Research and development - Articles

In this blog post, we will find out how electronic clinical outcome assessments are helping the clinical trials industry handle the ever-growing list of patient data and, at the same time, reduce patient burden!
With the rising demand for improving patient safety in clinical trials, the adoption of patient-centric solutions is considered the best route to enhance data accuracy and experience automated workflows. This is where eCOA comes into play. In this blog post, we will find out how electronic clinical outcome assessments are helping the clinical trials industry handle the ever-growing list of patient data and, at the same time, reduce patient burden! What is eCOA? Electronic clinical outcome assessment (eCOA) refers to the process of leveraging technology to better capture data and enh…

Electroplating intermediate is an additive material for electroplating modification in terms of grain size, gloss, thickness, and plating speed.
Electroplating intermediates refer to a class of fine chemicals used as electroplating additives. Unlike the salt used in the plating production process, the electroplating intermediate is an additive material for electroplating modification in terms of grain size, gloss, thickness, and plating speed. How Can Electroplating Intermediates be Classified? According to the different plating types, electroplating intermediates can be divided into nickel plating intermediates, copper plating intermediates, tin plating intermediates, gold plating intermediates, silver plating intermediates, etc. Meanwhile, according to different functions, electropla…

Amplexor partners share insights and predictions for the future of the Life Sciences Regulatory sector, ranging from transitioning to data-first ways of working to tackling resource challenges within condensed timeframes. Renato Rjavec of Amplexor Life Sciences reports.
Amplexor partners share insights and predictions for the future of the Life Sciences Regulatory sector, ranging from transitioning to data-first ways of working to tackling resource challenges within condensed timeframes. Renato Rjavec of Amplexor Life Sciences reports. The following Amplexor partners contributed to this article: Steve Gens, Managing Partner, Gens & Associates, a boutique Life Science benchmarking and advisory firm specialising in operational performance improvement, benchmarking, World Class RIM℠, and…

Carbon nanomaterials have been speedily developed due to their unique electronic, optical, thermal, mechanical, and chemical nature.
History of Development As early as 1985, the discovery of fullerene with the “football” structure immediately attracted the world’s attention. Then, carbon nanotubes with a hollow cylindrical structure are formed based on mild modifications toward fullerenes. In 1991, Japanese researchers discovered carbon nanotubes in carbon fibers for the first time. In 2004, researchers discovered the 2D planar nanomaterial whose planar thickness is confined to the nanoscale range. At the same time, researchers also developed a practical “scotch tape” technique to separate single-layer graphene from bulk graphene. Buckyballs (fullerenes), carbon nanotubes, and graphene all…

ICH Q3D presents major challenges to testing and risk assessments associated with meeting current rigorous limits for specific components to assess patient risk. The probability that sure elemental impurities area unit gift in a very healthful product ought to be determined through a legitimate risk assessment.
The mission of the International Council for Harmonisation of Technical needs for prescription drugs for Human Use (ICH) is to make sure safe, effective, and high-quality medicines area units are developed and distributed. This is often accomplished by making worldwide harmonization. Harmonization achievements within the quality space include: Essential milestones like the conduct of stability studies Process relevant thresholds for impurities testing A lot of versatile approaches t…

In the early 20th century, humans discovered vitamins, and then trace elements and minerals. It was only in the mid-1980s that humans realized the importance of enzymes. Nobel Prize in Physiology and Medicine Arthur Kornberg said: "For our lives, we can no longer find other substances as important as enzymes in nature." Enzymes control the entire body, and when enzymes function abnormally is fatal to human.
In the early 20th century, humans discovered vitamins, and then trace elements and minerals. It was only in the mid-1980s that humans realized the importance of enzymes. Nobel Prize in Physiology and Medicine Arthur Kornberg said: "For our lives, we can no longer find other substances as important as enzymes in nature." Enzymes control the entire body, and when enzymes function abnormall…

Fluorescent dyes are a valuable tool in biological analysis, as they can be used to visualize and track biomolecules such as proteins and nucleic acids. These dyes are able to emit light when exposed to certain wavelengths of light, which allows them to be easily detected and studied using specialized instruments such as fluorescence microscopes and spectrophotometers.
Fluorescent dyes are a valuable tool in biological analysis, as they can be used to visualize and track biomolecules such as proteins and nucleic acids. These dyes are able to emit light when exposed to certain wavelengths of light, which allows them to be easily detected and studied using specialized instruments such as fluorescence microscopes and spectrophotometers. Fluorescent dyes can be used to label biomolecules and tr…

Bioanalytical is a field that uses various techniques to study biological samples and detect, measure, and analyze biological molecules. This field is crucial for a wide range of applications, including drug development, environmental monitoring, and diagnostics.
Bioanalytical is a field that uses various techniques to study biological samples and detect, measure, and analyze biological molecules. This field is crucial for a wide range of applications, including drug development, environmental monitoring, and diagnostics. The bioanalytical market is a rapidly growing market that is driven by increasing demand for advanced analytical tools and techniques. This market is primarily driven by the need for high-quality, reliable, and accurate analysis of biological samples. One of the key driver…

The spotlight is on data as it becomes increasingly central to Life Sciences processes. Deloitte’s Patrick Middag and Dennie van de Voort set out recommendations for developing and embedding an effective enterprise data governance strategy.
The impact of any digital process transformation program relies heavily on the quality and reliability of the data that feeds into those processes. If that data is patchy, inconsistent, out of date, or incorrect, risks will be magnified each time someone re-uses that data. Operationally, inconsistent information exchanged with the regulators will lead to non-compliance risks, risks of poor quality and ultimately patient safety and public health risks. More strategically, it will limit companies’ ability to perform useful data analytics and to increase th…

Photosensitive resins, as a type of photosensitive materials, are widely used in medical, construction, printing, 3D printing and other industries due to their fast curing time and low pollution.
Photosensitive materials are made up of polymers that can undergo rapid physical and chemical changes in a relatively short period of time after being irradiated by light. Photosensitive materials are advanced by high production efficiency, high energy utilization rate, low organic volatile matter emission, and enhanced flexibility in coating various substrates, such as paper, plastic, leather, metal, glass, and ceramics. What are the uses of photosensitive materials? Photosensitive resins, as a type of photosensitive materials, are widely used in medical, co…

These experiences and lessons for the sensor based on biological engineering, such as molecular probes or the design of gene encoding vectors emerging diagnosis provides the basis for the sensors using the imbalance characteristics of the early tumor or its precursor, generate a signal amplification, these exogenous sensors using tumor dependency activation mechanism, such as enzyme amplification, to drive the synthesis of biomarkers and magnified. Cancer can also be detected by imaging systems that may have the essential features of synthetic biomarker approaches, such as reporter gene imaging. These emerging technologies have promoted the development of early cancer detection, and synthetic biomarkers may become the future method of early cancer detection.
Introduction   Early detect…

More than two decades after the discovery of RNAi, siRNA drugs have opened new avenues for innovative therapies for many diseases. Although there are several significant challenges and limitations, including siRNA delivery and side effects, that have slowed the clinical translation of this novel class of pharmacological compounds, several siRNA drugs have been approved for clinical use and several more are in late-stage clinical studies. siRNA targeting any target gene also highlights the need to identify the best target.
The concept of RNA interference (RNAi) was raised in 1998 and is a naturally occurring defense mechanism against exogenous nucleic acid invasion and control of gene expression. Soon thereafter, small interfering RNAs (siRNAs) were identified as mediators of RNAi in ma…

Fluorescent labeling is the process of covalently attaching fluorescent groups to molecules such as proteins and nucleic acids. Such processes are typically accomplished using derivatives of the fluorescein group that is capable of selectively reacting with functional groups present on the target molecule.
Fluorescent labeling is the process of covalently attaching fluorescent groups to molecules such as proteins and nucleic acids. Such processes are typically accomplished using derivatives of the fluorescein group that is capable of selectively reacting with functional groups present on the target molecule. The most common labeled molecules are antibodies, and labeled antibodies are often used to detect specific target molecules. Fluorescent labels can be used in a variety of detection sys…

Mobile medical applications development is a vibrant health IT field. According to Grand View Research, the mHealth market will see incremental growth at a CAGR of 11.8% from 2022 to 2030. Is it the right time to start and run such a project?
Carried away by the scope of work or its complexity, mHealth developers can lose track or miss some valuable steps. Here are some tips from a medical app development company.  Pre-project planning A mobile health app project could be challenging and require careful preparation. The work involves three main steps: Conducting a large-scale research Before launching a project, you should assess the market and the dominant health IT trends. It also makes sense to study potential user needs and competitor offers. You could estimate how well top existin…

Provided to more than a quarter of cancer patients, today’s targeted radiotherapy has come a long way from its experimental, and Nobel Prize winning, origins. When administering the treatment, shaping of the beam is an important way of minimising the absorbed radiation in healthy tissue and delivering an accurate dose. Here, Stewart Goulding, managing director of high torque DC motor supplier Electro Mechanical Systems explains how multileaf collimators (MLC) deliver accuracy in radiotherapy.
Provided to more than a quarter of cancer patients, today’s targeted radiotherapy has come a long way from its experimental, and Nobel Prize winning, origins. When administering the treatment, shaping of the beam is an important way of minimising the absorbed radiation in healthy tissue and delivering…

Due to their special energy level structure, quantum dots exhibit unique physical properties. This article mainly discusses some properties of quantum dots, including quantum confinement effect, quantum size effect, surface effect and luminescence property.
Quantum dots, also known as semiconductor nanocrystals, are nanoscale materials composed of a small number of atoms. The number of atoms in a quantum dot is usually between a few and a few hundred, and their size in all three dimensions are less than 100 nm. The movement of carriers in the three dimensions of quantum dots is limited by the size effect. Due to the quantum confinement effect, the energy levels of carriers in quantum dots are similar to those of atoms having a discontinuous energy level structure, so quantum dots are also c…

In the drug company trade, with more uncertainties from the method of a research project, project management becomes tougher.
In the drug company trade, with more uncertainties from the method of a research project, project management becomes tougher. Project management within the pharmaceutical trade involves: Scope management Project coming up with, executing, and watching Timeline and budget coming up with and management Stakeholder management Management of regulative and compliance ways Environmental safety Risk management Team management Challenges underlie each of those aspects of project management. The interdependencies between these components create even additional advanced. Whereas the developed product is also effective for the supposed use, it's going to need dangerous chemi…

The novel DUBTAC therapeutic platform enables the development of novel drugs against a wide range of human diseases, including cancer and neurodegenerative diseases as well as a variety of inherited diseases, by targeting abnormally degraded pathogenic proteins previously thought to be untargeted.
The use of Proteolysis Targeting Chimeras (PROTACs) to degrade dysfunctional proteins has shown great potential to target proteins that were previously considered “undruggable”, and several projects have entered clinical evaluation worldwide.   Aberrant protein degradation, in fact, is also a pathogenic mechanism in some diseases, such as cystic fibrosis (CF) and some forms of cancer. Therefore, for these diseases, targeted protein stabilizers (TPS), rather than targeted protein degraders (TP…

Staining is one of the most important steps in the preparation of biological microscope slides. First destroy the selective permeability of the cell membrane, and then use the dye to immerse the biological tissue in the dye, so that a certain part of the tissue cells is dyed with a different color or depth of color from other parts, resulting in different refractive indices for observation.
Staining is one of the most important steps in the preparation of biological microscope slides. First destroy the selective permeability of the cell membrane, and then use the dye to immerse the biological tissue in the dye, so that a certain part of the tissue cells is dyed with a different color or depth of color from other parts, resulting in different refractive indices for observation. Commonly used…

Nano-materials, which made of silicon, gallium arsenide and other semiconductor materials, possess many excellent properties.
Nano-magnetic materials In practice, most of the nanomaterials are artificial. Magnetic nano-materials made up of small-sized nano-particles and single-domain structures, so they have very special magnetic properties and high coercivity properties. Recording materials that made up of magnetic nanomaterials are not only possess good sound, image quality, and high SNR(signal to noise ratio), but also have several times recording density of?-Fe2O3. Superparamagnetic ferromagnetic nanoparticles can also be made into magnetic fluids for electroacoustic devices, damping devices, rotary seals, lubrication and beneficiation fields. Nano-ceramic materials Traditional ceramic…