Articles

what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper!
Introduction In the early years, your phone’s predictive text made you wonder, then came Gmail’s Smart Reply feature that utilizes machine learning to provide one-sentence responses. Since then we have come a long way, all thanks to Generative AI or GenAI. This technology is now capable of creating art, composing coherent paragraphs, writing code, and even assisting scientists in clinical research. But what exactly is Generative AI, how has it evolved, and what role can it play in clinical research? Let’s delve deeper! What is Generative AI? Generative AI, in simple terms, is a type of artificial intelligence that can create things on its own, like writing text, generating…

Medical Advisors play a crucial role in the healthcare industry by providing valuable guidance on medical care. They primarily perform case reviews to evaluate previous medical actions and determine whether to confirm the initial physician's findings and recommendations. They also build partnerships and networks with various medical professionals, such as prescribing physicians, medical investigators, pharmacists, and scientists, to enhance the quality of medical care delivered to patients.
Medical Advisors play a crucial role in the healthcare industry by providing valuable guidance on medical care. They primarily perform case reviews to evaluate previous medical actions and determine whether to confirm the initial physician's findings and recommendations. They also build partnerships and…

In today’s competitive job market, traditional hiring methods often struggle to keep pace with the evolving needs of the life science industry. Faced with an ever-increasing talent shortage, now is the time to explore new approaches to talent acquisition that will help to expand your talent pool, streamline your recruitment process, and improve employee engagement and retention.
In today’s competitive job market, traditional hiring methods often struggle to keep pace with the evolving needs of the life science industry. Faced with an ever-increasing talent shortage, now is the time to explore new approaches to talent acquisition that will help to expand your talent pool, streamline your recruitment process, and improve employee engagement and retention. Skills-based hiring presents a transf…

The field of biotechnology continues to thrive and expand, offering a wealth of opportunities for professionals seeking a rewarding career path. With the global biotechnology market reaching a staggering $1.37 trillion in 2022 and predicted to grow at a compound annual growth rate of 13.96% between 2023 and 2030, there has never been a more exciting time to consider a career in this dynamic industry.
The field of biotechnology continues to thrive and expand, offering a wealth of opportunities for professionals seeking a rewarding career path. With the global biotechnology market reaching a staggering $1.37 trillion in 2022 and predicted to grow at a compound annual growth rate of 13.96% between 2023 and 2030, there has never been a more exciting time to consider a career in this dynamic ind…

As one of the largest industrial sectors, the life science industry possesses the capacity to lead by example, setting the stage for other industries and astutely improving the well-being of individuals and ecosystems globally. And in this article, we focus on 10 companies in the US who are doing just that. Here, we’ve highlighted the top 10 life science companies included in the Barron’s 100 Most Sustainable U.S. Companies 2023 list.
As a major and expansive sector, the life science industry wields immense influence over the global environment. With its wide range of products and services encompassing pharmaceuticals, medical devices, biotechnology and more, the industry’s activities can have a profound impact on both human health and the planet at large. As one of the largest industrial s…

Immunity is an act of self-protection of the body. The immune response is divided into specific and non-specific. The antigen and antibody responses are generally referred to as specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune responses, which are part of the body's natural defense system.
Relationship Between Immunity, Inflammation and Cancer Immunity is an act of self-protection of the body. The immune response is divided into specific and non-specific. The antigen and antibody responses are generally referred to as specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune…

BioID (proximity-dependent biotin identification) is a proximity dependent labeling technology established by Roux et al in 2015 to study protein interactions. It can also be developed to study the interactions between proteins and RNA, and proteins and DNA.
What is BioID Technique? BioID (proximity-dependent biotin identification) is a proximity dependent labeling technology established by Roux et al in 2015 to study protein interactions. It can also be developed to study the interactions between proteins and RNA, and proteins and DNA.   How BioID technology works? A recombinant expression vector of the target protein with biotin ligase (BirA) is first constructed and then transfected into cells for amplified expression. Biotin is added to the medium of the transfected cells. Bir…

The molecular structure of therapeutic proteins is complex and diverse, and their properties vary widely. Therefore, specific analytical methods must be developed for various therapeutic protein molecules. The primary structure of a therapeutic protein usually refers to its amino acid sequence, which contains important structural, characteristic and genetic information. And it is the most fundamental form of describing the subcellular localization, structure and function of the protein, with potential impact on the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of its drug product. Therefore, various mass spectrometry-based analytical techniques are often required to characterize the primary structure of therapeutic proteins at multiple levels.
Why characterize protein primary stru…

Host cell proteins (HCPs) are process-related impurities produced by host cells and are typically present at low levels in recombinant biopharmaceutical products. Enzyme-linked immunosorbent assay (ELISA) has traditionally been used to monitor the total content of HCP in the production of therapeutic protein drugs. Now, with the continuous improvement and upgrading of technology, liquid chromatography-mass spectrometry (LC-MS) is also increasingly used for the qualitative or quantitative analysis of HCP in the purification process.
Host cell proteins (HCPs) are process-related impurities produced by host cells and are typically present at low levels in recombinant biopharmaceutical products. Enzyme-linked immunosorbent assay (ELISA) has traditionally been used to monitor the total content o…

Chemical cross-linking mass spectrometry (CXMS) is an important tool for resolving protein structures and studying protein interactions. The technique uses a chemical cross-linking agent to link two amino acids in close enough spatial proximity to each other in a covalent bond. The two amino acid sites where cross-linking occurs are identified by mass spectrometry. The distance between the two cross-linking sites should not exceed the arm length of the cross-linker due to the limitation of the cross-linker arm length. This distance information will provide important constraints for protein structure resolution and interaction studies.
Chemical cross-linking mass spectrometry (CXMS) is an important tool for resolving protein structures and studying protein interactions. The technique us…

The life sciences supply chains support life-saving business models. They supply medical institutions with quick turnaround deliveries while prioritizing consumers through each step of each company’s operations. Putting consumers first directly connects those supply chains with corporate social responsibility policies. Read about how these policies work and what they mean for the life sciences supply chains. They’re leading the health sector into the future with person-focused initiatives.
The life sciences supply chains support life-saving business models. They supply medical institutions with quick turnaround deliveries while prioritizing consumers through each step of each company’s operations. Putting consumers first directly connects those supply chains with corporate social responsibi…

Computational chemistry combines principles from physics, chemistry, and computer science to model and simulate the behavior of molecules and materials at the atomic level.
The discovery of new materials with desirable properties in the field of materials science used to heavily depend on laboratory experiments and trial-and-error methods. Yet, the introduction of computational chemistry has completely changed this process by giving researchers the ability to predict and optimize the behavior of materials even before they are created in the laboratory. This technique has had a significant impact on the field, leading to quicker and more effective material discovery and development. Understanding and Designing Materials at the Atomic Level Computational chemistry combines principles from phy…

The healthcare industry is on the brink of a transformational revolution, driven by cutting-edge technologies like Artificial Intelligence (AI), Big Data analytics, and Personalized Medicine.
The healthcare industry is on the brink of a transformational revolution, driven by cutting-edge technologies like Artificial Intelligence (AI), Big Data analytics, and Personalized Medicine. These advancements are reshaping the way healthcare is delivered, making it more efficient, precise, and patient-centric. In this article, we explore the future of healthcare and the profound impact of AI, Big Data, and Personalized Medicine. AI: Revolutionizing Diagnosis and Treatment Artificial Intelligence has emerged as a powerful tool in healthcare. Machine learning algorithms can analyze vast datasets, inclu…

AI-powered tools for CV screening are quickly becoming a go-to solution for talent acquisition professionals in the life science industry. In this article, we explore 10 AI-powered tools designed for CV screening. By leveraging these tools, you’ll be able to streamline your recruitment process, focus your time on the best candidates, and ultimately make better hiring decisions for your organisation.
AI-powered tools for CV screening are quickly becoming a go-to solution for talent acquisition professionals in the life science industry. In this article, we explore 10 AI-powered tools designed for CV screening. By leveraging these tools, you’ll be able to streamline your recruitment process, focus your time on the best candidates, and ultimately make better hiring decisions for your organisat…

Whole genome sequencing (WGS) provides great convenience for the research and diagnosis of genetic rare diseases.
The diagnosis and treatment of rare diseases have long been a daunting challenge due to their complex and often undefined nature. However, with recent advancements in technology, specifically in the realm of genomics, whole genome sequencing (WGS) has emerged as a powerful tool that has revolutionized the diagnosis and management of rare diseases. This groundbreaking technique offers hope to countless individuals and their families who have suffered from the uncertainties and lack of answers associated with these conditions.   What are rare diseases? Rare diseases are a diverse group of disorders that affect a small percentage of the population, often occurring as a result…

Gene isoforms are different variations or versions of a gene that can be produced by alternative splicing or alternative transcription initiation and termination. These isoforms are often present in the same organism or cell type but differ in their coding sequence or in the regulatory elements that control their expression.
What Is Gene Isoform? Gene isoforms are different variations or versions of a gene that can be produced by alternative splicing or alternative transcription initiation and termination. These isoforms are often present in the same organism or cell type but differ in their coding sequence or in the regulatory elements that control their expression.   Alternative splicing is a process in which different combinations of exons (coding regions) within a gene are spl…

SARS-CoV-2 is a newly discovered human coronavirus group (HCoV), which are single-stranded RNA viruses belonging to the family of Coronaviridae. A range of respiratory diseases have been induced by some of these pathogens in the past. SARS-CoV-1 infected more than 8,000 individuals around the world, for example. Human coronavirus linked to Middle East respiratory syndrome (MERS-CoV) also occurred in Saudi Arabia in 2012 and induced high mortality levels among infected individuals.
SARS-CoV-2 is a newly discovered human coronavirus group (HCoV), which are single-stranded RNA viruses belonging to the family of Coronaviridae. A range of respiratory diseases have been induced by some of these pathogens in the past. SARS-CoV-1 infected more than 8,000 individuals around the world, for examp…

Pan-genomes reflect structural variation (SV) and polymorphisms in the genome, allowing in-depth comparisons of variation at the species level or at higher taxonomic levels. Pan-genomes have potential applications in crop improvement, evolution and biodiversity research. To fully exploit the value of pan-genomes, a broader range of information such as phenotypic, environmental and expression data needs to be integrated to provide insight into the role of variable regions in the genome.
What is pan-genome? A pan-genome is the sum of all genomic information within a species. With the development of genomic technology, researchers have found that a single reference genome can no longer meet the needs of genomic data analysis, and more and more species, including the human genome, are choosing…

Presently, one-step quantitative RT-PCR (RT-qPCR) targeting SARS-CoV-2 is performed by the molecular diagnosis of COVID-19 using primers and probes established by China CDC, Charité, HKU, Japan NIID, Thailand NIH, and US CDC; WHO has posted these primer-probe sets.
Introduction to Quantitative Polymerase Chain Reaction A highly delicate technique for the amplification and identification of deoxyribonucleic acid is polymerase chain reaction (PCR). In molecular biology, its conceptual simplification has made it the most utilized method and can, in theory, identify as little as a single segment of DNA. Therefore, for a huge variety of bacterial, fungal, viral, and parasite pathogens, it is popularly utilized as a medical method. Even so, rather than DNA, the genome of coronaviruses…

RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding regions (introns). RNA splicing removes the introns from the pre-mRNA molecule and joins together the exons to form a mature mRNA molecule that can be translated into protein.
What Is RNA Splicing? RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding regions (introns). RNA splicing removes the introns from the pre-mRNA molecule and joins together the exons to form a mature mRNA molecule that can be transl…