Biotech - Articles
Chimeric RNA, also known as fusion RNA, refers to RNA molecules that are formed as a result of the fusion of two or more different RNA transcripts. Chimeric RNA, a unique class of RNA molecules formed through various molecular mechanisms, such as trans-splicing, read-through transcription, and fusion genes. These hybrid transcripts play a significant role in diverse biological processes and have gained substantial attention in recent years.
What is Chimeric RNA? Chimeric RNA, also known as fusion RNA, refers to RNA molecules that are formed as a result of the fusion of two or more different RNA transcripts. Chimeric RNA, a unique class of RNA molecules formed through various molecular mechanisms, such as trans-splicing, read-through transcription, and fusion genes. These hybrid transcripts…
What is Chimeric RNA? Chimeric RNA, also known as fusion RNA, refers to RNA molecules that are formed as a result of the fusion of two or more different RNA transcripts. Chimeric RNA, a unique class of RNA molecules formed through various molecular mechanisms, such as trans-splicing, read-through transcription, and fusion genes. These hybrid transcripts…
RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding regions (introns).
What Is RNA Splicing? RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding regions (introns). RNA splicing removes the introns from the pre-mRNA molecule and joins together the exons to form a mature mRNA molecule that can be translated into protein. What Is the Process of RNA Splicing? The process of splicing is carried out by a complex called the spliceosome, which is composed…
What Is RNA Splicing? RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding regions (introns). RNA splicing removes the introns from the pre-mRNA molecule and joins together the exons to form a mature mRNA molecule that can be translated into protein. What Is the Process of RNA Splicing? The process of splicing is carried out by a complex called the spliceosome, which is composed…
24-Jul-2024
Rare DNA changes within a population of cells are the first manifestations of mutations, which are the fuel for evolution. The research of genomic variation between species and individual organisms has been revolutionized by next-generation sequencing (NGS) technologies.
Introduction to Variant Analysis Rare DNA changes within a population of cells are the first manifestations of mutations, which are the fuel for evolution. The research of genomic variation between species and individual organisms has been revolutionized by next-generation sequencing (NGS) technologies. Variant detection and analysis refer to the sequencing and difference analysis of a genome from an individual or a population of a species using high-throughput sequencing technology in order to acquire a large p…
Introduction to Variant Analysis Rare DNA changes within a population of cells are the first manifestations of mutations, which are the fuel for evolution. The research of genomic variation between species and individual organisms has been revolutionized by next-generation sequencing (NGS) technologies. Variant detection and analysis refer to the sequencing and difference analysis of a genome from an individual or a population of a species using high-throughput sequencing technology in order to acquire a large p…
CRISPR-Cas9 is a gene editing technology that has changed the landscape of biological research. It stands for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-Associated Protein 9.
What is CRISPR-Cas9? CRISPR-Cas9 is a gene editing technology that has changed the landscape of biological research. It stands for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-Associated Protein 9. CRISPR-Cas9 uses a two-component system consisting of a guide RNA (gRNA) and a Cas9 protein. The gRNA is designed to complement specific target sequences in the genome to guide the Cas9 protein to the desired location. Once the Cas9 protein reaches the target site, it causes a double-strand break in the DNA helix, which initiates a cellular repair process that can lead t…
What is CRISPR-Cas9? CRISPR-Cas9 is a gene editing technology that has changed the landscape of biological research. It stands for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-Associated Protein 9. CRISPR-Cas9 uses a two-component system consisting of a guide RNA (gRNA) and a Cas9 protein. The gRNA is designed to complement specific target sequences in the genome to guide the Cas9 protein to the desired location. Once the Cas9 protein reaches the target site, it causes a double-strand break in the DNA helix, which initiates a cellular repair process that can lead t…
Carbon Quantum Dots range from simple organic molecules to complex functionalized materials and can be synthesized in various ways, making them an attractive candidate for a wide range of applications.
Carbon quantum dots (CQDs) are a newly discovered class of quantum materials that have generated significant interest in both academia and industry. With a diameter below 10 nm, they are a type of carbon nanoparticle that exhibits remarkable physical and chemical properties. They range from simple organic molecules to complex functionalized materials and can be synthesized in various ways, making them an attractive candidate for a wide range of applications. Introduction of Carbon Quantum Dots Carbon quantum dots are zero-dimensional nanoparticles made of sp2-hybridized carbon atoms. The…
Carbon quantum dots (CQDs) are a newly discovered class of quantum materials that have generated significant interest in both academia and industry. With a diameter below 10 nm, they are a type of carbon nanoparticle that exhibits remarkable physical and chemical properties. They range from simple organic molecules to complex functionalized materials and can be synthesized in various ways, making them an attractive candidate for a wide range of applications. Introduction of Carbon Quantum Dots Carbon quantum dots are zero-dimensional nanoparticles made of sp2-hybridized carbon atoms. The…
Nanoformulation leverages nanotechnology to create drug delivery systems that can improve the efficacy, reduce side effects, and precisely target disease sites.
Introduction In the ever-evolving landscape of drug delivery systems, nanoformulation stands out as a revolutionary approach. Nanoformulation leverages nanotechnology to create drug delivery systems that can improve the efficacy, reduce side effects, and precisely target disease sites. This cutting-edge technology has garnered significant attention from researchers and pharmaceutical companies alike, due to its potential to transform the way medications are formulated and administered. The nanoformulation platform embodies this innovative stride by providing a robust framework for engineering and delivering drugs at the nanosca…
Introduction In the ever-evolving landscape of drug delivery systems, nanoformulation stands out as a revolutionary approach. Nanoformulation leverages nanotechnology to create drug delivery systems that can improve the efficacy, reduce side effects, and precisely target disease sites. This cutting-edge technology has garnered significant attention from researchers and pharmaceutical companies alike, due to its potential to transform the way medications are formulated and administered. The nanoformulation platform embodies this innovative stride by providing a robust framework for engineering and delivering drugs at the nanosca…
11-Jul-2024
The development of antibody cocktails is a complex and meticulous process that requires a deep understanding of target biology, antibody engineering, and combinatorial approaches.
What is Antibody Cocktail Therapy? Antibody cocktail therapy is a treatment that mixes two or more monoclonal antibodies together. By combining the properties of different antibodies, this therapy can target multiple targets simultaneously, thereby enhancing the effectiveness of treatment and reducing the development of drug resistance. Antibody cocktail therapy has broad application prospects in fields such as tumors and autoimmune diseases. How to Develop Antibody Cocktail Therapy? The development of antibody cocktails is a complex and meticulous process that requires a deep understanding of target biology, anti…
What is Antibody Cocktail Therapy? Antibody cocktail therapy is a treatment that mixes two or more monoclonal antibodies together. By combining the properties of different antibodies, this therapy can target multiple targets simultaneously, thereby enhancing the effectiveness of treatment and reducing the development of drug resistance. Antibody cocktail therapy has broad application prospects in fields such as tumors and autoimmune diseases. How to Develop Antibody Cocktail Therapy? The development of antibody cocktails is a complex and meticulous process that requires a deep understanding of target biology, anti…
We are delighted to announce that the second edition of our popular introductory guide: ‘Market access stakeholders and processes for medical devices in key European markets’ is now available. Our market access experts have updated the guide with European market insights for 2024/25, along with a new section covering the US market.
An introductory guide to market access stakeholders and processes for medical devices in key European markets and the USA In this introductory guide, our Global market access experts provide an overview of the commercial launch landscape for medical devices in the USA and key European healthcare systems. We highlight the differences between selected markets and provide a go-to guide for those looking to bring medical device innovations to the…
An introductory guide to market access stakeholders and processes for medical devices in key European markets and the USA In this introductory guide, our Global market access experts provide an overview of the commercial launch landscape for medical devices in the USA and key European healthcare systems. We highlight the differences between selected markets and provide a go-to guide for those looking to bring medical device innovations to the…
Native Bacillus licheniformis protease stands out as a significant player in the realm of enzymatic solutions, offering a wide array of benefits and applications due to its unique properties.
Enzymes play a pivotal role in various industrial processes, catalyzing biochemical reactions with precision and efficiency. Among the diverse classes of enzymes, proteases are essential components with the ability to break down proteins into amino acids, enabling various biological functions and industrial applications. Native Bacillus licheniformis protease stands out as a significant player in the realm of enzymatic solutions, offering a wide array of benefits and applications due to its unique properties. Understanding Bacillus licheniformis Protease Bacillus licheniformis, a common Gram-pos…
Enzymes play a pivotal role in various industrial processes, catalyzing biochemical reactions with precision and efficiency. Among the diverse classes of enzymes, proteases are essential components with the ability to break down proteins into amino acids, enabling various biological functions and industrial applications. Native Bacillus licheniformis protease stands out as a significant player in the realm of enzymatic solutions, offering a wide array of benefits and applications due to its unique properties. Understanding Bacillus licheniformis Protease Bacillus licheniformis, a common Gram-pos…
Enzymes are the fundamental building blocks of life, playing crucial roles in countless biological processes. One such remarkable enzyme is Native Porcine Prolidase, which has garnered significant attention in the scientific community due to its unique properties and diverse applications. In this article, we will delve into the intricacies of this remarkable enzyme, exploring its structure, function, physiological importance, and the ways in which it is leveraged in various industries.
Enzymes are the fundamental building blocks of life, playing crucial roles in countless biological processes. One such remarkable enzyme is Native Porcine Prolidase, which has garnered significant attention in the scientific community due to its unique properties and diverse applications. In this article, we…
Enzymes are the fundamental building blocks of life, playing crucial roles in countless biological processes. One such remarkable enzyme is Native Porcine Prolidase, which has garnered significant attention in the scientific community due to its unique properties and diverse applications. In this article, we…
Bile, a complex fluid produced by the liver and stored in the gallbladder, plays a crucial role in the digestion and absorption of fats, fat-soluble vitamins, and other essential nutrients. Ox bile extract powder, derived from the bile of oxen, is a natural supplement that has garnered significant interest in the scientific and healthcare communities for its versatile physiological functions and potential therapeutic applications.
Bile, a complex fluid produced by the liver and stored in the gallbladder, plays a crucial role in the digestion and absorption of fats, fat-soluble vitamins, and other essential nutrients. Ox bile extract powder, derived from the bile of oxen, is a natural supplement that has garnered significant interest in the scientific and healthcare communities for its versa…
Bile, a complex fluid produced by the liver and stored in the gallbladder, plays a crucial role in the digestion and absorption of fats, fat-soluble vitamins, and other essential nutrients. Ox bile extract powder, derived from the bile of oxen, is a natural supplement that has garnered significant interest in the scientific and healthcare communities for its versa…
Leading Swiss peptide and oligonucleotide manufacturer Bachem explains the considerations behind choosing between peptide synthesis methodologies
The demand for the manufacturing of polypeptides has radically increased since the recent introduction of new diabetes, obesity and cardiovascular disease peptide drugs. Consequently, peptide API manufacturing has seen a radical industrial intensification in line with increased commercialization to drive efficiency, improve quality and lower cost. To achieve this at a commercial scale, peptide APIs can be produced through two principle processes: synthetic or recombinant. Both methodologies offer unique advantages, with their own respective drawbacks. Thus, it’s vital to ensure that stakeholders are fully aware of the limits and st…
The demand for the manufacturing of polypeptides has radically increased since the recent introduction of new diabetes, obesity and cardiovascular disease peptide drugs. Consequently, peptide API manufacturing has seen a radical industrial intensification in line with increased commercialization to drive efficiency, improve quality and lower cost. To achieve this at a commercial scale, peptide APIs can be produced through two principle processes: synthetic or recombinant. Both methodologies offer unique advantages, with their own respective drawbacks. Thus, it’s vital to ensure that stakeholders are fully aware of the limits and st…
11-Jul-2024
The design and synthesis of hydrophobic amino acids hold immense significance in various scientific domains, including drug development, biochemistry, and materials science.
Hydrophobic amino acids are vital components in the realm of protein structure and function. While hydrophilic amino acids establish interactions with water molecules in the cellular environment, hydrophobic amino acids tend to congregate in the interior of proteins, contributing to their three-dimensional fold and stability. The synthesis of hydrophobic amino acids involves intricate chemical processes aimed at constructing these organic molecules with specific structural characteristics while ensuring high purity and yield. One common method for synthesizing hydrophobic amino acids is through solid-phase…
Hydrophobic amino acids are vital components in the realm of protein structure and function. While hydrophilic amino acids establish interactions with water molecules in the cellular environment, hydrophobic amino acids tend to congregate in the interior of proteins, contributing to their three-dimensional fold and stability. The synthesis of hydrophobic amino acids involves intricate chemical processes aimed at constructing these organic molecules with specific structural characteristics while ensuring high purity and yield. One common method for synthesizing hydrophobic amino acids is through solid-phase…
Antibody-drug conjugates (ADCs) have emerged as a promising class of targeted therapeutics in the field of oncology.
These molecules combine the specificity of monoclonal antibodies with the cytotoxic potency of small molecule drugs, thereby enabling precise delivery of potent anticancer agents to tumor cells while minimizing harm to healthy tissues. The efficacy of ADCs hinges on a delicate interplay between various components, with the payload playing a crucial role in determining the therapeutic potential of these complex molecules. ADC payloads, also known as cytotoxic or chemotherapeutic agents, are the active drug molecules that are conjugated to the antibody component of an ADC. These payloads are designed to induce cell death within targeted cancer cells, thereby achieving th…
These molecules combine the specificity of monoclonal antibodies with the cytotoxic potency of small molecule drugs, thereby enabling precise delivery of potent anticancer agents to tumor cells while minimizing harm to healthy tissues. The efficacy of ADCs hinges on a delicate interplay between various components, with the payload playing a crucial role in determining the therapeutic potential of these complex molecules. ADC payloads, also known as cytotoxic or chemotherapeutic agents, are the active drug molecules that are conjugated to the antibody component of an ADC. These payloads are designed to induce cell death within targeted cancer cells, thereby achieving th…
PG is commonly used as an excipient in a variety of drugs and is also approved for use in food and cosmetics.
About Propylene Glycol Propylene glycol (PG) is a clear, odorless, and viscous liquid that is miscible with water and many organic solvents. It is a small molecule that is structurally different and unrelated to PEG, despite a similar name. PG is commonly used as an excipient in a variety of drugs and is also approved for use in food and cosmetics. In addition, it has a wide range of other practical applications, such as antifreeze agent, cutting fluid, and as an additive to latex paints and coatings to increase freeze-thaw capabilities. Propylene Glycol as An Excipient Excipients are essential supports for active ingredients in drugs, vaccines and other products, contributing…
About Propylene Glycol Propylene glycol (PG) is a clear, odorless, and viscous liquid that is miscible with water and many organic solvents. It is a small molecule that is structurally different and unrelated to PEG, despite a similar name. PG is commonly used as an excipient in a variety of drugs and is also approved for use in food and cosmetics. In addition, it has a wide range of other practical applications, such as antifreeze agent, cutting fluid, and as an additive to latex paints and coatings to increase freeze-thaw capabilities. Propylene Glycol as An Excipient Excipients are essential supports for active ingredients in drugs, vaccines and other products, contributing…
Mtech Access are now part of Petauri. This marks a significant and exciting milestone in our journey, and aligns with our commitment to partnering with industry to bring life-enhancing technologies to market, providing more patient choice and meeting the needs of the healthcare environment.
What this means for our clients: Enhanced services: This strategic move will allow us to offer greater breadth and depth of technical and consulting experience, as well as market coverage for our clients. Continuity and stability: The quality of work and client service that you have come to expect, along with your current projects and relationships, will remain unchanged. Innovative solutions: Leveraging the strengths of the Petauri group, we will build on our commitment to growth and inn…
What this means for our clients: Enhanced services: This strategic move will allow us to offer greater breadth and depth of technical and consulting experience, as well as market coverage for our clients. Continuity and stability: The quality of work and client service that you have come to expect, along with your current projects and relationships, will remain unchanged. Innovative solutions: Leveraging the strengths of the Petauri group, we will build on our commitment to growth and inn…
The growing number of investments in T-cell transfer looks promising for market growth. Several new clinical trial initiations for T-cell therapies have risen exponentially over the years. The lack of manufacturing capacity for commercial-scale gene therapy production and viral-vector manufacturing has led to the opening of a wide number of CDMOs and in-house facilities for gene therapy manufacturing. This is anticipated to build profitable opportunities for the players.
The need to treat rare genetic diseases, enhance quality of life, and unlock the next wave of treatment innovations is projected to promote the growth of the gene therapy market. Various universities and institutes are home to a broad-ranging portfolio of products in the pipeline. In addition, several researchers are…
The need to treat rare genetic diseases, enhance quality of life, and unlock the next wave of treatment innovations is projected to promote the growth of the gene therapy market. Various universities and institutes are home to a broad-ranging portfolio of products in the pipeline. In addition, several researchers are…
19-Jun-2024
Both liquid and semi-solid formulations require a series of steps during the preparation process to ensure the quality and stability of the final product.
Similarities and Differences Between Liquid Formulation and Semi-solid Formulation Both liquid and semi-solid formulations require a series of steps during the preparation process to ensure the quality and stability of the final product. The similarities and differences between them are mainly reflected in the following aspects: Overall process: The preparation process of liquid preparations is usually more straightforward, which involves dissolving the drug in a solvent and completing the steps of mixing and stirring. The preparation process of semi-solid preparations requires more steps, such as mixing, heating, cooling, stir…
Similarities and Differences Between Liquid Formulation and Semi-solid Formulation Both liquid and semi-solid formulations require a series of steps during the preparation process to ensure the quality and stability of the final product. The similarities and differences between them are mainly reflected in the following aspects: Overall process: The preparation process of liquid preparations is usually more straightforward, which involves dissolving the drug in a solvent and completing the steps of mixing and stirring. The preparation process of semi-solid preparations requires more steps, such as mixing, heating, cooling, stir…
13-Jun-2024
Different techniques have been developed to functionalize nanotubes, including covalent and non-covalent approaches.
Nanotubes, with their unique properties and structure, have revolutionized various fields of science and technology. Over the past few decades, tremendous efforts have been made to functionalize nanotubes, unlocking their true potential for a wide range of applications. Understanding Functionalization of Nanotubes Functionalization refers to the process of modifying the surface properties of nanotubes, enabling them to interact with specific molecules or materials. This modification plays a crucial role in tailoring the physical and chemical properties of nanotubes, making them suitable for a variety of applications. Different techniques have been developed to functionalize…
Nanotubes, with their unique properties and structure, have revolutionized various fields of science and technology. Over the past few decades, tremendous efforts have been made to functionalize nanotubes, unlocking their true potential for a wide range of applications. Understanding Functionalization of Nanotubes Functionalization refers to the process of modifying the surface properties of nanotubes, enabling them to interact with specific molecules or materials. This modification plays a crucial role in tailoring the physical and chemical properties of nanotubes, making them suitable for a variety of applications. Different techniques have been developed to functionalize…
A recent poll conducted among clinical trial professionals has highlighted the most significant trends expected to transform the industry over the next five years
A recent poll conducted among industry professionals reveals significant insights into the evolving landscape of clinical trials. With 70% of respondents identifying increased use of AI and machine learning (ML) as the biggest trend, it is clear that integrating advanced technologies will play a pivotal role in shaping the future of clinical trials. Other notable trends include the rise of decentralized trials (14%), enhanced patient engagement tools (13%), and regulatory harmonization (4%). The Future of Clinical Trials: Key Trends As the clinical trials industry evolves, it faces numerous challenges, including data management in…
A recent poll conducted among industry professionals reveals significant insights into the evolving landscape of clinical trials. With 70% of respondents identifying increased use of AI and machine learning (ML) as the biggest trend, it is clear that integrating advanced technologies will play a pivotal role in shaping the future of clinical trials. Other notable trends include the rise of decentralized trials (14%), enhanced patient engagement tools (13%), and regulatory harmonization (4%). The Future of Clinical Trials: Key Trends As the clinical trials industry evolves, it faces numerous challenges, including data management in…
