonal antibody characterization process to ensure quality and safety. Determination of amino acid composition and extinction coefficient ICH Q6b recommends the use of a variety of hydrolysis and a…
ICH Q6B provides a set of internationally recognized principles for the characterization of biotechnology products to support the market application of monoclonal antibodies. Before monoclonal antibody drugs are marketed, they must go through a detailed monoclonal antibody characterization process to ensure quality and safety. Determination of amino acid composition and extinction coefficient ICH Q6b recommends the use of a variety of hydrolysis and a…
Depending on the position of the first unsaturated bond, PUFAs can be divided into ω-3, ω-6, ω-7, ω-9 series. ω-3 PUFAs mainly include α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA), etc.
Polyunsaturated fatty acids (PUFAs) are fatty acids that contain two or more unsaturated double bond structures. Depending on the position of the first unsaturated bond, PUFAs can be divided into ω-3, ω-6, ω-7, ω-9 series. ω-3 PUFAs mainly include α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA), etc. ω-6 PUFAs mainly include linoleic acid (LA), dihomo-γ-linolenic acid (DHGLA), γ-linolenic acid (GLA) and arachidonic acid (AA), etc. There are also ω-7 series and ω-9 series, su…
Polyunsaturated fatty acids (PUFAs) are fatty acids that contain two or more unsaturated double bond structures. Depending on the position of the first unsaturated bond, PUFAs can be divided into ω-3, ω-6, ω-7, ω-9 series. ω-3 PUFAs mainly include α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA), etc. ω-6 PUFAs mainly include linoleic acid (LA), dihomo-γ-linolenic acid (DHGLA), γ-linolenic acid (GLA) and arachidonic acid (AA), etc. There are also ω-7 series and ω-9 series, su…
Despite Alzheimer’s being discovered over 100 years ago, the complexity of the brain and limitations surrounding research/diagnostic methods have historically acted as barriers for Alzheimer's disease (AD) drug development. As a result, market authorisations for AD have been particularly low, with only four drugs treating the symptoms, rather than the causes, approved between 1996 and 2020.
Despite Alzheimer’s being discovered over 100 years ago, the complexity of the brain and limitations surrounding research/diagnostic methods have historically acted as barriers for Alzheimer's disease (AD) drug development. As a result, market authorisations for AD have been particularly low, with only four drugs treating the symptoms, rather than the causes, approved between 1996 and 2020. Recently, how…
Despite Alzheimer’s being discovered over 100 years ago, the complexity of the brain and limitations surrounding research/diagnostic methods have historically acted as barriers for Alzheimer's disease (AD) drug development. As a result, market authorisations for AD have been particularly low, with only four drugs treating the symptoms, rather than the causes, approved between 1996 and 2020. Recently, how…
With the continuous innovation in bio-technologies, diagnostic development is expected to accelerate rare disease therapy development worldwide.
Rare diseases are characterized by their low prevalence, affecting a small number of people across the world. These diseases often come with significant challenges, including accurate diagnosis, availability of effective treatments, and limited resources for research and development. However, recent advancements in diagnostics technology hold promise for speeding up the field of rare disease therapies. Rare disease diagnosis can often be a complex and time-consuming process. Many rare diseases have symptoms that overlap with more common conditions, causing misdiagnosis or delayed diagnosis. Additionally, traditional diagnostics methods may…
Rare diseases are characterized by their low prevalence, affecting a small number of people across the world. These diseases often come with significant challenges, including accurate diagnosis, availability of effective treatments, and limited resources for research and development. However, recent advancements in diagnostics technology hold promise for speeding up the field of rare disease therapies. Rare disease diagnosis can often be a complex and time-consuming process. Many rare diseases have symptoms that overlap with more common conditions, causing misdiagnosis or delayed diagnosis. Additionally, traditional diagnostics methods may…
05-Apr-2024
Life scientists investigate the structure, function, behaviour, interactions, and evolution of living organisms, from the smallest microorganisms to complex ecosystems. They aim to understand the principles and processes that govern life, including biological systems, organisms’ mechanisms, and the relationship between living organisms and their environment. Life science plays a crucial role in fields such as medicine, biotechnology, agriculture, environmental science, and conservation.
What is Life Science? Life science is a branch of science that focuses on the study of living organisms. It encompasses various disciplines such as genetics, zoology, botany, microbiology, ecology, biochemistry, and physiology. Life scientists investigate the structure, function, behaviour, interactions, and…
What is Life Science? Life science is a branch of science that focuses on the study of living organisms. It encompasses various disciplines such as genetics, zoology, botany, microbiology, ecology, biochemistry, and physiology. Life scientists investigate the structure, function, behaviour, interactions, and…
29-Feb-2024
The COVID-19 pandemic has killed millions of people. Vaccines certainly are the most outstanding ways to prevent major diseases and death, though they haven't eliminated infections. At present, the most effective vaccine is the mRNA vaccine developed by Pfizer-BioNTech and Moderna. Before that, mRNA technology stopped in the lab phase. How to apply mRNA technology to more complex diseases in the future? The ideal and safe delivery vector may be the answer.
Although lipid nanoparticles (LNPs) are the most advanced mRNA delivery carriers in clinical practice, further optimization is still ongoing. An ideal ionizable cationic lipid needs to meet three characteristics: The ionizable hydrophilic amine head can fully realize mRNA enrichment Hydrophobic hydrocarbon tail can promote self-assem…
Although lipid nanoparticles (LNPs) are the most advanced mRNA delivery carriers in clinical practice, further optimization is still ongoing. An ideal ionizable cationic lipid needs to meet three characteristics: The ionizable hydrophilic amine head can fully realize mRNA enrichment Hydrophobic hydrocarbon tail can promote self-assem…
29-Feb-2024
Paclitaxel is a natural anticancer drug with the molecular formula C47H51NO14. It has been widely used in the clinical treatment of breast cancer, ovarian cancer, and certain head and neck cancers, as well as lung cancer. Its novel and complex chemical structure, extensive and significant biological activity, unique mechanism of action, and scarce natural resources have gained immense favor among botanists, chemists, pharmacologists, and molecular biologists, making it a prominent anticancer star and research focus in the latter half of the 20th century.
Paclitaxel is a natural anticancer drug with the molecular formula C47H51NO14. It has been widely used in the clinical treatment of breast cancer, ovarian cancer, and certain head and neck cancers, as well as lung cancer. Its novel and comp…
Paclitaxel is a natural anticancer drug with the molecular formula C47H51NO14. It has been widely used in the clinical treatment of breast cancer, ovarian cancer, and certain head and neck cancers, as well as lung cancer. Its novel and comp…
The cosmetics and skincare industry is constantly evolving and a recent trend that has emerged is the use of fermented ingredients in skincare products. Fermentation is a microbial metabolic process that has been used for centuries in food and beverage production, and now it has been extended to the cosmetic industry.
What are Fermented Raw Materials? Fermented raw materials are natural ingredients that have undergone a fermentation process. The substrates of fermentation utilized in cosmetics industry include rice, soybeans, milk, and fruits. The substrates are used by microorganisms like yeast, bacteria, and fungi for metabolism or biosynthesis to create beneficial compounds that served as the fermented raw materials for cosmetic skincare product. Here are a few examples of fermentation-g…
What are Fermented Raw Materials? Fermented raw materials are natural ingredients that have undergone a fermentation process. The substrates of fermentation utilized in cosmetics industry include rice, soybeans, milk, and fruits. The substrates are used by microorganisms like yeast, bacteria, and fungi for metabolism or biosynthesis to create beneficial compounds that served as the fermented raw materials for cosmetic skincare product. Here are a few examples of fermentation-g…
Diabetes is a common clinical disease, and with the improvement of living standards, an increase in the number of obese people, and the intensification of aging populations, the incidence of diabetes is increasing year by year.
Diabetes has various types and requires long-term treatment. Antidiabetic drugs are essential for people with the disease. These drugs can be classified into insulin injections and oral antidiabetic medications. Commonly used oral antidiabetic drugs in clinical practice include biguanides (such as metformin), sulfonylurea insulin secretagogues (e.g., glimepiride, glipizide, gliclazide), non-sulfonylurea insulin secretagogues (e.g., repaglinide, nateglinide), α-glucosidase inhibitors (acarbose, voglibose, miglitol), DPP-4 inhibitors (sitagliptin, etc.), and GLP-1 rec…
Diabetes has various types and requires long-term treatment. Antidiabetic drugs are essential for people with the disease. These drugs can be classified into insulin injections and oral antidiabetic medications. Commonly used oral antidiabetic drugs in clinical practice include biguanides (such as metformin), sulfonylurea insulin secretagogues (e.g., glimepiride, glipizide, gliclazide), non-sulfonylurea insulin secretagogues (e.g., repaglinide, nateglinide), α-glucosidase inhibitors (acarbose, voglibose, miglitol), DPP-4 inhibitors (sitagliptin, etc.), and GLP-1 rec…
Nanobodies are the smallest functional single-domain antibodies known to be able to stably bind to antigens, and have unique structural and functional advantages.
What is a Nanobody? The molecular weight of nanobodies is only 12-15 kDa, which retains the antigen binding ability of traditional antibodies. However, nanobodies have higher solubility and stability, and have unique advantages in biological function and biochemical characteristics. Therefore, nanobodies have shown good control effects in disease diagnosis, cancer and infectious diseases. What are Nanobody-Drug Conjugates (NDCs) The development concept of nanobody-drug conjugates (NDCs) is similar to that of antibody drug conjugates (ADC), that is, the antibody in ADC is replaced by a nanobody with higher affinity. Because nanobod…
What is a Nanobody? The molecular weight of nanobodies is only 12-15 kDa, which retains the antigen binding ability of traditional antibodies. However, nanobodies have higher solubility and stability, and have unique advantages in biological function and biochemical characteristics. Therefore, nanobodies have shown good control effects in disease diagnosis, cancer and infectious diseases. What are Nanobody-Drug Conjugates (NDCs) The development concept of nanobody-drug conjugates (NDCs) is similar to that of antibody drug conjugates (ADC), that is, the antibody in ADC is replaced by a nanobody with higher affinity. Because nanobod…
For a long time, the research and development of each new drug has faced the challenges of high cost and long cycle. In response to these challenges, major pharmaceutical companies have shifted from targeting common diseases to developing drugs for specific diseases. At the same time, these companies are constantly looking for new technologies for new drug development, such as high-throughput screening technology, DNA encoded chemical library, computer-aided drug discovery, and artificial intelligence.
The use of computer simulation for drug development may reduce costs and increase the efficiency and success rate of the drug development process. Since the 1990s, computer methods such as homology modeling, molecular docking, quantitative structure-activity relationship and molecular dynamic…
The use of computer simulation for drug development may reduce costs and increase the efficiency and success rate of the drug development process. Since the 1990s, computer methods such as homology modeling, molecular docking, quantitative structure-activity relationship and molecular dynamic…
Cytokinin is a potent growth hormone and is commonly used in plant tissue culture, induction of cell division and shoot proliferation, plant regeneration, and in vitro production of plant secondary metabolites and bioactive molecules.
Introduction of Cytokinin Cytokinin is an organic compound that belongs to the cytokinin family. It is widely used in plant physiology and agriculture due to its beneficial effects on plant growth and yield. Cytokinin is a potent growth hormone and is commonly used in plant tissue culture, induction of cell division and shoot proliferation, plant regeneration, and in vitro production of plant secondary metabolites and bioactive molecules. Cytokinins are a class of natural plant growth regulators that play a crucial role in the regulation of cell divisio…
Introduction of Cytokinin Cytokinin is an organic compound that belongs to the cytokinin family. It is widely used in plant physiology and agriculture due to its beneficial effects on plant growth and yield. Cytokinin is a potent growth hormone and is commonly used in plant tissue culture, induction of cell division and shoot proliferation, plant regeneration, and in vitro production of plant secondary metabolites and bioactive molecules. Cytokinins are a class of natural plant growth regulators that play a crucial role in the regulation of cell divisio…
Organic Field Effect Transistor (OFET) materials have shown great promise for their use in organic bioelectronic devices. These materials offer several advantages that make them attractive for biomedical applications.
What are the Organic Field Effect Transistors (OFETs)? Organic Field Effect Transistors (OFETs) have gained significant attention in recent years due to their unique properties and potential applications in the field of organic electronics. As the demand for flexible and stretchable electronics continues to grow, the development of OFET materials that can withstand mechanical stress and strain becomes crucial. What are the Advancements in Flexible and Stretchable OFET Materials? 1. Elastomeric Substrates: One of the key requirements for achieving flexibility and stretchability…
What are the Organic Field Effect Transistors (OFETs)? Organic Field Effect Transistors (OFETs) have gained significant attention in recent years due to their unique properties and potential applications in the field of organic electronics. As the demand for flexible and stretchable electronics continues to grow, the development of OFET materials that can withstand mechanical stress and strain becomes crucial. What are the Advancements in Flexible and Stretchable OFET Materials? 1. Elastomeric Substrates: One of the key requirements for achieving flexibility and stretchability…
New technologies are supercharging drug development. AI innovations enable pharmaceutical companies to bring safer, more effective medications to market faster. This new age of medicine creates exciting new possibilities for patients and drug manufacturers, but it also brings new challenges.
New technologies are supercharging drug development. AI innovations enable pharmaceutical companies to bring safer, more effective medications to market faster. This new age of medicine creates exciting new possibilities for patients and drug manufacturers, but it also brings new challenges. The recent surge of highly effective weight loss drugs demonstrates the revenue opportunities and complexities facing drug manufacturers. Drugs such as Ozempic and Wegovy deliver unprecedented benefits, skyrocketin…
New technologies are supercharging drug development. AI innovations enable pharmaceutical companies to bring safer, more effective medications to market faster. This new age of medicine creates exciting new possibilities for patients and drug manufacturers, but it also brings new challenges. The recent surge of highly effective weight loss drugs demonstrates the revenue opportunities and complexities facing drug manufacturers. Drugs such as Ozempic and Wegovy deliver unprecedented benefits, skyrocketin…
Embarking on a systematic literature review is a critical step in evidence synthesis, providing a foundation for robust decision-making in the healthcare landscape. As with most things, there are ways to cut corners on systematic reviews. Sometimes there are true efficiencies to be made. Yet, all compromises have consequences.
In this article, we delve into 11 common problems that may arise when cost-cutting compromises the quality of your systematic literature review.
1. Choosing the wrong type of systematic review methodology Selecting the wrong type of methodology for your review can have profound implications. A robust, gold standard Cochrane methodology involves two reviewers at all stages of the review, to avoid bias in the identification and presentation of the evidence, and ensur…
1. Choosing the wrong type of systematic review methodology Selecting the wrong type of methodology for your review can have profound implications. A robust, gold standard Cochrane methodology involves two reviewers at all stages of the review, to avoid bias in the identification and presentation of the evidence, and ensur…
Revenue in Australia’s pharmaceuticals market is projected to reach US$10.16bn in 2024, with the largest market being Oncology Drugs with a projected market volume of US$2.01bn. This revenue is expected to grow at an annual rate of 6.76% from 2024 to 2028, resulting in a market volume of US$13.20bn by 2028.
Revenue in Australia’s pharmaceuticals market is projected to reach US$10.16bn in 2024, with the largest market being Oncology Drugs with a projected market volume of US$2.01bn. This revenue is expected to grow at an annual rate of 6.76% from 2024 to 2028, resulting in a market volume of US$13.20bn by 2028. In this article, we round up 10 of the top pharmaceutical companies driving this growth in Australia, with the leading companies listed on the Australian Securities Exchange in 2023,…
Revenue in Australia’s pharmaceuticals market is projected to reach US$10.16bn in 2024, with the largest market being Oncology Drugs with a projected market volume of US$2.01bn. This revenue is expected to grow at an annual rate of 6.76% from 2024 to 2028, resulting in a market volume of US$13.20bn by 2028. In this article, we round up 10 of the top pharmaceutical companies driving this growth in Australia, with the leading companies listed on the Australian Securities Exchange in 2023,…
Preparing for a job interview can be a daunting task, especially when it comes to the competitive field of pharmaceutical sales. As a jobseeker, you must demonstrate your expertise, sales acumen, and ability to navigate challenging scenarios in a clear and confident manner. One thing you can do to help you achieve this is to practise answering some of the most commonly asked interview questions in the field, allowing you to refine your answers and ensure they are focused and concise.
Preparing for a job interview can be a daunting task, especially when it comes to the competitive field of pharmaceutical sales. As a jobseeker, you must demonstrate your expertise, sales acumen, and ability to navigate challenging scenarios in a clear and confident manner. One thing you can do to help you achi…
Preparing for a job interview can be a daunting task, especially when it comes to the competitive field of pharmaceutical sales. As a jobseeker, you must demonstrate your expertise, sales acumen, and ability to navigate challenging scenarios in a clear and confident manner. One thing you can do to help you achi…
08-Feb-2024
Photoresist resins are often used in conjunction with photosensitive agents and play a crucial role in making photoresist photosensitive.
Photoresist resin, also known as film-forming resin, is an inert polymer matrix. It is the core component of photoresist and constitutes the basic photoresist skeleton. Photoresist resins are often used in conjunction with photosensitive agents and play a crucial role in making photoresist photosensitive. The structures vary from different photoresist resins, which mainly determine the basic properties of the photoresist after exposure, including hardness, flexibility, adhesion, the solubility for specific solvents, optical properties, aging resistance, etching, thermal stability, etc. Resins for G/I-line resists The o-diazonaphthoquinone (DNQ)-phe…
Photoresist resin, also known as film-forming resin, is an inert polymer matrix. It is the core component of photoresist and constitutes the basic photoresist skeleton. Photoresist resins are often used in conjunction with photosensitive agents and play a crucial role in making photoresist photosensitive. The structures vary from different photoresist resins, which mainly determine the basic properties of the photoresist after exposure, including hardness, flexibility, adhesion, the solubility for specific solvents, optical properties, aging resistance, etching, thermal stability, etc. Resins for G/I-line resists The o-diazonaphthoquinone (DNQ)-phe…
08-Feb-2024
As research in cancer theranostics advances, engineered nanoparticles offer tailored drug delivery and simultaneous diagnosis. DNA and peptide-based supramolecular nanoassemblies present programmable strategies for precise drug delivery. Furthermore, microfluidic technologies have paved the way for improved cancer diagnostics and personalized drug delivery via engineered extracellular vesicles. These innovations collectively demonstrate a multidisciplinary approach, fueling greater optimism for the development of next-generation cancer therapies.
3 Recent Breakthroughs in Cancer Research Cancer continues to be one of the leading causes of mortality worldwide, despite extensive research and medical advancements. However, recent breakthroughs in nanotechnology, molecular biology, and bioengin…
3 Recent Breakthroughs in Cancer Research Cancer continues to be one of the leading causes of mortality worldwide, despite extensive research and medical advancements. However, recent breakthroughs in nanotechnology, molecular biology, and bioengin…
