Articles

The molecular structure of therapeutic proteins is complex and diverse, and their properties vary widely. Therefore, specific analytical methods must be developed for various therapeutic protein molecules. The primary structure of a therapeutic protein usually refers to its amino acid sequence, which contains important structural, characteristic and genetic information. And it is the most fundamental form of describing the subcellular localization, structure and function of the protein, with potential impact on the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of its drug product. Therefore, various mass spectrometry-based analytical techniques are often required to characterize the primary structure of therapeutic proteins at multiple levels.
Why characterize protein primary stru…

Host cell proteins (HCPs) are process-related impurities produced by host cells and are typically present at low levels in recombinant biopharmaceutical products. Enzyme-linked immunosorbent assay (ELISA) has traditionally been used to monitor the total content of HCP in the production of therapeutic protein drugs. Now, with the continuous improvement and upgrading of technology, liquid chromatography-mass spectrometry (LC-MS) is also increasingly used for the qualitative or quantitative analysis of HCP in the purification process.
Host cell proteins (HCPs) are process-related impurities produced by host cells and are typically present at low levels in recombinant biopharmaceutical products. Enzyme-linked immunosorbent assay (ELISA) has traditionally been used to monitor the total content o…

Chemical cross-linking mass spectrometry (CXMS) is an important tool for resolving protein structures and studying protein interactions. The technique uses a chemical cross-linking agent to link two amino acids in close enough spatial proximity to each other in a covalent bond. The two amino acid sites where cross-linking occurs are identified by mass spectrometry. The distance between the two cross-linking sites should not exceed the arm length of the cross-linker due to the limitation of the cross-linker arm length. This distance information will provide important constraints for protein structure resolution and interaction studies.
Chemical cross-linking mass spectrometry (CXMS) is an important tool for resolving protein structures and studying protein interactions. The technique us…

The life sciences supply chains support life-saving business models. They supply medical institutions with quick turnaround deliveries while prioritizing consumers through each step of each company’s operations. Putting consumers first directly connects those supply chains with corporate social responsibility policies. Read about how these policies work and what they mean for the life sciences supply chains. They’re leading the health sector into the future with person-focused initiatives.
The life sciences supply chains support life-saving business models. They supply medical institutions with quick turnaround deliveries while prioritizing consumers through each step of each company’s operations. Putting consumers first directly connects those supply chains with corporate social responsibi…

Computational chemistry combines principles from physics, chemistry, and computer science to model and simulate the behavior of molecules and materials at the atomic level.
The discovery of new materials with desirable properties in the field of materials science used to heavily depend on laboratory experiments and trial-and-error methods. Yet, the introduction of computational chemistry has completely changed this process by giving researchers the ability to predict and optimize the behavior of materials even before they are created in the laboratory. This technique has had a significant impact on the field, leading to quicker and more effective material discovery and development. Understanding and Designing Materials at the Atomic Level Computational chemistry combines principles from phy…

The healthcare industry is on the brink of a transformational revolution, driven by cutting-edge technologies like Artificial Intelligence (AI), Big Data analytics, and Personalized Medicine.
The healthcare industry is on the brink of a transformational revolution, driven by cutting-edge technologies like Artificial Intelligence (AI), Big Data analytics, and Personalized Medicine. These advancements are reshaping the way healthcare is delivered, making it more efficient, precise, and patient-centric. In this article, we explore the future of healthcare and the profound impact of AI, Big Data, and Personalized Medicine. AI: Revolutionizing Diagnosis and Treatment Artificial Intelligence has emerged as a powerful tool in healthcare. Machine learning algorithms can analyze vast datasets, inclu…

AI-powered tools for CV screening are quickly becoming a go-to solution for talent acquisition professionals in the life science industry. In this article, we explore 10 AI-powered tools designed for CV screening. By leveraging these tools, you’ll be able to streamline your recruitment process, focus your time on the best candidates, and ultimately make better hiring decisions for your organisation.
AI-powered tools for CV screening are quickly becoming a go-to solution for talent acquisition professionals in the life science industry. In this article, we explore 10 AI-powered tools designed for CV screening. By leveraging these tools, you’ll be able to streamline your recruitment process, focus your time on the best candidates, and ultimately make better hiring decisions for your organisat…

Whole genome sequencing (WGS) provides great convenience for the research and diagnosis of genetic rare diseases.
The diagnosis and treatment of rare diseases have long been a daunting challenge due to their complex and often undefined nature. However, with recent advancements in technology, specifically in the realm of genomics, whole genome sequencing (WGS) has emerged as a powerful tool that has revolutionized the diagnosis and management of rare diseases. This groundbreaking technique offers hope to countless individuals and their families who have suffered from the uncertainties and lack of answers associated with these conditions.   What are rare diseases? Rare diseases are a diverse group of disorders that affect a small percentage of the population, often occurring as a result…

Gene isoforms are different variations or versions of a gene that can be produced by alternative splicing or alternative transcription initiation and termination. These isoforms are often present in the same organism or cell type but differ in their coding sequence or in the regulatory elements that control their expression.
What Is Gene Isoform? Gene isoforms are different variations or versions of a gene that can be produced by alternative splicing or alternative transcription initiation and termination. These isoforms are often present in the same organism or cell type but differ in their coding sequence or in the regulatory elements that control their expression.   Alternative splicing is a process in which different combinations of exons (coding regions) within a gene are spl…

SARS-CoV-2 is a newly discovered human coronavirus group (HCoV), which are single-stranded RNA viruses belonging to the family of Coronaviridae. A range of respiratory diseases have been induced by some of these pathogens in the past. SARS-CoV-1 infected more than 8,000 individuals around the world, for example. Human coronavirus linked to Middle East respiratory syndrome (MERS-CoV) also occurred in Saudi Arabia in 2012 and induced high mortality levels among infected individuals.
SARS-CoV-2 is a newly discovered human coronavirus group (HCoV), which are single-stranded RNA viruses belonging to the family of Coronaviridae. A range of respiratory diseases have been induced by some of these pathogens in the past. SARS-CoV-1 infected more than 8,000 individuals around the world, for examp…

Pan-genomes reflect structural variation (SV) and polymorphisms in the genome, allowing in-depth comparisons of variation at the species level or at higher taxonomic levels. Pan-genomes have potential applications in crop improvement, evolution and biodiversity research. To fully exploit the value of pan-genomes, a broader range of information such as phenotypic, environmental and expression data needs to be integrated to provide insight into the role of variable regions in the genome.
What is pan-genome? A pan-genome is the sum of all genomic information within a species. With the development of genomic technology, researchers have found that a single reference genome can no longer meet the needs of genomic data analysis, and more and more species, including the human genome, are choosing…

Presently, one-step quantitative RT-PCR (RT-qPCR) targeting SARS-CoV-2 is performed by the molecular diagnosis of COVID-19 using primers and probes established by China CDC, Charité, HKU, Japan NIID, Thailand NIH, and US CDC; WHO has posted these primer-probe sets.
Introduction to Quantitative Polymerase Chain Reaction A highly delicate technique for the amplification and identification of deoxyribonucleic acid is polymerase chain reaction (PCR). In molecular biology, its conceptual simplification has made it the most utilized method and can, in theory, identify as little as a single segment of DNA. Therefore, for a huge variety of bacterial, fungal, viral, and parasite pathogens, it is popularly utilized as a medical method. Even so, rather than DNA, the genome of coronaviruses…

RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding regions (introns). RNA splicing removes the introns from the pre-mRNA molecule and joins together the exons to form a mature mRNA molecule that can be translated into protein.
What Is RNA Splicing? RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding regions (introns). RNA splicing removes the introns from the pre-mRNA molecule and joins together the exons to form a mature mRNA molecule that can be transl…

Bioorthogonal reactions are a series of chemical reactions that occur in biological environments with high yields, selectivity, efficiency, and no side reactions.
Bioorthogonal reactions are a series of chemical reactions that occur in biological environments with high yields, selectivity, efficiency, and no side reactions. These reactions include copper-catalyzed alkyne-azide cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition, inverse electron demand Diels-Alder (IEDDA) reaction, and more. These bioorthogonal reactions find extensive applications in various fields, including radionuclide conjugate, metabolic engineering, drug target identification, medicinal chemistry, and more. With continuous advancements in radiochemistry, bioorthogonal reactions have played an increasing…

Nucleic acid drugs are mainly divided into two major categories: small nucleic acid drugs and mRNA.
Nucleic acid drugs are mainly divided into two major categories: small nucleic acid drugs and mRNA. Small nucleic acid drugs, also known as oligonucleotide drugs, include antisense nucleotides (ASO), small interfering RNA (siRNA), microRNA, nucleic acid aptamers, and others. mRNA products can be further categorized into mRNA vaccines and mRNA drugs. Characteristics of Nucleic Acid Drugs Nucleic acid drugs offer distinct advantages. Traditional small molecule and antibody drugs primarily function by binding to target proteins, but their development is often constrained by the druggability of these target proteins. In contrast, nucleic acid drugs modulate genes associated with protein exp…

In the ever-evolving landscape of global healthcare, mRNA vaccines have emerged as an excellent tool in the fight against infectious diseases. This article explores the intricate and indispensable role that raw enzymes play in the manufacturing of mRNA vaccines, delving deep into their significance and impact on vaccine production. As we venture into this fascinating world, we will gain a comprehensive understanding of how these enzymes are the unsung heroes behind the remarkable success of mRNA vaccines.
In the ever-evolving landscape of global healthcare, mRNA vaccines have emerged as an excellent tool in the fight against infectious diseases. This article explores the intricate and indispensable role that raw enzymes play in the manufacturing of mRNA vaccines, delving deep into their sig…

In today's ever-evolving food industry landscape, Native Aspergillus oryzae exo-Inulinase, a food-grade enzyme preparation, has emerged as a true game-changer. Its remarkable attributes and multifaceted applications have firmly established it as a key player in food processing. This article aims to delve deeper into the pivotal role that Native Aspergillus oryzae exo-Inulinase plays in the food industry, along with its specialized applications.
In today's ever-evolving food industry landscape, Native Aspergillus oryzae exo-Inulinase, a food-grade enzyme preparation, has emerged as a true game-changer. Its remarkable attributes and multifaceted applications have firmly established it as a key player in food processing. This article aims to delve deeper into the pivotal role that Native Asper…

Nano-vesicles, also known as liposomes, have emerged as promising drug delivery systems due to their unique structure and properties.
Nano-vesicles, also known as liposomes, have emerged as promising drug delivery systems due to their unique structure and properties. These tiny spherical lipid bilayers can encapsulate various therapeutic agents, including protein drugs. In this article, we will explore the process of preparing nano-vesicles for encapsulating protein drugs, as well as the advantages of utilizing this innovative technology. How to Prepare Nano-vesicles for Protein Drug Encapsulation? The first step in preparing nano-vesicles is the selection of suitable lipids. Phospholipids such as phosphatidylcholine and phosphatidylglycerol are commonly used for their biocompatibility…

Embracing AI is not only important for professionals to stay competitive, but also to contribute towards the advancement of the life science industry, and ultimately enhance the well-being of patients across the globe. In this article, we outline 9 ways AI is already transforming the life science industry, focusing on key areas of the industry including drug discovery, patient safety, patient care and more.
AI is transforming the life science industry with its potential to improve safety, streamline clinical trials, personalise patient care, and enhance medical imaging diagnostics. As this technology continues to evolve and reshape various aspects of the industry, it’s crucial for professionals already working in the field and those looking to enter it to stay up to date with the latest dev…

The strain on the NHS is a familiar and perpetual struggle, with everything from funding issues to staffing problems and growing waiting lists mounting. In fact, the waiting list for hospital treatments rose to a record of nearly 7.5 million in May this year and cancer treatment times are currently at an all-time high. At the beginning of this year, only 54.7% of patients waited under 62 days for treatment after an urgent GP referral, compared with the target of 85%.
The strain on the NHS is a familiar and perpetual struggle, with everything from funding issues to staffing problems and growing waiting lists mounting. In fact, the waiting list for hospital treatments rose to a record of nearly 7.5 million in May this year and cancer treatment times are currently at an all-time high. At the b…