Biotech - Articles

Clinion's Clinical Trial Management System (CTMS) gives enhanced visibility into all aspects of the clinical trial process - from study plan, Remote monitoring, and Clinical data management.
Clinion CTMS is an integrated Clinical Trial Management System (CTMS) designed to give Contract Research Organizations (CROs) and Sponsors greater visibility and control over their clinical trials. Here's a breakdown of its key features and benefits: Real-time Visibility: Gain a comprehensive view of your entire trial at any time. This allows for faster decision-making and course correction, potentially accelerating study timelines. Reduced Trial Costs: Clinion CTMS helps streamline workflows, automate tasks, and optimize spending. This can lead to significant cost savings by minimizing redun…

510(k) is a premarket technical document submitted to the FDA before a product enters the U.S. market to demonstrate that the product has the same safety and efficacy as a legally marketed comparable product in terms of intended use, design, materials, implementation standards, etc.
People who want to market their either Class I or Class II device products in the U.S, and the device is not exempt from 510(k), must file a Premarket Notification with the FDA, it is also known as FDA 510(k) submission. The 510(k) is a complex application to the FDA, because the application is to demonstrate that the device is safe and effective, and it is equivalent to another device which is on the market. 510(k) is a premarket technical document submitted to the FDA before a product enters the U.S. market to…

Particles (or powder) in tablets can occasionally experience sticky punch phenomena that prevent the particles from flowing smoothly into the mold wells. Lubricants are mostly utilized in solid preparations, particularly pills and capsules.
IntroductionParticles (or powder) in tablets can occasionally experience sticky punch phenomena that prevent the particles from flowing smoothly into the mold wells. As a result, particles in tablets before are frequently required to add a small amount of lubricating effect of the material, in order to increase mobility and decrease friction with the die, and to ensure a clean and attractive tablet surface. These substances are typically referred to as lubricants. Lubricants are mostly utilized in solid preparations, particularly pills and capsules. Mech…

Monopotassium phosphite provides essential nutrients for plant growth and helps to promote healthy roots and overall plant development.
Monopotassium phosphite is a chemical compound with the molecular formula KH2PO3. It is a salt of phosphorous acid and is commonly used as a fertilizer in agriculture. Monopotassium phosphite provides essential nutrients for plant growth and helps to promote healthy roots and overall plant development. It is also known for its ability to enhance plant resistance to diseases and stress. Action Principle of Potassium Dihydrogen Phosphite Phosphite is a highly mobile molecule that can be easily absorbed by the leaves and roots of plants and moved throughout the plant. Therefore, phosphite can be used by foliar spraying and irrigation fertilization, and is…

Stability analysis consists of different methods such as influencing factors analysis, long-term accelerated shelf-life testing, and light stability analysis, each of which plays a significant role in determining the stability and shelf-life of pharmaceutical products.
In the field of pharmaceutical science, stability analysis plays a crucial role in ensuring the safety and efficacy of pharmaceutical products. It is a complex and multifaceted process that requires thorough investigation and understanding of various influencing factors. Stability analysis consists of different methods such as influencing factors analysis, long-term accelerated shelf-life testing, and light stability analysis, each of which plays a significant role in determining the stability and shelf-life of pharmaceutical…

Optimize your clinical trials with Clinion RTSM software the easy-to-use and innovative solution that puts patient safety and accurate randomization first
We at Clinion are excited to share our all-in-one Randomization and Trial Supply Management (RTSM) software designed to streamline clinical trial operations! Effortless Integration: Our RTSM seamlessly integrates with our EDC platform. Randomize patients and assign investigational product kits directly within the same system, eliminating the need to switch between applications and reducing the risk of data entry errors. Flexible Randomization Power: Clinion's RTSM caters to diverse study designs. Whether you require simple randomization or complex stratified/minimization approaches, our software can handle it! Real-ti…

AI is transforming medical coding by improving coding accuracy. In this blog, we’ll explore what this transformation means for clinical trial organizations.
Accuracy in medical coding is a vital aspect in aiding clinical trial operation success. It has presented an excellent opportunity for medical coders, working hand-in-hand with AI-enhanced computer-assisted coding systems, to quickly identify and validate the correct codes. Using natural language processing (NLP) and advanced Machine Learning algorithms, AI is transforming medical coding by improving coding accuracy. In this blog, we’ll explore what this transformation means for clinical trial organizations. What is Medical Coding? Medical coding is a critical process that involves assigning standardized codes to medical terms in clinic…

Clinion electronic data capture (EDC) software uses AI to simplify Study Build and set up your study in days instead of weeks with an easy-to-use interface
The Freedom And Flexibility To Built Studies On Your Own Clinion Electronic Data Capture (EDC) Software uses AI and Automation to simplify Study Build, Data Capture and Clinical Data Management (CDM). With advanced features like Medical Coding Automation, External Data Load, Visit Scheduling, Bulk locks, CRF versioning as part of a standard package Clinion makes things simpler for its users. Integrate Clinion Electronic Data Capture (EDC) Software with Clinion CTMS, IWRS/RTSM, and ePRO/eCOA for true end-to-end support of your Study, obviating the hassles of data reconciliation while dealing with multiple eCl…

Low-pass whole genome sequencing refers to shallow whole genome sequencing, the process of sequencing an individual's genome at a lower depth, typically around 0.1x to 5x coverage, as compared to the standard depth of 30x to 50x in traditional whole genome sequencing. This reduction in coverage significantly decreases the cost and time required for analysis while still providing valuable genomic information.
What is low-pass whole genome sequencing? In the rapidly advancing field of genomics, whole genome sequencing has become a powerful tool for deciphering the genetic blueprint of an individual. While traditional whole genome sequencing involves deep coverage to capture every base pair of an individual's genome, a newer approach known as shallow whole genome sequencing, or low-pass whole…

Gene transcription requires the unraveling of a higher structural part of the DNA. This part of the chromatin is called accessible chromatin region and this process is achieved mainly by the modification of chromosomal histones (especially acetylation). The property of chromatin is called chromatin accessibility, so that chromatin accessibility reflects the state of binding of regulatory factors to open chromatin, which is closely related to transcriptional regulation. ATAC-seq technique uses Tn5 transposase to cleave regions of DNA that are not protected by binding proteins, and is used to analyze chromatin openness and to determine dynamic changes in chromatin structure.
Gene transcription requires the unraveling of a higher structural part of the DNA. This part of the chromatin is called…

The human genome, the genetic code that makes us uniquely human, has been the subject of scientific study and fascination for decades. The human genome contains approximately 3.055 billion base pairs.
The human genome, the genetic code that makes us uniquely human, has been the subject of scientific study and fascination for decades. The human genome contains approximately 3.055 billion base pairs. These are the molecular building blocks of DNA, consisting of adenine (A) paired with thymine (T) and cytosine (C) paired with guanine (G). This vast number is a testament not only to the complexity of the human race, but also to the intricate interplay of genetic factors that influence our physiology, behavior, and predispositions. Billions of base pairs and complex sequences determine ever…

The Basic Local Alignment Search Tool (BLAST) a heuristic system, meaning it uses clever shortcuts to speed up the search process. "Local" alignments are performed by BLAST. Functional domains are frequently repeated within the same protein as well as across various proteins from different species, indicating that most proteins are modular in nature.
Introduction to FASTQ Format/Files A FASTQ file is a text file that stores the sequence data from clusters that pass the flow cell's filter. Demultiplexing is the first phase in creating a FASTQ file if specimens were multiplexed. Demultiplexing assigns clusters to a specimen based on the index sequence of each cluster (s). The assembled sequences are published to FASTQ files per specimen after demultiplexing. If specimens were not multiplexed…

A FASTQ file is a text file that stores the sequence data from clusters that pass the flow cell's filter. Demultiplexing is the first phase in creating a FASTQ file if specimens were multiplexed. Demultiplexing assigns clusters to a specimen based on the index sequence of each cluster (s). The assembled sequences are published to FASTQ files per specimen after demultiplexing. If specimens were not multiplexed, the demultiplexing step is skipped, and all clusters are allocated to a single specimen for each flow cell lane.
Introduction to FASTQ Format/Files A FASTQ file is a text file that stores the sequence data from clusters that pass the flow cell's filter. Demultiplexing is the first phase in creating a FASTQ file if specimens were multiplexed. Demultiplexing assigns clusters to a specim…

In this era of rapidly expanding biological technology, metagenomic screening for enzymes has emerged as a pivotal approach in many industrial and scientific processes. This process paves the way for the discovery of novel enzymes, serving as a powerful tool in biotechnology. To facilitate a better understanding of this intricate yet mind-boggling domain, we, at Creative Enzymes, are presenting a comprehensive yet easy-to-grasp overview of metagenome screening for enzymes.
In this era of rapidly expanding biological technology, metagenomic screening for enzymes has emerged as a pivotal approach in many industrial and scientific processes. This process paves the way for the discovery of novel enzymes, serving as a powerful tool in biotechnology. To facilitate a better understanding of this i…

Understanding the function and behavior of enzymes in various biological processes is essential to numerous scientific sectors, including pharmaceuticals, food, and chemical industries. As the catalytic machinery responsible for driving chemical reactions, the activity of enzymes plays a vital role in these processes. One crucial procedure that aids in the comprehensive understanding of enzymes is Enzyme Activity Measurement (EAM).
Understanding the function and behavior of enzymes in various biological processes is essential to numerous scientific sectors, including pharmaceuticals, food, and chemical industries. As the catalytic machinery responsible for driving chemical reactions, the activity of enzymes plays a vital role in these processes. One crucial procedure that aids in the compre…

From nurturing a positive work culture to empowering and developing your people for success, Pioneer Group sets out some top tips for building a high-performance team as a life science company.
When it comes to recruitment, the life sciences industry is undoubtedly highly competitive. With demand for skilled professionals often outpacing the supply, attracting (and retaining) qualified candidates with the right expertise can be a significant challenge for many life science companies. From nurturing a positive work culture to empowering and developing your people for success, Pioneer Group sets out some top tips for building a high-performance team as a life science company. Invest in Graduate Programmes Investing in graduate outreach can help to bridge the skills gap in life sciences, and…

One of the most promising technologies that has emerged in recent years is nanoparticle development for drug delivery systems. Nanoparticles are tiny particles with dimensions in the nanometer range, making them ideal for targeting specific tissues or cells in the body.
The field of medicine is constantly evolving, with researchers and scientists striving to find innovative ways to deliver drugs effectively and efficiently. One of the most promising technologies that has emerged in recent years is nanoparticle development for drug delivery systems. Nanoparticles are tiny particles with dimensions in the nanometer range, making them ideal for targeting specific tissues or cells in the body. In this article, we will explore different types of nanoparticle development that are revolutionizing…

Oxide nanoparticles have found applications in the field of medicine and healthcare. Metal oxide nanoparticles, such as iron oxide nanoparticles, are widely used as contrast agents in magnetic resonance imaging (MRI) due to their paramagnetic properties.
Oxides nanoparticles have gained significant attention in various fields due to their unique properties and potential applications. Synthesis Methods of Oxides Nanoparticles The synthesis of these nanoparticles requires careful consideration of the method employed, as it can greatly influence their physical and chemical characteristics. Chemical Precipitation Method The chemical precipitation method is one of the most widely used techniques for the synthesis of oxides nanoparticles. In this method, a precursor solution containing metal…

In recent years, some studies have been conducted on the delivery of anticancer drugs, genes and peptides through garphene derivatives.
The Importance of Drug and Gene Delivery Due to its poor water solubility, non-specific delivery and severe side effects, chemotherapy drugs have many limitations in fighting cancer clinically. On the other hand, gene therapy has also been widely explored as another option for cancer treatment, but the lack of safe, selective and effective gene delivery vectors hinders the further clinical application of gene therapy. Recently, various nanomaterial-based drug and gene delivery systems have been intensively studied and proved to be promising in cancer treatment. Accelerate Research and Practice of Graphene in Drug and Gene Delivery Graphene is cons…

• Baird Medical agreed to subject 30% of its shares to be received in the transaction to an earnout at a $12.50 trading price • Minimum cash condition of $15 million has been waived, cementing certainty and expediency to our transaction close • Upon closing, Baird Medical is expected to trade on Nasdaq under the ticker symbol “BDMD
Baird Medical and ExcelFin Acquisition Corp Announce Strategic Update to Business Combination Terms to Reinforce Long-Term Value Creation Opportunity and Alignment with Shareholders Baird Medical agreed to subject 30% of its shares to be received in the transaction to an earnout at a $12.50 trading price Minimum cash condition of $15 million has been waived, cementing certainty and expediency to our transaction close Upon closing, Baird Medical is expect…