Biotech - Articles

Non-coding RNAs (ncRNAs) are RNA molecules that cannot be translated into proteins. ncRNAs are found in a wide range of organisms and serve a number of roles. Transfer RNAs (tRNAs) are traditional noncoding RNAs (ncRNAs) that transform genetic information from messenger RNA (mRNA) to amino acid sequence information in nascent proteins.
Non-coding RNAs (ncRNAs) are RNA molecules that cannot be translated into proteins. ncRNAs are found in a wide range of organisms and serve a number of roles. Transfer RNAs (tRNAs) are traditional noncoding RNAs (ncRNAs) that transform genetic information from messenger RNA (mRNA) to amino acid sequence information in nascent proteins.   The anticodon loop of tRNAs may be precisely spliced into tRNA halves under the influence of sex hormone, hypoxia…

With the development of next-generation sequencing (NGS) technologies and new sequencers, the exponential growth of biological information generated by the scientific community has brought benefits as well as new challenges to researchers. In the era of big data, the field of bioinformatics has made significant progress in the analysis and interpretation of biological data. Therefore, there is a need to develop computational techniques and tools for effective data analysis and visualization to help understand biological processes.
With the development of next-generation sequencing (NGS) technologies and new sequencers, the exponential growth of biological information generated by the scientific community has brought benefits as well as new challenges to researchers. In the era of big data,…

Bioinformaticsis a rapidly evolving field filled with a plethora of tools for processing and manipulating next-generation sequencing (NGS) data. The performance of NGS alignment tools continues to improve, but it now takes more time to sort aligned data than to align it. SAMtools and sambamba are two commonly used tools for sorting binary alignment map (BAM) files.
Bioinformaticsis a rapidly evolving field filled with a plethora of tools for processing and manipulating next-generation sequencing (NGS) data. The performance of NGS alignment tools continues to improve, but it now takes more time to sort aligned data than to align it. SAMtools and sambamba are two commonly used tools for sorting binary alignment map (BAM) files.   SAMtools SAMtools, developed by the 1000 Genomes…

Whole genome bisulfite sequencing (WGBS) converts unmethylated cytosine (C) to thymine (T) with the bisulfite treatment on genomic DNA. Subsequently, whole genome resequencing of the treated DNA and comparison with the reference genome were performed to achieve single-base resolution and high-accuracy methylation level analysis from the genomic level.
DNA methylation is an important component of epigenetics and plays an important role in maintaining normal cellular function, genetic imprinting, embryonic development, and human tumorigenesis. Whole genome bisulfite sequencing (WGBS) converts unmethylated cytosine (C) to thymine (T) with the bisulfite treatment on genomic DNA. Subsequently, whole genome resequencing of the treated DNA and comparison with the…

RNA methylation stands as a pivotal focus within the realm of epigenetics. With a repertoire exceeding 100 distinct modifications, notable examples include methylation, hydroxymethylation, and acetylation. Among these, m6A stands as the most prevalent methylation modification on RNA, averaging 1 to 3 m6A modifications per transcript.
RNA methylation stands as a pivotal focus within the realm of epigenetics. With a repertoire exceeding 100 distinct modifications, notable examples include methylation, hydroxymethylation, and acetylation. Among these, m6A stands as the most prevalent methylation modification on RNA, averaging 1 to 3 m6A modifications per transcript. Ubiquitous across eukaryotes, encompassing mammals, insects, plants, yeast, and select viruses, m6A occurs not only on mRNA…

Lipids are the basic substances that make up biological membranes. Through lipid-lipid interactions and interactions between lipids and other biomolecules, a complex network of lipid metabolism is formed, which is involved in a large number of life activities. By studying lipid extracts, information about the lipidome can be obtained. Lipidomics studies lipids in organisms at a systematic level, revealing their interactions and interactions with other biomolecules.
Lipids are the basic substances that make up biological membranes. Through lipid-lipid interactions and interactions between lipids and other biomolecules, a complex network of lipid metabolism is formed, which is involved in a large number of life activities. By studying lipid extracts, information about the lipidome can be obta…

Trillions of microorganisms live in the gastrointestinal tract, far outnumbering the body's own cells. The intestinal flora is involved in many physiological and pathological processes in the host, including digestion and absorption of food, metabolism of certain nutrients and pharmaceutical compounds, development of host immunity, intestinal inflammatory states, and more. Dysbiosis of the intestinal flora is associated with a variety of human metabolic diseases, such as obesity, diabetes mellitus, and nonalcoholic fatty liver disease.
Trillions of microorganisms live in the gastrointestinal tract, far outnumbering the body's own cells. The intestinal flora is involved in many physiological and pathological processes in the host, including digestion and absorption of food, metabolism of cer…

Metabolomics is a quantitative study of the dynamic patterns of changes in the types and amounts of endogenous small molecule metabolites (generally MW < 1,000) in organisms under the influence of endogenous and exogenous factors (e.g. genetic variation, disease attack, drug intervention, environmental changes, etc.) and their association with physiological and pathological changes.
Metabolomics is a quantitative study of the dynamic patterns of changes in the types and amounts of endogenous small molecule metabolites (generally MW < 1,000) in organisms under the influence of endogenous and exogenous factors (e.g. genetic variation, disease attack, drug intervention, environmental changes, etc.) and their association with physiological and pathological changes.   Pharmacometabo…

Cancer is a complex disease that involves a delicate interplay between the tumor cells and the host immune system. Cytokines play a critical role in this interplay, mediating the communication between different cells of the immune system and modulating immune responses. As such, cytokine profiling is becoming increasingly important in the study of cancer and is being used to support research, diagnosis, and treatment decisions.
Cancer is a complex disease that involves a delicate interplay between the tumor cells and the host immune system. Cytokines play a critical role in this interplay, mediating the communication between different cells of the immune system and modulating immune responses. As such, cytokine profiling is becoming increasingly important in the study of cancer and is being…

Cancer is a complex disease that involves a delicate interplay between the tumor cells and the host immune system. Cytokines play a critical role in this interplay, mediating the communication between different cells of the immune system and modulating immune responses. As such, cytokine profiling is becoming increasingly important in the study of cancer and is being used to support research, diagnosis, and treatment decisions.
Cancer is a complex disease that involves a delicate interplay between the tumor cells and the host immune system. Cytokines play a critical role in this interplay, mediating the communication between different cells of the immune system and modulating immune responses. As such, cytokine profiling is becoming increasingly important in the study of cancer and is being…

Discover how Clinion's Electronic Trial Master File (eTMF) optimizes clinical trial management with secure, efficient, and compliant document handling
Ensure faster trials, regulatory compliance, and real-time oversight with Clinion's innovative eTMF software. In the dynamic world of clinical research, efficient management of data and documents is crucial. Clinion's Electronic Trial Master File (eTMF) simplifies this process by providing a centralized platform for storing, organizing, and tracking all your clinical trial essentials. Key Benefits:Rapid Deployment: Start quickly with pre-built models and a configurable structure, reducing setup time to weeks. Intuitive Interface: Clinion's eTMF utilizes industry-standard DIA TMF Reference Models for a user-friendly experience, allowing for ef…

Microneedle patches for the eyes and lips are small, adhesive patches that are infused with microneedles made of dissolvable materials such as hyaluronic acid or collagen.
In recent years, microneedle patches have emerged as a revolutionary technology in the beauty and skincare industry. These patches are designed to deliver active ingredients directly into the skin, providing targeted treatments for a variety of concerns. One area where microneedle patches have shown significant promise is in the treatment of the delicate skin around the eyes and lips. In this article, we will explore the latest innovations in microneedle eye and lip patch technologies, including advancements in manufacturing processes and delivery methods. Microneedle Eye and Lip Patch Microneedle patches for the eyes and…

The field of pharmaceuticals has seen rapid advancements in drug delivery technologies in recent years, one of which is long-lasting controlled-release microspheres technology.
The field of pharmaceuticals has seen rapid advancements in drug delivery technologies in recent years, one of which is long-lasting controlled-release microspheres technology. This technology involves the use of microscopic particles to deliver drugs in a controlled and sustained manner over an extended period of time. By encapsulating drugs within these microspheres, pharmaceutical companies are able to improve patient compliance, reduce dosing frequency, and enhance therapeutic outcomes. In this article, we will explore the benefits and applications of long-lasting controlled-release microspheres technology. Long-…

PEG is soluble in organic solvents and water has excellent physicochemical and physiological properties, and is non-toxic, non-antigenic, and non-immunogenic. PEG is biocompatible and exhibits low protein and platelet adsorption in vivo as well as low cellular adherence, which are features that have led to a wide range of applications in biomedical fields.
Polymers play an important role in the biomedical field, and polyethylene glycol (PEG) and its derivatives are among the multifunctional polymers that have attracted much attention. PEG is a synthetic macromolecule with a linear structure consisting of glycol units (-CH2CH2O-) repeatedly linked. Its unique properties give PEG a wide range of applications. PEG is soluble in organic solvents and water has excellent physicochemical and physi…

Traditionally, copper-catalyzed azide-alkyne cycloaddition (CuAAC) has been the cornerstone of click chemistry, but concerns about cytotoxicity and metal contamination have sparked increasing interest in copper-free alternatives.
Click chemistry has revolutionized the field of bioconjugation, offering a robust and versatile approach for linking biomolecules, such as proteins, peptides, nucleic acids, and carbohydrates, to create novel materials and probes. Traditionally, copper-catalyzed azide-alkyne cycloaddition (CuAAC) has been the cornerstone of click chemistry, but concerns about cytotoxicity and metal contamination have sparked increasing interest in copper-free alternatives. This article explores the diverse applications of copper-free click chemistry in biomedical research, hig…

Polyethylene glycol can be used as antistatic agent and softener in cosmetics, pharmaceuticals, chemical fibers, rubber, plastics, papermaking, paints, electroplating, pesticides, metal processing and food. It has a wide range of applications in processing and other industries.
What is Polyethylene Glycol? Polyethylene glycol is a high molecular polymer with the chemical formula HO(CH2CH2O)nH. It is non-irritating, has good water solubility, and has good compatibility with many organic components. It has excellent lubricity, moisturizing, dispersion and adhesion. It can be used as antistatic agent and softener in cosmetics, pharmaceuticals, chemical fibers, rubber, plastics, papermaking, paints, electroplating, pesticides, metal processing and food. It has a wide range of applications…

In today’s competitive clinical research landscape, seamless EDC-CTMS integration is not simply a convenience; it’s a strategic imperative
Clinical trials are complex endeavours that rely on meticulous data collection, efficient communication, and rigorous oversight. Two critical software systems underpin these needs: Electronic Data Capture (EDC) and Clinical Trial Management Systems (CTMS). This post explores why seamless integration between EDC and CTMS is paramount for effective trial management. What are EDC and CTMS? EDC (Electronic Data Capture): Imagine a digital filing cabinet for clinical trial data. EDC systems streamline participant data collection, ensuring accuracy and regulatory compliance. CTMS (Clinical Trial Management System): Think of CTMS system as t…

In 2020, the global landscape changed dramatically with the advent of COVID-19. The fatal virus strain soon infected millions of people worldwide, forcing everyone to live a masked life that became limited to their homes.
Problem Statement In 2020, the global landscape changed dramatically with the advent of COVID-19. The fatal virus strain soon infected millions of people worldwide, forcing everyone to live a masked life that became limited to their homes. Bharat Biotech is one of India’s leading Biotech companies and when India got hit by the COVID-19 pandemic, the company started looking for a proven and easy-to-use system that could accelerate COVID vaccine trials. Bharat Biotech’s Covaxin, one of the first COVID-19 vaccines developed by an Indian company, was approved to enter Phase 1…

Hannah Palin (Director – Market Access) and Calum Jones (Associate Director – Health Economics) explore the landscape for economic evaluation in the US. They highlight important considerations for companies seeking to infiltrate this key market.
Health economic modelling is fundamental to market access, in both health technology assessment (HTA) and pre and post-launch engagement. It is of value globally, but holds particular importance in markets across Europe, the UK, and Canada, among others. Its application in the US, however, is less established. With a dedicated Health Economics Team, economic modelling is a key area in which Mtech Access support clients. Whilst there are variations in the approaches between HTA markets, we can see commonalities in the requirement for e…

We are enthralled by the intricate dance of life's catalysts - enzymes. These remarkable protein molecules are the unsung heroes of the biological world, orchestrating the myriad chemical reactions that sustain and power the living organisms around us. To truly understand the structural and functional intricacies of these vital biomolecules, we turn to the powerful tool of enzyme molecular dynamics simulation.
We are enthralled by the intricate dance of life's catalysts - enzymes. These remarkable protein molecules are the unsung heroes of the biological world, orchestrating the myriad chemical reactions that sustain and power the living organisms around us. To truly understand the structural and functional intricacies of these vital biomolecules, we turn to the powerful tool of enzyme mole…