Articles

Enzymes are biological catalysts that facilitate chemical reactions by lowering the activation energy required for the reaction to occur. They are typically composed of proteins and exhibit high specificity for the chemical reactions they catalyze. Enzymes have numerous applications in industry, including pharmaceuticals, food, and biotechnology. However, enzymes can also be used in households to solve everyday problems.
Enzymes are biological catalysts that facilitate chemical reactions by lowering the activation energy required for the reaction to occur. They are typically composed of proteins and exhibit high specificity for the chemical reactions they catalyze. Enzymes have numerous applications in industry, including pharmaceuticals, food, and biotechnology. However, enzymes can also b…

Enzymes play important roles in research and diagnostic applications. Enzymes are natural biological catalysts that accelerate the rate of biochemical reactions, and they are widely used in many different fields. In this article, we have discussed the applications of enzymes in research and diagnostics, as well as some of the most common enzymes used.
Enzymes play important roles in research and diagnostic applications. Enzymes are natural biological catalysts that accelerate the rate of biochemical reactions, and they are widely used in many different fields. In this article, we have discussed the applications of enzymes in research and diagnostics, as well as some of the most common enzymes used.   Enzymes have a wide range of applications in research and diagnostics, including but n…

The chromatin microenvironment is a dynamically balanced system of organismal epigenetic regulation and thus regulation of gene expression. Any heritable modification mechanism in the chromatin can be used as a marker of epigenetic inheritance. The dynamic balance of chromatin is essential to maintain normal cell proliferation, differentiation, metabolism and functional activities.
The chromatin microenvironment is a dynamically balanced system of organismal epigenetic regulation and thus regulation of gene expression. Any heritable modification mechanism in the chromatin can be used as a marker of epigenetic inheritance. The dynamic balance of chromatin is essential to maintain normal cell proliferation, differentiation, metabolism and functional activities.   ATAC-seq, ChIP-seq&…

Gene transcription requires the unraveling of a higher structural part of the DNA. This part of the chromatin is called accessible chromatin region and this process is achieved mainly by the modification of chromosomal histones (especially acetylation).
Introduction Gene transcription requires the unraveling of a higher structural part of the DNA. This part of the chromatin is called accessible chromatin region and this process is achieved mainly by the modification of chromosomal histones (especially acetylation). The property of chromatin is called chromatin accessibility, so that chromatin accessibility reflects the state of binding of regulatory factors to open chromatin, which is closely related to transcriptional regulation. ATAC-seq technique uses Tn5 transposase to cleave regions o…

Considering that disease-causing and disease-protecting immune cells need to be transferred from lymphatic and secondary lymphoid organs through the peripheral circulation to their sites of action in disease, a clearer picture of the cells and their action gene expression is provided by identifying the components in whole blood. Blood transcriptome sequencing technologies are currently applied to rare disease analysis, immune disease research, and pathogenic infections.
What is Blood Transcriptomics? Considering that disease-causing and disease-protecting immune cells need to be transferred from lymphatic and secondary lymphoid organs through the peripheral circulation to their sites of action in disease, a clearer picture of the cells and their action gene expression is provided by identif…

Chromatin immunoprecipitation (ChIP) is an effective method for isolating DNA fragments bound to specific proteins in vivo. DNA-binding proteins can be transcription factors (TFs) or other chromatin-associated proteins, such as histones.
What is ChIP Sequencing? Chromatin immunoprecipitation (ChIP) is an effective method for isolating DNA fragments bound to specific proteins in vivo. DNA-binding proteins can be transcription factors (TFs) or other chromatin-associated proteins, such as histones. With the rapid development of DNA sequencing technology, the direct sequencing of DNA fragments obtained in ChIP using high-throughput sequencing is called ChIP-seq. Due to its high resolution and coverage, ChIP-seq has become a popular method for analyzing chromatin modifications and TF bindin…

We need to navigate past the lab shortages that have been preventing companies from scaling, and in some cases, blocking access completely for start-ups unable to find space or to meet the spiraling cost of rent. Expanding beyond the established boundaries to encompass more of the country’s scientific potential provides a valuable extension and unlocks further opportunity for growth and success.
The potential of life sciences to deliver game-changing medicines and technology has never been greater. And with discoveries will come high numbers of jobs and significant economic benefits. That is exciting news in a sector that already employs more than 250,000 people, supports 6,500 businesses, and generates an annual turnover of £94bn. (1) With increased funding from UK Life Sciences and the L…

The challenges of manufacturing and supply chain, the shortages of the most essential drugs highlighted during the pandemic, and the approved substances that we are not able to bring to the market fast enough, it is abundantly clear that we as an industry are inadequately prepared to meet these challenges if limited by current tools and methods used in product and process development.
If we look at patient needs, the challenges of manufacturing and supply chain, the shortages of the most essential drugs highlighted during the pandemic, and the approved substances that we are not able to bring to the market fast enough, it is abundantly clear that we as an industry are inadequately prepared to meet these challenges if limited by current tools and methods used in product and process developme…

Discover how Electronic Data Capture (EDC) revolutionizes clinical trials by streamlining data collection, improving accuracy, and ensuring compliance. Explore the advantages of EDC and its impact on efficient clinical research.
Electronic Data Capture (EDC) has transformed the landscape of clinical trials, revolutionizing the way data is collected, managed, and analyzed. This powerful tool offers numerous benefits that not only streamline the process but also enhance the quality and integrity of clinical data. Streamlined Data Collection: EDC simplifies the data collection process by providing a user-friendly interface that eliminates the need for complex programming. Setting up a complete clinical study becomes a matter of days, rather than months. Whether it's paper forms, web forms, o…

Unlock the power of clinical data management for accurate research and better Clinical research outcomes. Discover the key components, technology advancements, and benefits in this essential field.
Introduction: Clinical data management (CDM) plays a crucial role in the Clinical trials industry, ensuring the accuracy, completeness, and security of patient data. However, Clinical data management systems face numerous challenges in keeping up with the increasing volume of data and the evolving demands of clinical trials. This article explores the key challenges faced by CDM systems and discusses future trends that will shape the field. By addressing these challenges and embracing new technologies, Clinical data management systems can improve efficiency, enhance data quality, and ultimately…

Drug Safety Specialists are responsible for monitoring and analysing data related to the safety and efficacy of pharmaceutical products. Their role includes ensuring that drugs are manufactured, tested, and marketed in accordance with regulatory guidelines and that adverse events or product quality issues are reported to the relevant regulatory authorities.
Drug Safety Specialists are responsible for monitoring and analysing data related to the safety and efficacy of pharmaceutical products. Their role includes ensuring that drugs are manufactured, tested, and marketed in accordance with regulatory guidelines and that adverse events or product quality issues are reported to the relevant regulatory authorities. Drug Safety Specialists also work to develop risk management plans for drugs and…

Unquestionably, it has been a challenging couple of years for the healthcare industry as the country faced the largest public health crisis in living memory. In response, the industry has swelled. During the last 12 months for instance, new analysis shows that recruitment appears high on the agenda with a 37% increase in the number of people hired by the sector in 2022.
Unquestionably, it has been a challenging couple of years for the healthcare industry as the country faced the largest public health crisis in living memory. In response, the industry has swelled. During the last 12 months for instance, new analysis shows that recruitment appears high on the agenda with a 37% increase in the number of people hired by the sector in 2022. Recruitment software company Occupop has crunched the n…

Nano-TiO2 is of great significance for preventing disease transmission, purifying environment, and protecting human health.
Compared with common materials, nanomaterials have a series of excellent properties that make nano-antibacterial agents prepared by nanotechnology have excellent antibacterial effects unmatched by traditional antibacterial agents. Nano antibacterial agents can be divided into two categories according to their mechanism of action on microorganisms: one is photocatalytic semiconductor materials such as nano zinc oxide, Nano-TiO2 (nano titanium dioxide), etc.; the other is antibacterial active metal nanomaterials. As a new type of antibacterial material, nano-TiO2 (nano titanium dioxide) has the advantages of non-toxic, non-irritating, thermal stability, heat re…

Ageing global populations are increasing the demand for new drugs to treat diseases, both common and rare. The active pharmaceutical ingredients (APIs) needed for the research which will find the treatment for these diseases are therefore more important than ever. However, access to them is strained after supply chain disruption resulting from the pandemic and the was in Ukraine. As such, maximising the efficiency of the research conducted with versatile laboratory equipment is now of major importance.
Demand for innovative pharmaceutical products is growing because of the need to treat an ageing population with increasingly complex conditions. However, ongoing supply chain disruptions mean drug developers may only have access to small amounts of compound to work with, limiting the work the…

88% of HR decision-makers believe hiring in 2023 will be more or as difficult as in 2022. For HR and recruitment professionals in the Life Science industry, hiring top talent is just the first hurdle. The next biggest challenge facing the industry is employee retention, which is only becoming more essential in today’s unpredictable job market.
88% of HR decision-makers believe hiring in 2023 will be more or as difficult as in 2022. For HR and recruitment professionals in the Life Science industry, hiring top talent is just the first hurdle. The next biggest challenge facing the industry is employee retention, which is only becoming more essential in today’s unpredictable job market. To improve your employee retention, you need to understand what employees are actually looking for from their…

You may have heard that cancer is among the leading causes of death in the United States. And the numbers are pretty sobering; experts estimate nearly two million new cancer cases and 609,360 cancer-related deaths in 2022. Despite these seemingly dire figures, humans are quite a hardy bunch capable of overcoming adversities, so we shouldn’t lose hope. There are ways to prevent this disease and treatment options to help manage the symptoms. Functional medicine is among such options.
You may have heard that cancer is among the leading causes of death in the United States. And the numbers are pretty sobering; experts estimate nearly two million new cancer cases and 609,360 cancer-related deaths in 2022. Despite these seemingly dire figures, humans are quite a hardy bunch capable of overcoming…

In this article, Saama's Chief Technology Officer, Lisa Moneymaker, writes about how AI technology could be implemented to help data managers keep track of all the data coming in from clinical trials, explaining how AI technology will change the pharma industry as more and more companies race to be the first to reach FDA approval.
Over the past decade, data volume has increased threefold, according to the Tufts Center for the Study of Drug Discovery (CSDD). All of this data needs to be collected, secured and analyzed — so newer, better medications can be developed to help patients around the world. Traditional (read: manual) approaches to cleaning and monitoring data simply can’t scale — and the status quo of those processes and systems are coming under greater scrutiny. This has created a…

EHRs offer several benefits, such as improved patient outcomes and increased efficiency, but also come with challenges such as data privacy concerns and the need for standardization. We will discuss the various opportunities and challenges of EHRs and how they are affecting the healthcare industry.
Electronic Health Records (EHRs) in Healthcare Industry have transformed the sector in multiple ways in the last few years. With the widespread adoption of EHRs, medical professionals can organize patients' medical records in a more efficient manner, making them easy to access and share with different health units and departments. Also, the successful adoption of EHR in the healthcare industry leads to improved patient care and effective administrative management.  According to Statista, the…

Here, Bob Tilling, VP Global Sales at Kallik, explains how a comprehensive labelling and artwork management system can prepare manufacturers in highly regulated industries to make fast, efficient label changes when supply chains pressures force ingredients changes, new regulations come into force, or regionalisation is required for certain product lines.
The year 2022 was record year for product recalls in regulated industries with US recalls reaching an all-time high of 1.5 billion impacted units and, 10,545 product recall events across Europe, according to analysis by brand protection and recall risk experts, Sedgwick. When drilling down to the detail many recalls were due to errors on labels and packaging. These recalls were exacerbated by certain external pressures – such as short notic…

In recent years, eProtocol automation has emerged as a powerful tool for streamlining the protocol creation process, reducing errors, and improving efficiency.
Clinical trials are critical for bringing new treatments and therapies to market, but they are also time-consuming, expensive, and complex. Protocol development is a crucial component of the clinical trial process, but it can be a bottleneck that delays study start times. In recent years, eProtocol automation has emerged as a powerful tool for streamlining the protocol creation process, reducing errors, and improving efficiency. Key Features of eProtocol AutomationStandardized Protocol Templates: eProtocol tools offer a library of standardized protocol templates that can be customized to fit the specific needs of each study. These te…