Articles

Chimeric RNA, also known as fusion RNA, refers to RNA molecules that are formed as a result of the fusion of two or more different RNA transcripts. Chimeric RNA, a unique class of RNA molecules formed through various molecular mechanisms, such as trans-splicing, read-through transcription, and fusion genes. These hybrid transcripts play a significant role in diverse biological processes and have gained substantial attention in recent years.
What is Chimeric RNA? Chimeric RNA, also known as fusion RNA, refers to RNA molecules that are formed as a result of the fusion of two or more different RNA transcripts. Chimeric RNA, a unique class of RNA molecules formed through various molecular mechanisms, such as trans-splicing, read-through transcription, and fusion genes. These hybrid transcripts…

It is reported that the research team is conducting further toxicology experiments and verifying it in other models in preparation for entering human clinical trials.
Professor Saar Gill and Professor Carl June from the Perelman School of Medicine at the University of Pennsylvania published a research paper titled: Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy in Science Translational Medicine, a sub-journal of Science.   CD45 exists on the surface of almost all blood cells (including, of course, blood cancer cells), and this study developed an "epitope editing" strategy using adenine base editors (ABEs). After base editing, CD45 can work normally in the blood system without being recognized by CAR-T cells.   Using this "epitope edi…

In recent years, PROteolysis TArgeting Chimeras (PROTAC), which utilizes the cell's own degradation mechanisms to eliminate specific disease-related proteins, has emerged as one of the most promising methods.
In recent years, PROteolysis TArgeting Chimeras (PROTAC), which utilizes the cell's own degradation mechanisms to eliminate specific disease-related proteins, has emerged as one of the most promising methods. Apart from PROTAC, various targeted protein degradation (TPD) strategies are emerging, involving molecular glue, Autophagy-Targeting Chimera (AUTEC), Autophagosome Tethering Compound (ATTEC), and Autophagy Targeting Chimera (AUTOTAC). These compounds are generally bifunctional small molecules, consisting of two parts: one part contains an E3 recruitment ligand to activate the ubiq…

Typically, LNP is composed of 4 components: ionizable cationic lipids, phospholipids, cholesterol, and polyethylene glycol (PEG) lipids. Each component determines the stability, transfection efficiency, and safety of LNP. It plays a vital role. To design a drug carrier based on lipid nanoparticles, we first need to clarify the basic principles behind LNP design.
Compared with viral vectors, non-viral delivery vectors are easier to scale up and have the ability to solve the most critical safety issues. Thanks to the LNP-mRNA vaccine that came to the fore during the COVID-19 pandemic, lipid nanoparticles (LNP) are undoubtedly the most advanced and widely studied non-viral vectors at present. Typically, LNP is composed of 4 components: ionizable cationic lipids, phospholipids, choles…

In recent years, advances in biotechnology have led to the development of new methods for large-scale RNA production, including fermentation-based approaches.
Why RNA production by fermentation RNA is a vital biomolecule with numerous biological functions, and its importance has led to a growing demand for RNA-based therapeutics and diagnostic tools. However, producing RNA at a large scale has been a challenge, and traditional methods such as chemical synthesis are time-consuming and expensive. In recent years, advances in biotechnology have led to the development of new methods for large-scale RNA production, including fermentation-based approaches.   What is RNA production by fermentation Large-scale RNA Production Through Fermentation Fermentation is a process that involves the use…

In addition to single-target Trop-2 ADCs, some companies are also deploying dual-target ADCs. For example, Biocytogen’s Trop-2/PTK7 dual-antibody ADC BCG033, Trop-2/EGFR dual-antibody ADC DM001, and Trop-2/HER2 dual-antibody ADC YH012, etc. However, these are currently in preclinical research, and it will take time to verify how far they will go in the future.
Antibody drug conjugate (ADC) research involves more and more targets, such as HER-2, Trop-2, Claudin-18.2, B7-H3 and B7-H4, etc. Trop-2 is a transmembrane glycoprotein. Its high expression is associated with the occurrence of many tumors and poor prognosis. It is a very popular ADC research target, second only to HER2. Currently, only Gilead's Trop-2 ADC drug Trodelvy has been approved for marketing in the world. It is used to t…

The realm of modern medicine stands on the shoulders of groundbreaking scientific discoveries and milestones that have shaped our understanding of diseases, treatments, and patient care. Amongst these milestones, one particular event emerged as a turning point in the history of medical research – the first recorded clinical trial.
The realm of modern medicine stands on the shoulders of groundbreaking scientific discoveries and milestones that have shaped our understanding of diseases, treatments, and patient care. Amongst these milestones, one particular event emerged as a turning point in the history of medical research – the first recorded clinical trial. Taking place in the year 1747, this remarkable trial conducted by Scottish naval surgeon James Lind offers a captivating glimpse into t…

For life science recruiters, finding candidates with not only the right technical expertise but also strong soft skills is crucial for success. In this article, we’ve outlined 8 tools that harness the power of AI to identify top talent who possess the soft skills needed to excel in the life science industry.
For life science recruiters, finding candidates with not only the right technical expertise but also strong soft skills is crucial for success. In this article, we’ve outlined 8 tools that harness the power of AI to identify top talent who possess the soft skills needed to excel in the life science industry. Read the full article on PharmiWeb.Jobs.

Traumatic brain injuries (TBIs) often have devastating effects. However, in the future, pharmacological interventions could play a pivotal role in mitigating the long-term consequences of TBIs, offering positive outcomes to individuals affected by this life-altering condition. Ongoing research and promising developments suggest the future holds immense potential for pharmacological interventions in TBI treatment.
Traumatic brain injuries (TBIs) often have devastating effects. However, in the future, pharmacological interventions could play a pivotal role in mitigating the long-term consequences of TBIs, offering positive outcomes to individuals affected by this life-altering condition. Ongoing research and promising developments suggest the future holds immense potential for pharmacological…

Here, we’ve provided a list of some of the top training providers for clinical research to help you advance your career, whether you’re just starting out in the industry or are seeking to enhance your existing skills. These organisations are renowned for their commitment to offering high-quality education and training, helping to propel the industry forward and advocate for excellence in clinical research.
Here, we’ve provided a list of some of the top training providers for clinical research to help you advance your career, whether you’re just starting out in the industry or are seeking to enhance your existing skills. These organisations are renowned for their commitment to offering high-quality education and training, helping to propel the industry forward and advocate for excellence in…

- Understanding the definition and role of CD19 in the immune system. - Introduction to the structure, composition, and signal pathway of CD19. - Knowledge about CD19 related diseases and research purpose products
What is CD19 Understanding CD19: Definition and Role in the Immune System CD19, also known as Cluster of Differentiation 19, is a cell surface protein belonging to the immunoglobulin superfamily. It serves as a crucial marker for B cells, playing a pivotal role in the human immune system. While predominantly found on the surface of B cells, CD19 is rarely expressed on other immune cells. Its significance lies in its involvement in B cell development and activation, making it a valuable target for research and clinical applications. The Structural Composition of CD19 The human CD…

Joining a professional association dedicated to excellence in clinical research is an excellent way for you to enhance your career and stay at the forefront of the industry. These associations provide a platform for networking with peers and experts, offering valuable connections and collaboration opportunities. They also often organise educational programs that will keep you up to date with the latest developments, methodologies, and regulatory changes in the field.
Joining a professional association dedicated to excellence in clinical research is an excellent way for you to enhance your career and stay at the forefront of the industry. These associations provide a platform for networking with peers and experts, offering valuable connections and collaboration opportunities. They also often…

Effective job descriptions are of paramount importance in recruitment, and thanks to AI, you no longer need to spend countless hours manually crafting job descriptions. AI-powered tools can instead generate optimised, personalised, and targeted job descriptions for you in a matter of minutes. In this article, we outline 13 AI-powered tools that you can use to optimise your life science job descriptions.
Artificial Intelligence (AI) has proven to be a game-changer for life science recruitment, opening up access to a wide range of tools designed to streamline and enhance the hiring process. Effective job descriptions are of paramount importance in recruitment, and thanks to AI, you no longer need to spend countless hours manually crafting job descriptions. AI-powered tools can instead generat…

what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper!
Introduction In the early years, your phone’s predictive text made you wonder, then came Gmail’s Smart Reply feature that utilizes machine learning to provide one-sentence responses. Since then we have come a long way, all thanks to Generative AI or GenAI. This technology is now capable of creating art, composing coherent paragraphs, writing code, and even assisting scientists in clinical research. But what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper! What is Generative AI? Generative AI, in simple terms, is a type of artificial intelligence that can create things on its own, like writing text, generating…

Medical Advisors play a crucial role in the healthcare industry by providing valuable guidance on medical care. They primarily perform case reviews to evaluate previous medical actions and determine whether to confirm the initial physician's findings and recommendations. They also build partnerships and networks with various medical professionals, such as prescribing physicians, medical investigators, pharmacists, and scientists, to enhance the quality of medical care delivered to patients.
Medical Advisors play a crucial role in the healthcare industry by providing valuable guidance on medical care. They primarily perform case reviews to evaluate previous medical actions and determine whether to confirm the initial physician's findings and recommendations. They also build partnerships and…

In today’s competitive job market, traditional hiring methods often struggle to keep pace with the evolving needs of the life science industry. Faced with an ever-increasing talent shortage, now is the time to explore new approaches to talent acquisition that will help to expand your talent pool, streamline your recruitment process, and improve employee engagement and retention.
In today’s competitive job market, traditional hiring methods often struggle to keep pace with the evolving needs of the life science industry. Faced with an ever-increasing talent shortage, now is the time to explore new approaches to talent acquisition that will help to expand your talent pool, streamline your recruitment process, and improve employee engagement and retention. Skills-based hiring presents a transf…

The field of biotechnology continues to thrive and expand, offering a wealth of opportunities for professionals seeking a rewarding career path. With the global biotechnology market reaching a staggering $1.37 trillion in 2022 and predicted to grow at a compound annual growth rate of 13.96% between 2023 and 2030, there has never been a more exciting time to consider a career in this dynamic industry.
The field of biotechnology continues to thrive and expand, offering a wealth of opportunities for professionals seeking a rewarding career path. With the global biotechnology market reaching a staggering $1.37 trillion in 2022 and predicted to grow at a compound annual growth rate of 13.96% between 2023 and 2030, there has never been a more exciting time to consider a career in this dynamic ind…

As one of the largest industrial sectors, the life science industry possesses the capacity to lead by example, setting the stage for other industries and astutely improving the well-being of individuals and ecosystems globally. And in this article, we focus on 10 companies in the US who are doing just that. Here, we’ve highlighted the top 10 life science companies included in the Barron’s 100 Most Sustainable U.S. Companies 2023 list.
As a major and expansive sector, the life science industry wields immense influence over the global environment. With its wide range of products and services encompassing pharmaceuticals, medical devices, biotechnology and more, the industry’s activities can have a profound impact on both human health and the planet at large. As one of the largest industrial s…

Immunity is an act of self-protection of the body. The immune response is divided into specific and non-specific. The antigen and antibody responses are generally referred to as specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune responses, which are part of the body's natural defense system.
Relationship Between Immunity, Inflammation and Cancer Immunity is an act of self-protection of the body. The immune response is divided into specific and non-specific. The antigen and antibody responses are generally referred to as specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune…

BioID (proximity-dependent biotin identification) is a proximity dependent labeling technology established by Roux et al in 2015 to study protein interactions. It can also be developed to study the interactions between proteins and RNA, and proteins and DNA.
What is BioID Technique? BioID (proximity-dependent biotin identification) is a proximity dependent labeling technology established by Roux et al in 2015 to study protein interactions. It can also be developed to study the interactions between proteins and RNA, and proteins and DNA.   How BioID technology works? A recombinant expression vector of the target protein with biotin ligase (BirA) is first constructed and then transfected into cells for amplified expression. Biotin is added to the medium of the transfected cells. Bir…