Articles

With 2024 officially underway, the global life science marketing space finds itself, as always, facing challenges and opportunities. The need for innovation and to attract and convert buyers in a hugely competitive space whilst staying on top of industry advancements remains crucial.
With 2024 officially underway, the global life science marketing space finds itself, as always, facing challenges and opportunities. The need for innovation and to attract and convert buyers in a hugely competitive space whilst staying on top of industry advancements remains crucial. New marketing trends are always emerging across every sector and the pharmaceutical and contract outsourcing space is no different. Companies operating in life sciences are still feeling the aftermath of the COVID come down which h…

The global biotechnology market was estimated at $1.37 trillion in 2022, with an expected compound annual growth rate of 13.96% between 2023 and 2030. As the industry continues to evolve at an unprecedented rate, talent acquisition professionals within the life science industry face unique challenges when it comes to attracting and retaining the top talent needed to propel this growth.
The global biotechnology market was estimated at $1.37 trillion in 2022, with an expected compound annual growth rate of 13.96% between 2023 and 2030. As the industry continues to evolve at an unprecedented rate, talent acquisition professionals within the life science industry face unique challenges when it comes to attracting and retaining the top talent needed to propel this growth. In 2023, the industry u…

Chemotherapy with anti-tumor agents is currently one of the most important systemic treatments for cancer. However, direct treatment with drugs lacks specificity and sensitivity and tends to attack normal cells indiscriminately, resulting in side effects.
Introduction Liposomes, as drug carriers, provide a superior solution for maintaining or enhancing the efficacy of chemotherapy while reducing the severity of reactions and side effects. Classification When the surface of the liposome is modified, the properties of the liposome can be changed to control the release of the internal drug, to achieve better targeting effect and drug efficacy. Current liposome release triggers include heat, light, pH, temperature, ultrasound, enzymes, magnetism and et al., which have been widely used in anti-t…

Isotopes are different atoms of the same element with the same number of protons and different numbers of neutrons called isotopes of each other, which can also be interpreted as different nuclides of the same element called isotopes of each other.
What are Isotopes? An isotope is one of two or more atoms of the same chemical element with the same atomic number, occupying the same position on the periodic table and having almost identical chemical behavior, but with different atomic weights or mass numbers, which results in differences in mass spectral behavior, radioactive transitions, and physical properties (e.g., diffusion ability in the gaseous state). Isotopes can be categorized into the following two types according to their stability and the physical properties of radioactivity: Sta…

Adjuvants can help antigens induce long-term effective specific immune responses in vivo, leading to higher vaccine efficacy and prolonged protection from immune responses. Adjuvants can also reduce the amount of antigen used, the cost of production and the number of immunizations.
What are Adjuvants? Adjuvants, also known as immunomodulators or immune enhancers, are an additive to vaccines. Adjuvants are non-specific immune enhancers that enhance or alter the type of immune response to an antigen.  Based on their chemical properties, adjuvants can be broadly classified into the following categories: Inorganic adjuvants such as aluminum adjuvants; emulsion-based adjuvants such as MF59 and AS03; water-soluble adjuvants such as saponins; adjuvants targeting pattern-recognition recep…

Ergothioneine is a natural product found widely in various organisms, especially in ergot, where it is present in higher amounts.
What is Ergothioneine? At physiological pH, ergothioneine is stable since it mainly exists in the form of thione. It possesses various physiological functions, including scavenging free radicals, detoxification, maintaining DNA biosynthesis, promoting normal cell growth, and supporting cellular immunity. L-(+)-Ergothioneine can play a protective role in human cells, serving as an essential active substance in the body. Additionally, research indicates that ergothioneine can inhibit the activity of mitochondrial complex II, providing protection to mitochondria; and that ergothioneine has a protective effect on mice with dextran sulfate sodium (DSS)-induced colitis…

The linker is not only the molecule part of the covalent link between the antibody and the small molecule payload, but also a key element with design properties in targeted drug therapy.
The addition of the linker should not induce aggregation and needs to ensure acceptable PK characteristics, while limiting the premature release of the payload in plasma and enabling the effective release of active molecules at the targeted site. These linkers can be divided into cleavable linker and non-cleavable linker. ADCs based on non-cleavable linkers must be internalized and the antibody needs to be degraded by lysosomal proteases to release active molecules. Many non-cleavable linkers have been explored during the ADC development process, the most representative one is N-succinimide-4-(N-maleimideme…

In recent decades, PROTACs have become an attractive technology in drug development. Candidate drugs like ARV110 and ARV-471 have entered Phase I/II clinical trials, indicating the potential of PROTACs in the treatment of cancer and other diseases. The high selectivity, resistance-overcoming capabilities, and ability to target previously undruggable proteins make PROTACs effective in various diseases, including neurological disorders, inflammatory diseases, and cancer.
Proteolysis Targeting Chimeras (PROTACs) are a novel approach for degrading target proteins. Recently, a new split-and-mix PROTAC (SM-PROTAC) system based on liposome self-assembly, known as LipoSM-PROTAC, was reported in the Journal of the American Chemical Society. The LipoSM-PROTAC system exhibits selective degradatio…

Biomagnetism brings together old ideas and new creative thinking. It makes us wonder if it could improve health care. More science is still needed to prove if it works. But the concept makes us challenge what we think we know. It pushes the limits of what we think is possible. As we learn more, biomagnetism may find a special role. It might help make healthcare more complete and fit each person. Future research may show magnets can do more than pull in metal objects. Someday, they might transform people’s health around the world. For now, biomagnetism stands at a crossing point. It connects the past and future while we study its power to heal.
We are in the midst of a golden era of healthcare innovation and advancement. Breakthrough technologies like genetics, nanomedicine, robotics, and…

Alcohol use disorder is a difficult condition for many people to battle, from those who are experiencing it to the healthcare providers treating it. While each journey has its own timeline, several factors can slow down an individual’s recovery.
Alcohol use disorder is a difficult condition for many people to battle, from those who are experiencing it to the healthcare providers treating it. While each journey has its own timeline, several factors can slow down an individual’s recovery. It’s no secret that artificial intelligence (AI) has had quite an impact on many industries in recent years. When it comes to the healthcare landscape, AI may also be able to help people combat alcohol use disorder. What Is Alcohol Use Disorder? Alcohol use disorder is a term for chronic and compulsive drink…

Varicose veins cause considerable suffering for more than cosmetic reasons. This disorder also poses health risks, sometimes severe ones. What is the most significant risk factor for varicose veins? What genetic risks do scientists associate with the disorder?
Varicose veins cause considerable suffering for more than cosmetic reasons. This disorder also poses health risks, sometimes severe ones. What is the most significant risk factor for varicose veins? What genetic risks do scientists associate with the disorder? Researchers now have more answers than ever. Recent investigations have identified several genetic risk loci that predispose a person to the disorder. Knowing your risk helps you take the appropriate steps to protect your health. What should you know if you have concerns? Here…

CD73, also known as ecto-5′-nucleotidase, is a groundbreaking immunoinhibitory protein that assumes a pivotal role in tumor growth and metastasis. Its primary function revolves around converting extracellular ATP into immunosuppressive adenosine, working in tandem with CD39 within normal tissues to curtail excessive immune reactions. However, this mechanism is often hijacked by tumors, utilizing CD73 to foster an adenosinergic process that shields them from immune assaults.
Exploring the Structure and Function of CD73 The CD73 gene finds its home in the 6q14.3 region of human chromosome 6, encoding a protein comprised of 549 amino acid residues. CD73 functions as a glycosylphospholipase, residing on the cell membrane surface and engaging with the extracellular matrix through its extracellul…

The world of pharmacy is evolving at an unprecedented pace. Once considered a strategic choice, pharmacy workflow optimization has become a necessity. It encompasses a systematic approach to enhancing the processes and operations within a pharmacy, aiming to achieve higher efficiency, improved patient care, and compliance with ever-evolving healthcare regulations.
The world of pharmacy is evolving at an unprecedented pace. Once considered a strategic choice, pharmacy workflow optimization has become a necessity. It encompasses a systematic approach to enhancing the processes and operations within a pharmacy, aiming to achieve higher efficiency, improved patient care, and compliance with ever-evolving healthcare regulations. Benefits of Pharmacy Workflow Optimization 1. Improved Patient Care…

Pharmaceutical excipients play a crucial role in the formulation and production of drugs, supporting their stability, efficacy, and palatability.
Pharmaceutical excipients play a crucial role in the formulation and production of drugs, supporting their stability, efficacy, and palatability. Among the numerous excipients used in pharmaceutical preparations, preservatives, stabilizers, suspending agents, thickener excipients, and flavoring agents are commonly observed. Understanding their functions and characteristics is essential for pharmaceutical scientists and formulators. In this article, we will delve into each of these excipients to gain a comprehensive understanding of their roles in drug formulation. Preservatives Preservatives are vital components in pharmaceutical formulations as t…

With patients demanding more control over their health, patient-centered care has recently become the main trend in healthcare service delivery. But to make informed decisions, patients need to have a better insight into their health, which means they need to have access to their health records. At the same time, medical professionals also want to have patients’ health histories at hand to tailor care to particular patients and their unique needs.
This makes electronic health records one of the key tools in patient-centric healthcare. According to PEW research, 61% of US patients want to be able to access their medical records via a mobile device or an online patient portal. The same study states that most respondents also agree that clinicians should be able to easily exchange patients’ in…

On Thursday the 23 November 2023, the PDA Ireland Chapter hosted an event on Microbiology – The Key to Compliance with Annex 1 and Risk Based Regulations. This sold-out event was led by industry leaders, experts, regulators, and pharmaceutical company representatives and was attended by professionals from across Ireland as well as overseas. The latest revision of the Annex 1 came into force in August 2023 and remains a hot topic within the industry.
On Thursday the 23 November 2023, the PDA Ireland Chapter hosted an event on Microbiology – The Key to Compliance with Annex 1 and Risk Based Regulations. This sold-out event was led by industry leaders, experts, regulators, and pharmaceutical company representatives and was attended by professionals from across Ireland as well as overseas. The…

Life Sciences manufacturing has experienced a demanding year, with continued pressure to innovate, reduce costs and overcome global supply chain disruption through improved visibility and contingency planning. These will continue to be priorities over the coming year, which will also bring new challenges, outlined by REPHINE’s Dr. Eduard Cayón.
2023 has been a demanding year for Life Sciences manufacturing, with continued pressure to innovate, bring costs down and overcome very real global supply chain disruption through improved visibility and contingency planning. The most significant and serious pharma R&D projects are concentrated in the biotech space now. Although small-molecule developments are still a focus of investment, this once dominant field is becoming steadily less strateg…

Here, we’ve compiled a list of life science recognition and awareness days taking place in 2024.
Here, we’ve compiled a list of life science recognition and awareness days taking place in 2024. Read the full article on PharmiWeb.Jobs.

As we celebrate 25 years of PharmiWeb, we wanted to summarise some of the key ways we can help you to locate and engage top life science talent. Whether you’ve been partnering with us for years or are discovering us for the first time, this list of 25 services, features and free resources will ensure you’re getting the most out of our platforms.
As we celebrate 25 years of PharmiWeb, we wanted to summarise some of the key ways we can help you to locate and engage top life science talent. Whether you’ve been partnering with us for years or are discovering us for the first time, this list of 25 services, features and free resources will ensure you’re getting the most out of our platforms. Read the full article on PharmiWeb.Jobs.

In this article, we look at 25 of the most transformative milestones in the life science industry over this period, from decoding the human genome to the celebration of the 75th birthday of the NHS.
Over the past 25 years, the life science industry has witnessed an array of groundbreaking achievements that have revolutionised human health, fuelled industry expansion, and propelled innovation in healthcare, clinical research, biotechnology, and medical devices. In this article, we look at 25 of the most transformative milestones in the life science industry over this period, from decoding the human genome to the celebration of the 75th birthday of the NHS. Read the full article on PharmiWeb.Jobs.