Biotech - Articles

Pichia pastoris is a type of yeast that is commonly used in biotechnology for the production of recombinant proteins. It is known for its ability to efficiently produce heterologous proteins with high yields. Pichia pastoris offers several advantages for protein production:
What is pichia pastoris and their functions? Pichia pastoris is a type of yeast that is commonly used in biotechnology for the production of recombinant proteins. It is known for its ability to efficiently produce heterologous proteins with high yields. Pichia pastoris offers several advantages for protein production: Strong and tightly regulated promoters: Pichia pastoris has strong promoters, such as the alcohol oxidase (AOX) promoter, which can drive high levels of protein expression. The AOX promo…

Microsphere technology is at the intersection of cutting-edge disciplines such as materials science, polymer technology, medical technology, and microelectronics.
Microspheres are small spherical entities formed by dispersing or adsorbing drugs in a polymer matrix. The particle size is typically between 1 μm and 250 μm, and the largest can reach more than 800 μm. Microsphere technology is at the intersection of cutting-edge disciplines such as materials science, polymer technology, medical technology, and microelectronics. Once injected into the body, microspheres are gradually degraded in the body, allowing the drug to be released slowly at a certain rate, maintaining the drug concentration in the blood at the site of the lesion, thereby prolonging the half-life of the drug and achieving l…

MOFs have been extensively studied and used in the fields of gas storage, molecular separation, catalysis, and sustained drug release during the past 20 years.
Metal organic frameworks (MOFs) are a type of crystalline porous material with a periodic network structure formed by connecting and bridging inorganic metal centers (metal ions or metal clusters) with organic ligands. Because MOFs have many properties such as porosity, large specific surface area, strong designability, multi-metal sites, etc., they have been extensively studied and used in the fields of gas storage, molecular separation, catalysis, and sustained drug release during the past 20 years. Today, electrocatalytic technology plays an important role in the conversion of clean energy and contributes to the development of sus…

Host Cell Residual DNA (rcDNA) refers to fragments of DNA derived from host cells that may be present in biological products. These products must not contain foreign substances, particularly host DNA, to avoid immune rejection and potential threats to life safety. Regulatory agencies worldwide have imposed strict limits on the amount of rcDNA, and various pharmacopoeias have outlined several reliable methods for residual DNA quantification, including threshold methods, hybridization methods, and real-time quantitative PCR.
Host Cell Residual DNA (rcDNA) refers to fragments of DNA derived from host cells that may be present in biological products. These products must not contain foreign substances, particularly host DNA, to avoid immune rejection and potential threats to life safety. Regulat…

The presence of host cell proteins (HCPs) in therapeutic protein drugs can have adverse effects on the production process and product performance. To effectively assess and control the risks associated with HCPs in therapeutic protein products, it is crucial to develop methods that can identify and monitor all HCP components.
The presence of host cell proteins (HCPs) in therapeutic protein drugs can have adverse effects on the production process and product performance. To effectively assess and control the risks associated with HCPs in therapeutic protein products, it is crucial to develop methods that can identify and monitor all HCP components.   Traditional Methods and their Challenges The most commonly used method for HCP assay in therapeutic protein production is the enzyme-linke…

Nitric oxide (NO) plays a pivotal role in regulating various physiological processes, including vasodilation, platelet aggregation inhibition, neurotransmission, and antimicrobial activity. One of the key mechanisms by which NO exerts its effects is through protein S-nitrosylation. S-Nitrosylation involves the transfer of a nitroso group to cysteine residues, resulting in the formation of S-nitrosothiols (SNO). This reversible post-translational modification dynamically regulates protein activity, localization, stability, and intermolecular interactions, akin to the well-known phosphorylation process.
Introduction Nitric oxide (NO) plays a pivotal role in regulating various physiological processes, including vasodilation, platelet aggregation inhibition, neurotransmission, and antimicrobial…

Absolute Quantification (AQUA) is an innovative and powerful targeted quantitative proteomics technique that has gained widespread popularity across various proteomics studies. This cutting-edge approach allows for precise and accurate measurement of protein levels and their post-translational modification states.
Introduction: Absolute Quantification (AQUA) is an innovative and powerful targeted quantitative proteomics technique that has gained widespread popularity across various proteomics studies. This cutting-edge approach allows for precise and accurate measurement of protein levels and their post-translational modification states. By synthesizing peptides with stable isotopes as internal standards, AQUA effectively mimics native peptides generated through proteolysis. Moreover, thes…

Vaccine excipients can include adjuvants, stabilizers, preservatives, and additives. Each excipient serves a specific purpose in ensuring that vaccines are effective.
Infectious diseases seriously threaten human health, and various infectious diseases may cause millions of severe cases and even death every year. Vaccination has been one of the most effective public health interventions in history, preventing millions of deaths worldwide. However, the success of vaccines relies not only on the antigens they carry but also on additional components known as vaccine excipients. Vaccine excipients play a crucial role in the development and manufacturing of vaccines. These are substances added to the vaccine formulation to enhance its stability, efficacy, and safety. Vaccine excipients can includ…

Dive into our informative blog to discover how Clinion EDC's advanced AI-enabled features can revolutionize clinical trials. Read now to unlock valuable insights
Electronic Data Capture (EDC) software has revolutionized clinical trials, enabling clinical research teams to streamline data management and enhance operational efficiency. However, the true potential of EDC is realized when coupled with advanced features that leverage artificial intelligence (AI) and machine learning (ML). Among the sea of options, Clinion EDC stands out as a game-changer. Discover how Clinion EDC’s advanced AI-enabled features like eProtocol Automation, Global Libraries, AI Medical Coding and Remote SDV Automation set it apart from the competition, making it the ideal choice for accelerating your tr…

With the continuous development of high technology, the rapid analysis and detection technology of modern drugs has also been continuously improved.
Pharmaceutical analysis is a form of using all chemical, physical, biological, microbial and other means and methods to study the chemical properties of drugs. During the testing process, the stability of the drug itself, biological components and clinical drug use must be considered. With the continuous development of high technology, the rapid analysis and detection technology of modern drugs has also been continuously improved. Chromatography technology is a rapid detection method, and with continuous development, chromatographic detection technology is expected to have higher performance, higher stability and faster speed, which can ba…

The latest application of photocatalysis is for disease treatment, and the photocatalytic mosquito trap developed by Akira Fujishima has already been used in areas where malaria is rampant.
Photocatalyst is a general term for semiconductor materials with photocatalytic function represented by nano-scale titanium dioxide. The representative photocatalyst material is titanium dioxide, which can produce strong oxidizing substances under light irradiation, and can be used to decompose organic compounds, some inorganic compounds, bacteria and viruses. Photocatalyst Materials The commonly used photocatalyst semiconductor materials are titanium dioxide. ZrO2, ZnO, CdS, WO3, Fe2O3, PbS, SnO2, ZnS, SrTiO3, and SiO2 are also photocatalyst materials. Since 2000, it has been found that s…

Molecular dynamics simulation is a powerful and widely employed computational method that investigates the motion and interactions of molecules under different conditions, revealing the structure, dynamics, and physical-chemical properties of molecules. This article aims to delve into the fundamental principles, applications, and key techniques of molecular dynamics simulation, providing you with a better understanding of its significance and implications in the field.
Molecular dynamics simulation is a powerful and widely employed computational method that investigates the motion and interactions of molecules under different conditions, revealing the structure, dynamics, and physical-chemical properties of molecules. This article aims to delve into the fundamental principles, applications,…

Interleukin-2 (IL-2) is a 15kDa secretory protein with a 4-alpha-helical bundle structure. As a T-cell related growth factor, IL-2 can enhance the killing activity of NK cells and promote B cells to produce immunoglobulins. In addition, it aids in the development of regulatory T cells (Tregs), thereby producing peripheral T cell immune tolerance, as well as regulating the proliferation and differentiation of activated T cells. This article deliberates these traits and applications of IL-2, as an introductory material in the field of immunotherapy.
Interleukin-2 (IL-2) is a 15kDa secretory protein with a 4-alpha-helical bundle structure. As a T-cell related growth factor, IL-2 can enhance the killing activity of NK cells and promote B cells to produce immunoglobulins. In addition, it aids i…

Learn about the IL-17 family and its receptor complex in immune responses with Beta LifeScience. Explore our IL-17 series target proteins known for their high purity, variety, and activity. Take a look at these crucial proteins, highlighting their importance in immunity, antibody screening, and function evaluation.
Autoimmune disease target - IL-17 Family IL-17 plays an important role in promoting autoimmune diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis (AS). Currently, five large-molecule biopharmaceuticals targeting IL-17/IL-17R are available worldwide, including four IL-17 monoclonal antibodies and one IL-17RA monoclonal antibody, namely Secukinumab(Novartis), Ixekizumab(Eli Lilly), Netakimab(Biocad), Brodalumab(Kyowa Hakko Kirin), and Bimekizumab(UCB). &nbs…

Vascular Endothelial Growth Factor (VEGF) is a highly biologically active functional glycoprotein. It is a specific and potent mitogen for endothelial cells, playing a role in their proliferation, migration, and lumen formation. VEGF is involved in angiogenesis and increases capillary permeability. It can induce abnormal growth of tumor blood vessels, hinder the effective delivery of anti-tumor drugs to tumor tissues, and stimulate the production of new blood vessel growth factors.
Tumors and Blood Vessel Growth Tumor, as an abnormal mass of cells, has blood vessels of various sizes that can be seen everywhere on the surface and deep within it. Nutrients for life are continuously supplied to the depths of tumor cells through these blood vessels. As the tumor continues to grow, nearby bloo…

Matrix metalloproteinases (MMPs) are a family of enzymes belonging to the metzincin superfamily. There are 23 different types of secreted or membrane-anchored endopeptidases in the human body. It's been applied to the field of diagnostic research nowadays. This article is a brief introduction to the MMP3 family and its usage.
The MMP Family Matrix metalloproteinases (MMPs) are a family of enzymes belonging to the metzincin superfamily. There are 23 different types of secreted or membrane-anchored endopeptidases in the human body. MMPs are capable of degrading ECM proteins such as collagen, gelatin, laminin, fibronectin, fibrinogen, elastin, and proteoglycans. They were once considered regulators of the extracellular matrix. MMPs have multiple structural domains, including a signal peptide (…

Surfactants can increase the solubility of poorly soluble drugs in the dispersion medium, because surfactants can form micelles.
Surfactants have become a flexible and diverse class of fine chemical products due to their physical and chemical effects such as wetting or anti-sticking, emulsification or demulsification, foaming or defoaming, solubilization, dispersion, washing, anti-corrosion, etc. Currently, surfactants are most widely used as detergents in daily life, but they have been found potentially useful in many other fields. Characteristics of Surfactant Solubilization Surfactants can increase the solubility of poorly soluble drugs in the dispersion medium, because surfactants can form micelles, and surfactants are amphiphilic, if the polarity of the drug is small and the…

Pheromones have been widely used in pest management internationally in recent years as they are green and environmentally friendly, making fruit and vegetable safer.
Insect pheromones are compounds used to express various information such as aggregation, foraging, mating, and vigilance. Insect pheromones exist in insects in nature, and all insects produce and recognize pheromones. Insect pheromones have been widely used in pest management internationally in recent years as they are green and environmentally friendly, making fruit and vegetable safer. What are insect pheromones made of? Insect pheromones are mainly composed of alkanes and alkenes, most of which are straight-chain unsaturated acetates with 10-18 carbons and their alcohols or aldehydes, and a few contain epoxy s…

Valuation is a frequently employed practice in the pharma industry. It plays a pivotal role in a multitude of decision-making processes including new product planning, opportunity assessment, fund raising, investment, licensing, partnering and M&A. In this article, we address some of the critical aspects that must be considered when conducting valuation of pharmaceutical companies and their assets.
Valuation is a frequently employed practice in the pharma industry. It plays a pivotal role in a multitude of decision-making processes including new product planning, opportunity assessment, fund raising, investment, licensing, partnering and M&A. In this article, we address some of the critical aspects that must be considered when conducting valuation of pharmaceutical companies and their a…

Carbon fiber composite materials have begun to find use in various industries and its charm has been gradually recognized worldwide.
Carbon fiber is a new type of fiber material with high strength and with a carbon content of more than 95%. It is a microcrystalline graphite material obtained by piling up organic fibers such as flake graphite microcrystals along the fiber axial direction, and then undergoing carbonization and graphitization treatments. Carbon fiber is a new material with excellent mechanical properties. Its specific gravity is less than 1/4 of that of steel. The tensile strength of carbon fiber resin composites is generally above 3500Mpa, which is 7-9 times that of steel. The tensile modulus of elasticity is 23000 to 43000Mpa, also higher than steel. Performance of…