Biotech - Articles

Organic Field Effect Transistor (OFET) materials have shown great promise for their use in organic bioelectronic devices. These materials offer several advantages that make them attractive for biomedical applications.
What are the Organic Field Effect Transistors (OFETs)? Organic Field Effect Transistors (OFETs) have gained significant attention in recent years due to their unique properties and potential applications in the field of organic electronics. As the demand for flexible and stretchable electronics continues to grow, the development of OFET materials that can withstand mechanical stress and strain becomes crucial. What are the Advancements in Flexible and Stretchable OFET Materials? 1. Elastomeric Substrates: One of the key requirements for achieving flexibility and stretchability…

Embarking on a systematic literature review is a critical step in evidence synthesis, providing a foundation for robust decision-making in the healthcare landscape. As with most things, there are ways to cut corners on systematic reviews. Sometimes there are true efficiencies to be made. Yet, all compromises have consequences. In this article, we delve into 11 common problems that may arise when cost-cutting compromises the quality of your systematic literature review.
1. Choosing the wrong type of systematic review methodology Selecting the wrong type of methodology for your review can have profound implications. A robust, gold standard Cochrane methodology involves two reviewers at all stages of the review, to avoid bias in the identification and presentation of the evidence, and ensur…

Photoresist resins are often used in conjunction with photosensitive agents and play a crucial role in making photoresist photosensitive.
Photoresist resin, also known as film-forming resin, is an inert polymer matrix. It is the core component of photoresist and constitutes the basic photoresist skeleton. Photoresist resins are often used in conjunction with photosensitive agents and play a crucial role in making photoresist photosensitive. The structures vary from different photoresist resins, which mainly determine the basic properties of the photoresist after exposure, including hardness, flexibility, adhesion, the solubility for specific solvents, optical properties, aging resistance, etching, thermal stability, etc. Resins for G/I-line resists The o-diazonaphthoquinone (DNQ)-phe…

The selection and careful inclusion of flavoring agents, buffers, plasticizers, and fragrance agents are crucial elements in the formulation of cosmetics.
Introduction Cosmetic products have become an integral part of our daily lives, enhancing our natural beauty and boosting our self-confidence. Behind every cosmetic product lies a complex formulation consisting of various ingredients. Among these ingredients, flavoring agents, buffers, plasticizers, and fragrance agents play crucial roles in enhancing the user experience and improving the overall quality of the product. Flavoring Agents Flavoring agents are commonly used in lip products, such as lipsticks and lip balms, to add a pleasant taste. These agents, sourced from natural or synthetic origins, provide a tempting sensation when…

Microneedles have gained significant attention in recent years due to their potential applications in various fields such as drug delivery, diagnostics, and tissue engineering.
Introduction Microneedles have gained significant attention in recent years due to their potential applications in various fields such as drug delivery, diagnostics, and tissue engineering. The preparation of microneedles requires precise and efficient technologies to achieve desired features such as size, shape, and mechanical strength. This article provides an overview of different technologies used for microneedle preparation, including 3D printing, etching, photolithography, and micro-electromechanical systems (MEMS) technology. 3D Printing Technology for Microneedle Preparation 3D printing technology offers a pr…

Expandable graphite serves as a crucial component in fire-resistant applications across various industries.
Flame Retardant Properties of Expandable Graphite One of the most renowned characteristics of expandable graphite lies in its exceptional flame retardant properties. When exposed to high temperatures or open flames, this substance undergoes a remarkable transformation. Under these conditions, the layers of graphite expand, forming a highly insulating intumescent barrier. This intumescent mechanism effectively prevents heat transfer, flame propagation, and the release of toxic gases. Consequently, expandable graphite serves as a crucial component in fire-resistant applications across various industries. Notably, when incorporated into polymers, such as polyurethane foams, exp…

Cobalt carbonate is an important precursor to cobalt oxide, cobalt powder, ceramic additives, organic cobalt compounds, and other products, and its purity determines the properties of downstream products.
Cobalt carbonate is an inorganic compound, the chemical formula is CoCO3, a pink crystalline powder, almost insoluble in water, alcohol, ethyl ether methyl ester, and ammonia, mainly used as a mineral dressing agent, catalyst, camouflage paint pigments, feed, trace fertilizers, ceramics, and raw materials for the production of cobalt oxide. Cobalt carbonate is an important precursor to cobalt oxide, cobalt powder, ceramic additives, organic cobalt compounds, and other products, and its purity determines the properties of downstream products. The products prepared by precipitation of s…

The main function of parathyroid hormone (PTH) is to regulate calcium and phosphorus metabolism in vertebrates, resulting in increased blood calcium levels and decreased blood phosphorus levels. At present, PTH is a large protein drug, and its administration route is still limited to injection due to its poor stability, which causes great inconvenience when administered frequently.
The main function of parathyroid hormone (PTH) is to regulate calcium and phosphorus metabolism in vertebrates, resulting in increased blood calcium levels and decreased blood phosphorus levels. At present, PTH is a large protein drug, and its administration route is still limited to injection due to its poor stability, which causes great inconvenience when administered frequently. Microneedle preparation steps …

Antibacterial, anti-inflammatory, and antiviral drugs are commonly used clinically. However, with the spread and evolution of drug resistance, the efficacy of these drugs, especially antibacterial and antiviral drugs, is declining.
Antibacterial, anti-inflammatory, and antiviral drugs are commonly used clinically. However, with the spread and evolution of drug resistance, the efficacy of these drugs, especially antibacterial and antiviral drugs, is declining. At present, there is no effective means to deal with the problem of drug resistance clinically, and the development of new drugs is urgently needed. Antibacterial Series Antibacterial series can be divided into antifungal drugs and antibacterial drugs. Common antibacterial drugs include β-lactams, aminoglycosides, macrolides, quinolone…

Pioneer Group highlights five key factors that life science entrepreneurs and start-ups should focus on to capture investors attention and support.
Establishing a life science start-up can be both thrilling and challenging, especially when seeking valuable start-up funding from investors. Really understanding what investors are looking for can, significantly shape your start-up’s trajectory. With this in mind, Pioneer Group, a company combining laboratory development and operation with venture building, shares some top tips directly from investors themselves on what they’re looking for in a life sciences company and highlights five key factors that life science entrepreneurs and start-ups should focus on to capture the attention and support of potential investors. 1. The Right People W…

Phosphorus catalysts are widely used in organic chemistry laboratories to convert acetic acid and formaldehyde into acrylic acid or used to catalyze hydrodesulfurization (HDS) and hydrodenitrogenation (HDN).
Phosphorus catalysts are widely used in organic chemistry laboratories to convert acetic acid and formaldehyde into acrylic acid or used to catalyze hydrodesulfurization (HDS) and hydrodenitrogenation (HDN). It also plays an important role in photocatalyst or electrocatalyst by combining phosphorus with carbon materials or other metals and metal derivatives such as TiO2. Catalyst Used in Organic Chemistry Lab: Vanadium phosphorus oxide catalyst (VPO) can convert acetic acid and formaldehyde into acrylic acid for the conversion of oxidized butane to maleic anhydride or for certain…

Many individuals may not be familiar with hydroxybutyrate dehydrogenase, an enzyme that plays a pivotal role in human health and medical research. Today, we delve into the essence of this crucial enzyme, its remarkable functions, and its applications in biotechnology.
Many individuals may not be familiar with hydroxybutyrate dehydrogenase, an enzyme that plays a pivotal role in human health and medical research. Today, we delve into the essence of this crucial enzyme, its remarkable functions, and its applications in biotechnology.   So, what is hydroxybutyrate dehydrogenase? It is a catalytic enzyme involved in the metabolism of ketone bodies, primarily Beta-Hydroxybutyrate (BH), in living organisms. It performs a rather complex biochemical task - converting Beta-Hydroxybutyrate to Ac…

CD73, also known as ecto-5′-nucleotidase, is a groundbreaking immunoinhibitory protein that assumes a pivotal role in tumor growth and metastasis. Its primary function revolves around converting extracellular ATP into immunosuppressive adenosine, working in tandem with CD39 within normal tissues to curtail excessive immune reactions. However, this mechanism is often hijacked by tumors, utilizing CD73 to foster an adenosinergic process that shields them from immune assaults.
Exploring the Structure and Function of CD73 The CD73 gene finds its home in the 6q14.3 region of human chromosome 6, encoding a protein comprised of 549 amino acid residues. CD73 functions as a glycosylphospholipase, residing on the cell membrane surface and engaging with the extracellular matrix through its extracellul…

Pharmaceutical excipients play a crucial role in the formulation and production of drugs, supporting their stability, efficacy, and palatability.
Pharmaceutical excipients play a crucial role in the formulation and production of drugs, supporting their stability, efficacy, and palatability. Among the numerous excipients used in pharmaceutical preparations, preservatives, stabilizers, suspending agents, thickener excipients, and flavoring agents are commonly observed. Understanding their functions and characteristics is essential for pharmaceutical scientists and formulators. In this article, we will delve into each of these excipients to gain a comprehensive understanding of their roles in drug formulation. Preservatives Preservatives are vital components in pharmaceutical formulations as t…

The preparation of microspheres by spray drying method is a method of spraying the liquid raw excipients into the hot drying medium to convert the raw excipients into dry powder in the spray dryer.
Microsphere Preparation Steps The preparation of microspheres by spray drying method is a method of spraying the liquid raw excipients into the hot drying medium to convert the raw excipients into dry powder in the spray dryer. The specific preparation process can be divided into three steps: the atomizer atomizes the original excipient solution into small droplets; the drying gas cures and dries the small droplets; and the dry particles are separated from the drying medium. Advantages of Spray Drying Technology Applicable to a variety of drugs, especially protein and peptide drugs with biol…

CRISPR-Cas9 is a gene editing technology that has changed the landscape of biological research. It stands for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-Associated Protein 9. CRISPR-Cas9 uses a two-component system consisting of a guide RNA (gRNA) and a Cas9 protein. The gRNA is designed to complement specific target sequences in the genome to guide the Cas9 protein to the desired location. Once the Cas9 protein reaches the target site, it causes a double-strand break in the DNA helix, which initiates a cellular repair process that can lead to gene modification or insertion.  Explore with our CRISPR Screen Sequencing Data Analysis Service and CRISPR Validation Sequencing Data Analysis Service for more information.
What is CRISPR-Cas9? CRISPR-Cas9 is a gene edi…

Nanopore sequencing, a pivotal component of long-read sequencing technology, has emerged as a formidable and promising approach in the realm of genomics and molecular biology. Spearheaded by the Oxford Nanopore Company, this innovative technology bears the potential to revolutionize genomic research and clinical applications.
  Nanopore sequencing, a pivotal component of long-read sequencing technology, has emerged as a formidable and promising approach in the realm of genomics and molecular biology. Spearheaded by the Oxford Nanopore Company, this innovative technology bears the potential to revolutionize genomic research and clinical applications.   The fundamental principle of nanopore sequencing revolves around the passage of individual DNA or RNA molecules through nanometer-s…

MicroRNAs (miRNAs) are a class of small endogenous non-coding RNAs of about 22 nt in length, with hairpin structures as precursors, which are widely found in animal, plant and viral organisms. Numerous studies have shown that miRNAs are involved in a wide range of biological processes, including cell proliferation, apoptosis, differentiation, metabolism, tumor and growth development, as well as in response to stress (including drought, high salt and nutrient stress).
What is Degradome Sequencing? MicroRNAs (miRNAs) are a class of small endogenous non-coding RNAs of about 22 nt in length, with hairpin structures as precursors, which are widely found in animal, plant and viral organisms. Numerous studies have shown that miRNAs are involved in a wide range of biological processes, including ce…

A fusion gene is a chimeric gene formed by the fusion of partial sequences of two genes, usually due to chromosomal translocations or deletions. These chimeric genes can form abnormal transcripts or proteins in subsequent biological processes, which can lead to or promote the development of tumors.
What is fusion gene? What is Chimeric RNAs? A fusion gene is a chimeric gene formed by the fusion of partial sequences of two genes, usually due to chromosomal translocations or deletions. These chimeric genes can form abnormal transcripts or proteins in subsequent biological processes, which can lead to or promote the development of tumors.   For example, in chronic granulocytic leukemia, molecular biology is characterized by the detection of a BCR-ABL fusion gene; this fusion gene translat…

Experimental design plays a crucial role in various research areas, providing a systematic framework for conducting experiments and obtaining reliable and interpretable results. Experimental design is critical, especially when trying to avoid attrition bias.
Experimental design plays a crucial role in various research areas, providing a systematic framework for conducting experiments and obtaining reliable and interpretable results. Experimental design is critical, especially when trying to avoid attrition bias.   Components of Experimental Design Within the realm of scientific inquiry, the formulation of a rigorous experimental design necessitates a profound comprehension of its intricate components and their interrelationships. To embark upon such a design, the foremost task ent…