Biotech - Articles

Thermo Fisher Scientific (US) and Tecan Group (Switzerland) are Leading Players in the Lab Automation Market
Introduction In the fast-paced world of scientific research and discovery, time and precision are of the essence. Laboratories across the globe are constantly seeking ways to optimize their workflows, reduce manual errors, and enhance overall efficiency. This quest for progress has led to the rapid growth of the Lab Automation Market, offering innovative solutions that redefine the way science is conducted. From pharmaceuticals to biotechnology, from academics to industrial applications, Lab Automation has become an indispensable tool, empowering researchers and scientists alike. The global lab automation market is projected to reach USD 7.1 billion by 2028 from USD 5.1 billion in 20…

Enzymes, nature's molecular architects, have been at the heart of industrial processes for decades. Today, the dynamic field of Enzyme Engineering and Modification is driving these biocatalysts towards unprecedented capabilities, triggering a wave of transformative applications across diverse sectors.
Enzymes, nature's molecular architects, have been at the heart of industrial processes for decades. Today, the dynamic field of Enzyme Engineering and Modification is driving these biocatalysts towards unprecedented capabilities, triggering a wave of transformative applications across diverse sectors.   Decoding Enzyme Engineering Enzyme Engineering stands as a cornerstone of modern biotechnology, involving the strategic redesign of enzymes to amplify their inherent functionalities or int…

The expedition of harnessing the therapeutic potential of probiotics is intricately intertwined with Industrial Development Services, a pivotal enabler in propelling probiotic research and application.
In the realm of modern health and wellness, the symbiotic relationship between humans and their gut microbiota has taken center stage. Probiotics, or "friendly bacteria," have garnered immense interest for their potential to influence various physiological processes, from digestive health to immune modulation. The expedition of harnessing the therapeutic potential of probiotics is intricately intertwined with Industrial Development Services, a pivotal enabler in propelling probiotic research and application.   Deciphering Probiotics Probiotics, as live microorganisms, are predominantly s…

Fc-Fusion proteins exhibit intricate structural diversity and complex glycosylation modifications, necessitating sophisticated techniques for accurate analysis. This article outlines various methodologies for characterizing Fc-Fusion glycosylation, emphasizing the importance of site-specific information to elucidate their functional and safety implications.
Fc-Fusion proteins exhibit intricate structural diversity and complex glycosylation modifications, necessitating sophisticated techniques for accurate analysis. This article outlines various methodologies for characterizing Fc-Fusion glycosylation, emphasizing the importance of site-specific information to elucidate their functional and safety implications.   Glycoprotein Analysis Approaches Glycoprotein analysis is tailored based o…

Cytokines represent a class of small protein molecules that exhibit diverse biological activities. These molecules are synthesized and secreted primarily by immune cells (including monocytes, macrophages, T cells, B cells, and NK cells) as well as certain non-immune cells (such as endothelial cells, epidermal cells, and fibroblasts) upon specific stimulation. Cytokines play pivotal roles in regulating intrinsic and adaptive immunity, hematopoiesis, cell growth, pluripotent cells, and tissue repair.
Cytokines represent a class of small protein molecules that exhibit diverse biological activities. These molecules are synthesized and secreted primarily by immune cells (including monocytes, macrophages, T cells, B cells, and NK cells) as well as certain non-immune cells (such as endothelial cel…

Proximity labeling techniques represent a cutting-edge approach wherein a decoy protein of interest is fused with an enzyme capable of indiscriminately labeling neighboring proteins. These labeled proteins are referred to as "prey" proteins.
Proximity labeling techniques represent a cutting-edge approach wherein a decoy protein of interest is fused with an enzyme capable of indiscriminately labeling neighboring proteins. These labeled proteins are referred to as "prey" proteins.   The field of protein labeling has witnessed significant advancements, prominently featuring proximity-tagging enzymes. Among these, Biotin-dependent biotin identification (BioID) utilizing biotin ligase mutants, primarily the biotin ligase (BirA), has been instrumental. BirA labels lysine residues of proximat…

In recent years, nucleic acid therapy involving various types of ribonucleic acids (RNAs), including messenger RNA (mRNA), small interfering RNA (siRNA), and microRNA (miRNA), has rapidly emerged as a new cornerstone of modern medicine. Among them, the mRNA-based vaccines developed, particularly the COVID-19 vaccine, have played a significant role in combating the novel coronavirus (SARS-CoV-2) responsible for severe acute respiratory syndrome. The remarkable speed of sequence design and the ease of large-scale production associated with mRNA-based technologies have provided novel possibilities in addressing urgent and ever-evolving medical crises.
In the present context of successful mRNA drugs, the further synthesis of linear mRNA into circular RNA (circRNA) through end-to-end connec…

Antibody-drug conjugates (ADCs), as emerging anticancer drugs, can deliver highly cytotoxic molecules directly to cancer cells to kill them.
ADC is a monoclonal antibody covalently bound to cytotoxic chemical substances (payload) through linker. ADC linker plays a key role in the therapeutic effect of ADC, and its characteristics greatly affect the therapeutic index, pharmacodynamics and pharmacokinetics of ADC. For example, the linkage between linker-mAb determines the drug-antibody ratio (DAR), which determines the homogeneity and stability of ADC. In order to ensure the selectivity and efficacy of ADC, linker should strive to achieve three key features : (1) High cycle stability: Payload will not be released before it reaches the target, thereby minimizing the off-target effect…

Antibody-drug conjugates (ADCs) have revolutionized the field of targeted cancer therapy by combining the specificity of monoclonal antibodies with the potency of cytotoxic drugs. ADCs have shown remarkable clinical success, leading to several FDA-approved therapies. However, the development of the next generation of ADCs presents new strategies and challenges that must be addressed to improve efficacy, safety, and therapeutic index. This article explores the innovative approaches taken to optimize ADC design, enhance tumor targeting, and overcome resistance mechanisms, while also discussing the challenges faced in the development of these promising therapeutics.
Improved Linker and Payload Selection: The selection of suitable linkers and cytotoxic payloads greatly impacts ADC stability, ef…

During the research and development process of pharmaceutical preparations, comprehensive and reliable interaction studies are essential.
Pharmaceutical formulations consist of active pharmaceutical ingredients (APIs) and excipients. Appropriate excipient selection is critical to the final quality of pharmaceutical products. When designing pharmaceutical preparations, the choice of excipients should not only consider the dosage form factors and excipient functions but also the interaction and compatibility between APIs and excipients. Therefore, during the research and development process of pharmaceutical preparations, comprehensive and reliable interaction studies are essential. These studies not only serve as a foundat…

Post-translational modifications (PTMs) are essential chemical alterations that occur on proteins after their synthesis. These modifications play a crucial role in regulating protein function, cellular signaling, and overall biological processes. To unravel the mysteries of PTMs and understand their functional implications, scientists have developed PTM prediction tools that utilize computational approaches. In this article, we will explore the significance of PTMs, the power of PTM predictions, and their applications in protein research.
Post-translational modifications (PTMs) are essential chemical alterations that occur on proteins after their synthesis. These modifications play a crucial role in regulating protein function, cellular signaling, and overall biological processes. To unrave…

The Karl Fischer method is suitable for the determination of all kinds of substances: chemicals, oils, pharmaceuticals and food, etc.
The Karl Fischer method is an analytical method for the determination of moisture proposed by Karl Fischer in 1935. It is suitable for the determination of all kinds of substances: chemicals, oils, pharmaceuticals and food, etc. At present, Karl Fischer titration has developed into a moisture analysis method widely used in the world. In this article, we will discuss how the Karl Fischer moisture detection test can be applied to complex samples. Insoluble samples In the moisture detection of some samples, laboratory personnel may often encounter that some samples are difficult to dissolve or have poor solubility, resulting in the inability…

Alkaloids possess significant medicinal, pharmaceutical, and ecological importance, making them a subject of extensive research by leading companies.
In the realm of organic chemistry, one class of compounds has captured the scientific community's attention for decades - alkaloids. These naturally occurring compounds are known for their diverse chemical structures and profound biological activities. Many alkaloids have been discovered and studied extensively over the years, with more than 20,000 known alkaloids identified to date. Alkaloids possess significant medicinal, pharmaceutical, and ecological importance, making them a subject of extensive research by leading companies. In this article, we will delve into the intriguing world of alkaloids, exploring their sources, structures, and at…

How can you ensure that the market access materials, value proposition and evidence developed by global teams, will resonate for your local audience? In this article, our experts pool their knowledge to share their top tips for successfully taking global materials local.
How can you ensure that the market access materials, value proposition and evidence developed by global teams will resonate for your local audience? National market access teams and other local affiliates are regularly required to adapt global value materials to reflect the nuances and requirements of their local healthcare systems. At Mtech Access, we have a wealth of experience in developing customer communication materials at both global and affiliate level. Leading Pharma and Medtech companies regularly engage…

Dickkopf-1 (DKK1), is a protein that plays a critical role in regulating the Wnt signaling pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and embryonic development. It is an important antagonist of the Wnt pathway, meaning that it inhibits Wnt signaling by binding to specific receptors and preventing the activation of downstream signaling molecules.
Introduction to DKK1 Dickkopf-1 (DKK1), is a protein that plays a critical role in regulating the Wnt signaling pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and embryonic development. It is an important antagonist of the Wnt pathway, meaning that it inhibits Wnt signaling by binding to specific receptors and preventing the acti…

A tumor suppressor gene, also known as anti-onco gene, is an essential component of the body's defense against cancer. It usually facilitates apoptosis. With its absence, the human body will be functioning without its “brake” of cell proliferation. Cells are potent to go under abnormal growth processes and finally lead to tumor/cancer.
About Tumor Suppressor Genes A tumor suppressor gene, also known as anti-onco gene, is an essential component of the body's defense against cancer. It usually facilitates apoptosis. With its absence, the human body will be functioning without its “brake” of cell proliferation. Cells are potent to go under abnormal growth processes and finally lead to tumor/cancer. Here are some key features and functions of tumor suppressor genes: Inhibition of Cell Growth:…

Homocysteine, an important biomarker in the field of clinical diagnostics, plays a significant role in assessing cardiovascular disease risk, vitamin deficiencies, and genetic disorders. Accurate and sensitive detection of homocysteine levels is crucial for early intervention and personalized patient care. In this article, we delve into the fascinating world of enzymes for producing the Homocysteine Assay Kit, shedding light on the mechanisms behind this powerful diagnostic tool.
Homocysteine, an important biomarker in the field of clinical diagnostics, plays a significant role in assessing cardiovascular disease risk, vitamin deficiencies, and genetic disorders. Accurate and sensitive detection of homocysteine levels is crucial for early intervention and personalized patient care. In this…

In the world of enzymes, one remarkable protein stands out for its exceptional properties and diverse applications – Kex2 Protease from Saccharomyces cerevisiae, Recombinant. This cutting-edge enzyme has garnered significant attention in the biotechnology industry due to its versatile nature and remarkable catalytic abilities. In this article, we will delve into the world of Kex2 Protease, exploring its origins, structure, and remarkable potential across various fields.
Introduction In the world of enzymes, one remarkable protein stands out for its exceptional properties and diverse applications – Kex2 Protease from Saccharomyces cerevisiae, Recombinant. This cutting-edge enzyme has garnered significant attention in the biotechnology industry due to its versatile nature and remarkable catal…

The gut microbiota, a diverse community of microorganisms residing in our gastrointestinal tract, plays a crucial role in maintaining our overall health. Probiotics, live microorganisms with potential health benefits, have garnered significant attention for their ability to promote gut health. In this article, we will delve into the science behind probiotic formulas, exploring their mechanisms of action and scientific evidence supporting their use in maintaining a healthy gut.
The gut microbiota, a diverse community of microorganisms residing in our gastrointestinal tract, plays a crucial role in maintaining our overall health. Probiotics, live microorganisms with potential health benefits, have garnered significant attention for their ability to promote gut health. In this article, we will…

Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) is a powerful technique that allows for the quantification and characterization of proteins in cells and organisms. It involves the substitution of specific amino acids with their isotopically labeled counterparts in cell culture media. This labeling enables researchers to track and compare protein expression levels, protein-protein interactions, and post-translational modifications, among other biological processes.
Several recent breakthroughs have been made using SILAC, enhancing its applications and expanding its potential. Here are some notable advancements: Proteome-wide analysis: SILAC has been used to perform comprehensive proteome-wide quantification, enabling the identification and quantification of thousands of protei…